Full Text Journal Articles in
Journal Clin Lab Med

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Donor Screening and Deferral.

Lisa Rosochacki, Jaleah Hawkins,

The maintenance of an adequate and safe blood supply begins with choosing the right donor at the right time. The evolution of donor screening has been shaped by experience, donor satisfaction, and the ever-challenging emergence of relevant infectious diseases. Screening donors has been standardized over the past 6 decades to ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):563-577]

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Updates in Blood Banking and Transfusion Medicine.

Suzanne R Thibodeaux,

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):xiii-xiv]

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Blood Product (Donor) Noninfectious and Infectious Testing and Modification.

Tania Sarker, Louis M Katz, Evan M Bloch, Ruchika Goel,

Blood transfusion begins with safe donor selection and testing. In the United States, the blood supply and transfusion are highly regulated. Blood transfusion safety is multifaceted, whereby each of the elements of the blood safety value chain, spanning donor recruitment and qualification, to collection, blood processing, testing, transfusion practice, and ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):579-598]

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Performance evaluation of lateral flow assays for COVID-19 serology

Lucy Ochola, Paul Ogongo, Samuel Mungai, Jesse Gitaka, Sara Suliman,

The Coronavirus disease of 2019 (COVID-19) pandemic, caused by infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has undoubtedly resulted in significant morbidities, mortalities, and economic disruptions across the globe. Affordable and scalable tools to monitor the transmission dynamics of the SARS-CoV-2 virus and the longevity of induced antibodies ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, :]

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Sub-optimal Humoral immunity in SARS CoV-2 infection and viral variant generation

Shiv Pillai,

Abstract: This review describes the underlying basis for the sup-optimal humoral immune response in COVID-19 including the absence of evidence for affinity maturation in the vast majority of patients and the absence of germinal centers even in severe disease. Sub-optimal humoral and cellular immunity provide the optimal conditions for the ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, :]

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Vaccine-induced SARS-CoV-2 Antibody Response and the Path to Accelerating Development (Determining a Correlate of Protection)

Amy C. Sherman, Michael Desjardins, Lindsey R. Baden,

Clin Lab Med (Clinics in laboratory medicine)
[2021, :]

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Red Blood Cell Transfusion.

Yvette C Tanhehco,

Red blood cell (RBC) transfusions are necessary to increase a patient's oxygen carrying capacity. The optimal transfusion trigger remains elusive, but a restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce RBC transfusions without adversely affecting patient outcomes. Patient blood management programs have been shown effective at ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):611-619]

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Transfusion Medicine Informatics: A Review of Current Practice and a Glimpse into the Future.

Thomas Schneider, Ronald Jackups,

Clinical informatics has been described as the "relentless pursuit of assisting people" by using data and information technology to improve health care. A core principle is that a person supported by information technology is superior to either a person or machine alone. Striving toward this harmonization, the transfusion medicine field ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):713-725]

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A Concise Synopsis of Current Literature and Guidelines on the Practice of Plasma Transfusion.

Wen Lu,

Evidence-based indications for plasma transfusion are limited, and much of the clinical practice relies on expert opinion. This article highlights key studies, meta-analyses, and guidelines for plasma transfusion in adults. The goal is to limit non-evidence-based plasma transfusion that is outside of clinical guideline, because as with all transfusions, the ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):635-645]

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Transfusion Reactions and Adverse Events.

Rim Abdallah, Herleen Rai, Sandhya R Panch,

Blood transfusions are generally safe but can carry considerable risks. This review summarizes the different types of transfusion reactions and ways to diagnose and manage them. Symptoms are often overlapping and nonspecific. When a reaction is suspected, it is critical to stop the transfusion immediately and report the reaction to ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):669-696]

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Platelet Transfusion: An Update on Indications and Guidelines.

Shan Yuan, Zaher K Otrock,

Platelets are commonly transfused either therapeutically or prophylactically to maintain hemostasis. Most platelet transfusions are used to manage patients with hematologic malignancies. Although platelet transfusion guidelines have been published, platelet transfusion practices are still heterogeneous. Platelet transfusion guidelines partly lack recommendations or differ in the platelet threshold recommendations in some ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):621-634]

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Transfusion Blood Bank (Recipient) Testing.

Caroline R Alquist, Louise Helander,

Pretransfusion and post-transfusion recipient testing are routine blood bank functions. This article presents a review of request and sample requirements, routine and extended typing and antibody evaluation, and post-transfusion circumstances requiring additional work-up. Although the regimented approach of blood banking fundamentals may be viewed as tedious, these steps are defined ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):599-610]

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Update in Transfusion Medicine Education.

Alexis R Peedin,

Despite the high frequency with which blood transfusions are performed, transfusion medicine education remains variable in the United States and around the world. Educating medical students and nonpathology physicians is critical for safe and evidence-based transfusion. Many innovative curricula have been published to meet the needs of physicians training in ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):697-711]

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Whole Blood Transfusion: Past, Present, and Future.

Elizabeth A Godbey,

Transfusion of whole blood largely was replaced by component therapy in the 1970s and 1980s. The recent military operations in Iraq and Afghanistan returned whole blood to military trauma care. Eventually, whole blood use was incorporated into some civilian trauma care. It has been utilized in several other civilian populations ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):659-667]

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Granulocyte Transfusion: Clinical Updates and a Practical Approach to Transfusion.

Tobias Cohen, Sierra C Simmons, Huy P Pham, Elizabeth M Staley,

Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune function to prevent and/or treat infections in patients with severe neutropenia or neutrophil dysfunction. However, evidence ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):647-657]

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Infant Acute Leukemia.

Gerald Wertheim,

Infant acute leukemia is a rare but aggressive disease. Although infant acute leukemia is cytologically and histologically similar to acute leukemia seen in older children and adults, it displays unique and characteristic clinical and genetic characteristics. The features, as well as the extremely young age of the patients, present multiple ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):541-550]

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Hematopathology Gets Younger.

Vinodh Pillai,

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):xiii-xiv]

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Gene Rearrangement Detection in Pediatric Leukemia.

Marian H Harris,

The detection of gene rearrangements in pediatric leukemia is an essential component of the work-up, with implications for accurate diagnosis, proper risk stratification, and therapeutic decisions, including the use of targeted therapies. The traditional methods of karyotype and fluorescence in situ hybridization are still valuable, but many new assays are also ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):551-561]

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Update on Lymphoblastic Leukemia/Lymphoma.

Dragoș C Luca,

Lymphoblastic leukemias/lymphomas are predominantly diseases of childhood, where they represent almost all acute leukemias; however, they are also encountered with significant frequency in the adult population. These neoplastic processes can be of B-cell or T-cell derivation and are composed of immature precursors of either lineage. The classification of B-lymphoblastic neoplasms ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):405-416]

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Pediatric Myeloproliferative Neoplasms.

Farah El-Sharkawy, Elizabeth Margolskee,

Myeloproliferative neoplasms can present early in life and may present a diagnostic challenge. Very few studies have focused on the diagnosis, prognosis, and therapy for pediatric myeloproliferative neoplasms. This article focuses on chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, and primary myelofibrosis in children. ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):529-540]

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Clinics in Laboratory Medicine

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):xi-xi]

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The Hematological Differential Diagnosis of Mediastinal Masses.

Ahmed Aljudi, Elizabeth Weinzierl, Mohamed Elkhalifa, Sunita Park,

Mediastinal masses commonly present in children and may pose diagnostic challenges, particularly with limited sampling. This article aids the pathologist by reviewing the hematologic differential diagnosis of a pediatric mediastinal mass, along with ancillary testing useful for rendering the correct diagnosis. A review of the more common lymphomas is presented, ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):389-404]

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Role of Minimal Residual Disease Testing in Acute Myeloid Leukemia.

Xueyan Chen, Sindhu Cherian,

Minimal or measurable residual disease (MRD) after therapy is the most important independent prognostic factor in acute myeloid leukemia. MRD measured by multiparametric flow cytometry and real-time quantitative polymerase chain reaction has been integrated into risk stratification and used to guide future treatment strategies. Recent technological advances have allowed the ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):467-483]

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Molecular Genetics of Pediatric Acute Myeloid Leukemia.

Bryan Krock, Matthew J Oberley,

The genetic basis for pediatric acute myeloid leukemia (AML) is highly heterogeneous, often involving the cooperative action of characteristic chromosomal rearrangements and somatic mutations in progrowth and antidifferentiation pathways that drive oncogenesis. Although some driver mutations are shared with adult AML, many genetic lesions are unique to pediatric patients, and ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):497-515]

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Inherited Bone Marrow Failure Syndromes: Biology and Diagnostic Clues.

M Tarek Elghetany, Jyotinder Nain Punia, Andrea N Marcogliese,

Inherited bone marrow failure syndromes are a group of genetic disorders associated with bone marrow production defects resulting in single or multiple cytopenias. Many of these disorders predispose the patient to hematologic and nonhematologic malignancies, requiring life-long follow-up. A positive family history of hematologic disorders or malignancies is frequent, as ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(3):417-431]

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