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Journal Crit Care

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Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support.

Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L Staudacher, Tobias Wengenmayer,

<h4>Background</h4>There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients.<h4>Methods</h4>We report retrospective ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):410]

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Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic.

Christian Karagiannidis, Arthur S Slutsky, Thomas Bein, Wolfram Windisch, Steffen Weber-Carstens, Daniel Brodie,

Crit Care (Critical care (London, England))
[2021, 25(1):413]

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Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis.

Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata, Satoshi Hokari,

<h4>Background</h4>Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the previous meta-analyses, the effect of non-invasive ventilation was not evaluated according to ventilation modes in those patients. Furthermore, no meta-analyses comparing non-invasive ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):414]

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Effects of intermittent hemodialysis on plasmatic levels of endocan.

Maxence Hureau, Julien Poissy, Daniel Mathieu, Sylvain Dubucquoi, Alexandre Gaudet,

Crit Care (Critical care (London, England))
[2021, 25(1):412]

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Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry.

Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota, Shoji Yokobori,

<h4>Background</h4>Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomography (CT) scans, and their findings' relationship to risk factors and outcomes.<h4>Methods</h4>Patients with sepsis admitted to an intensive ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):411]

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Role of MR-proADM in the risk stratification of COVID-19 patients assessed at the triage of the Emergency Department.

Marilena Minieri, Vito N Di Lecce, Maria Stella Lia, Massimo Maurici, Sergio Bernardini, Jacopo M Legramante,

Crit Care (Critical care (London, England))
[2021, 25(1):407]

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Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno's paradox of the Tortoise and Achilles?

Tommaso Scquizzato, Paul J Young, Giovanni Landoni, Luisa Zaraca, Alberto Zangrillo,

Crit Care (Critical care (London, England))
[2021, 25(1):409]

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Dispatcher instructions for bystander cardiopulmonary resuscitation and neurologically intact survival after bystander-witnessed out-of-hospital cardiac arrests: a nationwide, population-based observational study.

Yoshikazu Goto, Akira Funada, Tetsuo Maeda, Yumiko Goto,

<h4>Background</h4>The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of-hospital cardiac arrest (OHCA). This study aimed to determine the optimal dispatcher-assisted CPR (DA-CPR) instructions for OHCA.<h4>Methods</h4>We analysed the records of 24,947 adult patients (aged ≥ 18 years) who received ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):408]

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The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study.

Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E A De Kraker, Stephan Harbarth, Michael Gasser, Niccolò Buetti,

<h4>Background</h4>Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):403]

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Indirect calorimetry is the gold standard to assess REE in ICU patients: some limitations to consider.

Patrick M Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels,

Crit Care (Critical care (London, England))
[2021, 25(1):406]

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Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol.

Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel, Onnen Moerer,

<h4>Background</h4>The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approaches the most relevant to ICU to design a whole-body ultrasound (WBU) protocol. Recommendations and training schemes for ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):405]

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Promises and challenges of personalized medicine to guide ARDS therapy.

Katherine D Wick, Daniel F McAuley, Joseph E Levitt, Jeremy R Beitler, Djillali Annane, Elisabeth D Riviello, Carolyn S Calfee, Michael A Matthay,

Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):404]

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Telomere shortening during human septic shock: influence of sepsis mediators, role in organ failures, and septic myocardial dysfunction.

Keyvan Razazi, Elisabeth Marcos, Sophie Hüe, Laurent Boyer, Serge Adnot, Armand Mekontso Dessap,

Crit Care (Critical care (London, England))
[2021, 25(1):401]

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Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study.

Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee, Won Young Kim, ,

<h4>Background</h4>We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns ("highly malignant," "malignant," and "benign") according to the EEG timing (early vs. late) and investigated the EEG features to enhance the predictive power for poor neurologic outcome at 1 month after cardiac arrest.<h4>Methods</h4>This prospective, multicenter, observational, cohort study using data ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):398]

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AVDS should not dethrone ARDS.

Yazine Mahjoub, Daniel Rodenstein, Vincent Jounieaux,

Crit Care (Critical care (London, England))
[2021, 25(1):400]

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Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis.

Flavia Torrini, Ségolène Gendreau, Johanna Morel, Guillaume Carteaux, Arnaud W Thille, Massimo Antonelli, Armand Mekontso Dessap,

<h4>Background</h4>Extubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review and meta-analysis to explore factors associated with extubation failure in ventilated patients who passed a spontaneous breathing trial and underwent planned extubation. This systematic review was registered ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):391]

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A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals.

Dustin C Krutsinger, Kuldeep N Yadav, Michael O Harhay, Karsten Bartels, Katherine R Courtright,

<h4>Background</h4>Enrollment problems are common among randomized controlled trials conducted in the ICU. However, little is known about actual trial enrollment rates and influential factors. We set out to determine the overall enrollment rate in recent randomized controlled trials (RCTs) of patients with acute respiratory distress syndrome (ARDS), acute lung injury ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):392]

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Targeted high mean arterial pressure aggravates cerebral hemodynamics after extracorporeal resuscitation in swine.

Yael Levy, Alice Hutin, Fanny Lidouren, Nicolas Polge, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Guillaume Debaty, Keith Lurie, Lionel Lamhaut, Bijan Ghaleh, Renaud Tissier,

<h4>Background</h4>Extracorporeal cardiopulmonary resuscitation (E-CPR) is used for the treatment of refractory cardiac arrest. However, the optimal target to reach for mean arterial pressure (MAP) remains to be determined. We hypothesized that MAP levels critically modify cerebral hemodynamics during E-CPR and tested two distinct targets (65-75 vs 80-90 mmHg) in a porcine ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):369]

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Equilibrating SSC guidelines with individualized care.

Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M E de Man, Xavier Monnet, V Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche, Sheila N Myatra, Daniel De Backer,

Crit Care (Critical care (London, England))
[2021, 25(1):397]

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The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality.

Eline G M Cox, Marisa Onrust, Madelon E Vos, Wolter Paans, Willem Dieperink, Jacqueline Koeze, Iwan C C van der Horst, Renske Wiersema, ,

<h4>Background</h4>Prognostic assessments of the mortality of critically ill patients are frequently performed in daily clinical practice and provide prognostic guidance in treatment decisions. In contrast to several sophisticated tools, prognostic estimations made by healthcare providers are always available and accessible, are performed daily, and might have an additive value to ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):393]

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Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS.

Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello, Jose L Izquierdo-Garcia,

<h4>Background</h4>Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):390]

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A combination of Bohr and Haldane effects provide a physiologic explanation for the increase in arterial oxygen saturation when a face mask is added to a high-flow nasal cannula in severely hypoxemic COVID-19 patients.

Pablo Born, Ricardo Castro,

Crit Care (Critical care (London, England))
[2021, 25(1):395]

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Cardiogenic shock in Taiwan from 2003 to 2017 (CSiT-15 study).

Shih-Chieh Chien, Chien-Yi Hsu, Hung-Yi Liu, Chao-Feng Lin, Chung-Lieh Hung, Chun-Yao Huang, Li-Nien Chien,

<h4>Background</h4>This study investigated temporal trends in the treatment and mortality of patients with cardiogenic shock (CS) in Taiwan in relation to acute myocardial infarction (AMI) accreditation implemented in 2009 and the unavailability of percutaneous ventricular assist devices.<h4>Methods</h4>Data of patients diagnosed as having CS between January 2003 and December 2017 were ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):402]

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Continuous wireless postoperative monitoring using wearable devices: further device innovation is needed.

William Xu, Armen A Gharibans, Ian P Bissett, Gregory O'Grady, Cameron I Wells, Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson, Sarah Vollam,

Crit Care (Critical care (London, England))
[2021, 25(1):394]

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In the eye of the storm: impact of COVID-19 pandemic on admission patterns to paediatric intensive care units in the UK and Eire.

Hari Krishnan Kanthimathinathan, Hannah Buckley, Peter J Davis, Richard G Feltbower, Caroline Lamming, Lee Norman, Lyn Palmer, Mark J Peters, Adrian Plunkett, Padmanabhan Ramnarayan, Barnaby R Scholefield, Elizabeth S Draper,

<h4>Background</h4>The coronavirus disease-19 (COVID-19) pandemic had a relatively minimal direct impact on critical illness in children compared to adults. However, children and paediatric intensive care units (PICUs) were affected indirectly. We analysed the impact of the pandemic on PICU admission patterns and patient characteristics in the UK and Ireland.<h4>Methods</h4>We performed ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):399]

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