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Journal Clin Exp Dermatol

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The Skin Manifestations of Autoinflammatory Diseases, First International Course.

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, 46(6):1178]

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Multiple nodules on the scrotal wall.

S Giacalone, G Genovese, M Cusini,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Ominous-appearing papulonodules in the genitocrural area.

S Kumar, M Batrani, P Kapoor, N Kaur, A Kubba,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Nail changes in diabetes.

P Yesudian, L Nwabudike, D de Berker,

Diabetes is a common condition that is increasing in incidence all over the world. Even though the skin manifestations of this condition are well described, there is scant literature of its nail changes. In this review, we allude to the various clinical features of nail changes in those with diabetes. ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Simplifying assessment of dimensions of oral lesions using a syringe and "impression planimetry" with printing paper.

Tejas Vishwanath, A K Bose, S Mahajan, S Chikhalkar, P Gole, V Kharkar, H Balaji,

Dermatoses with oral involvement such as lichen planus, vesiculobullous diseases etc are commonly encountered, cause considerable morbidity and require effective treatment. Quantifying therapeutic response and comparing relative efficacies of various topical agents mandate reproducible measurement of lesion dimensions. The dose of intraoral rituximab for oral pemphigus is ideally calculated based ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Incomplete excision of basal cell carcinoma: combining multi-disciplinary data gives a better overall understanding of risk.

G Hale, M Wiener, P Athavale,

Dear Editor, A recent systematic review and meta-analysis identified an overall rate of incomplete basal cell carcinoma (BCC) excision of 11%, rising to 20% for excisions attempted in primary care<sup>1</sup> . The spectrum of cases treated by a single specialty may not represent the entire spectrum of disease being managed ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Dupilumab in adolescents with moderate-to-severe atopic dermatitis: a 32-week real-world experience during the COVID-19 pandemic.

K Hansel, C Patruno, E Antonelli, G Dal Bello, M Napolitano, G Fabbrocini, T Grieco, G Pellacani, M C Fargnoli, M Esposito, V Piras, M Zucca, G Girolomoni, L Stingeni,

Real-life data concerning dupilumab effectiveness and safety in adolescents (≥12 to <18 years) with moderate-to-severe atopic dermatitis (AD) are rarely reported.<sup>1</sup> In the adolescent phase III randomized, placebo-controlled, clinical trial (LIBERTY AD ADOL)<sup>2</sup> and the phase IIa and subsequent phase III open label extension (LIBERTY AD PED-OLE)<sup>3</sup> dupilumab showed significant ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Athena: Speciality Certificate Examination case for Paediatrics and Genetics - A case of brittle hair.

L Asfour,

The parents of a 1-year-old boy are concerned regarding his hair being very brittle. He is being investigated for seizures. He has significant delay in psychomotor development. He had complete lack of scalp and eyebrow hair at birth. On examination, his hair was sparse, coarse in texture and twisted. Hair ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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A large annular plaque on the right forearm slowly extending into a graft site.

C Drumm, C Gulmann, S Ní Raghallaigh,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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The risk of chemical leucoderma with skin-lightening therapies.

S Odedra, J Yoo,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Tinea pseudoimbricata: observations from a clinico-epidemiological and mycological study from Eastern India.

A Das, A Sil, S Verma, S Kumar,

The Indian subcontinent is in the grips of a veritable epidemic like scenario of superficial dermatophytosis which is primarily attributed to the rampant use of topical corticosteroid containing fixed dose combination creams and a mutagenic epidemiological shift from Trichophyton rubrum to Trichophyton mentagrophytes. Steroid modified dermatophytosis has emerged as a ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Home viewing of educational video improves patient understanding of Mohs Surgery.

J Mann, L Li, E Kulakov, P Bassett, A Birnie,

<h4>Background</h4>Educational videos improve patient knowledge of wound care and skin cancer. However, the effect of viewing an educational video at home prior to Mohs surgery has not been demonstrated.<h4>Objective</h4>To evaluate the use of an educational video to improve patient understanding of MMS MATERIALS AND METHODS: Patients scheduled to undergo MMS ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Mixed vascular nevus syndrome: report of three paediatric patients with somatic GNA11 mutation and new systemic associations.

V Beteta-Gorriti, I Vázquez-Osorio, Á de Dios-Velázquez, L Rodriguez-Laguna, V Viana-Huete, C García Torrijos, V Martinez-Glez, E Rodríguez-Díaz,

Mixed vascular nevus (MVN) is characterized by the co-occurrence of telangiectatic capillary malformation and nevus anemicus, which can appear as a pure cutaneous phenotype or combined with systemic manifestations such as brain malformations, neurological abnormalities and musculoskeletal disorders. Recently, GNA11 and GNAQ somatic mutations have been reported in some patients ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Infective Dermatitis After Treatment with Secukinumab.

T Utiyama, C Zerbini, G Guimarães,

A 71-year-old female patient from Bahia, Brazil presented with psoriasis vulgaris. In the past 51 years, she has undergone several treatments, including phototherapy, methotrexate, and acitretin, resulting in poor response and intolerance. She started treatment with secukinumab and, two months after the introduction of the immunobiological, experienced a complete improvement ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Psychodermatology in psychiatry: awareness and education among psychiatry trainees.

I Blee, J Da Costa, N Powers, S Omanyondo, A Charles, J M R Goulding,

Survey data indicates that 98% of patients with skin disease report that their condition affects their emotional and psychological wellbeing.<sup>1</sup> Despite this, access to specialist mental health support for such patients remains limited throughout the UK.<sup>2</sup> A significant proportion of patients with psychodermatological disease manifest a primary psychiatric or psychological ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Severe cutaneous adverse reaction post Covid-vaccine and immunotherapy- a second hit?

K Hussain, A Kawsar, J Weir, L Au, S Turajlic, J Larkin, L Fearfield,

Dear Editor, A 62-year-old female with metastatic melanoma presented with shortness of breath four days after her fourth cycle of combination checkpoint inhibitor therapy (CPI) (nivolumab and ipilimumab) having previously received 12 months of adjuvant nivolumab 14 months earlier. Subsequent investigations confirmed CPI related myocarditis. She also described new onset ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Induction and exacerbation of subacute cutaneous lupus erythematosus following messenger-RNA or adenoviral-vector based SARS-CoV-2 vaccination.

A Kreuter, M J Licciardi-Fernandez, S-N Burmann, B Burkert, F Oellig, A-L Michalowitz,

Accumulating evidence exists that COVID-19 vaccines might induce or exacerbate autoimmune rheumatic diseases. Currently available COVID-19 vaccines include messenger-RNA (mRNA) and recombinant adenoviral (AdV) vector vaccines, both encoding SARS-CoV-2 spike protein production as the primary target for neutralizing antibodies. We herein report a case of subacute cutaneous lupus erythematosus (SCLE) ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Delayed localized hypersensitivity reactions to COVID-19 mRNA vaccines: A six-month retrospective study.

I Papadimitriou, K Bakirtzi, E Sotiriou, E Vakirlis, D Hatzibougias, D Ioannides,

The clinical trials of the two novel COVID-19 vaccines (Pfizer/BioNTech; Moderna) reported delayed local injection site reactions.<sup>1,2</sup> Since vaccination rates increase, awareness of the adverse reactions is needed. This research letter reports a series of delayed localized hypersensitivity reactions to mRNA SARS-CoV-2 vaccines with histopathologic confirmation. ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Clinical and serological predictors of relapse in pemphigus: a study of 143 patients.

G Genovese, C A Maronese, G Casazza, L Corti, L Venegoni, S Muratori, E Berti, D Fanoni, A V Marzano,

<h4>Background</h4>Pemphigus is an autoimmune bullous disease mediated by autoantibodies targeting epithelial cell-cell adhesion molecules. Predictors of relapse have not yet been uniquely identified.<h4>Objectives</h4>To identify factors at diagnosis and during follow-up which could be predictors of relapse.<h4>Methods</h4>Clinical and immunopathological data at diagnosis, clinical remission, and first relapse from patients with pemphigus ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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A pair of gout-like hands.

W Li, X Man,

A 65-year-old man presented to our hospital with a 1-year history of multiple nodules on his arms and hands without itching or pain. He is suffering from autoimmune thrombocytopenia for more than 20 years and taking long-term oral glucocorticoids. He also had history of diabetes, hypertension and hyperthyroidism. On physical ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Efficacy and safety of oral sirolimus for high-flow vascular malformations in real clinical practice. A case series of 9 patients.

A J Durán-Romero, J C Hernández Rodríguez, J Ortiz Álvarez, J J Domínguez Cruz, M T Monserrat García, J Conejo-Mir Sánchez, J Bernabeu Wittel,

<h4>Background and objectives</h4>Vascular malformations (VM) are a complex pathology with few treatment options. In previously published studies, oral sirolimus has shown promising results in the treatment of low-flow VM, while its usefulness in high-flow VM is controversial. The aim was to evaluate the efficacy and safety of sirolimus for the ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Probiotics in Hidradenitis Suppurativa: A potential treatment option?

H C Ring, J Thorsen, K Fuursted, T Bjarnsholt, L Bay, D M Saunte, S F Thomsen, G B Jemec,

New avenues for potential treatments or clinically applicable biomarkers for hidradenitis suppurativa (HS) may be discovered in view of the recent findings by several Next Generation 16S rRNA gene sequencing (NGS) studies on the cutaneous HS microbiome. ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Is Heritability of Alopecia Areata Sex-Specific? A Nationwide Population-Based Cohort Study.

C-K Wong, Y-L Chen, R C Hsiao, S C-S Hu, C-F Yen,

Previous studies have demonstrated the heritability of alopecia areata (AA). However, whether the heritability of AA is sex-specific has not been examined. A nationwide population-based retrospective cohort study was performed using the Taiwan Maternal and Child Health Database from 2004 to 2017. We examined the heritability of AA in 2,625,440 ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Severe ulcerative proctitis, pyoderma gangrenosum, hidradenitis suppurativa and fever in a patient with a rare variant of the PSTPIP1 gene.

N Hieta, H Nuutinen, J Roivas, K Salminen, H Kujari, L Talve, M Toivonen, M K Haanpää,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Characterization of Dermatologic Diagnoses Among Hospitalized Patients Experiencing Homelessness.

A Zakaria, E H Amerson, P Kim-Lim, L Fox, A Y Chang,

While previous studies have characterized the types of dermatologic disease among persons experiencing homelessness (PEH) in the outpatient setting, dermatologic disease among hospitalized PEH has never been evaluated. Therefore, we performed a cross-sectional analysis of hospitalized patients who received dermatology consultations at two San Francisco hospitals between March 2018 and ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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