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A strategy for the identification of paracrine regulators of cancer cell migration.

Bernardo Chavez, Elena Farmaki, Youwen Zhang, Diego Altomare, Ji Hao, Elham Soltnamohammadi, Michael Shtutman, Ioulia Chatzistamou, Hippokratis Kiaris,

We hypothesized that the correlation of the whole transcriptome with quantifiable phenotypes may unveil genes contributing to the regulation of the corresponding response. We tested this hypothesis in cultured fibroblasts exposed to diverse pharmacological and biological agents, to identify genes influencing chemoattraction of breast cancer cells. Our analyses revealed several ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1758-1763]

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Interleukin-4 increases phagocytosis of necrotic cells by macrophages through scavenger receptor CD36.

Mingzhuang Chen, Gary Tse, Wing Tak Wong,

OBJECTIVE:Interleukin-4 (IL-4) signalling pathways regulate the activity of macrophages, enhance their proteolytic capacity and drive resolution of inflammation during tissue repair. The aim of this study was to examine whether IL-4 can enhance phagocytosis of necrotic cells and elucidate the molecular mechanisms. METHODS:Phagocytosis of necrotic thymocytes by RAW264.7 cells, a ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Tenacissoside H Promotes Neurological Recovery of Cerebral Ischemia-reperfusion Injury in Mice by Modulating Inflammation and Oxidative stress via TrkB Pathway.

Rui Zhang, Cui Liu, Yang Li, Liang Chen, Jianfeng Xiang,

Cerebral ischemia/reperfusion (I/R)-induced acute brain injury remains to be a troublesome condition in clinical practice. The present study was aimed to investigate the protective effect of Tenacissoside H (TH) on I/R-induced cerebral injury in mice. Here, a mouse model of middle cerebral artery occlusion (MCAO) was established by improved Longa-Zea ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Paracetamol - An old drug with new mechanisms of action.

Grzegorz W Przybyła, Konrad A Szychowski, Jan Gmiński,

Paracetamol (acetaminophen) is the most commonly used over-the-counter (OTC) drug in the world. Despite its popularity and use for many years, the safety of its application and its mechanism of action are still unclear. Currently, it is believed that paracetamol is a multidirectional drug and at least several metabolic pathways ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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High-sucrose diet potentiates hyperaldosteronism and renal injury induced by stress in young adult rats.

Cristhian Neftaly Sánchez-Solís, Estela Cuevas Romero, Ida Soto-Rodríguez, María de Lourdes Arteaga-Castañeda, Yeimy Mar De León-Ramírez, Jorge Rodríguez-Antolín, Leticia Nicolás-Toledo,

Analyze the effect of stress and high-sucrose diet on serum aldosterone levels and the morphometric characteristics of the kidney in young adult rats. Wistar male rats aged 21 days old weaned were randomly assigned into four groups: control (C), stressed (St), high-sucrose diet (S30), and chronic restraint stress plus a ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Effects of maternal high-fat/high sucrose diet on hepatic lipid metabolism in rat offspring.

Camilla Ingvorsen, Christopher J Lelliott, Susanne Brix, Lars I Hellgren,

Maternal obesity and/or high-fat diet during pregnancy predispose the offspring to metabolic disease. It is however unclear how pre-natal and post-natal exposure respectively affect the risk of hepatic steatosis and the trajectory towards non-alcoholic steatohepatitis in the offspring. We investigate hepatic lipid metabolism and how these factors are related to ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Circulating Treg cells from patients with cerebral aneurysms displayed deficiency in ICOS expression and function.

Ming-Guang Zhao, Cheng Peng, Li-Ming Li, Lu Chen, Hai-Feng Zhang,

Inducible costimulator (ICOS) is a member of the CD28 family. When activated, ICOS signalling promotes FOXP3 CNS2 gene demethylation and stabilizes Treg differentiation. Cerebral aneurysm (CA) is the local ballooning of the cerebral vasculature, characterized by higher levels of inflammation mediators and tissue remodelling. FOXP3+ Treg cell dysfunction may contribute ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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ELABELA improves endothelial cell function via the ELA-APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells.

Xiujuan Wang, Guoqing Liang, Qing Guo, Wei Cai, Xin Zhang, Jianmei Ni, Yanyan Tao, Xiulong Niu, Shaobo Chen,

Destruction of endothelial cells (ECs) function is involved in the structural and functional pathophysiological processes of preeclampsia (PE). Vascular endothelial injury may pre-exist for several years in women that develop PE and may pose increased risks for hypertension, coronary artery disease, and type-2 diabetes mellitus. Previous findings showed that Elabela ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Assessment of the anti-hyperalgesic efficacy of J-2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP).

Andy Kuo, Jacintha Lourdesamy, Janet R Nicholson, Laura Corradini, Maree T Smith,

Chronic mechanical low back pain (cLBP) is a leading cause of disability and a major socio-economic burden internationally. The lifetime prevalence of non-specific LBP is approximately 84%, with the prevalence of cLBP at about 23%. Clinically available analgesic/adjuvant medications often provide inadequate pain relief in patients experiencing cLBP. Hence, the ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Baseline, delta, and achieved low-density lipoprotein cholesterol levels and cardiovascular risk in patients on statin therapy: A post-hoc resampling mediation analysis of treating new targets [TNT] trial.

Myung Han Hyun, Jae Won Jang, Eunmi Lee, Hyonggin An, Hong Seog Seo,

Clinical guidelines for monitoring low-density lipoprotein cholesterol (LDL-C) after statin therapy do not clearly define the clinical roles of baseline LDL-C, ΔLDL-C, and achieved LDL-C according to statin intensity. We performed post-hoc analysis of the Treating to New Target (TNT) study to evaluate individual LDL-C parameters after statin therapy. Primary ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1649-1658]

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Reversion of cardiovascular remodelling in renovascular hypertensive 2K-1C rats by renin-angiotensin system inhibitors.

José Wilson do Nascimento Corrêa, Cibele Maria Prado, Maria Elena Riul, Alice Valença Araújo, Marcos Antonio Rossi, Lusiane Maria Bendhack,

OBJECTIVES:Evaluate whether the RAS dual blockade would induce additional beneficial effects on cardiovascular remodelling when compared to monotherapy in renal hypertensive two kidneys-one clip (2K-1C) rats. METHODS:Hypertensive 2K-1C and normotensive (2K) rats were treated for 14 days with submaximal doses of losartan (LOS), enalapril (ENA), losartan plus enalapril (LOS + ENA) or vehicle ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Central interaction between the apelinergic and vasopressinergic systems in the regulation of the haemodynamic parameters in rats maintained on a high-fat diet.

Olena Wojno, Katarzyna Czarzasta, Liana Puchalska, Malgorzata Kowalczyk, Agnieszka Cudnoch-Jedrzejewska,

A high-fat diet can affect the central activity of the apelinergic and vasopressinergic systems, which can have a significant impact on cardiovascular regulation. The aim of the study was to investigate the role of the central interaction between apelin and vasopressin in the regulation of the cardiovascular system in Sprague ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor.

Carmem Luíza Sartório, Enildo Broetto Pimentel, Roger Lyrio Dos Santos, Wender N Rouver, Jose Geraldo Mill,

Diminazene aceturate (DIZE) has been described as an angiotensin-converting enzyme 2 (ACE2) activator. We aimed to investigate DIZE effects on blood pressure (BP) of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. BP was recorded in awake and unrestrained rats 24 hours after femoral artery catheterization. DIZE (15 mg/kg, s.c.) produced ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1723-1730]

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IL-33 promotes the progress of vascular restenosis after carotid artery balloon injuryby promoting carotid artery intimal hyperplasia and inflammatory response.

Qingfu Zeng, Yingqi Xu, Wenwen Zhang, Fanzhen Lv, Weimin Zhou,

IL-33 is associated with vascular restenosis after carotid artery balloon injury. This work aims to investigate the involvement of IL-33 in carotid artery balloon injury. We first constructed carotid artery balloon injury modelinmale Wistar rats.Then, we found that IL-33 was highly expressed in therats with carotid artery balloon injury 3, ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Sucralose causes non-selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study.

Thaís Pasqualli, Pamella Eduardha E Chaves, Lavínia da Veiga Pereira, Élvio Adílio Serpa, Luís Flávio Souza de Oliveira, Michel Mansur Machado,

One of the most widely used sweeteners in the world is sucralose. With sweetening power 600 times greater than sucrose, its use grows among those who seek to cut calories. Research shows that when heated, sucralose generates toxic products that attack the organism and interact with DNA. Our objective was ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1751-1757]

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Comparative studies of glial fibrillary acidic protein and brain-derived neurotrophic factor expression in two transgenic mouse models of Alzheimer's disease.

Stephen R Edwards, Nemat Khan, Elizabeth J Coulson, Maree T Smith,

In Alzheimer's disease (AD) glial fibrillary acidic protein (GFAP) is expressed by reactive astrocytes surrounding β-amyloid (Aβ) plaques, whereas brain-derived neurotrophic factor (BDNF) levels are typically reduced. We compared the expression of GFAP, BDNF, and its precursor proBDNF in the dorsal hippocampus of two transgenic AD mouse models. APPSwe YAC ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1740-1750]

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Cerebral Palsy: Etiology, Pathophysiology and Therapeutic Interventions.

J Upadhyay, N Tiwari, M N Ansari,

Cerebral palsy (CP) is the most common non-progressive neurodevelopmental disorder in which the impairment of motor and posture functions occurs. This condition may be present in many different clinical spectra. Various etiological and risk factors play a crucial role in the causation of CP. In various cases, the causes of ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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SuPAR, a potential inflammatory mediator in psoriasis pathogenesis.

Lamiaa Hamie, Edward Eid, Ossama Abbas, Remi Safi, Tarak Nammour, Hani Tamim, Maha Makki, Carla Stephan, Divina Hasbani, Hisham Wehbe, Nohra Ghaoui, Mariana Hawa, Nourhan Nasser, Assaad Eid, Abdul-Ghani Kibbi, Mazen Kurban,

Psoriasis is an inflammatory skin disorder that is strongly associated with the metabolic syndrome. The sole reliance on clinical examination to guide prognostication and treatment is insufficient at best; accurate diagnostic and prognostic psoriatic molecular biomarkers are needed. Soluble urokinase plasminogen activator receptor (suPAR) has been implicated in inflammation. The ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1705-1712]

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Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in rats via AMPK/SIRT1/NF-κβ.

Heba H Mansour, Mervat M Omran, Hesham F Hasan, Shereen M El Kiki,

The efficacy of bleomycin (BLM) as an antineoplastic drug is limited to the development of dose and time-dependent pulmonary fibrosis. This study was intended to investigate the effect of N-acetylcysteine (NAC) on BLM-induced pulmonary fibrosis in rats. Twenty rats were randomly divided to the following four groups: Group one served ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Immunodepression induced by influenza A virus (H1N1) in lymphoid organs functions as a pathogenic mechanism.

Li Xiang, Xiaoyan Hu, Jinping Zhang, Junping She, Mingyuan Li, Tiejun Zhou,

In recent years, the frequency of influenza epidemics around the world has posed a great threat to the lives of people, especially those in developing countries. However, it is unclear which organs are the targets of influenza A viruses (IAVs) and what histopathology is caused by IAVs. In this study, ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1664-1673]

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The pivotal relation between glucagon-like peptides, NFκB and inflammatory bowel disease.

Omnia Azmy Nabeh, Magdy Ishak Attallah, Nawal El-Sayed El-Gawhary,

Glucagon-like peptides (GLPs), GLP-1 and GLP-2, are released from intestinal enteroendocrine cells (L cells) in response to ingested nutrients. GLP-1 plays a crucial role in lowering blood glucose and controlling body weight, through stimulating the islet ß cells of pancreas to secrete insulin, inhibiting gastric emptying, and reducing food ingestion. ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1641-1648]

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ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.

Li Wang, Xiaojie Yang, Leilei Wan, Shiwei Wang, Jinsong Pan, Yuehua Liu,

Rho GTPase-activating protein (Rho-GAP) and Rho GDP dissociation inhibitor (Rho- GDI) are two main negative regulators of Rho GTPase. Our previous work has found that Rho-GDI and Rho GTPase are involved in the response of human periodontal ligament (PDL) cells to mechanical stress. However, whether Rho-GAP also has a role ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(9):1591-1599]

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Alpha-lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes.

Thekkuttuparambil A Ajith,

Alpha-lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. Due to its potential antioxidant activity, it is considered as "universal antioxidant". Previous studies reported the pharmacological benefits of ALA such as glycaemic control, improved insulin sensitivity and alleviation of diabetic complications ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Utility of urinary organic anion transporter 5 as an early biomarker of obstructive nephropathy.

Romina V Campagno, Evangelina C Nosetto, Anabel Brandoni, Adriana M Torres,

Ureteral obstruction is a relevant cause of kidney damage. The traditional parameters used in clinical practice for the detection of renal injury are insensitive and non-specific for the diagnosis of obstructive renal disease. The organic anion transporter 5 (Oat5) is a carrier expressed exclusively in the kidney. In this study, ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(10):1674-1681]

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The anti-tumourigenic effect of ellagic acid in SKOV-3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK.

Fahmy G Elsaid, Mohamed A Alshehri, Ali A Shati, Mohamed A Al-Kahtani, Ali S Alsheri, Ehab E Massoud, Attalla F El-Kott, Haitham I El-Mekkawy, Amira M Al-Ramlawy, Mohamed E Abdraboh,

This study investigated the effect of ellagic acid (EA) on SKOV-3 cell growth and invasiveness and tested if the underlying mechanism involves modulating autophagy. Cells were treated with EA in the presence or absence of chloroquine (CQ), an autophagy inhibitor, compound C (CC), an AMPK inhibitor, or an insulin-like growth ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(9):1611-1621]

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