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Journal Cell. Signal.

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Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.

Wei Wang, Li Zhou, Jinshu Wang, Xinzhong Zhang, Gang Liu,

Background Circular RNAs (circRNAs) have recently been identified in the development and progression of multiple human diseases. However, the significance of circRNAs in uterine leiomyoma (ULM) remains to be elucidated. Here, we aim to explore the expression profile of circRNAs in ULM and the potential of cicRNAs to be used ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109784]

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The membrane proximal proline-rich region and correct order of C-terminal tyrosines on the adaptor protein LAT are required for TCR-mediated signaling and downstream functions.

Mikaela M Tremblay, Tomye Ollinger, Jon C D Houtman,

The primary activating receptor for T cells is the T cell receptor (TCR), which is stimulated upon binding to an antigen/MHC complex. TCR activation results in the induction of regulated signaling pathways vital for T cell differentiation, cellular adhesion and cytokine release. A critical TCR-induced signaling protein is the adaptor ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109790]

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Post-translational regulation of cardiac myosin binding protein-C: A graphical review.

Alice Main, William Fuller, George S Baillie,

Cardiac myosin binding protein-C (cMyBP-C) is a fundamental component of the cardiac sarcomere involved in regulating systolic and diastolic activity, processes which must be tightly maintained to preserve cardiac function. Importantly, as a non-enzymatic protein, cMyBP-C relies solely on post-translational modifications and protein-protein interactions in order to modulate its function, ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109788]

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JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes.

Florentina Negoita, Magdalena Vavakova, Johanna Säll, Jurga Laurencikiene, Olga Göransson,

BACKGROUND:Salt-inducible kinase 2 (SIK2) is abundant in adipocytes, but downregulated in adipose tissue from individuals with obesity and insulin resistance. Moreover, SIK isoforms are required for normal insulin signalling and glucose uptake in adipocytes, but the underlying molecular mechanisms are currently not known. The adherens junction protein JUP, also termed ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109786]

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A promoter-driven assay for INSM1-associated signaling pathway in neuroblastoma.

Chiachen Chen, Michael S Lan,

Aggressive form of neuroblastoma (NB) is a malignant childhood cancer derived from granule neuron precursors and sympatho-adrenal lineage with N-MYC amplification. An insulinoma associated-1 (INSM1) transcription factor has emerged as a NB biomarker that plays critical role in facilitating tumor cell growth and transformation. N-myc activates INSM1 in NB was ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109785]

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Notoginsenoside R1 alleviates oxidized low-density lipoprotein-induced apoptosis, inflammatory response, and oxidative stress in HUVECS through modulation of XIST/miR-221-3p/TRAF6 axis.

Jian Zhao, Lin Cui, Jing Sun, Zhouliang Xie, Leilei Zhang, Zhiwei Ding, Xiaoqiang Quan,

BACKGROUND:Atherosclerosis is a common reason for acute cardio-cerebral vascular diseases. The purpose of this study was to clarify the functional effects of Notoginsenoside R1 (NGR1) on atherosclerosis. METHODS:HUVECS were exposed to oxidized low-density lipoprotein (ox-LDL) in the current study. The proliferation ability of HUVECS was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazol-3-ium ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109781]

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piR-001773 and piR-017184 promote prostate cancer progression by interacting with PCDH9.

Ling Zhang, Xiannan Meng, Dongmei Li, Xiaodong Han,

Prostate cancer is one of the most common malignancies and the major cause of cancer-related death in men. Increasing evidence has revealed that P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) play an important role in tumor progression. Few studies have been explored the functional mechanism of piRNAs in prostate cancer progression. In ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, :109780]

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Molecular architecture of postsynaptic Interactomes.

Brent Wilkinson, Marcelo P Coba,

The postsynaptic density (PSD) plays an essential role in the organization of the synaptic signaling machinery. It contains a set of core scaffolding proteins that provide the backbone to PSD protein-protein interaction networks (PINs). These core scaffolding proteins can be seen as three principal layers classified by protein family, with ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109782]

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Cell death signalling in virus infection.

Gergely Imre,

Apoptosis, necroptosis and pyroptosis represent three major regulated cell death modalities. Apoptosis features cell shrinkage, nuclear fragmentation and cytoplasm-blebbing. Necroptosis and pyroptosis exhibit osmotic imbalances in the cell accompanied by early membrane ruptures, which morphologically resembles necrosis. Importantly, these two lytic cell death forms facilitate the release of damage associated ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109772]

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Molecular pathways in peritoneal fibrosis.

Michael S Balzer,

Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other outcome parameters, yet providing superior quality-of-life measures and cost savings. However, long-term usage of the patient's peritoneal membrane as a dialyzer filter is unphysiological ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109778]

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Silencing TTTY15 mitigates hypoxia-induced mitochondrial energy metabolism dysfunction and cardiomyocytes apoptosis via TTTY15/let-7i-5p and TLR3/NF-κB pathways.

Han Zhang, Xiufang Zou, Feng Liu,

Noncoding RNAs are interweaved in pathological processes in myocardial ischemia (MI), such as long noncoding RNA (lncRNA) and microRNAs (miRNAs). The aim of this study was to figure out the role of Testis-specific transcript Y-linked 15 (TTTY15) and let-7i-5p in cell model of MI in cardiomyocytes. Hypoxia-induced cell injury was ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109779]

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TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death.

Paresh Prajapati, Dhruv Gohel, Anjali Shinde, Milton Roy, Kritarth Singh, Rajesh Singh,

Emerging evidence suggests that ubiquitin mediated post translational modification is a critical regulatory process involved in diverse cellular pathways including cell death. During ubiquitination, E3 ligases recognize target proteins and determine the topology of ubiquitin chains. Recruitment of E3 ligases to targets proteins under stress conditions including oxidative stress and ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109777]

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Nelfinavir inhibits human DDI2 and potentiates cytotoxicity of proteasome inhibitors.

Yuan Gu, Xin Wang, Yu Wang, Yebin Wang, Jie Li, Fa-Xing Yu,

Proteasome inhibitors (PIs) are currently used in the clinic to treat cancers such as multiple myeloma (MM). However, cancer cells often rapidly develop drug resistance towards PIs due to a compensatory mechanism mediated by nuclear factor erythroid 2 like 1 (NFE2L1) and aspartic protease DNA damage inducible 1 homolog 2 ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109775]

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The promoting role of lysosome-localized c-Src in autophagosome-lysosome fusion.

Ko Suzuki, Takuya Honda, Aki Akatsu, Noritaka Yamaguchi, Naoto Yamaguchi,

Src-family kinases (SFKs), such as c-Src, Lyn and Fyn, belong to non-receptor-type tyrosine kinases and play key roles in cell proliferation, adhesion, and migration. SFKs are anchored to the plasma membrane, Golgi membranes and lysosomal membranes through lipid modifications. Although the functions of SFKs being localized to the plasma membrane ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109774]

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Clostridium perfringens phospholipase C impairs innate immune response by inducing integrated stress response and mitochondrial-induced epigenetic modifications.

Neha Bunkar, Jahnavi Sharma, Anju Chouksey, Roshani Kumari, Pushpendra Kumar Gupta, Rajnarayan Tiwari, Lalit Lodhi, Rupesh Kumar Srivastava, Arpit Bhargava, Pradyumna Kumar Mishra,

Clostridium perfringens, a rod-shaped, gram-positive, anaerobic, spore-forming bacterium is one of the most widely occurring bacterial pathogens, associated with a spectrum of diseases in humans. A major virulence factor during its infection is the enzyme phospholipase C encoded by the plc gene, known as Clostridium perfringens phospholipase C (CpPLC). The ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109776]

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Milestones in the development and implementation of FRET-based sensors of intracellular signals: A biological perspective of the history of FRET.

J Deal, D J Pleshinger, S C Johnson, S J Leavesley, T C Rich,

Fӧrster resonance energy transfer (FRET) has been described for more than a century. FRET has become a mainstay for the study of protein localization in living cells and tissues. It has also become widely used in the fields that comprise cellular signaling. FRET-based probes have been developed to monitor second ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109769]

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Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling.

Dylan O'Toole, Ali Abdullah I Zaeri, Stuart A Nicklin, Anne T French, Christopher M Loughrey, Tamara P Martin,

Adverse cardiac remodelling clinically manifests as deleterious changes to heart architecture (size, mass and geometry) and function. These changes, which include alterations to ventricular wall thickness, chamber dilation and poor contractility, are important because they progressively drive patients with cardiac disease towards heart failure and are associated with poor prognosis. ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 76:109770]

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IL-36 family cytokines in protective versus destructive inflammation.

Yingying Han, Arnaud Huard, Javier Mora, Priscila da Silva, Bernhard Brüne, Andreas Weigert,

The IL-1 family of cytokines and receptors are critical regulators of inflammation. Within the IL-1 family and in contrast to its IL-1 and IL-18 subfamilies, the IL-36 subfamily is still poorly characterized. Three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, one IL-36 receptor (IL-1R6) antagonist, IL-36RA, and one putative IL-1R6 antagonist, IL-38, ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109773]

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KLF5-mediated COX2 upregulation contributes to tumorigenesis driven by PTEN deficiency.

Liang Zhang, Yuncui Wu, Jing Wu, Meng Zhou, Dapeng Li, Xiaofeng Wan, Fuquan Jin, Yani Wang, Wei Lin, Xiaojun Zha, Yehai Liu,

Tumor suppressor gene PTEN is frequently mutated in a wide variety of cancers. However, the downstream targets or signal transduction pathways of PTEN remain not fully understood. By analyzing Pten-null mouse embryonic fibroblasts (MEFs) cell lines and their isogenic counterparts, we showed that loss of PTEN led to increased cyclooxygenase2 ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109767]

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Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process.

Antero Salminen, Kai Kaarniranta, Anu Kauppinen,

Exosomes represent an evolutionarily conserved signaling pathway which can act as an alarming mechanism in responses to diverse stresses, e.g. chronic inflammation activates the budding of exosomal vesicles in both immune and non-immune cells. Exosomes can contain both pro- and anti-inflammatory cargos but in chronic inflammation, exosomes mostly carry immunosuppressive ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109771]

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Activation of autophagy inhibits epithelial to mesenchymal transition process of human lens epithelial cells induced by high glucose conditions.

Ji Li, Wei Ye, Wenqin Xu, Tianfang Chang, Luning Zhang, Jiyuan Ma, Rui Pei, Mengmei He, Jian Zhou,

Subcapsular cataracts are common phenotype of diabetic cataracts, and abnormal lens epithelial cells (LECs) under the lens capsules have been considered to involve in the pathogenesis. Our previous studies have shown that the epithelial to mesenchymal transition (EMT), which is responsible for the LECs to lose their original polarity and ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109768]

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Ubiquitin ligase TRUSS augments the expression of interleukin-10 via proteasomal processing of NF-κB1/p105 to NF-κB/p50.

Azfar Jamal, Atahar Husein, Chhagan Bihari, Vijay Kumar,

The NF-κB/Rel family of transcription factors that play critical roles in a variety of cellular processes. Their production in the cell and physiological activation are tightly regulated. The proteasomal processing of inactive NF-κB1/p105 to active p50, with an anti-inflammatory role, is not well characterized. Here we show that ubiquitin ligase ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109766]

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Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.

Faris Almutairi, Jae-Kyung Lee, Balázs Rada,

Regulator of G protein signaling 10 (RGS10) belongs to the superfamily of RGS proteins, defined by the presence of a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. RGS proteins act as GTPase activating proteins (GAPs), which accelerate GTP hydrolysis on the G-protein α subunits and result in ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109765]

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The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB.

Yizhong Ji, Xucan Tu, Xiuqi Hu, Zhenglin Wang, Sifan Gao, Qifan Zhang, Wei Zhang, Huabing Zhang, Wei Chen,

Colorectal cancer (CRC) is one of the most common malignant gastrointestinal cancers worldwide. RING finger protein 186 (RNF186) is a member of the RING finger protein family. RNF186 has been reported to be involved in the regulation of the intestinal homeostasis through the regulation of endoplasmic reticulum (ER) stress in ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109764]

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NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.

Yinyin Wang, Sihan Liu, Guancheng Jiang, Wanli Zhai, Liu Yang, Mengdi Li, Zhijie Chang, Bingtao Zhu,

Signal transducers and activators of transcription 3 (STAT3) is reported to regulate cell proliferation, survival, and differentiation, and thus plays a central role in development and carcinogenesis. Accumulating evidence demonstrated the involvement of cellular Src (c-Src) tyrosine kinase in the activation of STAT3. Additionally, novel oncogene with kinase-domain (NOK), a ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 75:109762]

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