Full Text Journal Articles in
Journal Cells

Advertisement

Find full text journal articles






Peripheral Blood Eosinophilia Is Associated with Poor Outcome Post-Lung Transplantation.

Janne Kaes, Elise Van der Borght, Arno Vanstapel, Anke Van Herck, Annelore Sacreas, Tobias Heigl, Bart M Vanaudenaerde, Laurent Godinas, Dirk E Van Raemdonck, Laurens J Ceulemans, Arne P Neyrinck, Robin Vos, Geert M Verleden, Stijn E Verleden, Group The Leuven Lung Transplant,

Eosinophils play a role in many chronic lung diseases. In lung transplantation (LTx), increased eosinophils in bronchoalveolar lavage (BAL) was associated with worse outcomes. However, the effect of peripheral blood eosinophilia after LTx has not been investigated thoroughly. A retrospective study was performed including all LTx patients between 2011-2016. Chronic ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



The Genomics of Myelodysplastic Syndromes: Origins of Disease Evolution, Biological Pathways, and Prognostic Implications.

Hassan Awada, Bicky Thapa, Valeria Visconte,

The molecular pathogenesis of myelodysplastic syndrome (MDS) is complex due to the high rate of genomic heterogeneity. Significant advances have been made in the last decade which elucidated the landscape of molecular alterations (cytogenetic abnormalities, gene mutations) in MDS. Seminal experimental studies have clarified the role of diverse gene mutations ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Advertisement

"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer.

Matteo Audano, Silvia Pedretti, Simona Ligorio, Maurizio Crestani, Donatella Caruso, Emma De Fabiani, Nico Mitro,

Mitochondria represent the energy hub of cells and their function is under the constant influence of their tethering with other subcellular organelles. Mitochondria interact with the endoplasmic reticulum, lysosomes, cytoskeleton, peroxisomes, and nucleus in several ways, ranging from signal transduction, vesicle transport, and membrane contact sites, to regulate energy metabolism, ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Cardiovascular Manifestations of COVID-19 Infection.

Ajit Magadum, Raj Kishore,

SARS-CoV-2 induced the novel coronavirus disease (COVID-19) outbreak, the most significant medical challenge in the last century. COVID-19 is associated with notable increases in morbidity and death worldwide. Preexisting conditions, like cardiovascular disease (CVD), diabetes, hypertension, and obesity, are correlated with higher severity and a significant increase in the fatality ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular Vesicles.

Laura C Zanetti-Domingues, Scott E Bonner, Marisa L Martin-Fernandez, Veronica Huber,

EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems.

Stefanie Zeitler, Fabian Schumacher, Juliana Monti, Daniela Anni, Debarpan Guhathakurta, Burkhard Kleuser, Kristina Friedland, Anna Fejtová, Johannes Kornhuber, Cosima Rhein,

: The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via microdomain and lipid raft organization. Several commonly used antidepressants, such as fluoxetine, rely on the ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Linking Autism Risk Genes to Disruption of Cortical Development.

Marta Garcia-Forn, Andrea Boitnott, Zeynep Akpinar, Silvia De Rubeis,

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by impairments in social communication and social interaction, and the presence of repetitive behaviors and/or restricted interests. In the past few years, large-scale whole-exome sequencing and genome-wide association studies have made enormous progress in our understanding of the genetic risk ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges.

Elizabeth Ford, Jodie Pearlman, Travis Ruan, John Manion, Matthew Waller, Gregory G Neely, Leslie Caron,

Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells are capable of differentiating into the multitude of cell types that compose the central and peripheral nervous systems and so have become the major focus of ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton.

Sebastian Martewicz, Camilla Luni, Xi Zhu, Meihua Cui, Manli Hu, Siqi Qu, Damiano Buratto, Guang Yang, Eleonora Grespan, Nicola Elvassore,

Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly understood. Here, we investigate a nucleus-intrinsic mechanism driving nuclear lobulation and segmentation concurrent with granulocyte specification, independently from extracellular forces and ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Light-Regulated Transcription of a Mitochondrial-Targeted K+ Channel.

Anja J Engel, Laura-Marie Winterstein, Marina Kithil, Markus Langhans, Anna Moroni, Gerhard Thiel,

The inner membranes of mitochondria contain several types of K+ channels, which modulate the membrane potential of the organelle and contribute in this way to cytoprotection and the regulation of cell death. To better study the causal relationship between K+ channel activity and physiological changes, we developed an optogenetic platform ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.

Emma Ristori, Vittoria Cicaloni, Laura Salvini, Laura Tinti, Cristina Tinti, Michael Simons, Federico Corti, Sandra Donnini, Marina Ziche,

The amyloid-β precursor protein (APP) is a ubiquitous membrane protein often associated with Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). Despite its role in the development of the pathogenesis, APP exerts several physiological roles that have been mainly investigated in neuronal tissue. To date, the role of APP in ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology.

Cristine Alves da Costa, Wejdane El Manaa, Eric Duplan, Frédéric Checler,

Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded protein response (UPR) has emerged as a key cellular dysfunction associated with the etiology of the disease. The UPR involves a coordinated response initiated in ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Clinical Actionability of the Genomic Landscape of Metastatic Castration Resistant Prostate Cancer.

Wout Devlies, Markus Eckstein, Alessia Cimadamore, Gaëtan Devos, Lisa Moris, Thomas Van den Broeck, Rodolfo Montironi, Steven Joniau, Frank Claessens, Thomas Gevaert,

The development of targeted therapies increases treatment options for metastatic castration resistant prostate cancer (mCRPC) patients. There is a need for strong predictive and prognostic signatures to guide physicians in treating mCRPC patients. In this review we unravel the possible actionability in the AR pathway, PI3K AKT signaling, and DNA ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments.

Sebastian Scholl, Maximilian Fleischmann, Ulf Schnetzke, Florian H Heidel,

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myeloid leukemia (AML) remains a challenge despite the development of novel FLT3-directed tyrosine kinase inhibitors (TKI); the relapse rate is still high even after allogeneic stem cell transplantation. In the era of next-generation FLT3-inhibitors, such as midostaurin and gilteritinib, ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



CITCO as an Adjuvant Facilitates CHOP-Based Lymphoma Treatment in hCAR-Transgenic Mice.

Ritika Kurian, William Hedrich, Bryan Mackowiak, Linhao Li, Hongbing Wang,

Non-Hodgkin's lymphoma (NHL) is a malignant cancer originating in the lymphatic system with a 25-30% mortality rate. CHOP, consisting of cyclophosphamide (CPA), doxorubicin, vincristine, and prednisone, is a first-generation chemotherapy extensively used to treat NHL. However, poor survival rates among patients in advanced stages of NHL shows a need to ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



CRISPR FokI Dead Cas9 System: Principles and Applications in Genome Engineering.

Maryam Saifaldeen, Dana E Al-Ansari, Dindial Ramotar, Mustapha Aouida,

The identification of the robust clustered regularly interspersed short palindromic repeats (CRISPR) associated endonuclease (Cas9) system gene-editing tool has opened up a wide range of potential therapeutic applications that were restricted by more complex tools, including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). Nevertheless, the high frequency ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.

Vanessa M Conn, Marta Gabryelska, Shashikanth Marri, Brett W Stringer, Rebecca J Ormsby, Timothy Penn, Santosh Poonnoose, Ganessan Kichenadasse, Simon J Conn,

High-throughput RNA sequencing (RNA-seq) and dedicated bioinformatics pipelines have synergized to identify an expansive repertoire of unique circular RNAs (circRNAs), exceeding 100,000 variants. While the vast majority of these circRNAs comprise canonical exonic and intronic sequences, microexons (MEs)-which occur in 30% of functional mRNA transcripts-have been entirely overlooked. CircRNAs which ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Liquid Biopsy of Non-Plasma Body Fluids in Non-Small Cell Lung Cancer: Look Closer to the Tumor!

Lucile Durin, Anne Pradines, Céline Basset, Bryan Ulrich, Laura Keller, Vincent Dongay, Gilles Favre, Julien Mazieres, Nicolas Guibert,

Liquid biopsy is a rapidly emerging field due to an increasing number of oncogenic drivers and a better understanding of resistance mechanisms to targeted therapies in non-small cell lung cancer (NSCLC). The sensitivity of the most widely used blood-based assays is, however, limited in particular in cases of low tumor ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target.

Jiepei He, Yuhan Zhou, Hector M Arredondo Carrera, Alexandria Sprules, Ramona Neagu, Sayyed Amin Zarkesh, Colby Eaton, Jian Luo, Alison Gartland, Ning Wang,

Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in many cancer types. However, its involvement in PCa progression is less understood. We hypothesized ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Extracellular ATP: A Feasible Target for Cancer Therapy.

Valentina Vultaggio-Poma, Alba Clara Sarti, Francesco Di Virgilio,

Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells. ATP can be released from cells via both specific ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences.

Charysse Vandendriessche, Arnout Bruggeman, Caroline Van Cauwenberghe, Roosmarijn E Vandenbroucke,

Alzheimer's disease (AD) and Parkinson's disease (PD) are incurable, devastating neurodegenerative disorders characterized by the formation and spreading of protein aggregates throughout the brain. Although the exact spreading mechanism is not completely understood, extracellular vesicles (EVs) have been proposed as potential contributors. Indeed, EVs have emerged as potential carriers of ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ.

Mikael Marttinen, Catarina B Ferreira, Kaisa M A Paldanius, Mari Takalo, Teemu Natunen, Petra Mäkinen, Luukas Leppänen, Ville Leinonen, Kenji Tanigaki, Gina Kang, Noboru Hiroi, Hilkka Soininen, Kirsi Rilla, Annakaisa Haapasalo, Mikko Hiltunen,

Alzheimer's disease (AD) is a neurodegenerative disease characterized by aberrant amyloid-β (Aβ) and hyperphosphorylated tau aggregation. We have previously investigated the involvement of SEPTIN family members in AD-related cellular processes and discovered a role for SEPTIN8 in the sorting and accumulation of β-secretase. Here, we elucidated the potential role of ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Retraction: Li, X.; et al. Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation. Cells 2019, 8, 616.

Cells Editorial Office,

It has come to our attention that two images in Figure 2A (100%), and Figure 2C (GM) of the manuscript [...]. ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Ribosomal Protein L10: From Function to Dysfunction.

Daniela Pollutri, Marianna Penzo,

Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.

Jan B Stöckl, Nina Schmid, Florian Flenkenthaler, Charis Drummer, Rüdiger Behr, Artur Mayerhofer, Georg J Arnold, Thomas Fröhlich,

Age-related changes in the human testis may include morphological alterations, disturbed steroidogenesis, and impaired spermatogenesis. However, the specific impact of cell age remains poorly understood and difficult to assess. Testicular peritubular cells fulfill essential functions, including sperm transport, contributions to the spermatogonial stem cell niche, and paracrine interactions within the ... Read more >>

Cells (Cells)
[2020, 9(11):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1465 s