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Journal Circulation

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The Relationship of LVEF and Myocardial Scar to Long-Term Mortality Risk and Mode of Death in Patients with Non-Ischemic Cardiomyopathy.

Igor Klem, Michael Klein, Mohammad Khan, Eric Y Yang, Faisal Nabi, Alexander Ivanov, Lubna Bhatti, Brenda Hayes, Edward A Graviss, Duc T Nguyen, Robert M Judd, Raymond J Kim, John F Heitner, Dipan J Shah,

<b>Background:</b> Non-ischemic cardiomyopathy (NICM) is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance imaging (CMR) is increasingly recognized as risk marker for adverse outcomes, however LV dysfunction remains the ... Read more >>

Circulation (Circulation)
[2021, :]

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Trends in US Cancer and Heart Disease Mortality, 1999-2018.

Christy L Avery, Annie Green Howard, Hazel B Nichols,

Circulation (Circulation)
[2021, 143(3):287-288]

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Letter by McEvoy Regarding Article, "Cardiovascular Risk of Isolated Systolic or Diastolic Hypertension in Young Adults".

John W McEvoy,

Circulation (Circulation)
[2021, 143(3):e20-e21]

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Diagnostic Performance of High Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite United States Cohort.

Brandon R Allen, Robert H Christenson, Scott A Cohen, Richard Nowak, R Gentry Wilkerson, Bryn Mumma, Troy Madsen, James McCord, Maite Huis In't Veld, Michael Massoomi, Jason P Stopyra, Cindy Montero, Michael T Weaver, Kai Yang, Simon A Mahler,

<b>Background:</b> European data support the use of low high-sensitivity troponin (hs-cTn) measurements or a 0/1-hour (0/1-h) algorithm for myocardial infarction (MI) or to exclude major adverse cardiac events (MACE) among Emergency Department (ED) patients with possible acute coronary syndrome (ACS). However, modest US data exist to validate these strategies. This ... Read more >>

Circulation (Circulation)
[2021, :]

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Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial Infarction.

J Caleb Snider, Lance A Riley, Noah T Mallory, Matthew R Bersi, Prachi Umbarkar, Rekha Gautam, Qinkun Zhang, Anita Mahadevan-Jansen, Antonis K Hatzopoulos, Luc Maroteaux, Hind Lal, W David Merryman,

<b>Background:</b> Myocardial infarction (MI) induces an intense injury response which ultimately generates a collagen-dominated scar. While required to prevent ventricular rupture, the fibrotic process is often sustained in a manner detrimental to optimal recovery. Cardiac myofibroblasts are the cells tasked with depositing and remodeling collagen and are a prime target ... Read more >>

Circulation (Circulation)
[2021, :]

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Complete Atrioventricular Block Cured by Atrial Pacing?: Nothing Is What It Seems.

Nina Soto, David González-Casal, Pablo Ávila,

Circulation (Circulation)
[2021, 143(3):283-286]

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Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients with Atrial Fibrillation After Acute Coronary Syndrome or PCI: Insights from The AUGUSTUS Trial.

Ziad Hijazi, John H Alexander, Zhuokai Li, Daniel M Wojdyla, Roxana Mehran, Christopher B Granger, Alexander Parkhomenko, M Cecilia Bahit, Stephan Windecker, Ronald Aronson, Otavio Berwanger, Sigrun Halvorsen, Suzanne de Waha-Thiele, Peter Sinnaeve, Harald Darius, Robert F Storey, Renato D Lopes,

<b>Background:</b> In the AUGUSTUS trial, apixaban resulted in less bleeding and fewer hospitalizations than vitamin K antagonists (VKA), and aspirin caused more bleeding than placebo in patients with atrial fibrillation and acute coronary syndrome or percutaneous coronary intervention treated with a P2Y<sub>12</sub> inhibitor. We evaluated the risk-benefit balance of antithrombotic ... Read more >>

Circulation (Circulation)
[2021, :]

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Microthrombi As A Major Cause of Cardiac Injury in COVID-19: A Pathologic Study.

Dario Pellegrini, Rika Kawakami, Giulio Guagliumi, Atsushi Sakamoto, Kenji Kawai, Andrea Gianatti, Ahmed Nasr, Robert Kutys, Liang Guo, Anne Cornelissen, Lara Faggi, Masayuki Mori, Yu Sato, Irene Pescetelli, Matteo Brivio, Maria Romero, Renu Virmani, Aloke V Finn,

<b>Background:</b> Cardiac injury is common in hospitalized patients with COVID-19 and portends poorer prognosis. However, the mechanism and the type of myocardial damage associated with SARS-CoV-2 remain uncertain. <b>Methods:</b> We conducted a systematic pathologic analysis of 40 hearts from hospitalized patients dying of Coronavirus Disease 2019 (COVID-19) in Bergamo, Italy ... Read more >>

Circulation (Circulation)
[2021, :]

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Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression.

Anthony M Gacita, Dominic E Fullenkamp, Joyce Ohiri, Tess Pottinger, Megan J Puckelwartz, Marcelo A Nobrega, Elizabeth M McNally,

<b>Background:</b> Inherited cardiomyopathy associates with a range of phenotype, mediated by genetic and non-genetic factors. Non-inherited cardiomyopathy also displays varying progression and outcomes. Expression of cardiomyopathy genes is under the regulatory control of promoters and enhancers, and human genetic variation in promoters and enhancers may contribute to this variability. <b>Methods:</b> ... Read more >>

Circulation (Circulation)
[2021, :]

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Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial.

Sören J Backhaus, Torben Lange, Elisabeth F George, Kristian Hellenkamp, Roman J Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuß, Tim Seidler, Andreas Schuster,

<b>Background:</b> Right heart catheterisation (RHC) using exercise-stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiovascular magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may ... Read more >>

Circulation (Circulation)
[2021, :]

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Medium- and Large-Vessel Vasculitis.

David Saadoun, Mathieu Vautier, Patrice Cacoub,

Systemic vasculitides are multisystem blood vessel disorders, which are defined by the size of the vessel predominantly affected, namely small, medium, or large vessels. The term "large vessel" relates to the aorta and its major branches; "medium vessel" refers to the main visceral arteries and veins and their initial branches. ... Read more >>

Circulation (Circulation)
[2021, 143(3):267-282]

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Evaluation of 2 Existing Diagnostic Scores for Heart Failure With Preserved Ejection Fraction Against a Comprehensively Phenotyped Cohort.

Timothy W Churchill, Shawn X Li, Lisa Curreri, Emily K Zern, Emily S Lau, Elizabeth E Liu, Robyn Farrell, Mark W Shoenike, John Sbarbaro, Rajeev Malhotra, Matthew Nayor, Carsten Tschöpe, Rudolf A de Boer, Gregory D Lewis, Jennifer E Ho,

Circulation (Circulation)
[2021, 143(3):289-291]

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Changing the Paradigm in the Management of Valvular Heart Disease: In Addition to Left Ventricular Ejection Fraction, Focus on the Myocardium.

Federico Fortuni, Jeroen J Bax, Victoria Delgado,

Circulation (Circulation)
[2021, 143(3):209-211]

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The Heart Rate of Ventricular Tachycardia.

Arvindh N Kanagasundram, Travis D Richardson, William G Stevenson,

Circulation (Circulation)
[2021, 143(3):227-229]

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Response by Lee et al to Letter Regarding Article, "Cardiovascular Risk of Isolated Systolic or Diastolic Hypertension in Young Adults".

Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Donald M Lloyd-Jones, Hyeon Chang Kim,

Circulation (Circulation)
[2021, 143(3):e22-e23]

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Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T Cell Activation in the Heart and Promote Cardiac Dysfunction.

Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velázquez, Francisco Carrillo-Salinas, Ane M Salvador, Tania Nevers, Venkataraman Amarnath, Albert Tai, Robert M Blanton, David G Harrison, Pilar Alcaide,

<b>Background:</b> Despite the well-established association between T cell-mediated inflammation and non-ischemic heart failure (HF), the specific mechanisms triggering T cell activation during the progression of HF and the antigens involved are poorly understood. We hypothesized that myocardial oxidative stress induces the formation of isolevuglandin (IsoLG)-modified proteins that function as cardiac ... Read more >>

Circulation (Circulation)
[2021, :]

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Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects.

Wenzhu Li, Chase W Kessinger, Makoto Orii, Hang Lee, Lang Wang, Ido Weinberg, Michael R Jaff, Guy L Reed, Peter Libby, Ahmed Tawakol, Peter K Henke, Farouc A Jaffer,

<b>Background:</b> Up to 50% of patients with proximal deep venous thrombosis (DVT) will develop the post-thrombotic syndrome (PTS) characterized by limb swelling and discomfort, hyperpigmentation, skin ulcers, and impaired quality-of-life. While catheter-based interventions enabling restoration of blood flow (RBF) have demonstrated little benefit on PTS, the impact on the acuity ... Read more >>

Circulation (Circulation)
[2021, :]

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Clinical Efficacy and Safety of Alirocumab after Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial.

Gregory G Schwartz, Philippe Gabriel Steg, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Shaun G Goodman, J Wouter Jukema, Yong-Un Kim, Qian H Li, Garen Manvelian, Robert Pordy, Timothée Sourdille, Harvey D White, Michael Szarek, ,

<b>Background:</b> Recent international guidelines have lowered recommended target levels of low-density lipoprotein-cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below conventional targets. Inferences from prior analyses are limited because patients who achieve lower ... Read more >>

Circulation (Circulation)
[2021, :]

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Cell-Free DNA to Detect Heart Allograft Acute Rejection.

Sean Agbor-Enoh, Palak Shah, Ilker Tunc, Steven Hsu, Stuart Russell, Erika Feller, Keyur Shah, Maria E Rodrigo, Samer S Najjar, Hyesik Kong, Mehdi Pirooznia, Ulgen Fideli, Alfiya Bikineyeva, Argit Marishta, Kenneth Bhatti, Yanqin Yang, Cedric Mutebi, Kai Yu, Moon Kyoo Jang, Charles Marboe, Gerald J Berry, Hannah A Valantine, ,

<b>Background:</b> After heart transplantation, Endomyocardial biopsy (EMBx) is used to monitor for acute rejection (AR). Unfortunately, EMBx is invasive and its conventional histologic interpretation has limitations. This is a validation study to assesses the performance of a sensitive blood biomarker- percent donor-derived cell-free DNA (%ddcfDNA) - for detection of AR ... Read more >>

Circulation (Circulation)
[2021, :]

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Response by Nahrendorf to Letter Regarding Article, "Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus".

Matthias Nahrendorf,

Circulation (Circulation)
[2021, 143(2):e7-e8]

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Brown Adipose Tissue and the Take (12,13-di)HOME Message to the Heart.

Ileana Badi, Charalambos Antoniades,

Circulation (Circulation)
[2021, 143(2):160-162]

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Association of Inducible Myocardial Ischemia With Long-Term Mortality and Benefit From Coronary Artery Bypass Graft Surgery in Ischemic Cardiomyopathy: Ten-Year Follow-Up of the STICH Trial.

Kevin O'Fee, Julio A Panza, David L Brown,

Circulation (Circulation)
[2021, 143(2):205-207]

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DAMPening Mortality in COVID19: Therapeutic Insights from Basic Cardiometabolic Studies on S100A8/A9.

Nordin M J Hanssen, Bart Spaetgens, Prabhakara R Nagareddy, Andrew J Murphy,

Circulation (Circulation)
[2021, :]

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Cardiomyocyte Krüppel-like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.

Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang, Thomas D Bannister, Agnieszka B Bialkowska, Craig H Selzman, Stavros G Drakos, Konstantinos Drosatos,

<b>Background:</b> We previously showed that cardiomyocyte Krüppel-like factor (KLF)-5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid oxidation, we investigated the role of cardiomyocyte KLF5 in lipid metabolism and pathophysiology of ischemic heart failure. <b>Methods:</b> Using rtPCR and Western Blot, we investigated the ... Read more >>

Circulation (Circulation)
[2021, :]

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Current Indications for Transcatheter Mitral Valve Replacement Using Transcatheter Aortic Valves: Valve-in-Valve, Valve-in-Ring, and Valve-in-Mitral Annulus Calcification.

Marina Urena, Alec Vahanian, Eric Brochet, Gregory Ducrocq, Bernard Iung, Dominique Himbert,

Use of transcatheter mitral valve replacement (TMVR) using transcatheter aortic valves in clinical practice is limited to patients with failing bioprostheses and rings or mitral valve disease associated with severe mitral annulus calcification. Whereas the use of valve-in-valve TMVR appears to be a reasonable alternative to surgery in patients at ... Read more >>

Circulation (Circulation)
[2021, 143(2):178-196]

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