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Journal Curr Med Res Opin

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Knowledge, attitude, perceived barriers, and practices among pharmacists regarding risk assessment of cardiovascular disease: a cross-sectional study in Yemen.

Fahmi Y Al-Ashwal, Syed Azhar Syed Sulaiman, Siti Maisharah Sheikh Ghadzi, Mohammed Abdullah Kubas, Abdulsalam Halboup,

Risk evaluation of atherosclerotic cardiovascular diseases can guide the decision-making on various preventive measures such as initiating or deferring statin therapy. Pharmacists can play an active part in the risk evaluation and primary prevention of atherosclerotic cardiovascular diseases. Thus, our study aimed to assess the pharmacists' knowledge, attitude, perceived barriers, ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-25]

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Retrospective descriptive analysis of a managed care population with obesity.

Andrew Osterland, Claire King, Neela Kumar, Michelle Mocarski, Abhilasha Ramasamy, Courtney Walker, Himani Darji, Paul Godley,

<h4>Objectives</h4>To reveal the extent of obesity in a single healthcare system and provide a blueprint for other health systems to perform similar analyses, this study describes characteristics and weight change patterns of patients classified with overweight and obesity at a large integrated delivery network (IDN) in the South-Central United States.<h4>Methods</h4>A ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-20]

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Adherence and persistence to rivaroxaban in non-valvular atrial fibrillation patients receiving 30- or 90-day supply prescription fills.

Craig I Coleman, Thomas J Bunz, Veronica Ashton,

<h4>Background</h4>It is unclear whether 90-day supply fills with rivaroxaban result in better adherence and persistence compared to 30-day supply fills. We assessed patients' adherence and persistence to rivaroxaban at 12- and 24-months in nonvalvular atrial fibrillation (NVAF) patients whose rivaroxaban prescriptions were filled every 30- vs. 90-days.<h4>Methods</h4>Using the IBM MarketScan ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-8]

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Combination anticoagulant or P2Y12 inhibitor with low-dose aspirin versus low-dose aspirin alone in patients at risk or with documented coronary and/or peripheral artery disease.

Craig I Coleman, Akshay A Kharat, Brahim Bookhart, William L Baker,

<h4>Objective</h4>To perform a systematic literature review and indirect treatment comparison (ITC) to identify, summarize, and quantify randomized controlled trial (RCT) evidence evaluating combination anticoagulant or P2Y12 inhibitor with low dose aspirin versus low dose aspirin alone for the prevention of atherothrombotic events in patients with stable coronary artery disease (CAD) ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-22]

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Triiodothyronine alongside levothyroxine in the management of hypothyroidism?

Ulrike Gottwald-Hostalek, George J Kahaly,

The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial minority still report symptoms of hypothyroidism unexplained by a comorbid medical condition. LT4 is essentially ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-8]

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Study of patient characteristics, treatment patterns, EGFR testing patterns and outcomes in real-world patients with EGFRm+ non-small cell lung cancer.

Katherine B Winfree, Kristin M Sheffield, Zhanglin Lin Cui, Tomoko Sugihara, Josephine Feliciano,

<h4>Objective</h4>This retrospective, observational study examined patient characteristics, treatment patterns, testing patterns, and outcomes of US patients receiving first-/second- or third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs).<h4>Methods</h4>This study used an electronic health record-derived de-identified database. Eligible patients had advanced <i>EGFR</i>m<sup>+</sup> non-small cell lung cancer. Descriptive statistics were used ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-9]

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A survey of physicians' treatment switching practice in people on long-term prophylaxis for hemophilia in five European countries.

Marijn van der Sluijs, Nicole Huyghe, Caroline Wood, Sally Tawil,

<h4>Objective</h4>Recombinant factor VIII and factor IX Fc fusion proteins (rFVIIIFc and rFIXFc) were developed with an extended half-life (EHL) to improve the management of people with hemophilia A (PwHA) and B (PwHB), respectively.<h4>Methods</h4>This survey gathered physician-reported treatment decisions and physician views on outcomes in PwHA or PwHB who switched to ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-23]

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Cost-effectiveness of tapentadol immediate release versus oxycodone immediate release for acute post-operative pain after major hip surgeries.

Xinyi Wang, Jonathan Penm, Asad E Patanwala,

<h4>Objective</h4>To evaluate the cost-effectiveness of tapentadol immediate release (IR) versus oxycodone IR for post-operative pain after major hip surgery.<h4>Methods</h4>This study has been conducted using an Australian societal perspective, focusing on adult patients after major hip surgery. A cost-effectiveness analysis was conducted using a decision analytic model. The model incorporated drug ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-19]

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Lipid management across Europe in the real-world setting: a rapid evidence review.

Vivencio Barrios, Jarkko Soronen, Angela M Carter, Anastassia Anastassopoulou,

<h4>Objective</h4>To provide a contemporary overview of recent real-world lipid-lowering therapy (LLT) practices and outcomes in patients with hypercholesterolemia/dyslipidemia at high/very high risk of atherosclerotic cardiovascular disease in Europe.<h4>Methods</h4>A structured literature review of recent (July 2015-July 2020) real-world studies reporting lipid management and outcomes was conducted using a rapid evidence synthesis. ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-11]

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Efficacy and safety of valsartan in children aged 1-5 years with hypertension, with or without chronic kidney disease: a randomized, double-blind study followed by open-label phase.

Augustina Jankauskiene, Dorota Drozdz, Anna Wasilewska, Rejane de Paula-Bernardes, Robert Glazer, Michele Valentin, Monique Tan, YannTong Chiang, Kiran Bapatla,

<h4>Objective</h4>To assess the dose-response relationship for reduction in mean systolic blood pressure (MSBP) with valsartan solution, in young children with hypertension with or without chronic kidney disease (CKD).<h4>Methods</h4>In this multicenter, randomized, double-blind, double-dummy study, 127 young children aged 1-5 years with hypertension (MSBP ≥95th percentile) were randomized (1:1) to receive valsartan ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-10]

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Treatment patterns and sequencing in patients with rheumatic diseases: a retrospective claims data analysis.

Genevieve Gauthier, Rebecca Levin, Francis Vekeman, Juan Manuel Reyes, Esteban Chiarello, Dario Ponce de Leon,

<h4>Objectives</h4>Long-term real-world management of inflammatory rheumatic diseases remains unclear, especially with the advent of new treatment options. This study characterizes the number of advanced treatments used by patients with selected rheumatic diseases (rheumatoid arthritis [RA], psoriatic arthritis [PsA], ankylosing spondylitis, juvenile idiopathic arthritis) and provides a contemporary portrait of treatment ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-12]

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The burden of undertreatment and non-treatment among patients with non-valvular atrial fibrillation and elevated stroke risk: a systematic review.

Matthew Sussman, Geoffrey D Barnes, Jennifer D Guo, Charles Y Tao, John A Gillespie, Mauricio Ferri, Nicholas Adair, Matthew S Cato, Ilnaz Shirkhorshidian, Manuela Di Fusco,

<h4>Objective</h4>Global treatment guidelines recommend treatment with oral anticoagulants (OACs) for patients with non-valvular atrial fibrillation (NVAF) and an elevated stroke risk. However, not all patients with NVAF and an elevated stroke risk receive guideline-recommended therapy. A literature review and synthesis of observational studies were undertaken to identify the body of ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-12]

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Positivity rate: an indicator for the spread of COVID-19.

Ahmed Al Dallal, Usama AlDallal, Jehad Al Dallal,

<h4>Objective</h4>This paper investigates the relationship between the positivity rate and numbers of deaths and intensive care unit (ICU) patients. In addition, it explores the use of the positivity rate as an indicator for the spread of COVID-19.<h4>Methods</h4>We used COVID-19 datasets for eight countries - Canada, USA, UK, Italy, Belgium, Ireland, ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-10]

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Prevalence of drug-induced constipation and severity of associated biopsychosocial effects in patients with nonmalignant pain: a cross-sectional review of depersonalized data from the German Pain e-Registry.

Michael A Ueberall, Ute Essner, Gerhard Müller-Schwefe, Johannes Horlemann, Martin Storr,

<h4>Background</h4>Drug-induced constipation (DIC) is a well-known comorbidity of cancer pain, however, data on its prevalence in nonmalignant pain (NMP) and its biopsychosocial effects are few.<h4>Objective</h4>To assess prevalence and impact of DIC in patients with NMP.<h4>Methods</h4>Exploratory noninterventional, retrospective, cross-sectional analysis of depersonalized routine data of the German Pain e-Registry on 150,488 ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-21]

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Patient and physician factors contributing to polypharmacy among older patients.

Kathryn A Martinez, Debra T Linfield, Niyati M Gupta, Mohana Vamsi Alapati, Daniel Moussa, Bo Hu, Luke Dogyun Kim, Simon Lam, Giavanna Russo-Alvarez, Michael B Rothberg,

<h4>Objective</h4>Polypharmacy, or use of multiple medications, is associated with patient factors. Less is known regarding variation in polypharmacy by individual physicians. The objective of this study was to assess patient and physician factors associated with polypharmacy among older patients.<h4>Methods</h4>This is a cross-sectional study of patients aged ≥65 years with a primary ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-8]

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Correction.

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-12]

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The financial burden of treating patients presenting with acute and chronic cough.

Surinder S Birring, Craig J Currie, Sarah E Holden, Sara Jenkins-Jones, Ellen R Berni, Bethan Jones, Thomas R Berni, Haya Langerman,

<h4>Objective</h4>Coughing is a common symptom and responsible for a large number of healthcare visits. This study aimed to characterize healthcare resource use and associated financial costs in people with acute or chronic cough.<h4>Methods</h4>A retrospective cohort study using routine data from the UK National Health Service. Adults (≥18 years) were selected if ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-10]

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Impact of the COVID-19 pandemic on adolescent vaccinations: projected time to reverse deficits in routine adolescent vaccination in the United States.

Kunal Saxena, Jessica R Marden, Cristina Carias, Alexandra Bhatti, Oscar Patterson-Lomba, Andres Gomez-Lievano, Lixia Yao, Ya-Ting Chen,

<h4>Objective</h4>The COVID-19 pandemic has led to significant reductions in the administration of routinely recommended vaccines among adolescents in the US including tetanus, diphtheria, and acellular pertussis (Tdap); meningococcal (ACWY); and human papillomavirus (HPV) vaccines. The extent to which these deficits could persist in 2021 and beyond is unclear. To address ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-11]

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A Taiwanese study on real-world evidence with vortioxetine in patients with major depression in Asia (TREVIDA).

Yen Kuang Yang, Cheng-Sheng Chen, Chia-Fen Tsai, Chia-Ming Chang, Te-Jen Lai, Chun-Te Lee, Chih-Chien Lin, Tsuo-Hung Lan, Keira Joann Herr,

<h4>Objective</h4>The TREVIDA study aimed to evaluate vortioxetine for the treatment of major depressive disorder (MDD) in Taiwanese adults.<h4>Methods</h4>Patients with active depressive episode were recruited in this non-interventional, prospective, multi-site study conducted between June 2019 and August 2020 in Taiwan. Patient eligibility was independent of the physician's decision to prescribe vortioxetine ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-11]

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Real world clinical experience with a new formulation of levothyroxine engineered to meet new and stricter regulatory requirements.

Ulrike Gottwald-Hostalek, Yorki Tayrouz,

<h4>Objectives</h4>A new LT4 formulation (Euthyrox [LT4 NF]) was developed to meet new regulatory standards, and has replaced the older formulation (LT4 OF) in a number of countries. We evaluated the possibility of tolerability/safety concerns associated with the switch by analysing spontaneous adverse event (AE) reports before and after switching.<h4>Methods</h4>We examined ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-6]

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Cross-cultural adaptation and validation of the Persian version of the painDETECT questionnaire.

Leila Ghamkhar, S Mohaddesseh Saghaeian, Hoda Niknam, Seyed-Masoud Hashemi, Rainer Freynhagen, Amir H Kahlaee,

<h4>Objective</h4>The purpose of this study was to translate and cross-culturally adapt the painDETECT questionnaire into the Persian language and assess the clinometric properties of the translated version (P-PDQ).<h4>Methods</h4>This is a single-center prospective observational study. After forward and backward translations, consensus was achieved by the expert panel on the pre-final version. ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-7]

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Adherence and persistence in the use of statins and ezetimibe over 8 years in a real-life study.

Fiorenzo Santoleri, Alessia Romagnoli, Alberto Costantini,

<h4>Background</h4>Adherence and persistence to treatment are crucial in statin therapy as they are synonymous with efficacy and quality of care. The aim of this study was the real-life assessment of adherence and persistence over eight years in treatment-naive patients receiving atorvastatin, lovastatin, simvastatin, pravastatin, ezetimibe.<h4>Methods</h4>Adherence to treatment was calculated using ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-6]

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Isoflurane not at the expense of postoperative nausea and vomiting in cardiac anesthesia - an observational study.

Christine H Meyer-Frießem, Sabeth Hüsken, Miriam Kaisler, Nathalie M Malewicz, Peter K Zahn, Andreas Baumann,

<h4>Objectives</h4>Inhalative anesthesia is of common use, but is generally known to potentiate postoperative nausea and vomiting (PONV). With an internal change of anesthesia regimen from total intravenous anesthesia (TIVA) to isoflurane (in terms of myocardial protection) in cardiac anesthesia a higher incidence of PONV was to be expected. Therefore, we ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-8]

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In-hospital mortality, length of stay and hospital costs for hospitalized breast cancer patients with comorbid heart failure in the USA.

Chanhyun Park, Sun-Kyeong Park, Jenica N Upshaw, Mara A Schonberg,

<h4>Objectives</h4>Breast cancer and heart failure (HF) are frequently interconnected due to shared risk factors and the cardiotoxicity of breast cancer treatment. However, the association between HF and hospital outcomes among breast cancer patients has not been studied. This study examined the association between HF and hospital outcomes among hospitalized patients ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-5]

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Administrative health claims and laboratory data to identified mCRPC or mCSPC patients: the way to go looks long but promising.

Viviana Frantellizzi, Mariano Pontico, Giuseppe De Vincentis,

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-2]

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