Full Text Journal Articles in
Journal Curr Opin Organ Transplant

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Patient selection for heart transplant: balancing risk.

Aditya Mantha, Ramon O Lee, Aaron M Wolfson,

<h4>Purpose of review</h4>Heart failure incidence continues to rise despite a relatively static number of available donor hearts. Selecting an appropriate heart transplant candidate requires evaluation of numerous factors to balance patient benefit while maximizing the utility of scarce donor hearts. Recent research has provided new insights into refining recipient risk ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):36-44]

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Novel biomarkers of chronic lung allograft dysfunction: is there anything reliable?

Stijn E Verleden, Geert M Verleden,

<h4>Purpose of review</h4>Chronic lung allograft dysfunction (CLAD) remains a major barrier preventing long-term survival following lung transplantation. As our clinical knowledge regarding its definition and presentation has significantly improved over the last years, adequate biomarkers to predict development of CLAD, phenotype of CLAD or prognosis post-CLAD diagnosis are definitely needed.<h4>Recent ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):1-6]

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HIV in kidney transplantation.

Daniel Glicklich, Rajat Nog,

<h4>Purpose of review</h4>The aim of this study was to describe recent developments in renal transplantation for HIV-positive recipients, especially the HIV Organ Policy Equity (HOPE) trial results.<h4>Recent findings</h4>HOPE trial data show that HIV-positive D+/R+ results are excellent and similar to D-/R+ in patients controlled on antiretroviral therapy (ART). Patients coinfected ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):64-69]

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Kidney transplant program specific reporting and transplant metrics.

Kenneth A Andreoni,

<h4>Purpose of review</h4>Kidney transplantation is a heavily regulated medical procedure with the Secretary of HHS ultimately responsible for oversight and authority derived from the NOTA and the Final Rule. Transplant Programs undergo publicly reported evaluations every 6 months based on outcomes from a 2-and-a-half-year period. The current Bayesian metrics for kidney ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):70-74]

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Cardiovascular risk stratification in the noncardiac solid organ transplant candidate.

Lauren K Truby, Robert J Mentz, Richa Agarwal,

<h4>Purpose of review</h4>Solid organ transplantation (SOT) has become a widely accepted therapy for end-stage disease across the spectrum of thoracic and abdominal organs. With contemporary advances in medical and surgical therapies in transplantation, candidates for SOT are increasingly older with a larger burden of comorbidities, including cardiovascular disease (CVD). CVD, ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):22-28]

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Donor selection for multiorgan transplantation.

Stephanie Hsiao, Kiran K Khush,

<h4>Purpose of review</h4>There is limited data and guidance on donor selection for multiorgan transplantation. In this article, we review the current Organ Procurement and Transplantation Network policy on multiorgan allocation and the ideal donor criteria for each specific organ, in order to provide a framework to guide donor selection for ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):52-56]

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Noninvasive biomarkers in heart transplant: 2020-2021 year in review.

Xiaoxiao Qian, Palak Shah, Sean Agbor-Enoh,

<h4>Purpose of review</h4>Endomyocardial biopsy (EMB), the current gold standard for cardiac allograft monitoring is invasive, may have a low sensitivity and is associated with significant variability in histopathologic interpretation. Fortunately, on-going research is identifying noninvasive biomarkers that address some of these limitations. This review provides an update on noninvasive blood-based ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):7-14]

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Two is better than one: when to consider multiorgan transplant.

Daniel J Miklin, Matthew Mendoza, Eugene C DePasquale,

<h4>Purpose of review</h4>Patients with end-stage heart failure often present with concomitant end-stage renal or end-stage liver disease requiring transplantation. There are limited data regarding the risks, benefits and long-term outcomes of heart-kidney (HKT) and heart-liver transplantation (HLT), and guidelines are mainly limited to expert consensus statements.<h4>Recent findings</h4>The incidence of HKT ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):86-91]

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The use of marginal kidneys in dual kidney transplantation to expand kidney graft utilization.

Robert J Stratta, David Harriman, Venkat Gurram, Komal Gurung, Berjesh Sharda,

<h4>Purpose of review</h4>The purpose of this review is to chronicle the history of dual kidney transplantation (DKT) and identify opportunities to improve utilization of marginal deceased donor (MDD) kidneys through DKT.<h4>Recent findings</h4>The practice of DKT from adult MDDs dates back to the mid-1990s, at which time the primary indication was ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):75-85]

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Management of long-term cardiovascular risk factors post organ transplant.

Juan Carlos de la Fuente-Mancera, Ilana Forado-Bentar, Marta Farrero,

<h4>Purpose of review</h4>Cardiovascular disease is one of the leading causes of death in solid organ transplant (SOT) recipients. Early identification of cardiovascular risk factors and their adequate management in this population is key for prevention and improved outcomes.<h4>Recent findings</h4>Approximately 80% of SOT present one or more cardiovascular risk factors, with ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):29-35]

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Balancing the tug of war: intraoperative and postoperative management of multiorgan transplantation.

S Shiva Patlolla, Timothy Gong, Shelley Hall,

<h4>Purpose of review</h4>Multiorgan heart transplants (MOHT) have steadily increased and account for approximately 4% of all heart transplants performed. Although long-term outcomes of MOHT are similar to heart transplant alone, perioperative management remains an issue with nearly double the rate of prolonged hospitalization. Better understanding of hemodynamic environments encountered and ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):57-63]

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Emerging biomarkers in kidney transplantation and challenge of clinical implementation.

Scott G Westphal, Roslyn B Mannon,

<h4>Purpose of review</h4>Despite improvement in short-term outcomes after kidney transplantation, long-term outcomes remain suboptimal. Conventional biomarkers are limited in their ability to reliably identify early immunologic and nonimmunologic injury. Novel biomarkers are needed for noninvasive diagnosis of subclinical injury, prediction of response to treatment, and personalization of the care of ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):15-21]

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Noninvasive methods to reduce cardiac complications postheart transplant.

Leon Zhou, Aaron Wolfson, Ajay S Vaidya,

<h4>Purpose of review</h4>Long-term success of heart transplantation is limited by allograft rejection and cardiac allograft vasculopathy (CAV). Classic management has relied on frequent invasive testing to screen for early features of rejection and CAV to allow for early treatment. In this review, we discuss new developments in the screening and ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2022, 27(1):45-51]

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New insights into the microbiome in kidney transplantation.

Joshua S Kim, Christina Sze, Tarek Barbar, John R Lee,

<h4>Purpose of review</h4>Research in the past decade has revealed important implications for the microbiome in human health. Studies have defined a distinct gut microbiota in kidney transplant recipients and have recently linked the microbiota to infectious complications, similar to the allogeneic stem cell transplant population.<h4>Recent findings</h4>In this review, we focus ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):582-586]

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Effects of obesity and weight-loss surgery shift the microbiome and impact alloimmune responses.

Hao Zhou, Stefan G Tullius,

<h4>Purpose of review</h4>Obesity is a worldwide health problem with increasing rates in both children and adults. Bariatric surgery (BS) represents the only effective long-term treatment. Beneficial effects of BS may be mediated through shifts of the gut microbiome. Here, we introduce data linking the microbiome to alloimmune responses.<h4>Recent findings</h4>The rapid ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):603-608]

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The impact of the gut microbiome on liver transplantation.

Nikki Duong, Jasmohan Singh Bajaj,

<h4>Purpose of review</h4>Although gut dysbiosis can hasten disease progression in end-stage liver disease and contribute to disease severity, morbidity and mortality, its impact during and after transplant needs further study.<h4>Recent findings</h4>Changes in the microbiome are associated with hepatic decompensation. Immune homeostasis is further disrupted during transplant and with immunosuppressants required ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):587-594]

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Risk constellations, viral infections, and prophylaxis in uterine transplantation.

Courtney E Harris, Nicolas C Issa,

<h4>Purpose of review</h4>Uterine transplantation (UTx) is a burgeoning new category of solid organ transplantation (SOT) that is practiced at several centers worldwide (first transplantation in 2013). Although there are still relatively low numbers of transplants (<75 published in literature), they are increasing in frequency and thus we attempt to discuss ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):646-653]

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Immunosuppression after uterus transplantation.

Friederike Martin, Stefan G Tullius,

<h4>Purpose of review</h4>Clinical uterus transplantation (UTx) is growing rapidly. The procedure represents the only therapy for women with absolute uterine factor infertility to give birth to a biological baby. Immunosuppression after UTx needs to carefully balance effects with the healthy mother and baby. Unique for UTx is the 'temporary' character ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):627-633]

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Uterus transplantation: the importance of uterine natural killer cells.

Aaron C K Lucander, Paige M Porrett,

<h4>Purpose of review</h4>Murine studies have established that uterine natural killer (uNK) cells are critical regulators of normal placentation and fetal development in mammals. However, the biology of uNK cells in humans remains poorly understood. This ignorance represents a costly knowledge gap, as disordered placentation is thought to underpin a variety ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):654-659]

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Uterus transplantation: ethical considerations.

Briget da Graca, Liza Johannesson, Giuliano Testa, Anji Wall,

<h4>Purpose of review</h4>Uterus transplantation (Utx) offers women with absolute uterine factor infertility the opportunity to carry their own pregnancies. As Utx transitions from an experimental to standard clinical procedure, we review the status of the ethical issues applicable to the stakeholders involved.<h4>Recent findings</h4>With more than 65 Utx procedures reported to ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):664-668]

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Uterus transplantation - donor and recipient work-up.

Liza Johannesson, Anji Wall,

<h4>Purpose of review</h4>Uterus transplantation (UTx) is transitioning from an experimental procedure to a clinical treatment for absolute uterine factor infertility (AUFI). Standardized protocols for the evaluation and selection of donors and recipients that maximize chances of success - a healthy live birth - are needed.<h4>Recent findings</h4>To date, recipient eligibility has ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):634-639]

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Editorial: Uterus transplantation: the only curative treatment for absolute uterine factor infertility is moving forward.

Stefan G Tullius,

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):615]

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Progress and challenges in diagnosis and treatment of rejection following liver transplantation.

Mateo Cuervo Florez, Julia Bruner, Ali Zarrinpar,

<h4>Purpose of review</h4>Liver biopsy remains the most widely utilized method for diagnosis of allograft rejection following liver transplantation. However, associated risks and limitations present an opportunity for emerging noninvasive diagnostic techniques to improve upon the current standard of care. This review evaluates progress toward development of new noninvasive methods for ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):669-674]

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Microbiota in heart and lung transplantation: implications for innate-adaptive immune interface.

Yun Zhu Bai, Sophia H Roberts, Daniel Kreisel, Ruben G Nava,

<h4>Purpose of review</h4>Transplantation continues to be the only treatment option for end-stage organ failure when other interventions have failed. Although short-term outcomes have improved due to advances in perioperative care, long-term outcomes continue to be adversely affected by chronic rejection. Little is known about the role microbiota play in modulating ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):609-614]

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The human microbiome in transplantation: the past, present, and future.

Kenneth J Dery, Jerzy W Kupiec-Weglinski, Tien S Dong,

<h4>Purpose of review</h4>Over the past 20 years, DNA sequencing technology has transformed human microbiome research from identity characterizations to metagenomics approaches that reveal how microbials correlate with human health and disease. New studies are showing unprecedented opportunity for deep characterization of the human microbial ecosystem, with benefits to the field ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):595-602]

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