Full Text Journal Articles in
Journal Curr. Opin. Infect. Dis.

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Central nervous system infections produced by varicella zoster virus.

Maria A Nagel, Christy S Niemeyer, Andrew N Bubak,

PURPOSE OF REVIEW:Varicella zoster virus (VZV) causes varicella, establishes latency, then reactivates to produce herpes zoster. VZV reactivation can also cause central nervous system (CNS) disease with or without rash. Herein, we review these CNS diseases, pathogenesis, diagnosis, and treatment. RECENT FINDINGS:The most common CNS manifestation of VZV infection is ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):273-278]

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Tuberculous meningitis: where to from here?

Joseph Donovan, Guy E Thwaites, Julie Huynh,

PURPOSE OF REVIEW:Tuberculous meningitis (TBM) is associated with significant mortality and morbidity yet is difficult to diagnose and treat. We reviewed original research published in the last 2 years, since 1 January 2018, which we considered to have a major impact in advancing diagnosis, treatment and understanding of the pathophysiology ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):259-266]

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Update on group A streptococcal vaccine development.

James B Dale, Mark J Walker,

PURPOSE OF REVIEW:There is a global need for well tolerated, effective, and affordable vaccines to prevent group A streptococcal infections and their most serious complications. The aim of this review is to highlight the recent progress in the identification of promising vaccine antigens and new approaches to vaccine design that ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):244-250]

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Antibody glycosylation in pregnancy and in newborns: biological roles and implications.

Thomas F Rice, Beth Holder, Beate Kampmann,

PURPOSE OF REVIEW:Glycosylation patterns have the potential to affect the function of antibody, antibody half-life and transplacental transfer from mother to foetus. Here, we review recent advances in our understanding of how glycosylation patterns of antibodies may be altered during pregnancy, vaccination and infection. RECENT FINDINGS:During pregnancy, there is preferential ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):225-230]

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Unraveling Haemophilus influenzae virulence mechanisms enable discovery of new targets for antimicrobials and vaccines.

Jeroen D Langereis, Marien I de Jonge,

PURPOSE OF REVIEW:The human upper respiratory tract is colonized with a variety of bacterial microorganisms including Haemophilus influenzae. The species H. influenzae consists of typeable and nontypeable H. influenzae (NTHi) variants. Typeable H. influenzae are subdivided into types a through f, based on the polysaccharide capsule, whereas the NTHi strains ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):231-237]

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Acute infectious myelopathies.

Carlos M Isada, Ryan Miller,

PURPOSE OF REVIEW:The patient who presents with an acute spinal cord syndrome with weakness/paralysis of the limbs presents a diagnostic. Two important syndromes are acute transverse myelitis (ATM) and acute flaccid paralysis (AFP). Both can be caused by a number of infectious and noninfectious causes. Since 2014 there have been ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):251-258]

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CNS infections in HIV.

Kiran T Thakur,

PURPOSE OF REVIEW:Central nervous system (CNS) infections associated with HIV remain significant contributors to morbidity and mortality, particularly among people living with HIV (PLWH) in resource-limited settings worldwide. In this review, we discuss several recent important scientific discoveries in the prevention, diagnosis, and management around two of the major causes ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):267-272]

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Anatomical site-specific immunomodulation by bacterial biofilms.

Christina N Morra, Carlos J Orihuela,

PURPOSE OF REVIEW:The human body plays host to bacterial biofilms across diverse anatomical sites. The treatment of pathogenic biofilm infection is confounded by their high rate of antibiotic resistance. Therefore, it is critical to understand the interplay between these biofilms and the host immune system to develop new tactics to ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):238-243]

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New treatment options for multiresistant gram negatives.

David L Paterson, Burcu Isler, Adam Stewart,

PURPOSE OF REVIEW:Multidrug-resistant (MDR) Gram-negative bacteria infections are listed among the top public health threats of the current era. As a result, there has been an increase in efforts to develop new therapeutic agents against MDR Gram-negatives. The purpose of this review is to summarize the clinical and preclinical findings ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):214-223]

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Advances in the diagnosis and treatment of latent tuberculosis infection.

Ye Eun Grace Jung, Neil W Schluger,

PURPOSE OF REVIEW:This review describes the major developments in the rationale for treating latent tuberculosis infection; new approaches to identifying persons with latent infection who are most likely to progress to active disease; and the development of novel short-course regimens for treatment of latent tuberculosis. RECENT FINDINGS:As many as one-third ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):166-172]

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Optimizing aerosol delivery of antibiotics in ventilated patients.

Stephan Ehrmann, Charles-Edouard Luyt,

PURPOSE OF REVIEW:The aim of the article is to review the evidence to select ventilated patients most likely to benefit from inhaled antibiotic therapy and summarize the optimal implementation setup to favor clinical success. RECENT FINDINGS:Although a large body of literature describes the optimal ventilator circuit and settings to implement ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):197-204]

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Community-acquired pneumonia in chronic obstructive pulmonary disease.

Rodrigo Cavallazzi, Julio Ramirez,

PURPOSE OF REVIEW:The aim of this study was to discuss the literature on community-acquired pneumonia (CAP) in patients with chronic obstructive pulmonary disease (COPD). RECENT FINDINGS:Well designed studies show that COPD is the strongest risk factor for development of CAP. Lung microbiome, abnormal lung immunity and pathogen virulence are important ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):173-181]

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Fungal infections of the skin and soft tissue.

Sibel Dogan Gunaydin, Sevtap Arikan-Akdagli, Murat Akova,

PURPOSE OF REVIEW:This review aims to update on recent findings about epidemiology, risk factors and therapeutic options for fungi causing skin and soft tissue infections. The latest data on emerging antifungal resistance are also discussed. RECENT FINDINGS:In parallel with increased use of immunosuppression, the incidence of fungal infections is also ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):130-136]

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Pulmonary infections in the hematopoietic cell transplant patient.

Emily S Ford, Kristina Crothers, Guang-Shing Cheng,

PURPOSE OF REVIEW:Despite progress in the management of pulmonary infections in the hematopoietic cell transplant (HCT) population, substantial diagnostic, and therapeutic uncertainty remains. RECENT FINDINGS:A growing HCT population reflects more transplants and improved long-term survival. We continue to learn about the epidemiologic and prognostic significance of posttransplant pulmonary infections. Mold-active ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):205-213]

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The interplay between acute bacterial skin and skin structure infections and depression: a vicious circle of major clinical importance.

Matteo Bassetti, Benito Almirante, Evangelos J Giamarellos-Bourboulis, Rossetos Gournellis, Iria Grande, Maria Giulia Marini, Matteo Balestrieri,

PURPOSE OF REVIEW:Previous studies suggest an association between depression and increased risk of various type of infections, including acute bacterial skin and skin structure infections (ABSSSI). Here, we review the latest advancement in our understanding of immunity in patients with depression and its relevance to disease management and diagnosis, with ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):155-165]

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The skin and soft tissue infections in hematological patients.

Riccardo Ungaro, Malgorzata Mikulska,

PURPOSE OF REVIEW:Skin and soft tissue infections (SSTIs) in patients with hematological malignancies are frequent, but dedicated epidemiological studies are limited. The aim of this review is to provide updated description of the main etiological agents, differential diagnosis, and treatment. RECENT FINDINGS:In addition to common causes of bacterial skin infections ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):101-109]

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Managing and preventing exacerbation of bronchiectasis.

Hani Abo-Leyah, James D Chalmers,

PURPOSE OF REVIEW:Pulmonary exacerbations are key events in the natural history of bronchiectasis given their impact on quality of life, prognosis, and their contribution to healthcare costs. Preventing and managing exacerbations is a priority for clinicians and in this review, we discuss measures that should be utilized to achieve this ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):189-196]

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Risk stratification for multidrug-resistant bacteria in patients with skin and soft tissue infection.

François Barbier, Jean-François Timsit,

PURPOSE OF REVIEW:This article summarizes the available evidence enabling a stratification of risk for multidrug-resistant bacteria (MDRB) in patients with skin and soft tissue infection (SSTI). RECENT FINDINGS:MDRB are increasingly reported in both healthcare-associated (HCA) and community-acquired (CA)-SSTI, including in patients with life-threatening presentations for whom early initiation of adequate ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):137-145]

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Treatment of multidrug-resistant Gram-negative skin and soft tissue infections.

Jean-Francois Jabbour, Sima L Sharara, Souha S Kanj,

PURPOSE OF REVIEW:The increase in skin and soft tissue infections (SSTI) because of multidrug-resistant (MDR) pathogens is a global concern. Although MDR Gram-negative bacteria (GNB) are often overlooked as a cause of SSTIs, their burden on the morbidity of many subgroups of patients is high. There is a paucity in ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):146-154]

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The role of multidrug and extensive-drug resistant Gam-negative bacteria in skin and soft tissue infections.

Adrian J Brink, Guy A Richards,

PURPOSE OF REVIEW:Whereas Staphylococcus aureus remains the leading cause of skin and soft tissue infections (SSTI), Gram-negative bacilli (GNB) are increasingly reported as a cause of monomicrobial or polymicrobial infections. This review examines the expanding role of GNB in SSTI and discusses the risks for and the frequency of multidrug-resistance ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):93-100]

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Role of new antibiotics in the treatment of acute bacterial skin and skin-structure infections.

Matteo Bassetti, Laura Magnasco, Filippo Del Puente, Daniele Roberto Giacobbe,

PURPOSE OF REVIEW:To summarize the available efficacy and safety data of novel agents for treating acute bacterial skin and skin-structure infections (ABSSSI), focusing on those active against methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:There are now several agents active against MRSA that are approved for the treatment of ABSSSI, including tedizolid, ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):110-120]

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Ventilator-associated pneumonia: new principles guiding empiric antibiotic therapy.

Cristina Dominedò, Adrian Ceccato, Antoni Torres,

PURPOSE OF REVIEW:Ventilator-associated pneumonia (VAP) is a serious event in critically ill patients. We aim to review the most recent evidences about VAP, including its cause, the main differences between the American and European guidelines in the definition of risk factors for multidrug-resistant pathogens, the main principles guiding empirical antibiotic ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):182-188]

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Parasitic skin infections: neglected diseases or just challenging for diagnosis?

Giulia Gardini, Lina Rachele Tomasoni, Francesco Castelli,

PURPOSE OF REVIEW:The aim of the article is to review the most recent evidence concerning parasitic skin infections. RECENT FINDINGS:Parasitic skin infections are increasingly reported worldwide. Special at-risk categories are migrants, returning travelers, and immunocompromised individuals, who are at higher risk to present disseminated disease. The number of reported cases ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):121-129]

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Two drugs regimens for HIV.

Laura Waters, Hannah Church,

PURPOSE OF REVIEW:As the evidence for two-drug regimens (2DR) for HIV treatment accumulates and 2DR start to enter consensus guidelines, this review covers the history, rationale and current evidence for 2DR in first-line and switch settings. RECENT FINDINGS:Until recently, most evidence for 2DR was for boosted protease inhibitor-based therapies but ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(1):28-33]

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Digital health for sexually transmitted infection and HIV services: a global scoping review.

Bolin Cao, Huanyu Bao, Emmanuela Oppong, Siyang Feng, Kumi M Smith, Joseph D Tucker, Weiming Tang,

PURPOSE OF REVIEW:The current study aimed to review how digital health has been used for sexually transmitted infection (STI)/HIV prevention, testing, and treatment. RECENT FINDINGS:A scoping review was conducted by searching five databases for peer-reviewed literature published between March 2018 to August 2019. 23 out of 258 studies met the ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(1):44-50]

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