Igor Klem, Michael Klein, Mohammad Khan, Eric Y Yang, Faisal Nabi, Alexander Ivanov, Lubna Bhatti, Brenda Hayes, Edward A Graviss, Duc T Nguyen, Robert M Judd, Raymond J Kim, John F Heitner, Dipan J Shah,
<b>Background:</b> Non-ischemic cardiomyopathy (NICM) is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance imaging (CMR) is increasingly recognized as risk marker for adverse outcomes, however LV dysfunction remains the ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Christy L Avery, Annie Green Howard, Hazel B Nichols,
Circulation (Circulation)
[2021, 143(3):287-288]
Cited: 0 times
Circulation (Circulation)
[2021, 143(3):e20-e21]
Cited: 0 times
Brandon R Allen, Robert H Christenson, Scott A Cohen, Richard Nowak, R Gentry Wilkerson, Bryn Mumma, Troy Madsen, James McCord, Maite Huis In't Veld, Michael Massoomi, Jason P Stopyra, Cindy Montero, Michael T Weaver, Kai Yang, Simon A Mahler,
<b>Background:</b> European data support the use of low high-sensitivity troponin (hs-cTn) measurements or a 0/1-hour (0/1-h) algorithm for myocardial infarction (MI) or to exclude major adverse cardiac events (MACE) among Emergency Department (ED) patients with possible acute coronary syndrome (ACS). However, modest US data exist to validate these strategies. This ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
J Caleb Snider, Lance A Riley, Noah T Mallory, Matthew R Bersi, Prachi Umbarkar, Rekha Gautam, Qinkun Zhang, Anita Mahadevan-Jansen, Antonis K Hatzopoulos, Luc Maroteaux, Hind Lal, W David Merryman,
<b>Background:</b> Myocardial infarction (MI) induces an intense injury response which ultimately generates a collagen-dominated scar. While required to prevent ventricular rupture, the fibrotic process is often sustained in a manner detrimental to optimal recovery. Cardiac myofibroblasts are the cells tasked with depositing and remodeling collagen and are a prime target ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Nina Soto, David González-Casal, Pablo Ávila,
Circulation (Circulation)
[2021, 143(3):283-286]
Cited: 0 times
Ziad Hijazi, John H Alexander, Zhuokai Li, Daniel M Wojdyla, Roxana Mehran, Christopher B Granger, Alexander Parkhomenko, M Cecilia Bahit, Stephan Windecker, Ronald Aronson, Otavio Berwanger, Sigrun Halvorsen, Suzanne de Waha-Thiele, Peter Sinnaeve, Harald Darius, Robert F Storey, Renato D Lopes,
<b>Background:</b> In the AUGUSTUS trial, apixaban resulted in less bleeding and fewer hospitalizations than vitamin K antagonists (VKA), and aspirin caused more bleeding than placebo in patients with atrial fibrillation and acute coronary syndrome or percutaneous coronary intervention treated with a P2Y<sub>12</sub> inhibitor. We evaluated the risk-benefit balance of antithrombotic ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Dario Pellegrini, Rika Kawakami, Giulio Guagliumi, Atsushi Sakamoto, Kenji Kawai, Andrea Gianatti, Ahmed Nasr, Robert Kutys, Liang Guo, Anne Cornelissen, Lara Faggi, Masayuki Mori, Yu Sato, Irene Pescetelli, Matteo Brivio, Maria Romero, Renu Virmani, Aloke V Finn,
<b>Background:</b> Cardiac injury is common in hospitalized patients with COVID-19 and portends poorer prognosis. However, the mechanism and the type of myocardial damage associated with SARS-CoV-2 remain uncertain. <b>Methods:</b> We conducted a systematic pathologic analysis of 40 hearts from hospitalized patients dying of Coronavirus Disease 2019 (COVID-19) in Bergamo, Italy ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Anthony M Gacita, Dominic E Fullenkamp, Joyce Ohiri, Tess Pottinger, Megan J Puckelwartz, Marcelo A Nobrega, Elizabeth M McNally,
<b>Background:</b> Inherited cardiomyopathy associates with a range of phenotype, mediated by genetic and non-genetic factors. Non-inherited cardiomyopathy also displays varying progression and outcomes. Expression of cardiomyopathy genes is under the regulatory control of promoters and enhancers, and human genetic variation in promoters and enhancers may contribute to this variability. <b>Methods:</b> ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Sören J Backhaus, Torben Lange, Elisabeth F George, Kristian Hellenkamp, Roman J Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuß, Tim Seidler, Andreas Schuster,
<b>Background:</b> Right heart catheterisation (RHC) using exercise-stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiovascular magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
David Saadoun, Mathieu Vautier, Patrice Cacoub,
Systemic vasculitides are multisystem blood vessel disorders, which are defined by the size of the vessel predominantly affected, namely small, medium, or large vessels. The term "large vessel" relates to the aorta and its major branches; "medium vessel" refers to the main visceral arteries and veins and their initial branches. ... Read more >>
Circulation (Circulation)
[2021, 143(3):267-282]
Cited: 0 times
Timothy W Churchill, Shawn X Li, Lisa Curreri, Emily K Zern, Emily S Lau, Elizabeth E Liu, Robyn Farrell, Mark W Shoenike, John Sbarbaro, Rajeev Malhotra, Matthew Nayor, Carsten Tschöpe, Rudolf A de Boer, Gregory D Lewis, Jennifer E Ho,
Circulation (Circulation)
[2021, 143(3):289-291]
Cited: 0 times
Federico Fortuni, Jeroen J Bax, Victoria Delgado,
Circulation (Circulation)
[2021, 143(3):209-211]
Cited: 0 times
Arvindh N Kanagasundram, Travis D Richardson, William G Stevenson,
Circulation (Circulation)
[2021, 143(3):227-229]
Cited: 0 times
Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Donald M Lloyd-Jones, Hyeon Chang Kim,
Circulation (Circulation)
[2021, 143(3):e22-e23]
Cited: 0 times
Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velázquez, Francisco Carrillo-Salinas, Ane M Salvador, Tania Nevers, Venkataraman Amarnath, Albert Tai, Robert M Blanton, David G Harrison, Pilar Alcaide,
<b>Background:</b> Despite the well-established association between T cell-mediated inflammation and non-ischemic heart failure (HF), the specific mechanisms triggering T cell activation during the progression of HF and the antigens involved are poorly understood. We hypothesized that myocardial oxidative stress induces the formation of isolevuglandin (IsoLG)-modified proteins that function as cardiac ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Wenzhu Li, Chase W Kessinger, Makoto Orii, Hang Lee, Lang Wang, Ido Weinberg, Michael R Jaff, Guy L Reed, Peter Libby, Ahmed Tawakol, Peter K Henke, Farouc A Jaffer,
<b>Background:</b> Up to 50% of patients with proximal deep venous thrombosis (DVT) will develop the post-thrombotic syndrome (PTS) characterized by limb swelling and discomfort, hyperpigmentation, skin ulcers, and impaired quality-of-life. While catheter-based interventions enabling restoration of blood flow (RBF) have demonstrated little benefit on PTS, the impact on the acuity ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Gregory G Schwartz, Philippe Gabriel Steg, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Shaun G Goodman, J Wouter Jukema, Yong-Un Kim, Qian H Li, Garen Manvelian, Robert Pordy, Timothée Sourdille, Harvey D White, Michael Szarek, ,
<b>Background:</b> Recent international guidelines have lowered recommended target levels of low-density lipoprotein-cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below conventional targets. Inferences from prior analyses are limited because patients who achieve lower ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Sean Agbor-Enoh, Palak Shah, Ilker Tunc, Steven Hsu, Stuart Russell, Erika Feller, Keyur Shah, Maria E Rodrigo, Samer S Najjar, Hyesik Kong, Mehdi Pirooznia, Ulgen Fideli, Alfiya Bikineyeva, Argit Marishta, Kenneth Bhatti, Yanqin Yang, Cedric Mutebi, Kai Yu, Moon Kyoo Jang, Charles Marboe, Gerald J Berry, Hannah A Valantine, ,
<b>Background:</b> After heart transplantation, Endomyocardial biopsy (EMBx) is used to monitor for acute rejection (AR). Unfortunately, EMBx is invasive and its conventional histologic interpretation has limitations. This is a validation study to assesses the performance of a sensitive blood biomarker- percent donor-derived cell-free DNA (%ddcfDNA) - for detection of AR ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Circulation (Circulation)
[2021, 143(2):e7-e8]
Cited: 0 times
Ileana Badi, Charalambos Antoniades,
Circulation (Circulation)
[2021, 143(2):160-162]
Cited: 0 times
Kevin O'Fee, Julio A Panza, David L Brown,
Circulation (Circulation)
[2021, 143(2):205-207]
Cited: 0 times
Nordin M J Hanssen, Bart Spaetgens, Prabhakara R Nagareddy, Andrew J Murphy,
Circulation (Circulation)
[2021, :]
Cited: 0 times
Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang, Thomas D Bannister, Agnieszka B Bialkowska, Craig H Selzman, Stavros G Drakos, Konstantinos Drosatos,
<b>Background:</b> We previously showed that cardiomyocyte Krüppel-like factor (KLF)-5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid oxidation, we investigated the role of cardiomyocyte KLF5 in lipid metabolism and pathophysiology of ischemic heart failure. <b>Methods:</b> Using rtPCR and Western Blot, we investigated the ... Read more >>
Circulation (Circulation)
[2021, :]
Cited: 0 times
Marina Urena, Alec Vahanian, Eric Brochet, Gregory Ducrocq, Bernard Iung, Dominique Himbert,
Use of transcatheter mitral valve replacement (TMVR) using transcatheter aortic valves in clinical practice is limited to patients with failing bioprostheses and rings or mitral valve disease associated with severe mitral annulus calcification. Whereas the use of valve-in-valve TMVR appears to be a reasonable alternative to surgery in patients at ... Read more >>
Circulation (Circulation)
[2021, 143(2):178-196]
Cited: 0 times