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Journal Clin Nucl Med

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Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT.

Peipei Wang, Guozhu Hou, Fang Li, Xin Cheng,

<h4>Abstract</h4>A 62-year-old man presented with a huge lesion of left kidney on ultrasound in a health examination 1 month ago. The mass showed hypervascularity on enhanced CT and intense FDG uptake on FDG PET/CT in the lower pole of kidney, which suggested renal malignancy. The histopathological result after surgical resection ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):510-511]

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18F-FDG PET/CT in the Hyperparathyroidism-Jaw-Tumor Syndrome.

Tina Nazerani Hooshmand, Birgit Pernthaler, Kinga Szurian, Mauro Pau, Reingard Maria Aigner,

<h4>Abstract</h4>Hyperparathyroidism-jaw-tumor syndrome (HPT-JTS) is a rare autosomal dominant disorder. A typical manifestation of HPT-JTS is the association of jaw-ossifying fibroma with primary hyperparathyroidism. Due to its rarity and diversity in its manifestations, it is a challenging diagnosis. A 33-year-old woman was referred due to painful swelling of the right maxilla ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):497-498]

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Unexpected 99mTcO4- Uptake by Lung Adenocarcinoma.

Luisa Knappe, Barbara Muoio, Paola Migliora, Gaetano Paone, Luca Giovanella,

<h4>Abstract</h4>A 76-year-old woman underwent 99mTcO4- thyroid scintigraphy to clarify thyrotoxicosis. In addition to suppressed thyroid uptake, an atypical tracer accumulation appeared on already know pulmonary adenocarcinoma in the left lung upper lobe. Surgical pathology was reviewed confirming the diagnosis of lung adenocarcinoma with focal mucins production and excluding a misdiagnosed ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e342-e343]

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Levodopa-Induced Dyskinesia in Parkinson Disease Specifically Associates With Dopaminergic Depletion in Sensorimotor-Related Functional Subregions of the Striatum.

Miguel A Labrador-Espinosa, Michel J Grothe, Daniel Macías-García, Silvia Jesús, Astrid Adarmes-Gómez, Laura Muñoz-Delgado, Paula Fernández-Rodríguez, Juan Francisco Martín-Rodríguez, Ismael Huertas, David García-Solís, Pablo Mir,

<h4>Purpose</h4>To determine whether the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) specifically relates to dopaminergic depletion in sensorimotor-related subregions of the striatum.<h4>Methods</h4>Our primary study sample consisted of 185 locally recruited PD patients, of which 73 (40%) developed LID. Retrospective 123I-FP-CIT SPECT data were used to quantify the specific ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e296-e306]

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Benign Adrenal Nodule Mimicking Lymphoma Differentially Diagnosed by 18F-FDG and 18F-FGln PET/CT.

Xiaoxia Xu, Hua Zhu, Hank F Kung, Nan Li, Zhi Yang,

<h4>Abstract</h4>18F-FDG and 18F-(2S,4R)4-fluoroglutamine (18F-FGln) PET/CT were performed in a 58-year-old woman with suspected small intestinal malignancy for differential diagnosis and staging. 18F-FDG and 18F-FGln PET images showed consistent intense hypermetabolic lesion activity in part of the small intestine. Moreover, 18F-FDG/PET demonstrated a focal of increased radiotracer uptake in left adrenal ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):474-476]

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Response to Treatment in IgG4-Related Disease Assessed by Quantitative PET/CT Scan.

Olimpia Orozco-Gálvez, Andreu Fernández-Codina, Marc Simó-Perdigo, Iago Pinal-Fernández, Fernando Martínez-Valle,

<h4>Objective</h4>The aim of this study was to assess disease activity by different PET/CT measurements in IgG4-related disease (IgG4-RD) flares and their correlation with the IgG4-RD responder index (IgG4-RI).<h4>Patients and methods</h4>Patients were retrospectively recruited from a single center in Barcelona, Spain. They all had IgG4-RD flares with an 18F-FDG PET/CT examination ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e307-e311]

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Paraneoplastic Limbic Encephalitis Secondary to SCLC on 18F-FDG PET/CT.

Alinne Fernanda Amaral Verçosa, Isabella Araújo Mota, Maria Eduarda Duarte de Mello Flamini, Rodrigo de Carvalho Flamini,

<h4>Abstract</h4>A 67-year-old man with rapidly neurologic deterioration and 15 kg weight loss in 2 months was extensively evaluated by several medical specialties and conventional image examinations, with no diagnostic definition. 18F-FDG PET/CT was performed, showing glycolytic hypermetabolism in the hippocampus, cerebral hypometabolism with posterior temporoparietal pattern, multiple cervical and supraclavicular ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):494-496]

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Efficacy and Safety of the 64Cu(II)Cl2 PET/CT for Urological Malignancies: Phase IIa Clinical Study.

Manlio Mascia, Carlo Villano, Valerio De Francesco, Luigi Schips, Michele Marchioni, Luca Cindolo,

<h4>Purpose of the report</h4>The aim of this study was to evaluate safety and efficacy of copper-64(II)dichloride (64Cu(II)Cl2) as a new PET tracer for urological malignancies (UMs).<h4>Methods</h4>Patients with UM were enrolled in a prospective study. All patients were staged with preoperative CT and 64Cu(II)Cl2 PET/CT. Patient characteristics, anatomical and functional imaging, ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):443-448]

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The Appearance of Sjögren Syndrome on 68Ga-PSMA-11 PET/CT.

Rou Li, Danni Li, Xiao Li, Changjing Zuo, Chao Cheng,

<h4>Abstract</h4>Significant 68Ga-PSMA-11 activity is commonly observed in the lacrimal and salivary glands on PSMA PET/CT. An 80-year-old man after radical prostatectomy was evaluated with 68Ga-PSMA-11 PET/CT. There was no obvious PSMA uptake in the bilateral lacrimal, parotid, and submandibular glands. Subsequently, based on laboratory examination results and 99mTcO4 salivary gland ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):517-519]

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Detection of Cauda Equine Syndrome With 18F-FDG PET/CT and Leptomeningeal Metastasis by 68Ga-DOTATATE in the Same Patient With Large Cell Neuroendocrine Carcinoma of Lung.

Esra Arslan, Özge Erol, Ediz Beyhan, Rahime Şahin, Tevfik Fikret Çermik,

<h4>Abstract</h4>Leptomeningeal metastasis is the metastatic spread of the disease to leptomeninges from solid tumors such as breast, lung cancer, and melanoma. Cauda equine syndrome is a neurological condition caused by compression of the cauda equine. The incidence of large cell neuroendocrine carcinoma in resected lung cancers appears to be 2.1% ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):488-490]

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FDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis.

Federico Massa, Laura Filippi, Luana Benedetti, Silvia Morbelli, Flavio Nobili,

<h4>Abstract</h4>In paraneoplastic cerebellar degeneration (PCD), the standard diagnostic workup might be inconclusive, especially in seronegative subtypes. Brain 18F-FDG PET is an accurate supportive diagnostic tool in immune-mediated disorders, but findings in PCD are controversial. Semiquantitative analysis of 18F-FDG PET can meaningfully assist visual assessment in different neurological conditions and has ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e327-e328]

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Parotid Oncocytoma on 99mTc-Sestamibi Scintigraphy and SPECT/CT.

John W Kirkland, Jason M Zhao, Nathan E McWhorter, Kevin P Banks,

<h4>Abstract</h4>Oncocytomas in the parotid gland are a rare benign neoplasm composed of mitochondrial-rich oncocytes. Here we present the case of an 85-year-old man with a history of biopsy-proven right parotid gland oncocytoma who underwent 99mTc-sestamibi scintigraphy and SPECT/CT in the context of primary hyperparathyroidism. Focal intense uptake of radiotracer is ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):480-482]

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Hemangioblastoma: An Unsuspected Pitfall in PSMA PET/CT.

Nicolas Gohimont, Patrice Jissendi Tchofo, Marie-Lucie Racu, Kim Entezari, Isabelle Salmon, Marianne Tondeur, Diana Ene,

<h4>Abstract</h4>Hemangioblastoma (HB) is the most common primary intra-axial posterior fossa tumor in adults and is a benign vascular neoplasm. We report the case of a 73-year-old man suffering from biochemical recurrence of prostate cancer where intense overexpression of prostate-specific membrane antigen (PSMA) was observed in HB in a PSMA PET/CT. ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):485-487]

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Quality and Safety in Healthcare, Part LXX: Qualifications and Leadership of the Chief Medical Officer.

Jay A Harolds,

<h4>Abstract</h4>The chief medical officer ideally has a degree in business, hospital administration, or related subjects and has also pursued training in leadership. This is very important to be able to read and interpret financial documents, understand the language of hospital executives, and be able to advise the administrators and physicians ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):471-473]

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Erratum: Predicting Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer: Combined Statistical Modeling Using Clinicopathological Factors and FDG PET/CT Texture Parameters.

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):525]

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Peptide Receptor Radionuclide Therapy in Patients With Neurofibromatosis Type 2: Initial Experience.

Olivia Kertels, Maria Breun, Heribert Hänscheid, Malte Kircher, Philipp E Hartrampf, Andreas Schirbel, Camelia-Maria Monoranu, Ralf-Ingo Ernestus, Andreas K Buck, Mario Löhr, Cordula Matthies, Constantin Lapa,

<h4>Purpose</h4>Neurofibromatosis type 2 (NF2) is a genetic disorder that is associated with multiple tumors of the nervous system, and approximately one half of patients present with meningiomas. For patients with multifocal disease, somatostatin receptor-targeted peptide receptor radionuclide therapy (PRRT) might be a suitable systemic treatment option.<h4>Patients and methods</h4>Between March 2015 ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e312-e316]

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Elevated 99mTcO4- Activity in Adenocarcinoma of the Lung.

Hui Ming, Yuanhao Chen, Hui Yu,

<h4>Abstract</h4>A 73-year-old man experienced chest tightness and shortness of breath for 9 months. Chest CT revealed a large right upper lobe mass. Pathology from CT-guided biopsy demonstrated poorly differentiated adenocarcinoma of the lung. Whole-body bone scan was acquired to evaluate possible bone metastasis. However, he was injected with 99mTcO4- erroneously ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):483-484]

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FAPI Uptake in a Vertebral Body Fracture in a Patient With Lung Cancer: A FAPI Imaging Pitfall.

Junhao Wu, Huipan Liu, Lei Ou, Guohao Jiang, Chunyin Zhang,

<h4>Abstract</h4>A left pulmonary nodule was identified by CT scan in a 53-year-old woman who had a car accident 10 days earlier. 18F-FDG PET/CT showed multiple FDG-avid lesions located at the left lung nodule, mediastinal lymph nodules, and L4 vertebral body. 68Ga-FAPI PET/CT was performed for further evaluation. However, 68Ga-FAPI demonstrated ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):520-522]

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Unsuspected Bladder Diverticulum Resulted in False-Positive 68Ga-DOTATATE Uptake.

Ying Deng, Yan Deng, Limeng He, Wei Zhang,

<h4>Abstract</h4>A 67-year-old woman with medullary thyroid cancer was referred for a 68Ga-DOTATATE PET/CT scan for staging. The images showed abnormal activity in the left thyroid gland and the left cervical lymph nodes. Surprisingly, increased activity was also noted in the posterolateral aspect of the urinary bladder without corresponding anatomical abnormality. ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):477-479]

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An Intravenous 100-mL Lipid Emulsion Infusion Dramatically Improves Myocardial Glucose Metabolism Extinction in Cardiac FDG PET Clinical Practice.

Matthieu Dietz, Benoît Paulmier, Frédéric Berthier, Filippo Civaia, François Mocquot, Benjamin Serrano, Valérie Nataf, Florent Hugonnet, Marc Faraggi,

<h4>Purpose</h4>Physiological myocardial accumulation of FDG impairs the diagnosis of inflammatory/infectious or tumoral myocardial detection by FDG PET/CT. We prospectively evaluated the addition, 3 hours before imaging, of an intravenous 100-mL lipid emulsion infusion (Intralipid) to a high-fat, low-carbohydrate diet (HFLCD) for at least 2 meals followed by a fast of ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):e317-e324]

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Posttraumatic Scab on 131I Whole-Body Scan-A False-Positive Finding.

Abdul Waheed Chowdhary, Anwin Joseph Kavanal, Ashwani Sood, Sarika Prashar, Ritesh Upadhyay, Anish Bhattacharya, Bhagwant Rai Mittal,

<h4>Abstract</h4>131I scan plays a crucial role in the management of patients with differentiated thyroid cancer for the evaluation of remnant thyroid tissue, residual/recurrent metastatic disease, posttherapy tracer distribution, and response assessment to high-dose 131I therapy. Different causes secondary to physiological, pathological, and anatomical variations have been described for false-positive findings ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):512-514]

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Elevated 68Ga-FAPI Activity in the Plasmacytoma of the Ribs.

Wenxin Tang, Qixin Wang, Songsong Yang, Yue Chen,

<h4>Abstract</h4>68Ga-labeled quinoline-based fibroblast activation protein inhibitors (68Ga-FAPIs) has been used in the evaluation of a variety of malignancies. We report the case of a patient with rib plasmacytoma, which showed elevated 68Ga-FAPI activity. This case indicated fibroblast activation protein overexpression and some degree of fibrosis in the plasmacytoma lesion. Therefore, ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):523-524]

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18F-FET PET/CT in Early Subventricular Zone Recurrence of Adult Glioblastoma.

Gurvan Dissaux, Brieg Dissaux, David Bourhis, Ulrike Schick, Solène Querellou,

<h4>Abstract</h4>Glioma stem cells (GSCs) are the source of tumor recurrence in glioblastoma and are capable of whole tumor regeneration once the treatment has concluded. Compelling evidence from the last decade suggests that GSC may arise from neural stem cells residing in the adult subventricular zone (SVZ). We report the findings ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):499-500]

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68Ga-DOTATATE PET/CT Imaging of Refractory Pituitary Macroadenoma Invading the Orbit.

Noah Lybik, Daniel J Wale, Ka Kit Wong, Eric Liao, Benjamin L Viglianti,

<h4>Abstract</h4>In addition to gastroenteropancreatic neuroendocrine neoplasms, a wide variety of tumors express somatostatin receptors. Somatostatin receptor imaging, heavily utilized in neuroendocrine oncology, may also have utility in the diagnosis of other neoplasms and raises the possibility of potential therapeutic options. We describe the case of a 60-year-old man who underwent ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):505-506]

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Incremental Role of 18F-FDG-Labeled Autologous Leukocyte PET/CT in Suspected Postoperative Recurrence of Skull Base Osteomyelitis.

Venkata Subramanian Krishnaraju, Rajender Kumar, Sourabha K Patro, Anish Bhattacharya, Harmandeep Singh, Bhagwant Rai Mittal,

<h4>Abstract</h4>Skull base osteomyelitis is 1 of the complications of a middle ear infection seen mainly in immunocompromised individuals. A 3-phase bone scan and clinical, laboratory, and other radiological imaging are used for the diagnosis. However, in previously operated cases, bone scan findings are not reliable. We present a case of ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):507-509]

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