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Journal Clin Genitourin Cancer

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Molecular and Clinical Characterization of Patients With Metastatic Castration Resistant Prostate Cancer Achieving Deep Responses to Bipolar Androgen Therapy.

Mark C Markowski, Sushant Kachhap, Angelo M De Marzo, Laura A Sena, Jun Luo, Samuel R Denmeade, Emmanuel S Antonarakis,

<h4>Background</h4>Bipolar androgen therapy (BAT) is an emerging treatment strategy for men with metastatic castration resistant prostate cancer (mCRPC) whereby serum testosterone is cycled from supraphysiologic to near-castrate levels each month. BAT has been shown to induce clinical responses in a significant proportion of patients, some of which are extreme. We ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Outcomes of metastatic urothelial carcinoma following discontinuation of enfortumab-vedotin.

Catherine Curran, Elio Adib, Vera Kazakova, Petros Grivas, Leonidas Nikolaos Diamantopoulos, Ajjai Shivaram Alva, Christopher Su, Rohit K Jain, Ankita Tandon, Andrea Necchi, Laura Marandino, Trisha M Plastini, Jaime R Merchan, Guru Sonpavde,

<h4>Background</h4>Enfortumab vedotin (EV) is approved to treat metastatic urothelial carcinoma (mUC) following platinum and PD1/L1 inhibitors. Since the outcomes and patterns of therapy of patients following discontinuation of EV are unknown, we conducted a retrospective study to assess this issue.<h4>Methods</h4>Data were retrospectively obtained from patients with mUC following discontinuation of ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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A Phase II, Randomized, Open-Label, Multi-arm Study of TAS-115 for Castration-Resistant Prostate Cancer Patients With Bone Metastases.

Nobuaki Matsubara, Hirotsugu Uemura, Satoshi Nagamori, Hiroyoshi Suzuki, Hiroji Uemura, Go Kimura,

<h4>Introduction</h4>TAS-115 is an oral multikinase inhibitor targeting the MET proto-oncogene, vascular endothelial growth factor receptor, and colony-stimulating factor 1 receptor. We evaluated the efficacy and safety of TAS-115 in castration-resistant prostate cancer (CRPC) patients with bone metastases.<h4>Patients and methods</h4>This phase II study, conducted in Japan, comprised 2 cohorts of CRPC ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Analysis of the Prognostic Significance of Circulating Tumor DNA in Metastatic Castrate Resistant Prostate Cancer.

Justin Shaya, Taylor Nonato, Angelo Cabal, James Michael Randall, Frederick Millard, Tyler Stewart, Rana R McKay,

<h4>Background</h4>There has been considerable interest in ctDNA next generation sequencing platforms to assess genomic alterations in mCRPC given its accessibility and identification of temporal genomic data.<h4>Patientsand methods</h4>In this retrospective analysis, we analyzed 63 patients who underwent ctDNA genomic profiling during their mCRPC disease course using a CLIA-certified commercial assay. The ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Targeting the PI3K-AKT-mTOR Pathway in Castration Resistant Prostate Cancer: A Review Article.

Jason Cham, Aparajit Ram Venkateswaran, Munveer Bhangoo,

<h4>Background</h4>Prostate cancer is one of leading causes of cancer death among men worldwide. Androgen deprivation therapy is a central part of the prostate cancer treatment algorithm, however, resistance to androgen deprivation commonly leads to disease progression. Mutations in the phosphoinositide-3-kinase pathway (PI3K) have been implicated in cancer progression and the ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Histological Variants of Urothelial Carcinoma Predict No Response to Neoadjuvant Chemotherapy.

Katia Ramos Moreira Leite, Leonardo Lima Borges, Leopoldo Ribeiro Filho, Daher Chade, Rafael Ferreira Coelho, Mauricio Cordeiro, Miguel Srougi, Willian Carlos Nahas,

<h4>Background</h4>Platinum-based neoadjuvant chemotherapy (NAC) in muscle-invasive urothelial bladder cancer (MIBC) has been adopted as a standard of care related to better survival outcomes. However, there is a considerable number of patients who do not respond, experiencing toxicity and delay in the surgical treatment. Our aim is to find biomarkers of ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Oncologic Outcomes for Robotic Vs. Open Radical Cystectomy Among Locally Advanced and Node-Positive Patients: Analysis of The National Cancer Database.

Akshay G Reddy, Andrew D Sparks, Christina Darwish, Michael J Whalen,

<h4>Introduction</h4>Despite concerns of atypical recurrence following robotic-assisted radical cystectomy (RARC), utilization of the modality is increasing. The presumed mechanisms of peritoneal immunomodulation and pneumoperitoneum-induced tumor cell intravasation are especially relevant for higher stage, locally advanced disease, where intrinsic metastatic potential of tumor cells may be greater. This study aims to ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Changing pattern of radiation therapy for bone metastases in an Australian population-based cohort of men with prostate cancer.

Wee Loon Ong, Roger L Milne, Farshad Foroudi, Jeremy L Millar,

<h4>Introduction</h4>To evaluate the pattern of use of single-fraction conformal radiation therapy (SF-RT) and advanced radiation therapy techniques (ART), including stereotactic body radiation therapy (SBRT), for management of bone metastases (BM) in a population-based cohort of Australian men with prostate cancer (PCa) PATIENT AND METHODS: We reviewed men with metastatic PCa ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Impact of Histology and Tumor Grade on Clinical Outcomes Beyond 5 Years of Follow-Up in a Large Cohort of Renal Cell Carcinomas.

Manuela Costantini, Maria Luana Poeta, Ruth M Pfeiffer, Dana Hashim, Catherine L Callahan, Steno Sentinelli, Laura Mendoza, Marco Vicari, Vincenzo Pompeo, Angela Cecilia Pesatori, Curt T DellaValle, Giuseppe Simone, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi,

<h4>Introduction</h4>The optimal length for clinical follow-up of renal cell carcinoma (RCC) patients is unclear. We evaluated the impact of ISUP/WHO tumor grade and histological subtype on short- and long-term survival and risk of recurrence/metastasis in a large cohort of RCC patients.<h4>Patients and methods</h4>We studied 1679 RCC patients from a single ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Prostate Cancer Characteristics and Outcomes after Prostatectomy in Asian-American Men.

Tanya Dorff, James Shen, Nora Ruel, Rick Kittles, Yung Lyou, Savita Dandapani, Jeff Wong, Huiqing Wu, Sumanta Pal, Clayton Lau, Bertram Yuh,

<h4>Background</h4>Prostate cancer is the most commonly diagnosed cancer in American men, with striking differences between ethnic groups. Given the potential for lifestyle or genetic variations between subsets of Asian-American men to impact prostate cancer behavior, we sought to define the outcomes after radical prostatectomy among various Asian groups treated at ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Validation of Prognostic Scores in Patients With Metastatic Urothelial Cancer Enrolling in Phase I Targeted Therapy or Next Generation Immunotherapy Trials.

Omar Alhalabi, Andrew W Hahn, Pavlos Msaouel, Funda Meric-Bernstam, Nathaniel Wilson, Aung Naing, Sarina Piha-Paul, Filip Janku, Shubham Pant, Timothy A Yap, David S Hong, Siqing Fu, Daniel Karp, Kimberly Beltran, Erick Campbell, Hung Le, Matthew T Campbell, Amishi Shah, Nizar M Tannir, Arlene Siefker-Radtke, Jianjun Gao, Jason Roszik, Vivek Subbiah,

<h4>Introduction</h4>Enrolling patients with metastatic urothelial carcinoma (mUC) in phase I trials provides an opportunity to identify biological drug activity. Developing prognostic scores may aid in patient selection for phase 1 trials.<h4>Patients and methods</h4>We analyzed records of patients with mUC who participated in targeted therapy and immunotherapy phase I clinical trials ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Diagnostic Utility of RNA-Seq for Evaluation of PD-L1 Expression in Clear Cell Renal Cell Carcinoma.

Maria Sorokina, Danil Stupichev, Yang Lyu, Akshaya Ramachandran, Natalia Miheecheva, Jessica H Brown, Krystle Nomie, Ekaterina Postovalova, Alexander Bagaev, Maria Tsiper, James J Hsieh,

<h4>Background</h4>Although there are immune checkpoint inhibitors (ICIs) available for the treatment of renal cell carcinoma (RCC), the utility of PD-L1 detection by immunohistochemistry (IHC) as a predictive biomarker in clear cell RCC (ccRCC) remains controversial. Nevertheless, alternative methods for PD-L1 detection, such as RNA sequencing (RNA-Seq), may be clinically useful ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Beyond Frontline Therapy with Abiraterone and Enzalutamide in Metastatic Castration-Resistant Prostate Cancer: A Real-World US Study.

Neal D Shore, Raluca Ionescu-Ittu, François Laliberté, Lingfeng Yang, Dominique Lejeune, Louise Yu, Mei Sheng Duh, Malena Mahendran, Jeri Kim, Sameer R Ghate,

<h4>Background</h4>Real-world evidence suggest that next generation hormonal agents (NHAs) abiraterone and enzalutamide were preferred as first-line (1L) therapies for metastatic castration-resistant prostate cancer (mCRPC) in the United States (US) pre-2020, with chemotherapies, particularly docetaxel, being preferred in subsequent lines (2L+). This real-world study described patient characteristics, treatment patterns, time on ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Molecular Subtypes and Gene Expression Signatures as Prognostic Features in Fully Resected Clear Cell Renal Cell Carcinoma: A Tailored Approach to Adjuvant Trials.

Eduard Roussel, Annelies Verbiest, Lisa Kinget, Bram Boeckx, Jessica Zucman-Rossi, Gabrielle Couchy, Stefano Caruso, Sylvie Job, Aurélien de Reyniès, Liesbeth De Wever, Marcella Baldewijns, Hendrik Van Poppel, Steven Joniau, Diether Lambrechts, Maarten Albersen, Benoit Beuselinck,

<h4>Background</h4>Trials with adjuvant vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) failed to demonstrate meaningful benefit in clinically high-risk, fully resected clear cell renal cell carcinoma (ccRCC). We evaluated whether the ccrcc1-4 molecular subtypes and gene expression signatures (GES) are associated with outcomes in this setting.<h4>Materials and methods</h4>We determined ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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A Prospective Multicenter Evaluation of Initial Treatment Choice in Metastatic Renal Cell Carcinoma Prior to the Immunotherapy Era: The MaRCC Registry Experience.

Brian A Costello, Nrupen A Bhavsar, Yousef Zakharia, Sumanta K Pal, Ulka Vaishampayan, Heather Jim, Mayer N Fishman, Ana M Molina, Christos E Kyriakopoulos, Che-Kai Tsao, Leonard J Appleman, Benjamin A Gartrell, Arif Hussain, Walter M Stadler, Neeraj Agarwal, Russell K Pachynski, Thomas E Hutson, Hans J Hammers, Christopher W Ryan, Jack Mardekian, Azah Borham, Daniel J George, Michael R Harrison,

<h4>Introduction</h4>The Metastatic Renal Cell Carcinoma (MaRCC) Registry provides prospective data on real-world treatment patterns and outcomes in patients with metastatic renal cell carcinoma (mRCC).<h4>Methods and materials</h4>Patients with mRCC and no prior systemic therapy were enrolled at academic and community sites. End of study data collection was in March 2019. Outcomes ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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p53 and p16ink4a As Predictive and Prognostic Biomarkers for Nodal metastasis and Survival in A Contemporary Cohort of Penile Squamous Cell Carcinoma.

Sambit K Mohanty, Sourav K Mishra, Nitin Bhardwaj, Ruhani Sardana, Sunil Jaiswal, Niharika Pattnaik, Dinesh Pradhan, Shivani Sharma, Seema Kaushal, Manas R Baisakh, Suren Das, Manas R Pradhan, Kaliprasad Satapathy, Ashis Pattnaik, Shailendra K Sharma, Chira R Khadenga, Subodh Das, Debadarshi Rath, Biswajit Nanda, Anil V Parwani,

<h4>Background</h4>Human papilloma virus (HPV) infection is implicated in a proportion of invasive squamous cell carcinoma of the penis (PC). A subset of PC involves dysregulation of the p53 pathway. HPV in situ hybridization (ISH) and p16<sup>ink4a</sup> positivity are surrogate markers for HPV infection, and p53 immunohistochemistry (IHC) denotes abnormality in ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Intravesical Bacillus Calmette-Guérin Treatment Is Inversely Associated With the Risk of Developing Alzheimer Disease or Other Dementia Among Patients With Non-muscle-invasive Bladder Cancer.

Joseph I Kim, Denzel Zhu, Emily Barry, Evan Kovac, Ahmed Aboumohamed, Ilir Agalliu, Alex Sankin,

<h4>Background</h4>The immune system plays an important role in the pathogenesis of Alzheimer disease (AD), but it remains unclear whether bacillus Calmette-Guérin (BCG) may affect the risk of AD or not.<h4>Methods</h4>Using retrospective chart review, we collected data regarding demographics, comorbidities, cancer diagnosis, BCG treatment, and subsequent diagnosis of AD or other ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Performance of Indocyanine Green Fluorescence for Detecting Lymph Node Metastasis in Prostate Cancer: A Systematic Review and Meta-analysis.

Fumihiko Urabe, Shoji Kimura, Keiji Yasue, Takafumi Yanagisawa, Shunsuke Tsuzuki, Takahiro Kimura, Jun Miki, Shin Egawa,

<h4>Purpose</h4>The use of sentinel lymph node dissection in several cancers has been gaining attention with the emergence of indocyanine green fluorescence. We performed a meta-analysis to assess the diagnostic performance of indocyanine green fluorescence in detecting lymph node metastasis in prostate cancer patients.<h4>Methods</h4>A literature search was conducted using PubMed, Cochrane ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Active Surveillance in Metastatic Renal Cell Carcinoma: Results From the Canadian Kidney Cancer Information System.

Igal Kushnir, Naveen S Basappa, Sunita Ghosh, Aly-Khan A Lalani, Aaron R Hansen, Lori Wood, Christian K Kollmannsberger, Daniel Y C Heng, Georg A Bjarnason, Denis Soulières, David E Dawe, Simon Tanguay, Rodney H Breau, Frédéric Pouliot, Anil Kapoor, Jeffrey Graham, M Neil Reaume,

<h4>Background</h4>Active surveillance (AS) is a commonly used strategy in patients with slow-growing disease. We aimed to assess the outcomes and safety of AS in patients with metastatic renal cell carcinoma (mRCC).<h4>Patients and methods</h4>We used the Canadian Kidney Cancer information system (CKCis) to identify patients with mRCC diagnosed between January 1, ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Temporal Trends and Predictors in Diagnosing Pathologic Node-Positive Prostate Cancer in Clinically Node-Negative Patients.

Ryan J Hutten, Matthew W Parsons, Christopher R Weil, Jonathan D Tward, Shane Lloyd, Alejandro Sanchez, Nataniel Lester-Coll, Skyler B Johnson,

<h4>Introduction</h4>Managing pathologically node positive (pN+) prostate cancer (PCa) is controversial. We describe temporal patterns and predictors of pN+ PCa in men with initially surgically managed clinically node negative (cN-) PCa.<h4>Materials and methods</h4>This observational retrospective analysis of nonmetastatic, cN- PCa uses the National Cancer Database. Multivariable logistic regression was used to ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Anaplastic Features in Advanced Prostate Cancer With and Without DNA Damage Repair Mutations.

Vincent Chau, Ravi A Madan, Marijo Bilusic, Helen Owens, Lisa M Cordes, Jennifer L Marte, James L Gulley, Jung-Min Lee, William L Dahut, Fatima Karzai,

<h4>Background</h4>Anaplastic prostate cancer has a poor prognosis with limited treatment options. Seven clinical features of anaplastic prostate cancer have been prospectively identified. In this phase II clinical trial, we identified mutations, including DNA damage repair (DDR) mutations, in patients with metastatic castration-resistant prostate cancer (mCRPC) who were treated with durvalumab ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Real-world Clinical Effectiveness of Lenvatinib/Everolimus in a Heavily Pretreated Advanced/Metastatic Renal Cell Carcinoma Population in the US Community Oncology Setting.

Nicholas J Vogelzang, Alisha M Monnette, Yunfei Wang, Yin Wan, Yiqiong Xie, Nicholas J Robert, Nizar M Tannir,

<h4>Introduction</h4>Few studies have evaluated real-world effectiveness of lenvatinib (Len)/everolimus (Eve) for advanced/metastatic renal cell carcinoma (a/mRCC). This study evaluated patient profiles and clinical outcomes of second- and subsequent-line (≥ 2L) Len/Eve for a/mRCC.<h4>Patients and methods</h4>A longitudinal retrospective study examined adult patients initiating ≥ 2L Len/Eve for a/mRCC from May 13, ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Combining Stereotactic Body Radiotherapy and Microwave Ablation Appears Safe and Feasible for Renal Cell Carcinoma in an Early Series.

Grace C Blitzer, Andrzej Wojcieszynski, E Jason Abel, Sara Best, Fred T Lee, J Louis Hinshaw, Shane Wells, Timothy J Ziemlewicz, Meghan G Lubner, Marci Alexander, Poonam Yadav, John E Bayouth, John Floberg, Greg Cooley, Paul M Harari, Michael F Bassetti,

Microwave (MW) ablation and stereotactic body radiation therapy (SBRT) are both used in treating inoperable renal cell carcinoma (RCC). MW ablation and SBRT have potentially complementary advantages and limitations. Combining SBRT and MW ablation may optimize tumor control and toxicity for patients with larger (> 5 cm) RCCs or those ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma.

Rohit K Jain, William Paul Skelton Iv, Gregory Russell Pond, Mahrukh Naqvi, Youngchul Kim, Catherine Curran, Dory Freeman, Pier Vitale Nuzzo, Sarah Abou Alaiwi, Amin H Nassar, Rakesh K Jain, Guru Sonpavde,

<h4>Background</h4>The renin-angiotensin system is involved in the regulation of angiogenesis and cell proliferation. Angiotensin inhibition may improve drug delivery by enhancing tumor perfusion partly by downregulating transforming growth factor (TGF)-β. Because TGF-β is associated with resistance in patients with metastatic urothelial carcinoma (mUC) receiving programmed cell death protein 1/programmed cell ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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A Phase I/II Study to Assess the Safety and Efficacy of Pazopanib and Pembrolizumab Combination Therapy in Patients with Advanced Renal Cell Carcinoma.

Simon Chowdhury, Jeffery R Infante, Robert Hawkins, Martin H Voss, Rodolfo Perini, Tobias Arkenau, Mark Voskoboynik, Paola Aimone, Isabelle Naeije, Albert Reising, David F McDermott,

<h4>Background</h4>This study assessed whether antiangiogenic treatment may potentiate immune checkpoint blockade in patients with advanced renal cell carcinoma.<h4>Patients and methods</h4>This was an open-label, two-part, multicenter study involving treatment-naïve patients with advanced renal cell carcinoma. Part 1 consisted of a phase I dose escalation and expansion of pazopanib plus pembrolizumab (combination ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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