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Renal water conservation and the volume kinetics of fluid-induced diuresis; a retrospective analysis of two cohorts of elderly men.

Robert G Hahn,

Renal water conservation after an overnight fast mirrors the habitual intake of liquid. The hypothesis in the present studywasthatwater conservation influences the diuretic response to infusion of two types of crystalloid fluid. Twenty-three elderly male patients (mean age 72 years) underwent a total of 46 intravenous infusions of 1.0 or ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-β1, and oxidative stress.

Sarawoot Bunbupha, Kwanjit Apaijit, Prapassorn Potue, Putcharawipa Maneesai, Poungrat Pakdeechote,

The protective effect of hesperidin on vascular and renal alterations and possible underlying mechanisms involved in Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats were investigated in this study. Male Sprague-Dawley rats were administered L-NAME (40 mg/kg/day), L-NAME plus hesperidin (30 mg/kg/day), and L-NAME plus captopril (2.5 mg/kg/day) for 5 weeks. Hesperidin and captopril ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Association of natriuretic peptide and adverse outcomes in patients with atrial fibrillation: A meta-analysis.

Hong Du, Lei Yang, Hui Zhang, Xiaolin Zhang, Huiyu Shao,

Studies on the association of elevated B-type natriuretic peptide (BNP)/N-terminal pro-B-type natriuretic peptide (NT-proBNP) level with adverse clinical outcomes have yielded conflicting results in patients with atrial fibrillation (AF). This meta-analysis aimed to assess the prognostic value of BNP/NT-proBNP level in AF patients. A comprehensive literature search was conducted using ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.

Bingbing Zhao, Siwei Li, Zuoming Guo, Zhe Chen, Xinying Zhang, Changqing Xu, Junting Chen, Can Wei,

Diabetic hepatic fibrosis (DHF) is a progressive liver disease and a chronic complication of diabetes mellitus. The main cause of DHF is the activation of quiescent hepatic stellate cells (HSCs) by high glucose stimulation. Dopamine receptor D2 (DRD2)-mediated dopamine signalling can be involved in the regulation of diabetic liver disease, ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Metabolomics reveal dynamic changes in eicosanoid profile in patients with ST-elevation myocardial infarction after percutaneous coronary intervention.

Liuyang Zhang, Zhi Dai, Ruifeng Guo, Xiao Wang, Wei Gong, Juanhui Duan, Zhiqing He, Xu Zhang, Shaoping Nie, Chun Liang,

Eicosanoids play important roles in the cardiovascular system. The metabolic disorders involving some eicosanoids in the pathophysiologic process include myocardial infarction and myocardial ischemia-reperfusion injury. Percutaneous coronary intervention (PCI) is often the first-choice strategy for acute ST segment elevation myocardial infarction (STEMI) according to current guidelines. This study aimed to ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma.

Abdifetah Ibrahim Omar, Tullayakorn Plengsuriyakarn, Chuda Chittasupho, Kesara Na-Bangchang,

Atractylodes lancea (Thunb) DC. and its bioactive compound atractylodin (ATD), have been shown to exert promising anticancer activity against cholangiocarcinoma (CCA) both in vitro and in vivo. However, its clinical development of ATD could be hindered due to hydrophobicity and poor pharmacokinetic properties, and thus, the requirement of high dose ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells.

Fatma J Al-Saeedi,

Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of mangiferin (MAN) in vascular endothelial cells induced through activating the Nrf2 signalling pathway on dietary ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Corrigendum.

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(11):1880]

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Lytic and sublytic effects of gossypol on red blood cells and thymocytes.

Nargiza M Chorieva, Diyor D Fayziev, Nargiza A Tsiferova, Gulnoza A Toshtemirova, Ozoda J Khamidova, Petr G Merzlyak, Ranokhon Sh Kurbannazarova, Khayrulla L Ziyaev, Makhmud B Gafurov, Ravshan Z Sabirov,

Gossypol is a natural polyphenol presently considered as a promising biological phytochemical with a range of activities including anticancer. We examined volume regulation-dependent effects of gossypol using erythrocytes and thymic lymphocytes. Gossypol effectively lysed human red blood cells (RBC) with a half-maximal concentration of 67.4 ± 1.6 μmol/L and in a non-colloid osmotic ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Corrigendum.

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(11):1879]

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Covid-19: From structure to therapeutic targeting in studying approved drugs and local DNA vaccination.

Zhiguo Wang, Xiaojing Hong, Hongyan Wang, Jun Liu, Jun-Ping Liu,

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(11):1771-1773]

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Local uncoordinated gene 5H2 contributes to nerve injury-induced mechanical allodynia associated to its role in autophagy.

Jing-Yan Chen, Zi Huang, Pei-Yao Xiao, Jian Yu, Song-Jie Liao,

Lesions of the peripheral nerves can lead to lifelong neuropathic pain (NP). Autophagic deficiency in the Schwann cells (SCs) is an early event in the origin of NP chronification. Uncoordinated gene 5H2 (UNC5H2), one of the repulsive netrin receptors, mediated the effect of netrin-1 on autophagic activation and cell survival ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Cucurbitacin IIb improved active chromatin-induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells.

Dongke Wu, Dasheng Dong, Xiongjie Bi, Yuping Liu, Yunqing Ma,

The pathogenesis of systemic lupus erythematosus (SLE) is closely associated with aberrant immune system. Here, the aim of our study was to explore the regulation of cucurbitacin IIb (CuIIb) to Th17/Treg cells in SLE. Compared with normal mice, the percentage of Treg cells was downregulated in SLE mouse model, and ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome.

Kana Maruyama-Fumoto, John J McGuire, David P Fairlie, Kazumasa Shinozuka, Satomi Kagota,

Metabolic syndrome (MetS) increases the risk of kidney disease. In SHRSP.Z-Leprfa /IzmDmcr (SHRSP.ZF) rats with MetS, protease-activated receptor 2 (PAR2)-mediated vasorelaxation is preserved in the aorta at 20 weeks of age (weeks) via enhancement of nitric oxide production but impaired at 30 weeks by oxidative stress. However, impairment of PAR2-mediated vasorelaxation of ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Comparative effectiveness of Lopinavir/Ritonavir-based regimens in COVID-19.

Jian Qu, Guo-Hua Li, Jiao-Jiao Wang, Ge-Fei He, Juan-Juan Huang, Ying Chen, Qiang Qu, Xiang-Yu Chen, Qiong Lu,

The coronavirus disease 2019 (COVID-19) is an epidemic disease caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) and spreading throughout the world rapidly. Here we evaluated the efficacy of the Lopinavir/Ritonavir (LPV/r) and its combination with other drugs in the treatment of COVID-19. We included 170 confirmed ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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The impact of vitamin D status on cardiometabolic effects of fenofibrate in women with atherogenic dyslipidemia.

Robert Krysiak, Karolina Kowalcze, Bogusław Okopień,

Vitamin D deficiency is a risk factor for cardiometabolic disease. The aim of this study was to determine the role of vitamin D status in the impact of fenofibrate on plasma levels of cardiometabolic risk factors. The study population (n = 61) consisted of three matched groups of women with atherogenic dyslipidaemia: ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Statement of Retraction.

Feng Xie, Shen Gao, Chengyan He, Lihong Li, Lu Qiao,

Recently, we have found an anomaly of Fig 3B. The results of our invasion assay of A549 cells with transduction with the siRNA-control or the siRNA-KIF20A has shown that no significant suppression of cells infected with siRNA-KIF20A when compared with that of the siRNA-control cells. In this manuscript, this anomalous ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats.

Nashwa M Saied, Gehan S Georgy, Rokaya M Hussien, Wafaa A Hassan,

Anti-inflammatory products may represent the future for depressive disorder therapies. Curcumin (CUR) is a polyphenol and an active component of the turmeric plant Curcuma longa. The aim of this study was to investigate the impact of CUR, as a natural anti-inflammatory agent, on neuro-inflammation related to depression and compare it ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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The effect of family history of hypertension and polymorphism of the ACE gene (rs1799752) on cardiac autonomic modulation in adolescents.

Carlos Alberto Alves Dias-Filho, Nivaldo de Jesus Silva Soares Junior, Maria Rosa Quaresma Bomfim, Carlos José Dias, Flavia Castello Branco Vidal, Bruna Cruz Magalhães, Andressa Coelho Ferreira, Sally Cristina Moutinho Monteiro, Emanuel Péricles Salvador, Carlos Castilho de Barros, Poliana Espíndola Correia, Bruno Rodrigues, Cristiano Teixeira Mostarda,

To analyze the behavior of cardiac autonomic modulation in adolescents with a family history of hypertension along with polymorphism of the ACE gene (rs1799752). The study involved 141 adolescents, with a mean age of 14.89, divided into the following six groups: offspring of normotensive parents - ONP: DD, DI and II, and offspring ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Effect of Orexin-A on Mitochondrial Biogenesis, Mitophagy and Structure in HEK293-APPSWE Cell Model of Alzheimer's Disease.

Zhengyu Zhu, DeYan Cao, LinLin Xu, ChaoYuan Song, YuZhen Wang, Maoyu Li, Jieke Yan, ZhaoHong Xie,

Mitochondrial dysfunction plays a key role in the pathogenesis and progression of Alzheimer's Disease. Our previous studies showed that over expression of AD-associated mutant APP led to abnormalities of mitochondrial biogenesis and mitophagy, leading to mitochondrial dysfunction. However the mechanism remains unclear. In this study, we investigated the effect of ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Magnolol inhibits sodium currents in freshly isolated mouse dorsal root ganglion neurons.

Jie Qiu, Lulu Zhang, Jiangru Hong, Xiao Ni, Jun Li, Guang Li, Guangqin Zhang,

The voltage-gated sodium channel (VGSC) currents in dorsal root ganglion (DRG) neurons contain mainly TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) Na+ currents. Magnolol (Mag), a hydroxylated biphenyl compound isolated from the bark of Magnolia officinalis, has been well documented to exhibit analgesic effects, but its mechanism is not yet fully understood. ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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The effect and associated mechanism of action of phosphodiesterase 4 (PDE4) inhibitor on CD4+ lymphocyte proliferation.

Shin Young Kim, Tai Joon An, Chin Kook Rhee, Chan Kwon Park, Ji Hye Kim, HyoungKyu Yoon,

PDE4 inhibitors are involved in anti-inflammatory and immunomodulatory responses. Recently, they have been getting attention as a new class of drugs treating inflammatory airway diseases. The T lymphocyte is a major cell type present in the inflammatory infiltrate in the airway wall in patients with chronic obstructive pulmonary disease (COPD), ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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iTRAQ- and LC-MS/MS-based quantitative proteomics reveals Pqlc2 as a potential regulator of hepatic glucose metabolism and insulin signalling pathway during fasting.

Di-Yang Sun, Jiang-Tao Fu, Guo-Qiang Li, Wen-Jie Zhang, Fei-Yan Zeng, Jie Tong, Chao-Yu Miao, Dong-Jie Li, Pei Wang,

Glucose homeostasis is tightly controlled by balance between glucose production and uptake in liver tissue upon energy shortage condition. Altered glucose homeostasis contributes to the pathophysiology of metabolic disorders including diabetes and obesity. Here, we aimed to analyze the change of proteomic profile upon prolonged fasting in mice with isobaric ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial.

Jia-Wei Chen, Lin Tian, Le Zhang, Jian-Ying Hu, Shao-Qiang Huang, Jing Jiao,

The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynaecological malignancies. A total of 100 patients with American Society of Anesthesiologists (ASA) physical status I-II undergoing laparoscopic radical hysterectomy under general anaesthesia were enrolled. The patients ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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JTP-109192, a novel G protein-coupled receptor 119 agonist, prevents atherosclerosis by improving hypercholesterolaemia in congenic spontaneously hyperlipidaemic mice.

Hironobu Tadaki, Naoto Ogawa, Masao Yamanaka, Yu Motohashi, Tomohiko Sasase, Takashi Kawai, Yasufumi Toriniwa, Sumiaki Fukuda, Nobuya Ogawa, Kazuhito Harada, Takeshi Ohta, Takahisa Yamada,

G protein-coupled receptor 119 (GPR119) expression in pancreatic β-cells and intestinal L-cells is a potential therapeutic target for the treatment of type 2 diabetes. Previously, we have reported that the GPR119 agonist JTP-109192 improves glucose metabolism with single and repeated administration. Conversely, overexpression of the Gpr119 gene reportedly regulates cholesterol ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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