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Journal Circulation

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Heart Xenotransplant: A Door that is Finally Opening.

Maryjane A Farr, Josef Stehlik,

Circulation (Circulation)
[2022, :]

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Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.

Connie W Tsao, Aaron W Aday, Zaid I Almarzooq, Alvaro Alonso, Andrea Z Beaton, Marcio S Bittencourt, Amelia K Boehme, Alfred E Buxton, April P Carson, Yvonne Commodore-Mensah, Mitchell S V Elkind, Kelly R Evenson, Chete Eze-Nliam, Jane F Ferguson, Giuliano Generoso, Jennifer E Ho, Rizwan Kalani, Sadiya S Khan, Brett M Kissela, Kristen L Knutson, Deborah A Levine, Tené T Lewis, Junxiu Liu, Matthew Shane Loop, Jun Ma, Michael E Mussolino, Sankar D Navaneethan, Amanda Marma Perak, Remy Poudel, Mary Rezk-Hanna, Gregory A Roth, Emily B Schroeder, Svati H Shah, Evan L Thacker, Lisa B VanWagner, Salim S Virani, Jenifer H Voecks, Nae-Yuh Wang, Kristine Yaffe, Seth S Martin, ,

<h4>Background</h4>The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular ... Read more >>

Circulation (Circulation)
[2022, :CIR0000000000001052]

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The Clinical Impact of Device Lead-Associated Tricuspid Regurgitation: Need for a Multidisciplinary Approach.

Aviral Vij, Clifford J Kavinsky,

Circulation (Circulation)
[2022, 145(4):239-241]

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Highlights From the Circulation Family of Journals.

Circulation (Circulation)
[2022, 145(4):309-314]

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Letter by Costantine et al Regarding Article, "Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia".

Maged M Costantine, Kirsten Lawrence-Cleary, Georges Saade, Ronald J Wapner,

Circulation (Circulation)
[2022, 145(4):e115-e116]

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Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart.

Liang Chen, Kui Hua, Ningning Zhang, Jingyu Wang, Jian Meng, Zhenliang Hu, Haoxiang Gao, Fanhong Li, Yang Chen, Jie Ren, Liyang Liu, Qiming Zhou, Jin Gu, Jiangping Song, Xuegong Zhang, Shengshou Hu,

Circulation (Circulation)
[2022, 145(4):315-318]

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A Patient-Level Meta-Analysis: The End of the Era of Direct Oral Anticoagulant Developmental Trials in Patients With Atrial Fibrillation?

Shinya Goto, Shinichi Goto,

Circulation (Circulation)
[2022, 145(4):256-258]

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Preventing Anthracycline-Induced Cardiotoxicity Using Functional Genomics and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Valentina Lo Sardo, Timothy J Kamp,

Circulation (Circulation)
[2022, 145(4):295-298]

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Association Between Endovascular Therapy Time to Treatment and Outcomes in Patients with Basilar Artery Occlusion.

Raed A Joundi, Jie-Lena Sun, Ying Xian, Brooke Alhanti, Raul G Nogueira, Deepak L Bhatt, Gregg C Fonarow, Jeffrey Saver, Lee H Schwamm, Eric E Smith,

<h4>Background</h4>Basilar artery occlusion (BAO) is a devastating condition without definitive evidence to guide treatment. While the association between faster treatment times with endovascular therapy (EVT) and better outcomes in anterior circulation is well established, whether this relationship exists for those with BAO is not well delineated.<h4>Methods</h4>We used individual-level patient data ... Read more >>

Circulation (Circulation)
[2022, :]

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Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.

Riham R E Abouleisa, Abou Bakr M Salama, Qinghui Ou, Xian-Liang Tang, Mitesh Solanki, Yiru Guo, Yibing Nong, Lindsey McNally, Pawel K Lorkiewicz, Kamal M Kassem, Brooke M Ahern, Krishna Choudhary, Reuben Thomas, Yu Huang, Hamzah R Juhardeen, Aisha Siddique, Zainab Ifthikar, Sally K Hammad, Ayman S El-Baz, Kathryn N Ivey, Daniel J Conklin, Jonathan Satin, Bradford G Hill, Deepak Srivastava, Roberto Bolli, Tamer M A Mohamed,

<b>Background:</b> The regenerative capacity of the heart after myocardial infarction (MI) is limited. Our previous study showed that ectopic introduction of Cdk1/CyclinB1 and Cdk4/CyclinD1 complexes (4F) promotes cardiomyocyte proliferation in 15-20% of infected cardiomyocytes <i>in vitro</i> and <i>in vivo</i> and improves cardiac function after MI in mice. <b>Methods:</b> Here, using ... Read more >>

Circulation (Circulation)
[2022, :]

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Cost Effectiveness of Coronary-Artery Bypass Surgery versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial.

Derek S Chew, Patricia A Cowper, Hussein Al-Khalidi, Kevin J Anstrom, Melanie R Daniels, Linda Davidson-Ray, Yanhong Li, Robert E Michler, Julio A Panza, Ileana L Piña, Jean L Rouleau, Eric J Velazquez, Daniel B Mark, ,

<b>Background:</b> The Surgical Treatment for Ischemic Heart Failure Trial (STICH) demonstrated that coronary artery bypass grafting (CABG) reduced all-cause mortality rates out to 10 years compared with medical therapy alone (MED) in patients with ischemic cardiomyopathy and reduced left ventricular function (ejection fraction ≤35%). We examined the economic implications of ... Read more >>

Circulation (Circulation)
[2022, :]

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E-Cigarettes and Cardiopulmonary Health: Review for Clinicians.

Evan W Neczypor, Matthew J Mears, Arunava Ghosh, M Flori Sassano, Richard J Gumina, Loren E Wold, Robert Tarran,

Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with ... Read more >>

Circulation (Circulation)
[2022, 145(3):219-232]

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Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox.

Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun,

<b>Background:</b> The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated ... Read more >>

Circulation (Circulation)
[2022, :]

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Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough.

Jordana B Cohen, Tammy M Brady,

Circulation (Circulation)
[2022, 145(2):94-96]

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The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data.

Seng Chan You, Harlan M Krumholz,

Circulation (Circulation)
[2022, 145(2):107-109]

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Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts.

Brian A Aguado, Cierra J Walker, Joseph C Grim, Megan E Schroeder, Dilara Batan, Brandon J Vogt, Andrea Gonzalez Rodriguez, Jessica A Schwisow, Karen S Moulton, Robert M Weiss, Donald D Heistad, Leslie A Leinwand, Kristi S Anseth,

<b>Background:</b> Aortic valve stenosis (AVS) is a sexually dimorphic disease, with women often presenting with sustained fibrosis and men with more extensive calcification. However, the intracellular molecular mechanisms that drive these clinically important sex differences remain under explored. <b>Methods:</b> Hydrogel scaffolds were designed to recapitulate key aspects of the valve ... Read more >>

Circulation (Circulation)
[2022, :]

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Bidirectional Changes in Myocardial 18F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading.

Tiberiu A Pana, Jainy Savla, Ingrid Kepinski, Adam Fairbourn, Aneela Afzal, Pradeep Mammen, Mark Drazner, Rathan M Subramaniam, Chao Xing, Kathryn A Morton, Stavros G Drakos, Vlad G Zaha, Hesham A Sadek,

Circulation (Circulation)
[2022, 145(2):151-154]

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Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias.

Yuko Wada, Tao Yang, Christian M Shaffer, Laura L Daniel, Andrew M Glazer, Giovanni E Davogustto, Brandon D Lowery, Eric H Farber-Eger, Quinn S Wells, Dan M Roden,

<h4>Background</h4>Multiple reports associate the cardiac sodium channel gene (<i>SCN5A</i>) variants S1103Y and R1193Q with type 3 congenital long QT syndrome and drug-induced long QT syndrome. These variants are too common in ancestral populations to be highly arrhythmogenic at baseline, however: S1103Y allele frequency is 8.1% in African Americans and R1193Q ... Read more >>

Circulation (Circulation)
[2022, 145(4):299-308]

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Celebrating The Next Generation of Cardiovascular Investigators.

James A de Lemos, Darren K McGuire, Joseph A Hill,

Circulation (Circulation)
[2022, 145(2):91-93]

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Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association.

Joshua J Joseph, Prakash Deedwania, Tushar Acharya, David Aguilar, Deepak L Bhatt, Deborah A Chyun, Katherine E Di Palo, Sherita H Golden, Laurence S Sperling, ,

Cardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in ... Read more >>

Circulation (Circulation)
[2022, :CIR0000000000001040]

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Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex.

Anthony P Carnicelli, Hwanhee Hong, Stuart J Connolly, John Eikelboom, Robert P Giugliano, David A Morrow, Manesh R Patel, Lars Wallentin, John H Alexander, M Cecilia Bahit, Alexander P Benz, Erin A Bohula, Tze-Fan Chao, Leanne Dyal, Michael Ezekowitz, Keith A A Fox, Baris Gencer, Jonathan L Halperin, Ziad Hijazi, Stefan H Hohnloser, Kaiyuan Hua, Elaine Hylek, Eri Toda Kato, Julia Kuder, Renato D Lopes, Kenneth W Mahaffey, Jonas Oldgren, Jonathan P Piccini, Christian T Ruff, Jan Steffel, Daniel Wojdyla, Christopher B Granger, ,

<h4>Background</h4>Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages over study-level data.<h4>Methods</h4>We used individual patient data from the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in Atrial Fibrillation) ... Read more >>

Circulation (Circulation)
[2022, 145(4):242-255]

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ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis.

Paul Cheng, Robert C Wirka, Lee Shoa Clarke, Quanyi Zhao, Ramendra Kundu, Trieu Nguyen, Surag Nair, Disha Sharma, Hyun-Jung Kim, Huitong Shi, Themistocles Assimes, Juyong Brian Kim, Anshul Kundaje, Thomas Quertermous,

<b>Background:</b> Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic plaque. To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate ... Read more >>

Circulation (Circulation)
[2022, :]

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Colchicine in Cardiovascular Disease: In-Depth Review.

Spyridon G Deftereos, Frans J Beerkens, Binita Shah, George Giannopoulos, Dimitrios A Vrachatis, Sotiria G Giotaki, Gerasimos Siasos, Johny Nicolas, Clare Arnott, Sanjay Patel, Mark Parsons, Jean-Claude Tardif, Jason C Kovacic, George D Dangas,

Inflammation plays a prominent role in the development of atherosclerosis and other cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular outcomes. For years, colchicine has been used as a safe and well-tolerated agent in diseases such as gout and familial Mediterranean fever. The widely available therapeutic has several anti-inflammatory effects, ... Read more >>

Circulation (Circulation)
[2022, 145(1):61-78]

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Policy Change Needed to Improve Maternal Cardiovascular Health.

Keith Churchwell, Donald M Lloyd-Jones, Suzette Rochat Harris, Laxmi S Mehta,

Circulation (Circulation)
[2022, 145(1):e1-e3]

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Continued Refinement of the Treatment for Light-Chain Cardiac Amyloidosis.

Justin L Grodin, Larry D Anderson, Ankit Kansagra,

Circulation (Circulation)
[2022, 145(1):18-20]

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