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Journal Curr Opin Neurol

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Drug interactions and risks associated with the use of triptans, ditans and monoclonal antibodies in migraine.

Linda Al-Hassany, Antoinette MaassenVanDenBrink,

<h4>Purpose of review</h4>The aim of this study was to review current evidence concerning potential risks and interactions associated with concomitant use of drugs indicated for the abortive treatment of migraine, namely triptans and ditans, and more recently developed drugs used for the preventive treatment. The latter drug class encompasses monoclonal ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):330-338]

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Targets for migraine treatment: beyond calcitonin gene-related peptide.

David Moreno-Ajona, María Dolores Villar-Martínez, Peter J Goadsby,

<h4>Purpose of review</h4>Despite the development of several medications for the acute and preventive treatment of migraine, there are still many patients in whom lack of efficacy, tolerability, interactions or contraindications make other options necessary. CGRP-based drugs have opened the door to a new era of migraine-targeted treatments. Beyond CGRP, there ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):363-372]

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Acute bacterial meningitis.

Emma C Wall, Jia Mun Chan, Eliza Gil, Robert S Heyderman,

<h4>Purpose of review</h4>Community-acquired bacterial meningitis is a continually changing disease. This review summarises both dynamic epidemiology and emerging data on pathogenesis. Updated clinical guidelines are discussed, new agents undergoing clinical trials intended to reduce secondary brain damage are presented.<h4>Recent findings</h4>Conjugate vaccines are effective against serotype/serogroup-specific meningitis but vaccine escape variants ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):386-395]

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Sinus, disabling tension-type, and temporomandibular joint headaches.

Robert Kaniecki,

<h4>Purpose of review</h4>Clinicians frequently face questions from headache patients regarding the roles played by sinus issues, muscle tension, and temporomandibular joint (TMJ) problems. This review highlights new concepts regarding the diagnosis and management of these headache conditions and their differentiation from migraine.<h4>Recent findings</h4>Recent research has clarified the roles played by ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):344-349]

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Evaluating thunderclap headache.

Chun-Yu Chen, Jong-Ling Fuh,

<h4>Purpose of review</h4>Thunderclap headache (TCH) is an abrupt-onset of severe headache that needs to be thoroughly investigated because the most common secondary cause is subarachnoid hemorrhage (SAH). There has been no consensus guideline regarding the diagnostic workup. This review aims to provide an update on the evaluation of TCH.<h4>Recent findings</h4>The ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):356-362]

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Editorial: Challenges in the diagnosis and treatment of multiple sclerosis.

Per S Sørensen,

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):275-276]

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Toxin-associated infectious diseases: tetanus, botulism and diphtheria.

Bettina Pfausler, Verena Rass, Raimund Helbok, Ronny Beer,

<h4>Purpose of review</h4>The incidence rates of the toxin-related infectious diseases, tetanus, diphtheria and botulism declined dramatically over the past decades mainly because of the implementation of immunization programs also in low-and-middle-income countries (LAMICs) and by improving hygiene conditions. But still, single cases occur, and they need fastest possible recognition and ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):432-438]

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Neurosyphilis and Lyme neuroborreliosis.

Rick Dersch, Ameeta E Singh,

<h4>Purpose of review</h4>Neurosyphilis (NS) and Lyme neuroborreliosis (LNB) are spirochetal diseases with distinct clinical manifestations. The diagnosis of NS remains challenging due to imperfect diagnostic criteria and testing modalities. With LNB, misconceptions about diagnosis and treatment lead to considerable morbidity and drug related adverse effects.<h4>Recent findings</h4>Although studies continue investigating alternate ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):403-409]

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Neuro-COVID-19 is more than anosmia: clinical presentation, neurodiagnostics, therapies, and prognosis.

Finja Schweitzer, Nina N Kleineberg, Yasemin Göreci, Oezguer A Onur, Christiana Franke, Clemens Warnke,

<h4>Purpose of review</h4>To provide an overview on current knowledge of neurological symptoms and complications of COVID-19, and to suggest management concepts.<h4>Recent findings</h4>Headache, dizziness, excessive tiredness, myalgia, anosmia/hyposmia, and ageusia/dysgeusia are common nonspecific neurological manifestations during early COVID-19 disease found in the majority of patients. Less frequent but more severe and ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):423-431]

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Central nervous system tuberculosis.

Sofiati Dian, Ahmad Rizal Ganiem, Arjan van Laarhoven,

<h4>Purpose of review</h4>Central nervous system (CNS) tuberculosis is the most devastating form of tuberculosis (TB), with mortality and or neurological sequelae in over half of individuals. We reviewed original research and systematic reviews published since 1 January 2019 for new developments in CNS TB pathophysiology, diagnosis, management and prognosis.<h4>Recent findings</h4>Insight ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):396-402]

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Neuropathogenesis of acute coronavirus disease 2019.

Shelli F Farhadian, Danielle Seilhean, Serena Spudich,

<h4>Purpose of review</h4>Over the course of the coronavirus disease (COVID-19) pandemic, it has become increasingly clear that there is a high prevalence of neurological complications in people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).<h4>Recent findings</h4>Studies of central nervous system (CNS) tissue in brain model systems and from adults ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):417-422]

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Editorial: A 2021 update on migraine.

Mark W Green,

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):329]

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Emerging infectious encephalitides.

Arun Venkatesan,

<h4>Purpose of review</h4>The COVID-19 pandemic has cast increased attention on emerging infections. Clinicians and public health experts should be aware of emerging infectious causes of encephalitis, mechanisms by which they are transmitted, and clinical manifestations of disease.<h4>Recent findings</h4>A number of arthropod-borne viral infections -- transmitted chiefly by mosquitoes and ticks ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):410-416]

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Updates on management of headache in women and transgender women.

Jessica Ailani,

<h4>Purpose of review</h4>Gender differences exist in headache disorders. A greater understanding of the role of hormones in headache can help the clinician better approach and manage common primary headache disorders.<h4>Recent findings</h4>Recent studies highlight differences in how migraine and cluster headache present in women and men. Updates to the ongoing debate ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):339-343]

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Vector-borne protozoal infections of the CNS: cerebral malaria, sleeping sickness and Chagas disease.

Gagandeep Singh, Alfred K Njamnshi, Josemir W Sander,

<h4>Purpose of review</h4>Malaria, Chagas Disease and Human African Trypanosomiasis are vector-borne protozoan illnesses, frequently associated with neurological manifestations. Intriguing but ignored, limited mainly to resource-limited, tropical settings, these disorders are now coming to light because of globalisation and improved diagnosis and treatment. Enhanced understanding of these illnesses has prompted this ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):439-446]

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Early multiple sclerosis: diagnostic challenges in clinically and radiologically isolated syndrome patients.

Massimiliano Calabrese, Damiano Marastoni, Francesco Crescenzo, Antonio Scalfari,

<h4>Purpose of review</h4>With the introduction of new diagnostic criteria, the sensibility for multiple sclerosis (MS) diagnosis increased and the number of cases with the clinically isolated syndrome (CIS) decreased. Nevertheless, a misdiagnosis might always be around the corner, and the exclusion of a 'better explanation' is mandatory.There is a pressing ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):277-285]

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Invasive neuromonitoring and neurological intensive care unit management in life-threatening central nervous system infections.

Verena Rass, Mario Kofler, Ronny Beer, Raimund Helbok,

<h4>Purpose of review</h4>Patients with infectious diseases of the central nervous system (CNS) commonly require treatment in the intensive care unit (ICU). In a subset of patients with a life-threatening course, a more aggressive and invasive management is required. Treatment relies on the expertise of the intensivists as most recommendations are ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):447-455]

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Highly effective disease-modifying treatment as initial MS therapy.

Klaus Schmierer, Per S Sørensen, David Baker,

<h4>Purpose of review</h4>Using highly effective (HE) compounds right from the beginning of disease-modifying immunotherapy (DMT) in people with multiple sclerosis (pwMS) has gained popularity among clinicians and pwMS alike. We discuss the most recent evidence supporting this approach, and whether any of the associated risks should stop us adopting it ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):286-294]

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Central nervous system infections and antimicrobial resistance: an evolving challenge.

Roland Nau, Fritz Sörgel, Helmut Eiffert,

<h4>Purpose of review</h4>Antimicrobial resistance is an increasing threat to patients also in nosocomial central nervous system (CNS) infections. The present review focusses on optimizing intravenous treatment in order to achieve sufficient concentrations of antibiotics in the different compartments of the CNS when the causative pathogens have reduced sensitivity to antibiotics ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):456-467]

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Vaccinations in multiple sclerosis patients receiving disease-modifying drugs.

Susana Otero-Romero, Alberto Ascherio, Christine Lebrun-Frénay,

<h4>Purpose of review</h4>This review focuses on new evidence supporting the global immunization strategy for multiple sclerosis (MS) patients receiving disease-modifying drugs (DMDs), including the recently available vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.<h4>Recent findings</h4>New data strengthen the evidence against a causal link between MS and vaccination. Recent ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):322-328]

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Predicting disability worsening in relapsing and progressive multiple sclerosis.

Sarah B Simmons, Sven Schippling, Gavin Giovannoni, Daniel Ontaneda,

<h4>Purpose of review</h4>Multiple sclerosis (MS) is a clinically heterogeneous disease, which complicates expectant management as well as treatment decisions. This review provides an overview of both well established and emerging predictors of disability worsening, including clinical factors, imaging factors, biomarkers and treatment strategies.<h4>Recent findings</h4>In addition to well known clinical predictors ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):312-321]

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Facial pain beyond trigeminal neuralgia.

Arne May, Jan Hoffmann,

<h4>Purpose of review</h4>Trigeminal neuralgia is a well-known facial pain syndrome with several treatment options. In contrast, non-neuralgiform idiopathic facial pain syndromes are relatively rare, reflected by the fact that, until 2020, no internationally accepted diagnostic classification existed. Like trigeminal neuralgia, these non-dental facial pain syndromes need to be managed by ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):373-377]

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Editorial: Infections of the nervous system: a continuing challenge and a plea to join forces for neurology, (neuro-)intensive care, epidemiology, internal medicine, pediatrics, family medicine, public health and the global health system.

Erich Schmutzhard,

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):384-385]

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Targeting B cells in multiple sclerosis.

Finn Sellebjerg, Martin S Weber,

<h4>Purpose of review</h4>Treatments targeting B cells are increasingly used for patients with multiple sclerosis (MS). We review the mechanisms of action, clinical effectiveness and safety of treatment, with emphasis on recently published studies.<h4>Recent findings</h4>Several monoclonal antibodies targeting the surface molecule CD20 on B cells are approved or being developed for ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):295-302]

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Use of disease-modifying drugs during pregnancy and breastfeeding.

Ruth Dobson, Kerstin Hellwig,

<h4>Purpose of review</h4>The fact that multiple sclerosis (MS) predominantly affects women has been recognized for many years. As the age at diagnosis is decreasing, and treatment options are becoming more complex, increasing numbers of women are facing decisions about the use of disease modifying therapy (DMT) in and around pregnancy.<h4>Recent ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(3):303-311]

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