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Journal Curr Ther Res Clin Exp

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Multiple Relapses of Visceral Leishmaniasis in HIV Co-Infected Patients: A Case Series from Ethiopia.

Rezika Mohammed, Helina Fikre, Angela Schuster, Tigist Mekonnen, Johan van Griensven, Ermias Diro,

Background:Human visceral leishmaniasis (VL) is a life-threatening protozoan disease caused by parasites belonging to the Leishmania donovani complex. Ethiopia has the highest VL-HIV co-infection rate in the world, with several of these patients presenting with repeated episodes of VL disease (ie, relapse). However, we lack data on how HIV patients ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100583]

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Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats.

Li Shan Chiu, Ryan S Anderton, Vince W Clark, Jane L Cross, Neville W Knuckey, Bruno P Meloni,

Background:Despite extensive studies, there are still no clinically available neuroprotective treatments for traumatic brain injury. Objectives:In previous studies we demonstrated beneficial treatment effects of polyarginine peptides R18 (18-mer of arginine; 300 nmol/kg) and R18D (18-mer of D-arginine; 1000 nmol/kg) in a rat model of impact-acceleration closed-head injury. Methods:We examined the ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100584]

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Drug-Induced Liver Injury in Critically Ill Children Taking Antiepileptic Drugs: A Retrospective Study.

Kannan Sridharan, Amal Al Daylami, Reema Ajjawi, Husain A M Al Ajooz,

Background:Antiepileptic drugs are among the leading causes of drug-induced liver injury (DILI). Due to critical illness, children admitted to intensive care units are more prone to DILI. Objective:We attempted to elucidate the association between antiepileptic drug use and the associated factors resulting in DILI in a pediatric intensive care unit ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100580]

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Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Postmarket, Open-Label, Long-Term Historical Control Study with Analysis Detailed per Krellgren-Lawrence Radiologic Osteoarthritis Scale Grade.

Patrice Vincent, Thibaut Lucas de Couville, Thierry Thomas,

Background:Intra-articular injections of hyaluronic acid-also called viscosupplementation (VS)-is frequently used for the symptomatic treatment of knee osteoarthritis, a painful and debilitating long-term disease, affecting an important fraction of elderly populations. Severity of knee osteoarthritis is generally described by Kellgren-Lawrence (KL) radiological classification. VS has been widely studied in many clinical ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100575]

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Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study.

Hailemaryam Alemu, Workagegnehu Hailu, Aynishet Adane,

Background:Chronic kidney disease (CKD) is increasingly recognized as a global health issue and it affects 10% to 15% of the world population. Diabetes mellitus is the leading cause of end-stage renal disease. More than 422 million adults in the world populations are living with diabetes mellitus, 40% of whom will ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100578]

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Medical Reversals in Family Practice: A Review.

Alyson Haslam, Catherine Livingston, Vinay Prasad,

Background:Primary care physicians are challenged by the need to stay abreast of current research on a wide variety of topics in an environment of time constraints, evolving literature, and misinformation on health topics that are sometimes promulgated to the public. Objective:We sought to identify and discuss common clinical situations encountered ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100579]

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The Effects of Clinical Pharmacist Education on Lifestyle Modifications of Postmyocardial Infarction Patients in South India: A Prospective Interventional Study.

Sarumathy Sundararajan, Shanmugarajan Thukani Sathanantham, Shanmugasundaram Palani,

Background:Myocardial infarction (MI) is associated with significant short-term and long-term mortality and morbidity. Secondary prevention and treatment of post-MI patients through medication and lifestyle modification is becoming an important aspect of patient care regimens. Pharmacists have a crucial role in providing these disease-prevention interventions compared with other health care professionals. ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100577]

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Synergistic Effect of 1,3,6-Trihydroxy-4,5,7-Trichloroxanthone in Combination with Doxorubicin on B-Cell Lymphoma Cells and Its Mechanism of Action Through Molecular Docking.

Isnatin Miladiyah, Emmy Yuanita, Satyo Nuryadi, Jumina Jumina, Sofia Mubarika Haryana, Mustofa Mustofa,

Background:The increasing rate of cancer chemoresistance and adverse side effects of therapy have led to the wide use of various chemotherapeutic combinations in cancer management, including lymphoid malignancy. Objective:We investigated the effects of a combination of 1,3,6-trihydroxy-4,5,7-trichloroxanthone (TTX) and doxorubicin on the Raji lymphoma cell line. Methods:Raji cells were treated ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100576]

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Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1.

Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A Kendall,

Background:Structure-activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1. Objectives:Here, several derivatives of PSNCBAM-1 were synthesized with the aim of reducing the number of rings within its structure and enhancing the solubility of the compounds. ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100574]

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Gonadotropin versus Follicle-Stimulating Hormone for Ovarian Response in Patients Undergoing in vitro Fertilization: A Retrospective Cohort Comparison.

Zhisong Ji, Xiaozhen Quan, Yanli Lan, Meng Zhao, Xiaolong Tian, Xuezhou Yang,

Background:Poor ovarian responders generally refer to patients who respond poorly to ovarian stimulation for assisted reproductive techniques (ART) such as in-vitro fertilization (IVF) and hence experience low live birth rate. Various controlled ovarian stimulation (COS) protocols have been developed during the past 3 decades for IVF/ICSI to improve oocyte quality ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2020, 92:100572]

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Hepatoprotective Effects of a Ruthenium(II) Schiff Base Complex in Rats with Diet-Induced Prediabetes.

Lindokuhle Patience Mabuza, Mlindeli Wilkinson Gamede, Sanam Maikoo, Irvin Noel Booysen, Phikelelani Siphosethu Nguban, Andile Khathi,

Background:Progressive insulin resistance in a prediabetic state has been reported to be the predominant causative factor for the development of nonalcoholic fatty liver disease. The combination of dietary modification and pharmacotherapy has been recommended to manage diabetic liver complications. However, poor patient compliance and toxicity of current drug therapy on ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:66-72]

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Injections intra articulaires (IA) d'acide hyaluronique (AH) dans le traitement symptomatique de la gonarthrose : une méta-analyse des injections uniques (mono-injections).

Patrice Vincent,

Introduction:La viscosupplémentation du liquide synovial par injections intra articulaires (IA) d'acide hyaluronique (AH), est un traitement symptomatique bien connu dans la gonarthrose. La question se pose de savoir si les traitements par injection unique (mono-injection) peuvent présenter autant d'efficacité que les multi-injections (3 à 5). Méthodes:Une méta-analyse des résultats publiés ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:52-65]

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Dupilumab in the Treatment of Moderate to Severe Asthma: An Evidence-Based Review.

Kiran Kumar Rathinam, Justin Jacob Abraham, Thangavel Mahalingam Vijayakumar,

Background:Asthma affects millions of patients across the globe and also accounts for numerous mortalities every year. The current pharmacologic approach to the treatment of asthma includes the use of glucocorticoids and beta-agonists mainly. However, these conventional therapies have poor controllability of moderate-to-severe asthma and also produce several side effects on ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:45-51]

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Factors Associated with Compliance with World Health Organization-Recommended Infant-Feeding Practices by Mothers with HIV Infection in Northwest Ethiopia.

Amare Belachew Dagnew, Tilahun Tewabe, Asmamaw Birhie, Mastewal Birehanu, Tirualem Alehegn, Abigiya Simachew, Agereselam Tsegaw,

Background:The World Health Organization has recommended either exclusive replacement feeding or exclusive breastfeeding options for HIV-exposed infants for the first 6 months of life. Objective:The purpose of this study was to assess the factors associated with noncompliance with these recommendations among a population of HIV-infected mothers of young infants in ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:39-44]

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The Effect of Glutamatergic Modulators on Extracellular Glutamate: How Does this Information Contribute to the Discovery of Novel Antidepressants?

Marcos Emilio Frizzo,

Background:In the search for new antidepressants, clinical researchers have been using drugs that simultaneously modulate multiple targets. During preclinical and clinical trials, the glutamatergic modulators riluzole and ketamine have received particular attention. Glutamatergic agents have a modulatory effect on synaptic transmission, so they can act on both neurons and astrocytes. ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:25-32]

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Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach.

Ayorinde Adehin, Sharon I Igbinoba, Julius O Soyinka, Cyprian O Onyeji, Chinedum P Babalola, Oluseye O Bolaji,

Background:The varied disposition of the antimalarial quinine partly explains its poor tolerance and toxicity in humans. Objective:Using a population approach, the disposition of quinine in healthy subjects and patients with acute uncomplicated symptomatic malaria from Nigeria was re-examined with a view to providing population-specific attributes. Methods:Concentration versus time profiles of ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:33-38]

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Periodic Intensive Insulin Therapy Remains Experimental.

Amy Chang, Athena Philis-Tsimikas,

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:24]

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Efficacy of Periodic Intensive Insulin Therapy on secondary complications of diabetes warrants larger prospective randomized clinical trials.

Jonathan Lakey,

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:23]

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Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers.

Somruedee Chatsiricharoenkul, Yanisorn Nanchaipruek, Patcharaporn Manopinives, Suparat Atakulreka, Suvimol Niyomnaitham,

Background:Cilostazol is a vasodilator with anticoagulant effect for treatment of peripheral vascular disease. Cilostazol 100-mg tablet was shown to increase walking distance in this patient population. Objective:The aim of this study was to investigate and compare the pharmacokinetic profiles and safety of Bestazol 100-mg tablet (Berlin Pharmaceutical Industry Co Ltd, ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:11-16]

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Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery.

Ahmet Aydin, Mustafa Kaçmaz, Adem Boyaci,

Background:Postoperative nausea and vomiting (PONV) are 2 of the most frequent adverse effects of anesthesia. PONV prolongs hospital stays and also delays the recovery of patients. Objective:In this study, the effects of ondansetron, tropisetron, and palonosetron on PONV in patients who had undergone middle ear surgeries such as mastoidectomy or ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 91:17-21]

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Schistosomiasis: Life Cycle, Diagnosis, and Control.

Martin L Nelwan,

Background:Human schistosomiasis is a parasitic disease caused by blood-worms that infect multiple organs, including the liver, intestine, bladder, and urethra. This disease may be eliminated with Praziquantel, vaccines, and gene therapy. Aims:In this review, the author describes the progress in a study of schistosomiasis that focused on the life cycle, ... Read more >>

Curr Ther Res Clin Exp (Current Therapeutic Research, Clinical and Experimental)
[2019, 91:5-9]

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Effects of Periodic Intensive Insulin Therapy: An Updated Review.

Shu Dong, Hien Lau, Cody Chavarria, Michael Alexander, Allison Cimler, John P Elliott, Sandra Escovar, Jack Lewin, James Novak, Jonathan R T Lakey,

Background:Traditional insulin treatment for diabetes mellitus with insulin administered subcutaneously yields nonpulsatile plasma insulin concentrations that represent a fraction of normal portal vein levels. Oral hypoglycemic medications result in the same lack of pulsatile insulin response to blood glucose levels. Intensive treatments of significant complications of diabetes are not recommended ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:61-67]

Cited: 2 times

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Inyección Intraarticular Única de Ácido Hialurónico en la Artrosis de Rodilla: Estudio Multicéntrico Prospectivo Abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo.

Dominique Baron, Christian Flin, Jérôme Porterie, Jacques Despaux, Patrice Vincent,

Introducción:La viscosuplementación del líquido sinovial mediante la inyección intraarticular (IA) de ácido hialurónico (AH) es un tratamiento sintomático ampliamente utilizado en la artrosis de rodilla (AR). Además de los productos diseñados para realizar inyecciones múltiples (normalmente de 3 a 5 inyecciones, en intervalos de 1 semana), se presta especial atención ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:69-83]

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Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model.

Syed Wasif Gillani, Irfan Altaf Ansari, Hisham A Zaghloul, Syed Azhar Syed Sulaiman, Hassaan Anwar Rathore, Mirza R Baig, Mohi Iqbal Mohammad Abdul, Sultan Althagfan,

Background:Diabetes Mellitus is a progressive, chronic and multifactorial endocrine disorder characterized by elevated serum glucose levels. It has a direct effect to social and health related quality of life. Objective:This study aimed to determine the health-related quality of life among patients with type II diabetes mellitus (T2DM) using insulin therapy. ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:53-60]

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Intra-Articular Hyaluronic Acid in the Symptomatic Treatment of Knee Osteoarthritis: A Meta-Analysis of Single-Injection Products.

Patrice Vincent,

Background:Viscosupplementation of the synovial fluid with intra-articular hyaluronic acid (IA HA) is a well-known symptomatic treatment of knee osteoarthritis. The question arises whether a monoinjection (ie, single injection) could be as efficient as multi-injection (ie, 3-5 injections) regimens. Methods:A meta-analysis of published studies relating to IA HA monoinjection trials was ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:39-51]

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