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Journal Cell Death Dis

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Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop.

Yan Ding, Guiping Wang, Meixiao Zhan, Xiaohan Sun, Yanran Deng, Yunhe Zhao, Bin Liu, Qingxin Liu, Shian Wu, Zizhang Zhou,

Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell metastasis in vivo. Silence of hpo or its downstream wts promotes tumor ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1126]

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Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis.

Hyeon-Ok Jin, Sung-Eun Hong, Ji-Young Kim, Se-Kyeong Jang, In-Chul Park,

Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell survival under low amino acid availability. In the present study, we investigated AKT activation in ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1127]

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LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells.

Youguang Pu, Yiao Tan, Chunbao Zang, Fangfang Zhao, Cifeng Cai, Lingsuo Kong, Hui Deng, Fengmei Chao, Ran Xia, Minghua Xie, Fangfang Ge, Yueyin Pan, Shanbao Cai, Dabing Huang,

Long-noncoding RNAs (lncRNAs) play roles in regulating cellular functions. High-throughput sequencing analysis identified a new lncRNA, termed LAMTOR5-AS1, the expression of which was much higher in the chemosensitive osteosarcoma (OS) cell line G-292 than in the chemoresistant cell line SJSA-1. Further investigations revealed that LAMTOR5-AS1 significantly inhibits the proliferation and ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1125]

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Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling.

Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou,

Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling. Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for core fucosylation, and aberrant fucosylation by dysregulated expression of fucosyltransferases is responsible for the growth of various types ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1124]

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Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments.

Iga K Mieczkowska, Garyfallia Pantelaiou-Prokaki, Evangelos Prokakis, Geske E Schmidt, Lukas C Müller-Kirschbaum, Marcel Werner, Madhobi Sen, Taras Velychko, Katharina Jannasch, Christian Dullin, Joanna Napp, Klaus Pantel, Harriet Wikman, Maria Wiese, Christof M Kramm, Frauke Alves, Florian Wegwitz,

Breast cancer (BC) is the most common cancer occurring in women but also rarely develops in men. Recent advances in early diagnosis and development of targeted therapies have greatly improved the survival rate of BC patients. However, the basal-like BC subtype (BLBC), largely overlapping with the triple-negative BC subtype (TNBC), ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1118]

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MICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging.

Yun-Fei Yang, Wu Yang, Zhi-Yin Liao, Yong-Xin Wu, Zhen Fan, Ai Guo, Jing Yu, Qiu-Nan Chen, Jiang-Hao Wu, Jing Zhou, Qian Xiao,

Age-related loss of skeletal muscle mass and function, termed sarcopenia, could impair the quality of life in the elderly. The mechanisms involved in skeletal muscle aging are intricate and largely unknown. However, more and more evidence demonstrated that mitochondrial dysfunction and apoptosis also play an important role in skeletal muscle ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1115]

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Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells.

Haiyang Zhang, Meng Wang, Yi He, Ting Deng, Rui Liu, Weixue Wang, Kegan Zhu, Ming Bai, Tao Ning, Haiou Yang, Ying Liu, Junyi Wang, Yi Ba,

Cancer stem cells (CSCs) are an important cause of tumor recurrence and drug resistance. As a new type of cell death that relies on iron ions and is strictly regulated by intracellular and extracellular signals, the role of ferroptosis in tumor stem cells deserves extensive attention. Mass spectrum was applied ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1116]

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Correction: The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging.

Zhong-Xin Jiang, Yi-Ning Wang, Zi-Yuan Li, Zhi-Hui Dai, Yi He, Kun Chu, Jia-Yi Gu, Yi-Xuan Ji, Ning-Xia Sun, Fu Yang, Wen Li,

Cell Death Dis (Cell death & disease)
[2021, 12(12):1114]

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MORC protein family-related signature within human disease and cancer.

Huan Wang, Ling Zhang, Qiuhua Luo, Jia Liu, Guiling Wang,

The microrchidia (MORC) family of proteins is a highly conserved nuclear protein superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type zinc finger and coiled-coil domain) yet exhibit diverse biological functions. Despite the advancing research in previous decades, much of which focuses on their role as epigenetic regulators and in ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1112]

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SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer.

Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He, Nan Wang,

Abnormal lipid metabolism has been commonly observed in various human cancers, including colorectal cancer (CRC). The mitochondrial citrate carrier SLC25A1 (also known as mitochondrial citrate/isocitrate carrier, CIC), has been shown to play an important role in lipid metabolism regulation. Our bioinformatics analysis indicated that SLC25A1 was markedly upregulated in CRC. ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1108]

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ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.

Danfei Liu, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Wenjie Huang, Limin Xia,

Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here, we reported that transcription factor One Cut homeobox 2 (ONECUT2) functioned as an oncogene to facilitate HCC metastasis. Elevated ONECUT2 expression was positively correlated with ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1113]

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HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer.

Jie Xu, Qingtao Meng, Hao Sun, Xinwei Zhang, Jun Yun, Bin Li, Shenshen Wu, Xiaobo Li, Hongbao Yang, Haitao Zhu, Michael Aschner, Michela Relucenti, Giuseppe Familiari, Rui Chen,

Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients fails because of metastasis and recurrence. The human epidermal growth factor receptor 2 ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1109]

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Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3.

Matthew D Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T Field, Philip Kawalec, Spencer B Gibson, Richard Keijzer, Ayesha Saleem, Grant M Hatch, Christine A Doucette, Jason M Karch, Vernon W Dolinsky, Ian M Dixon, Adrian R West, Christof Rampitsch, Joseph W Gordon,

Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating mitochondrial permeability transition (MPT). Emerging evidence suggests a cardioprotective role ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1105]

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Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.

Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhigang Zhang, Yanli Zhang, Xu Wang, Shu-Heng Jiang,

Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely unknown. In this study, we identify that lysyl oxidase-like 2 (LOXL2) is a hypoxia-responsive gene ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1106]

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PACS-2 attenuates diabetic kidney disease via the enhancement of mitochondria-associated endoplasmic reticulum membrane formation.

Mei Xue, Ting Fang, Hongxi Sun, Ying Cheng, Ting Li, Chaofei Xu, Chao Tang, Xiaohuan Liu, Bei Sun, Liming Chen,

The altered homeostasis of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) was closely associated with the pathological process of nervous system diseases and insulin resistance. Here, the exact implication of phosphofurin acidic cluster sorting protein 2 (PCAS-2), an anchor protein in the MAM interface, in diabetic kidney disease was investigated. In ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1107]

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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Ya Meng, Chengcheng Song, Zhili Ren, Xiaohong Li, Xiangyu Yang, Nana Ai, Yang Yang, Dongjin Wang, Meixiao Zhan, Jiaxian Wang, Chon Lok Lei, Weiwei Liu, Wei Ge, Ligong Lu, Guokai Chen,

Nicotinamide, the amide form of Vitamin B3, is a common nutrient supplement that plays important role in human fetal development. Nicotinamide has been widely used in clinical treatments, including the treatment of diseases during pregnancy. However, its impacts during embryogenesis have not been fully understood. In this study, we show ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1119]

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Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy.

Adriana Marcelo, Inês T Afonso, Ricardo Afonso-Reis, David V C Brito, Rafael G Costa, Ana Rosa, João Alves-Cruzeiro, Benedita Ferreira, Carina Henriques, Rui J Nobre, Carlos A Matos, Luís Pereira de Almeida, Clévio Nóbrega,

Spinocerebellar ataxia type 2 (SCA2) is an incurable and genetic neurodegenerative disorder. The disease is characterized by progressive degeneration of several brain regions, resulting in severe motor and non-motor clinical manifestations. The mutation causing SCA2 disease is an abnormal expansion of CAG trinucleotide repeats in the ATXN2 gene, leading to ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1117]

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Single-cell transcriptome profiling reveals intratumoural heterogeneity and malignant progression in retinoblastoma.

Jie Yang, Yongyun Li, Yanping Han, Yiyi Feng, Min Zhou, Chunyan Zong, Xiaoyu He, Renbing Jia, Xiaofang Xu, Jiayan Fan,

Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,739 cells from two retinoblastoma samples to delineate the heterogeneity and the underlying mechanism ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1100]

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Lipid droplets contribute myogenic differentiation in C2C12 by promoting the remodeling of the acstin-filament.

Yanjie Tan, Yi Jin, Pengxiang Zhao, Jian Wu, Zhuqing Ren,

Lipid droplet (LD), a multi-functional organelle, is found in most eukaryotic cells. LDs participate in the regulation of many cellular processes including proliferation, stress, and apoptosis. Previous studies showed the athlete's paradox that trained athletes accumulate LDs in their skeletal muscle. However, the impact of LDs on skeletal muscle and ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1102]

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Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis.

Huey-En Tzeng, Syuan-Ling Lin, Louis Anoop Thadevoos, Ming-Yu Lien, Wei-Hung Yang, Chih-Yuan Ko, Chih-Yang Lin, Yu-Wen Huang, Ju-Fang Liu, Yi-Chin Fong, Hsien-Te Chen, Chih-Hsin Tang,

Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the progression and metastasis of several different types of tumors, although the effects ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1101]

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Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages.

Jian Pu, Wenchuan Li, Anmin Wang, Ya Zhang, Zebang Qin, Zuoming Xu, Jianchu Wang, Yan Lu, Qianli Tang, Huamei Wei,

The crosstalk between cancer cells and tumor microenvironment plays critical roles in hepatocellular carcinoma (HCC). The identification of long non-coding RNAs (lncRNAs) mediating the crosstalk might promote the development of new therapeutic strategies against HCC. Here, we identified a lncRNA, HOMER3-AS1, which is over-expressed in HCC and correlated with poor ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1103]

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MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance.

Dawid Mehlich, Michał Łomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Łukasz M Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K Prełowska, Adam Gorczyński, Paweł Jabłoński, Ewa Iżycka-Świeszewska, Dominika Nowis, Anna A Marusiak,

Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the functional role of MLK4 in resistance to chemotherapy has not been ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1111]

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Initiation of hepatic stellate cell activation extends into chronic liver disease.

Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A van Grunsven,

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus on targeting the aHSCs in the perpetuation phase. However, the importance of HSC initiation during chronic liver disease ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1110]

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Correction: PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.

Tian Xia, Ming Liu, Quan Zhao, Jian Ouyang, Peipei Xu, Bing Chen,

Cell Death Dis (Cell death & disease)
[2021, 12(12):1099]

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Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder.

Xuelian Zhang, Bin Zhang, Chenyang Zhang, Guibo Sun, Xiaobo Sun,

Tribbles homolog 1 (TRIB1) belongs to the Tribbles family of pseudokinases, which plays a key role in tumorigenesis and inflammation. Although genome-wide analysis shows that TRIB1 expression is highly correlated with blood lipid levels, the relationship between TRIB1 and adipose tissue metabolism remains unclear. Accordingly, the aim of the present ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1098]

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