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Journal Clin Cardiol

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Predictors of dronedarone plasma drug concentrations and effect on atrial fibrillation/atrial flutter recurrence: Analyses from the EURIDIS and ADONIS studies.

Munveer Thind, David S McKindley, James A Reiffel, Gerald V Naccarelli, John Stewart, Peter R Kowey,

<h4>Background</h4>In this post hoc analysis, we assessed patient characteristics as predictors of dronedarone trough concentrations and characterized the relationship of trough concentrations of dronedarone with its efficacy and safety.<h4>Hypothesis</h4>Dronedarone is recommended as a 400 mg twice daily dose taken orally with meals. We hypothesize that drug concentration/bioavailability of dronedarone, measured as ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Early and late recurrent cardiovascular events among high-risk patients with an acute coronary syndrome: Meta-analysis of phase III studies and implications on trial design.

Gerald Chi, Jane J Lee, Syed H A Kazmi, Clara Fitzgerald, Sahar Memar Montazerin, Arzu Kalayci, Serge Korjian, Mark Heise, Lawrence I Deckelbaum, Peter Libby, Deepak L Bhatt, C Michael Gibson,

<h4>Background</h4>Despite low-density lipoprotein cholesterol-lowering therapies and other standard-of-care therapy, there remains a substantial residual atherosclerotic risk among patients with an acute coronary syndrome (ACS). This study aims to estimate the risk of early and late recurrent major adverse cardiovascular events (MACE) and address its implications on trial design.<h4>Methods</h4>A literature search ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Value of M2BP in predicting in-stent restenosis in patients after coronary drug-eluting stent implantation.

Le Yang, Haijun Zhu, Yuanyuan Sun, Pengcheng Yan, Xiaoning Song, Fayun Xu, Haitao Yuan, Liming Chen,

<h4>Objective</h4>We evaluated the association between plasma levels of mac-2 binding protein (M2BP) with the risk of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).<h4>Methods</h4>Plasma M2BP levels were compared between 258 patients who experienced ISR at 12-months post-PCI and 258 patients, matched for age and sex, without angiographic evidence of ISR.<h4>Results</h4>The ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Ventricular repolarization heterogeneity in patients with COVID-19: Original data, systematic review, and meta-analysis.

Elham Mahmoudi, Reza Mollazadeh, Pejman Mansouri, Mohammad Keykhaei, Shayan Mirshafiee, Behnam Hedayat, Mojtaba Salarifar, Matthew F Yuyun, Hirad Yarmohammadi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) has been associated with an increased risk of acute cardiac events. However, the effect of COVID-19 on repolarization heterogeneity is not yet established. In this study, we evaluated electrocardiogram (ECG) markers of repolarization heterogeneity in patients hospitalized with COVID-19. In addition, we performed a systematic review and ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS-ADONIS trials.

Munveer Thind, Wojciech Zareba, Dan Atar, Harry J G M Crijns, Jun Zhu, Hui-Nam Pak, James Reiffel, Ulf Ludwigs, Mattias Wieloch, John Stewart, Peter Kowey,

<h4>Background</h4>The use of antiarrhythmic drugs (AADs) in patients with chronic kidney disease (CKD) is complex because impaired renal clearance can cause increased drug levels, and risk of intolerance or adverse events. Due to the propensity for CKD to occur alongside atrial fibrillation/atrial flutter (AF/AFL), it is essential that AAD safety ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Proteomic differences among patients with heart failure taking furosemide or torsemide.

Lauren B Cooper, Scott Bruce, Mitchell Psotka, Robert Mentz, Rachel Bell, Stephen L Seliger, Christopher O'Connor, Christopher deFilippi,

<h4>Background</h4>Loop diuretics are commonly used for patients with heart failure (HF) but it remains unknown if one loop diuretic is clinically superior.<h4>Hypothesis</h4>Biomarkers and proteomics provide insight to how different loop diuretics may differentially affect outcomes.<h4>Methods</h4>Blood and urine were collected from outpatients with HF who were taking torsemide or furosemide for ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Single-center experience of ultra-high-density mapping guided catheter ablation of focal atrial tachycardia.

Antonia Kellnar, Stephanie Fichtner, Michael Mehr, Thomas Czermak, Moritz F Sinner, Korbinian Lackermair, Heidi L Estner,

<h4>Introduction</h4>Catheter ablation is the treatment of choice for recurrent focal atrial tachycardia (FAT) as medical therapy is limited. Routinely, a three-dimensional mapping system is used. Whether or not optimized signal detection does improve ablation success rates has not yet been investigated. This retrospective cohort study compared ablation procedures using an ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Association between cumulative blood pressure in early adulthood and right ventricular structure and function in middle age: The CARDIA study.

Shenrong Liu, Yanfen Liao, Zongyuan Zhu, Shushui Wang, Yifan Li, Dongpo Liang, Yumei Xie, Zhiwei Zhang,

<h4>Objective</h4>Cumulative blood pressure (BP) exposure is a known risk factor for cardiovascular disease. This study sought to investigate the association between cumulative BP from early adulthood to middle age and right ventricular (RV) structure and function in middle age.<h4>Methods</h4>We included 2844 participants from the CARDIA study (Coronary Artery Risk Development ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Lesion characteristics and procedural complications of chronic total occlusion percutaneous coronary intervention in patients with prior bypass surgery: A meta-analysis.

Yuchen Shi, Songyuan He, Jesse Luo, Wen Jian, Xueqian Shen, Jinghua Liu,

Coronary artery bypass graft (CABG) accelerates the prevalence of native coronary chronic total occlusion (CTO), and this kind of CTO shows extensive challenging and complex atherosclerotic pathology. As a result, the procedural success rate of percutaneous coronary intervention (PCI) is inferior to another kind of lesions. The present meta-analysis aims ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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A comparison of long-term clinical outcomes between percutaneous coronary intervention (PCI) and medical therapy in patients with chronic total occlusion in noninfarct-related artery after PCI of acute myocardial infarction.

Qing Qin, Lu Chen, Lei Ge, Juying Qian, Jianying Ma, Junbo Ge,

<h4>Background</h4>Chronic total occlusion (CTO) in a noninfarct-related artery (IRA) is one of the risk factors for mortality after acute myocardial infarction (AMI). However, there are limited data comparing the long-term outcomes of patients undergoing percutaneous coronary intervention (PCI) with patients having medical therapy (MT) in CTO lesion after AMI PCI.<h4>Methods</h4>We ... Read more >>

Clin Cardiol (Clinical cardiology)
[2022, :]

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Trends in conventional cardiovascular risk factors and myocardial infarction subtypes among young Chinese men with a first acute myocardial infarction.

Min Zhang, Hui-Juan Zuo, Hong-Xia Yang, Nan Nan, Xian-Tao Song,

<h4>Background</h4>There is limited data on the characteristics of conventional risk factors (RFs) in young Chinese men hospitalized with a first acute myocardial infarction (AMI).<h4>Hypothesis</h4>We analyzed the trends in and prevalence of cardiovascular RFs and subtypes of MI during the first AMI in young Chinese men.<h4>Methods</h4>A total of 2739 men aged 18-44 ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Associations of anemia with death and major bleeding in patients with atrial fibrillation: A report from the Chinese Atrial Fibrillation Registry Study.

Zhuxin Zhang, Chao Jiang, Liu He, Yu Bai, Jiahui Wu, Rong Hu, Qiang Lv, Man Ning, Li Feng, Ribo Tang, Caihua Sang, Deyong Long, Jianzeng Dong, Xin Du, Gregory Y H Lip, Changsheng Ma,

<h4>Background</h4>Anemia is a common comorbidity in patients with atrial fibrillation (AF). Reports on the association of anemia and adverse events in patients with AF, especially from Asia, are limited.<h4>Methods and results</h4>Based on data from the Chinese Atrial Fibrillation Registry Study (CAFR), a total of 18,106 AF patients enrolled between August ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Natriuretic peptides to differentiate constrictive pericarditis and restrictive cardiomyopathy: A systematic review and meta-analysis.

Carlos Diaz-Arocutipa, Jose Saucedo-Chinchay, Massimo Imazio, Edgar Argulian,

Previous studies have shown that natriuretic peptide levels are increased in patients with restrictive cardiomyopathy (RCM) but not in constrictive pericarditis (CP). We performed a systematic review and meta-analysis to evaluate the diagnostic utility of B-type natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) to differentiate CP and RCM. ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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A randomized controlled clinical trial of cardiac telerehabilitation with a prolonged mobile care monitoring strategy after an acute coronary syndrome.

Ernesto Dalli Peydró, Nuria Sanz Sevilla, María T Tuzón Segarra, Vicente Miró Palau, Jorge Sánchez Torrijos, Juan Cosín Sales,

<h4>Background</h4>Center-based cardiac rehabilitation (CBCR) improves health outcomes but has some limitations. We designed and validated a telerehabilitation system to overcome these barriers.<h4>Methods</h4>We included 67 low-risk acute coronary syndrome patients in a randomized controlled trial allocated 1:1 to a 10-month cardiac telerehabilitation (CTR) program or an 8-week CBCR program. Patients underwent ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Use of oral anticoagulants and its associated factors among nonvalvular atrial fibrillation patients with new-onset acute ischemic stroke: A report from the China Atrial Fibrillation Registry study.

Jing-Rong Wang, Xin Du, Jian-Zeng Dong, San-Shuai Chang, Chao Jiang, Cai-Hua Sang, De-Yong Long, Ri-Bo Tang, Hai-Bin Zhang, Jin-Cheng Guo, Yu-Mei Wen, Liu He, Chang-Sheng Ma,

<h4>Background</h4>The adherence of oral anticoagulant (OAC) therapy among nonvalvular atrial fibrillation (NVAF) patients with acute ischemic stroke (AIS) in China during recent years was unclear, and the possible factors that influenced the initiation and persistent use of OAC were needed to be explored.<h4>Methods</h4>A total of 1085 NVAF patients, who experienced ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Expected and observed in-hospital mortality in heart failure patients before and during the COVID-19 pandemic: Introduction of the machine learning-based standardized mortality ratio at Helios hospitals.

Sebastian König, Vincent Pellissier, Johannes Leiner, Sven Hohenstein, Laura Ueberham, Andreas Meier-Hellmann, Ralf Kuhlen, Gerhard Hindricks, Andreas Bollmann, ,

<h4>Background</h4>Reduced hospital admission rates for heart failure (HF) and evidence of increased in-hospital mortality were reported during the COVID-19 pandemic. The aim of this study was to apply a machine learning (ML)-based mortality prediction model to examine whether the latter is attributable to differing case mixes and exceeds expected mortality ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Comparison of subclavian vein to inferior vena cava collapsibility by ultrasound in acute heart failure: A pilot study.

Yvonne E Kaptein, Elaine M Kaptein,

<h4>Background</h4>Management of acute decompensated heart failure (ADHF) requires accurate assessment of relative intravascular volume, which may be technically challenging. Inferior vena cava (IVC) collapsibility with respiration reflects intravascular volume and right atrial pressure (RAP). Subclavian vein (SCV) collapsibility may provide an alternative.<h4>Hypothesis</h4>The purpose of this study was to examine the ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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NT Pro-BNP can be used as a risk predictor of clinical atrial fibrillation with or without left atrial enlargement.

Xiao Zhao, Hao Li, Cai Liu, Yuanyuan Ren, Chaofeng Sun,

<h4>Background</h4>NT Pro-BNP is a blood marker secreted by cardiomyocytes. Myocardial stretch is the main factor to stimulate NT Pro-BNP secretion in cardiomyocytes. NT Pro-BNP is an important risk factor for cardiac dysfunction, stroke, and pulmonary embolism. So does atrial myocyte stretching occur when patients have atrial fibrillation (AF)? Whether atrial ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Symptoms and health-related quality of life 5 years after catheter ablation of atrial fibrillation.

Ulla Walfridsson, Anders Hassel Jönsson, Lars O Karlsson, Ioan Liuba, Henrik Almroth, Emma Sandgren, Håkan Walfridsson, Emmanouil Charitakis,

To investigate the effect of catheter ablation (CA) on symptoms and health-related quality of life (HRQoL) after 5 years, and analyze predictors of recurrence of symptoms. The primary indication for CA of atrial fibrillation (AF) is to reduce symptoms and improve HRQoL where long-term follow-up are sparse. In this observational, ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Ultrafiltration and cardiopulmonary bypass associated acute kidney injury: A systematic review and meta-analysis.

Omneya A Kandil, Karam R Motawea, Edward Darling, Jeffrey B Riley, Jaffer Shah, Mohamed Abdalla Mohamed Elashhat, Bruce Searles, Hani Aiash,

<h4>Background</h4>Cardiopulmonary bypass is known to raise the risk of acute kidney injury (AKI). Previous studies have identified numerous risk factors of cardiopulmonary bypass including the possible impact of perioperative ultrafiltration. However, the association between ultrafiltration (UF) and AKI remains conflicting. Thus, we conducted a meta-analysis to further examine the relationship ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(12):1700-1708]

Cited: 1 time

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Left atrial appendage size is a marker of atrial fibrillation recurrence after radiofrequency catheter ablation in patients with persistent atrial fibrillation.

Judit Simon, Mohammed El Mahdiui, Jeff M Smit, Lili Száraz, Alexander R van Rosendael, Szilvia Herczeg, Emese Zsarnóczay, Anikó Ilona Nagy, Márton Kolossváry, Bálint Szilveszter, Nándor Szegedi, Klaudia Vivien Nagy, Tamás Tahin, László Gellér, Rob J van der Geest, Jeroen J Bax, Pál Maurovich-Horvat, Béla Merkely,

<h4>Introduction</h4>There are no consistently confirmed predictors of atrial fibrillation (AF) recurrence after catheter ablation. Therefore, we aimed to study whether left atrial appendage volume (LAAV) and function influence the long-term recurrence of AF after catheter ablation, depending on AF type.<h4>Methods</h4>AF patients who underwent point-by-point radiofrequency catheter ablation after cardiac computed ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Obstructive sleep apnea therapy for cardiovascular risk reduction-Time for a rethink?

Hasthi U Dissanayake, Juliana T Colpani, Kate Sutherland, Weiqiang Loke, Anna Mohammadieh, Yi-Hui Ou, Philip de Chazal, Peter A Cistulli, Chi-Hang Lee,

Obstructive sleep apnea (OSA) is a highly prevalent and underdiagnosed medical condition, which is associated with various cardiovascular and metabolic diseases. The current mainstay of therapy is continuous positive airway pressure (CPAP); however, CPAP is known to be poorly accepted and tolerated by patients. In randomized controlled trials evaluating CPAP ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(12):1729-1738]

Cited: 1 time

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The relationship between the body mass index and in-hospital mortality in patients admitted for sudden cardiac death in the United States.

Guy Rozen, Gabby Elbaz-Greener, Ibrahim Marai, E Kevin Heist, Jeremy N Ruskin, Shemy Carasso, Edo Y Birati, Offer Amir,

While obesity has been shown to be associated with elevated risk for Sudden Cardiac Death (SCD), studies examining its effect on outcomes in SCD victims have shown conflicting results. We aimed to describe the body mass index (BMI) distribution in a nationwide cohort of patients admitted for an out of ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(12):1673-1682]

Cited: 1 time

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Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction: A meta-analysis.

Zhenzhen Mai, Lina Guan, Yuming Mu,

<h4>Background</h4>Valvular dysfunction is a common complication in patients with bicuspid aortic valves (BAV). The aim of this study was to determine the relationship between BAV morphology patterns and valve dysfunction.<h4>Methods</h4>We searched the PubMed, The Cochrane Library, Web of Science, and CNKI until May 31, 2020, to identify all studies investigating ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(12):1683-1691]

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Proenkephalin and the risk of new-onset heart failure: data from prevention of renal and vascular end-stage disease.

Johanna E Emmens, Jozine M Ter Maaten, Frank P Brouwers, Lyanne M Kieneker, Kevin Damman, Oliver Hartmann, Janin Schulte, Stephan J L Bakker, Rudolf A de Boer, Adriaan A Voors,

<h4>Background</h4>Enkephalins of the opioid system exert several cardiorenal effects. Proenkephalin (PENK), a stable surrogate, is associated with heart failure (HF) development after myocardial infarction and worse cardiorenal function and prognosis in patients with HF. The association between plasma PENK concentrations and new-onset HF in the general population remains to be ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(12):1662-1672]

Cited: 1 time

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