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Journal Curr Opin Organ Transplant

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Epigenetic modifications and the development of kidney graft fibrosis: Erratum.

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):346]

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Current opinion in pediatric heart transplantation.

John D Cleveland, S Ram Kumar,

<h4>Purpose of review</h4>Cardiac transplant remains the most effective therapy for children with end-stage heart disease. Outcomes remain better than any alternative therapy for this condition, but its use is limited by donor organ availability. As a result, waitlist times and mortality on the waiting list remain unacceptably high. Novel approaches ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):290-295]

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The evolving role of ECMO in liver transplantation.

Rachel Hogen, Ashraf H Sedra, Arash Motamed, Juliet Emamaullee,

<h4>Purpose of review</h4>To review the indications for extra-corporeal membrane oxygenation (ECMO) in liver transplantation (LT) recipients and their optimal management on ECMO.<h4>Recent findings</h4>Recent studies have reported a 30-40% survival rate among LT recipients that receive ECMO. Increasingly, case reports have documented successful outcomes of LT performed for patients on preoperative ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):333-338]

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The effect of COVID-19 on liver transplantation: impact, practice patterns, therapeutics, and next steps.

Alan L Hutchison, Anjana Pillai,

<h4>Purpose of review</h4>To assess the impact of coronavirus disease 2019 (COVID-19) and the pandemic on liver transplant candidates, recipients, and donors, and review guidelines and recommendations for integrating COVID-19 therapies into current practice.<h4>Recent findings</h4>COVID-19 has high morbidity and mortality for transplant candidates; interestingly, posttransplant comorbidities play a larger role than ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):339-345]

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The current state of artificial intelligence in cardiac transplantation.

Rohan Goswami,

<h4>Purpose of review</h4>The field of heart transplantation is a complex practice that combines both science and art to optimize the quality and quantity of an organ transplant recipient's life span. In the current age of Transplant Medicine there are many limiting factors that prevent potentially usable organs to be transplanted ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):296-301]

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Lung transplantation: candidate selection and timing of transplant.

Purav Shah, David C Neujahr,

<h4>Purpose of review</h4>Over the past two decades, lung transplant has become the mainstay of treatment for several end-stage lung diseases. As the field continues to evolve, the criteria for referral and listing have also changed. The last update to these guidelines was in 2014 and several studies since then have ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):302-308]

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Complex interventions in the failing heart.

Anandbir S Bath, Joel Raja, Miguel A Maturana, Rami N Khouzam,

<h4>Purpose of review</h4>Heart failure is a complex clinical syndrome with a substantial disease burden. We aim to review the interventional aspects of management of advanced heart failure, focusing on the role of management of coronary artery disease, valvular heart disease, and mechanical circulatory support.<h4>Recent findings</h4>The patients with coronary artery disease ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):267-272]

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Primary graft dysfunction.

Rachel N Criner, Emily Clausen, Edward Cantu,

<h4>Purpose of review</h4>Primary graft dysfunction (PGD) is a devastating complication in the acute postoperative lung transplant period, associated with high short-term mortality and chronic rejection. We review its definition, pathophysiology, risk factors, prevention, treatment strategies, and future research directions.<h4>Recent findings</h4>New analyses suggest donation after circulatory death and donation after brain ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):321-327]

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Organ allocation and procurement in cardiac transplantation.

Peter J Altshuler, Mark R Helmers, Pavan Atluri,

<h4>Purpose of review</h4>There is a critical shortage of organs in cardiac transplantation. Recent advancements in both organ allocation and donor utilization have intended to address this shortage and optimally allocate allografts. This review evaluates several important aspects of recipient and donor management. For recipients, the focus is placed on the ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):282-289]

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Tolerance, immunosuppression, and immune modulation: impacts on lung allograft survival.

Hailey M Shepherd, Jason M Gauthier, Daniel Kreisel,

<h4>Purpose of review</h4>Immune responses following lung transplantation continue to result in high rates of allograft failure and rejection, and current immunosuppression does not address the unique immunologic properties of the lung. Here, we review recent studies on lung allograft tolerance and alloimmunity and discuss implications for immunosuppression.<h4>Recent findings</h4>Processes governing tolerance ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):328-332]

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Editorial introductions.

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):v]

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Desensitization and management of allograft rejection.

Lorenzo Zaffiri,

<h4>Purpose of review</h4>Chronic lung allograft dysfunction (CLAD) limits the success of lung transplantation. Among the risk factors associated with CLAD, we recognize pretransplant circulating antibodies against the human leukocyte antigens (HLA), acute cellular rejection (ACR) and antibody-mediated rejection (AMR). This review will summarize current data surrounding management of desensitization, ACR, ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):314-320]

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Mechanical circulatory support in pre and postheart transplant period.

Andrew R Kolodziej, Gaurang N Vaidya, Neeti Reddy, Emma J Birks,

<h4>Purpose of review</h4>Progression of heart failure (HF) and its unpredictable and volatile nature, often requires advanced therapies including heart transplant. Mechanical circulatory support plays an integral part in the advanced treatment options. This technology can be deployed in several ways, particularly in the preparation and patient optimization for heart transplants. ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):273-281]

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Procedural mechanical support for lung transplantation.

Stefan Schwarz, Konrad Hoetzenecker, Walter Klepetko,

<h4>Purpose of review</h4>The use of procedural mechanical support during lung transplantation (LTx) varies between centers and the optimal support strategy is still controversially discussed. The two main questions are if cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) should be preferred and whether mechanical support should be reserved for specific ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):309-313]

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Long-term outcomes of intestinal transplantation.

Jonathan M Hind,

<h4>Purpose of review</h4>In this article, data from the intestinal transplant registry, recent publications and reviews in the field will be used to describe mortality, morbidity, complications, nutritional and psychosocial outcomes in intestinal transplant recipients with a focus on those furthest out from transplant.<h4>Recent findings</h4>Registry data show static long-term survival data ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):192-199]

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Current status: meeting the regulatory goals of your liver transplant program.

Ramesh K Batra, David C Mulligan,

<h4>Purpose of review</h4>The regulatory framework set by the Organ Procurement and Transplantation Network (OPTN) and Center for Medicare and Medicaid Services (CMS) for practice of liver transplantation in US is periodically updated and risk adjusted. Therefore, it is prudent for transplant centers to know the rules of engagement as it ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):146-151]

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Current status of adult liver transplantation: utilization of living donor versus deceased donor graft.

Lillian Tran, Abhinav Humar,

<h4>Purpose of review</h4>This article will summarize prior and recent studies comparing outcomes between living donor and deceased donor liver transplantation (LT) in adults and provide a rationale and framework for expanding living donor liver transplantation (LDLT) in Western countries to address the growing critical organ shortage.<h4>Recent findings</h4>There is a growing ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):133-138]

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Intestinal transplantation.

Jennifer Garcia, Gennaro Selvaggi, Akin Tekin, Rodrigo Vianna,

<h4>Purpose of review</h4>Intestinal transplantation has evolved to be a viable treatment option for patients with intestinal failure. This review shows the most current tendencies and practices of intestinal transplant centers and an overall comparison to intestinal rehabilitation.<h4>Recent findings</h4>This review outlines that timing for referral and advances in preoperative and postoperative ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):229-233]

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Editorial: Recent controversies in abdominal organ transplantation.

Jonathan A Fridell,

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):152]

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Delayed kidney transplantation in combined liver-kidney transplantation.

Burcin Ekser, William C Goggins,

<h4>Purpose of review</h4>To review the impact of delayed kidney transplantation approach in combined (simultaneous) liver-kidney transplantation (CLKT).<h4>Recent findings</h4>CLKT offers a life-saving procedure for patients with both end-stage liver disease and chronic kidney disease or prolonged acute kidney injury. It is the most common multiorgan transplant procedure in the US accounting ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):153-159]

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Disease recurrence after gut transplantation.

Mohammed Osman, Neha Parekh, Masato Fujiki, Giuseppe D'Amico, Kareem Abu-Elmagd,

<h4>Purpose of review</h4>Despite three decades of clinical experience, this article is the first to comprehensively address disease recurrence after gut transplantation. Pertinent scientific literature is reviewed and management strategies are discussed with new insights into advances in gut pathobiology and human genetics.<h4>Recent findings</h4>With growing experience and new perspectives in the ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):207-219]

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Role of the purinergic signaling network in lung ischemia-reperfusion injury.

Nathan Haywood, Huy Q Ta, Evan Rotar, Zdravka Daneva, Swapnil K Sonkusare, Victor E Laubach,

<h4>Purpose of review</h4>Primary graft dysfunction (PGD) is the leading cause of early mortality following lung transplantation and is typically caused by lung ischemia-reperfusion injury (IRI). Current management of PGD is largely supportive and there are no approved therapies to prevent lung IRI after transplantation. The purinergic signaling network plays an ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):250-257]

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Oncologic indications of liver transplantation and deceased donor liver allocation in the United States.

Chandrashekhar Kubal, Plamen Mihaylov, John Holden,

<h4>Purpose of review</h4>Liver transplantation is a standard therapy for certain liver cancers. The majority of liver transplantation in the United States is through deceased donor liver transplantation (DDLT). A significant disparity between the demand of livers and patients awaiting liver transplantation still remains, relying on United Network for Organ Sharing ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):168-175]

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Late graft loss after intestinal transplantation.

Tanyaporn Kaenkumchorn, Danielle Wendel, M Cristina Pacheco, Simon P Horslen,

<h4>Purpose of review</h4>Despite improvement in short-term outcomes after intestinal transplantation in the last 20 years, long-term rates of graft attrition and patient survival remain unchanged, with worse outcomes compared with other solid organ transplants. This review investigates the multiple causes of late graft loss, including chronic rejection, infection, graft-versus-host disease, ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):220-228]

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Grant monitoring after intestinal transplantation.

Robert S Venick,

<h4>Purpose of review</h4>The current review aims to describe in detail the most common practices utilized to monitor graft function in intestinal transplant (ITx) recipients. In addition, to discussing the role of endoscopy and stool studies it will examine the use of other potential biomarkers which have been utilized. Data will ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):234-239]

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