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Journal Curr Diabetes Rev

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Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus.

Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Fujiwara, Kazuya Murata,

BACKGROUND:When considering the administration of glucagon-like peptide-1 receptor agonists (GLP-1RAs), sodium-glucose cotransporter-2 (SGLT2) inhibitors, or metformin, it is important to understand their weight loss effect as well as the degree of muscle loss caused by each drug in clinical practice. OBJECTIVE:To comparatively examine the effects of GLP-1RAs and oral antidiabetic ... Read more >>

Curr Diabetes Rev (Current diabetes reviews)
[2020, :]

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Prevalence and Factors Associated with Lower Limb Amputation in Patients Hospitalized for Diabetic Foot: a Cross-sectional Study.

Abdourahmane Ndong, Jacques Noel Tendeng, Mohamed Lamine Diao, Diatou Gueye Dia, Amadou Diop Dia, Arona Ba, Adja Coumba Diallo, Diago Anta Dia, Blaise Magloire Ngouamba, Philippe Manyacka Ma Nyemb, Ibrahima Konaté,

BACKGROUND:Diabetes is the leading cause of non-traumatic amputation of the lower limb. Several factors associated with amputation are described in the literature, but they remain not well studied in our context. OBJECTIVES:Our aim is to determine the prevalence and factors associated with amputation in patients hospitalized for diabetic foot. METHODS:This ... Read more >>

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[2020, :]

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A systematic review and meta-analysis on efficacy of exercise on posture and balance in patients suffering from Diabetic Neuropathy.

Neerja Thukral, Jaspreet Kaur, Manoj Malik,

BACKGROUND:Peripheral neuropathy is a major and chronic complication of diabetes mellitus affecting more than 50% of patients suffering from diabetes. There is involvement of both large and small diameter nerve fibres leading to altered somatosensory and motor sensations, thereby causing impaired balance and postural instability. OBJECTIVE:To assess the effects of ... Read more >>

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[2020, :]

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GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.

Hend Al-Jaber, Layla Al-Mansoori, Mohamed A Elrayess,

BACKGROUND:Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. DISCUSSION:The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for impairment of adipogenesis. The expression of GATA-3 is higher in ... Read more >>

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[2020, :]

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Design and Development of Key Chain Held Insulin injectable device.

Irfan Anjum Manarvi, Nader Maher Matta,

BACKGROUND:Diabetes affects people of all ages regardless of gender and geographical location. A diabetic patient unlike other diseases; may appear healthy and living a normal life under medication. Therefore a tendency of being noncompliant with medicine especially insulin dosage is observed. One of the reasons of such behavior is that ... Read more >>

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[2020, :]

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Quality Evaluation of English Mobile Applications for Gestational Diabetes: App Review using Mobile Application Rating Scale (MARS).

Sharareh Rostam Niakan Kalhori, Morteza Hemmat, Tayebe Noori, Saeede Heydarian, Meysam Rahmani Katigari,

BACKGROUND:Mobile applications and social media serve their users as convenient tools to improve and monitor diseases and conditions such as pregnancy. These tools exert a positive impact on Gestational diabetes mellitus (GDM) self-management. INTRODUCTION:Despite the expansion of mobile health apps for the management of GDM, no study has evaluated these ... Read more >>

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[2020, :]

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Pharmacological effects of secondary bile acid microparticles in diabetic murine model.

Armin Mooranian, Nassim Zamani, Bozica Kovacevic, Corina Mihaela Ionescu, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Sanja Kojic, Hani Al-Salami,

AIM:Examine bile acids effects in Type 2 diabetes. BACKGROUND:In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti-inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid chenodeoxycholic acid ... Read more >>

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Wound With Diabetes: Present Scenario And Future.

Kuldeep B Pawar, Shivani Desai, Ramesh R Bhonde, Ritesh P Bhole, Atul A Deshmukh,

Diabetes is a chronic metabolic disorder of endocrine system characterized by increase in blood glucose level. Several factors such as pancreatic damage, oxidative stress, infection, genetic factor, obesity, liver dysfunction play a vital role in pathogenesis of diabetes which further lead to serious diabetic complications. Diabetic wound is one such ... Read more >>

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[2020, :]

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Proportion of type 2 diabetic patients achieving treatment goals and the survey of patient's attitude towards insulin initiation in patients with inadequate glycaemic control with oral anti-diabetic drugs.

Shivashankara Bhat, Mukta Chowta, Nithyananda Chowta, Rajeshwari Shastry, Priyanka Kamath,

BACKGROUND:Type 2 diabetic patients often require insulin therapy for better glycaemic control. However, many of these patients do not receive insulin or do not receive it in a timely manner. OBJECTIVE:The study was planned to assess the proportion of type 2 diabetic patients attaining treatment goals as per the ADA ... Read more >>

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[2020, :]

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Anti-Insulin Receptor Antibodies in the Pathology and the Therapy of Diabetes Mellitus.

Arshida Ashraf, Abdulrasheed Palakkott, Mohammed Akli Ayoub,

Diabetes mellitus (DM) is recognized as the most common and the world's fastestgrowing chronic disease with severe complications leading to increased mortality. Many strategies exist for the management of DM and its control including treatment with insulin and insulin analogs, oral hypoglycemic therapy such as insulin secretion stimulators and insulin ... Read more >>

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Cardiovascular Disease among Patients with Diabetes: The Current Scenario in Saudi Arabia.

Asirvatham Alwin Robert, Mohamed Abdulaziz Al Dawish,

One of the well-recognized conditions linked to diabetes mellitus (DM) is cardiovascular disease (CVD). Those affected by DM face greater risk for early onset of CVD. Although huge strides have been made in cardiovascular therapy and prevention, with striking results in decreasing diabetes-related coronary mortality in developed countries, the morbidity ... Read more >>

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[2020, :]

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Evaluation of the Prevalence of Sleep Disorder among Patients with Type 2 Diabetes Mellitus Referring to Ghaem Hospital from 2016 to 2017.

Zahra Mazloum Khorasani, Vahid Roshan Ravan, Sepideh Hejazi,

OBJECTIVES:Diabetes is the most common metabolic disease in primary health care. The prevalence and severity of diabetes can be influenced through lifestyle modification. This study was aimed to identify the prevalence of sleep disorders as a modifiable lifestyle factor among diabetic patients. MATERIALS AND METHODS:This cross-sectional study was conducted on ... Read more >>

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[2020, :]

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Quality of life and Self-care behavior among people living with diabetes- A study from Coastal South India.

Laksita Joshi, Darshan Bhagawan, Ramesh Holla, Vaman Kulkarni, Bhaskaran Unnikrishnan, Faizan Mohamed, Nithin Kumar, Rekha Thapar, Prasanna Mithra, Avinash Kumar,

BACKGROUND:Diabetes mellitus is a serious chronic condition affecting millions of people globally. The focus of our future health care providers should not lie primarily on increasing the "quantity" of life but also on improving the quality of life of the patient. There has been found to be serious lack of ... Read more >>

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[2020, :]

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High prevalence of vitamin D deficiency and correlation with cystatin-C and other cardiovascular and renal risk biomarkers in patients with type 2 diabetes mellitus complicated with hypertension.

Mohammad J Alkhatatbeh, Sajedah A Smadi, Khalid K Abdul-Razzak, Nesreen A Saadeh,

BACKGROUND:Vitamin D is increasingly investigated as having a role in Type 2 Diabetes Mellitus (T2DM) and its cardiovascular and renal complications. OBJECTIVE:To investigate association between 25-hydroxyvitamin D (25-OHD) and biomarkers of cardiovascular and renal complications including cystatin-C. METHODS:This cross-sectional study involved 117 participants with T2DM that was not complicated with ... Read more >>

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[2020, :]

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Glucagon-Like Peptide-1 Receptor Agonists Cardio-protective effects: an umbrella review.

Asim Ahmed Elnour, Noura Al Hajri, Israa Yousif El Khidir, Abdulla Al Amoodi, Sahar Asim Ahmed, Adel Sadeq,

BACKGROUND:We thought to delve deeper seven meta-analyses of major clinical trials focusing on GlucagonLike Peptide-One Receptor Agonist (GLP-1 RA) cardio-protective effect. AIM:We explored the role of GLP-1 RA in cardiovascular risk protection as primary outcome in subjects with type 2 diabetes mellitus. METHODOLOGY:The current review has explored and critically appraised ... Read more >>

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[2020, :]

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A Review of Statistical and Machine Learning Techniques for Microvascular Complications in Type 2 Diabetes.

Nitigya Sambyal, Poonam Saini, Rupali Syal,

Background and Introduction: Diabetes mellitus is a metabolic disorder that has emerged as a serious public health issue worldwide. According to the World Health Organization (WHO), without interventions, the number of diabetic incidences is expected to be at least 629 million by 2045. Uncontrolled diabetes gradually leads to progressive damage ... Read more >>

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[2020, :]

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The possible role of Saponin in Type-II Diabetes- A review.

Neeraj Choudhary, Gopal Lal Khatik, Ashish Suttee,

BACKGROUND:The possible role of secondary metabolites in the management of diabetes is a great concern and constant discussion. This characteristic seems relevant and should be the subject of thorough discussion with respect to saponin. OBJECTIVE:Current data mainly focus on the impact of saponin in the treatment of type-II diabetes. The ... Read more >>

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[2020, :]

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Microrna 21 Emerging Role in Diabetic Complications: A Critical Update.

Dipayan Roy, Anupama Modi, Manoj Khokar, Shrimajunath Sankanagoudar, Dharamveer Yadav, Shailja Sharma, Purvi Purohit, Praveen Sharma,

BACKGROUND:Diabetes Mellitus is a multifactorial disease encompassing various pathogenic pathways. To avoid morbidity and mortality related to diabetic complications, early detection of disease complications as well as targeted therapeutic strategies, are essential. INTRODUCTION:MicroRNAs (miRs) are short non-coding RNA molecules that regulate eukaryotic post-transcriptional gene expression. MicroRNA-21 has diverse gene regulatory ... Read more >>

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Type 1 Diabetes Mellitus - Risk Factor for Cardiovascular Disease Morbidity and Mortality.

T Chalakova, Y Yotov, K Tzotchev, S Galcheva, B Balev, Y Bocheva, N Usheva, V Iotova,

Type 1 diabetes mellitus (T1DM) is a chronic disease which starts early in life and often leads to micro- and macrovascular complications. The incidence of the disease is lower than that of type 2 DM and varies in different countries and ethnical groups, and the etiological and pathogenetic factors are ... Read more >>

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Inter-Tissue and Intra-Tissue Co-Expression Networks in Human Metabolism: Morphological Evaluation of the Link Between Transcription Factors ERβ and NFAT in Morbid Obesity.

Athina Chasapi, Kostas Balampanis, Eleni Kourea, Fotios Kalfaretzos, Vaia Lambadiari, George I Lambrou, Maria Melachrinou, Georgia Sotiropoulou-Bonikou,

BACKGROUND:Estrogen receptor β (ERβ) plays an important role in human metabolism and some of its metabolic actions are mediated by a positive "cross-talk" with Nuclear Factor of Activated T cells (NFAT) and the key metabolic transcriptional coregulator Transcriptional Intermediary Factor 2 (TIF2). INTRODUCTION:Our study is an "in situ" morphological evaluation ... Read more >>

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Stem Cell Therapies for the Treatment of Diabetic Neuropathies: Future Perspectives.

Camila Saggioro de Figueiredo, Luiz Carlos Dos Reis,

BACKGROUND:Diabetic neuropathies (DN) are the most common complications in diabetic patients, affecting about 70% of them. Patients with DN may lose sensation in certain areas of the body, facilitating the onset of foot ulcers, as well as chronic pain. This is due to the progressive degeneration of nerve fibers, demyelination, ... Read more >>

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[2020, :]

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A Review on natural products and herbs used in the management of diabetes.

Deepshikha Patle, Manish Vyas, Gopal L Khatik,

We aimed to review the importance of the natural products and herbs used in the management of diabetes mellitus (DM) as medicinal agents. Naturally obtaining phytoactive compounds and herbs are very important because they found to be effective against several diseases. DM is a commonly occurring endocrinological disorder with the ... Read more >>

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Vaccines For Type 1 Diabetes: Prevention Or Reversal?

Shivani Desai, Shubhangi Buchade, Sohan Chitlange, Hitt Sharma, Dhiraj Bhombe, Sunil Shewale, Pramod Pujari,

Type 1 diabetes mellitus (T1DM) is an autoimmune disease which leads to destruction of pancreatic β-cells, thereby causing insufficient insulin production. Globally, around 98, 200 children and adolescents below 15 years of age and almost 128,900 subjects below 20 years of age develop T1DM annually, along with severe complications deteriorating ... Read more >>

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Insulin U-500, the practical solution for treatment of patients with high insulin requirements.

Nasser Mikhail,

Human regular insulin 500 (U-500) is 5 five times more concentrated than traditional regular human insulin (U-100). Thus, each 1 ml of U-500 contains 500 units of insulin as opposed to 100 units/ml with most types of insulin. Review of all pertinent clinical studies related to insulin U-500 up to ... Read more >>

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[2020, :]

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Prediabetic dysglycemia: Call for action.

Åke Sjöholm,

Different dysglycemic states precede overt type 2 diabetes. Prediabetic dysglycemia also carries an increased cardiovascular risk per se. Prediabetic dysglycemia may be divided into impaired fasting glycemia, impaired glucose tolerance and intermediate hyperglycemia. Mixed forms of these are very common. Dysglycemia develops insidiously for many years and usually produces no ... Read more >>

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