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Journal Clin. Chem. Lab. Med.

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Critica appraisal and meta-analysis of lbiological variation estimates for kidney related analytes.

Niels Jonker, Berna Aslan, Beatriz Boned, Fernando Marqués-García, Carmen Ricós, Virtudes Alvarez, William Bartlett, Federica Braga, Anna Carobene, Abdurrahman Coskun, Jorge Diaz-Garzón, Pilar Fernández-Calle, Elisabet Gonzalez-Lao, Joana Minchinela, Carmen Perich, Margarita Simón, Sverre Sandberg, Aasne K Aarsand, ,

Objective Kidney markers are some of the most frequently used laboratory tests in patient care, and correct clinical decision making depends upon knowledge and correct application of biological variation (BV) data. The aim of this study was to review available BV data and to provide updated BV estimates for the ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Effect of two organizational interventions on the frequency of haemoglobin A1c and erythrocyte sedimentation rate testing.

Janne Cadamuro, Cornelia Mrazek, Martin H Keppel, Thomas K Felder, Hannes Oberkofler, Elisabeth Haschke-Becher,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Upper respiratory samples pooling for screening SARS-CoV-2 infection: ready for the prime time?

Giuseppe Lippi,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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SARS-CoV-2 antibody performances: we need better criteria.

Claudio Galli, Mario Plebani,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Successfully meeting analytical expectations for the fast 0/1-h algorithm for NSTEMI by internal control procedures for cardiac troponin T.

Wendy Endlich, Willemina J Mensink, Wendy P J den Elzen, Laurens F Tops, Christa M Cobbaert,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Minimum retesting intervals in practice: 10 years experience.

Tim Lang,

Background Minimum retesting intervals (MRI) are a popular demand management solution for the identification and reduction of over-utilized tests. In 2011 Association of Clinical Biochemistry and Laboratory Medicines (ACB) published evidence-based recommendations for the use of MRI. Aim The aim of the paper was to review the use of MRI ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Validation of a liquid chromatography tandem mass spectrometry method for the simultaneous determination of hydroxychloroquine and metabolites in human whole blood.

Donna Austin, Catharine John, Beverley J Hunt, Rachel S Carling,

Objectives Hydroxychloroquine (HCQ) is an anti-malarial and immunomodulatory drug reported to inhibit the Corona virus, SARS-CoV-2, in vitro. At present there is insufficient evidence from clinical trials to determine the safety and efficacy of HCQ as a treatment for COVID-19. However, since the World Health Organisation declared COVID-19 a pandemic ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Measurement uncertainty estimation for derived biological quantities.

Raúl Rigo-Bonnin, Francesca Canalias,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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The early antibody response to SARS-Cov-2 infection.

Ruggero Dittadi, Haleh Afshar, Paolo Carraro,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e201-e203]

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Volumetric absorptive microsampling and dried blood spot microsampling vs. conventional venous sampling for tacrolimus trough concentration monitoring.

Herman Veenhof, Remco A Koster, Lenneke A T Junier, Stefan P Berger, Stephan J L Bakker, Daan J Touw,

Objectives Monitoring tacrolimus blood concentrations is important for preventing allograft rejection in transplant patients. Our hospital offers dried blood spot (DBS) sampling, giving patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. In this study, both ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):1687-1695]

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Limitations of rapid diagnostic testing in the work-up of dengue infection - a case report.

Shaun S Tan, Sharon Saw, Gabriel Yan, Ai Teng Chong, Zhixin Yang, Ai Ping Tan, Anantharaman Vathsala, Sunil K Sethi,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e245-e246]

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Interleukin-6 chemiluminescent immunoassay on Lumipulse G600 II: analytical evaluation and comparison with three other laboratory analyzers.

Ludovic Glady, Thomas Lavaux, Rim Charchour, Jean-Marc Lacorte, Jean-Marc Lessinger,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e229-e231]

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Persistently increased vitamin B12 concentration due to cobalamin macrocomplexes: a case report and review of the literature.

José A Delgado Rodríguez, María I Pastor García, Josep Miquel Bauça, Ramón Vidal Mullor, Antònia Barceló,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e237-e239]

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Measurement uncertainty and the importance of correlation.

Ian Farrance, Robert Frenkel,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures.

Christina C Rolling, Julia Tomada, Andreas M Frölich, Brigitte Holst, Katharina Holstein, Minna Voigtländer, Snjezana Janjetovic, Munif Haddad, Thomas Renné, Jens Fiehler, Carsten Bokemeyer, Thierry Rolling, Florian Langer,

Objectives Dual platelet inhibition is commonly used for prevention of cardiovascular events in patients undergoing neuroendovascular procedures. Non-responsiveness to platelet inhibitors may be associated with adverse outcomes. The aim of this study was to evaluate the reliability of the platelet function analyzer PFA-100® in comparison to light transmittance aggregometry (LTA) ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Response of anti-SARS-CoV-2 total antibodies to nucleocapsid antigen in COVID-19 patients: a longitudinal study.

Julien Favresse, Christine Eucher, Marc Elsen, Kim Laffineur, Jean-Michel Dogné, Jonathan Douxfils,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e193-e196]

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Towards the rational utilization of SARS-CoV-2 serological tests in clinical practice.

Mario Plebani, Andrea Padoan, Laura Sciacovelli, Daniela Basso,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e189-e191]

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Exact time of venous blood sample collection - an unresolved issue, on behalf of the European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for Preanalytical Phase (WG-PRE).

Alexander von Meyer, Giuseppe Lippi, Ana-Maria Simundic, Janne Cadamuro,

Objectives An accurate knowledge of blood collection times is crucial for verifying the stability of laboratory analytes. We therefore aimed to (i) assess if and how this information is collected throughout Europe and (ii) provide a list of potentially available solutions. Methods A survey was issued by the European Federation ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):1655-1662]

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The European Biological Variation Study (EuBIVAS): weekly biological variation of cardiac troponin I estimated by the use of two different high-sensitivity cardiac troponin I assays.

Ferruccio Ceriotti, Jorge Díaz-Garzón Marco, Pilar Fernández-Calle, Alessio Maregnani, Aasne K Aarsand, Abdurrahman Coskun, Niels Jonker, Sverre Sandberg, Anna Carobene, ,

Background Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation of biological variation (BV) of cTn. The knowledge of BV is important to define analytical performance specifications (APS) and reference ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):1741-1747]

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Interference from immunocomplexes on a high-sensitivity cardiac troponin T immunoassay.

Luca Dalle Carbonare, Michela Pizzini, Valentina Micheletti, Claudia Lo Cascio, Chiara Bovo, Domenico Girelli, Giuseppe Lippi,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):e225-e227]

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Influence of pancreatic status on circulating plasma sterols in patients with cystic fibrosis.

Monica Gelzo, Paola Iacotucci, Concetta Sica, Renato Liguori, Marika Comegna, Vincenzo Carnovale, Antonio Dello Russo, Gaetano Corso, Giuseppe Castaldo,

Background Patients with cystic fibrosis (CF) have a reduced intestinal absorption of cholesterol and in a preliminary study we observed differences in plasma sterol profile between patients with pancreatic sufficiency (PS) and those with pancreatic insufficiency (PI). Therefore, we hypothesized that the sterol analysis may contribute to study the digestion ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):1725-1730]

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Development, optimization and validation of an absolute specific assay for active myeloperoxidase (MPO) and its application in a clinical context: role of MPO specific activity in coronary artery disease.

Alessandro Trentini, Valentina Rosta, Savino Spadaro, Tiziana Bellini, Paola Rizzo, Francesco Vieceli Dalla Sega, Angelina Passaro, Giovanni Zuliani, Valentina Gentili, Gianluca Campo, Carlo Cervellati,

Background Myeloperoxidase (MPO) is an enzyme with a recognized prognostic role in coronary artery disease (CAD), which is also emerging as a promising biomarker for cardiac risk stratification. However, the lack of a consensus method for its quantification has hindered its implementation in clinical practice. The aim of our work ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(10):1749-1758]

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Determination of free light chains: assay-dependent differences in interpretation.

Xavier Bossuyt, Koen Poesen, Ben Sprangers, Martin Reynders, Martine Vercammen, Michel Delforge,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Emicizumab, the factor VIII mimetic bi-specific monoclonal antibody and its measurement in plasma.

Armando Tripodi, Veena Chantarangkul, Cristina Novembrino, Erica Scalambrino, Massimo Boscolo-Anzoletti, Marigrazia Clerici, Federica Rossi, Flora Peyvandi,

Objectives Emicizumab, a monoclonal antibody mimicking the function of factor (F) VIII in the activation of FX by FIXa, is widely used for prophylaxis in hemophilia patients with or without inhibitors to FVIII. Although it is administered at fixed dose, its measurement could be occasionally required. In principle, the emicizumab ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study.

Rita Christiane Baron, Lorenz Risch, Myriam Weber, Sarah Thiel, Kirsten Grossmann, Nadia Wohlwend, Thomas Lung, Dorothea Hillmann, Michael Ritzler, Susanna Bigler, Konrad Egli, Francesca Ferrara, Thomas Bodmer, Mauro Imperiali, Sonja Heer, Harald Renz, Lukas Flatz, Philipp Kohler, Pietro Vernazza, Christian R Kahlert, Matthias Paprotny, Martin Risch,

Objectives The sensitivity of molecular and serological methods for COVID-19 testing in an epidemiological setting is not well described. The aim of the study was to determine the frequency of negative RT-PCR results at first clinical presentation as well as negative serological results after a follow-up of at least 3 weeks. ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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