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Journal Cell Commun. Signal

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Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model.

Benfan Wang, Qinyan Li, Jinyan Wang, Siting Zhao, Bayaer Nashun, Li Qin, Xiaoping Chen,

BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in China. The lack of an effective treatment for this disease results in a high recurrence rate in patients who undergo radical tumor resection, and the 5-year survival rate of these patients remains low. Our previous studies demonstrated ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):157]

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Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice.

Xin-Yi Xu, Yan Du, Xue Liu, Yilin Ren, Yingying Dong, Hong-Yu Xu, Jin-Song Shi, Dianhua Jiang, Xin Xu, Lian Li, Zheng-Hong Xu, Yan Geng,

BACKGROUND:Hepatic fibrosis is a pathological response of the liver to a variety of chronic stimuli. Hepatic stellate cells (HSCs) are the major source of myofibroblasts in the liver. Follistatin like 1 (Fstl1) is a secreted glycoprotein induced by transforming growth factor-β1 (TGF-β1). However, the precise functions and regulation mechanisms of ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):151]

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Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane depolarization.

Luigi Fattore, Debora Malpicci, Ciro Milite, Sabrina Castellano, Gianluca Sbardella, Gerardo Botti, Paolo A Ascierto, Rita Mancini, Gennaro Ciliberto,

Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance imposes the necessity to conceive novel therapeutic strategies capable to achieve a more durable disease control. In the last years, ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):150]

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LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP.

Lin Hu, Jing Wang, Yunliang Wang, Linpeng Wu, Chao Wu, Bo Mao, E Maruthi Prasad, Yuhong Wang, Y Eugene Chin,

BACKGROUND:LOX-like 1 (LOXL1) is a lysyl oxidase, and emerging evidence has revealed its effect on malignant cancer progression. However, its role in colorectal cancer (CRC) and the underlying molecular mechanisms have not yet been elucidated. METHODS:LOXL1 expression in colorectal cancer was detected by immunohistochemistry, western blotting and real-time PCR. In ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):148]

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Differential regulation of rho GTPases during lung adenocarcinoma migration and invasion reveals a novel role of the tumor suppressor StarD13 in invadopodia regulation.

Maria Al Haddad, Rayane El-Rif, Samer Hanna, Leila Jaafar, Rayanne Dennaoui, Sandra Abdellatef, Veronika Miskolci, Dianne Cox, Louis Hodgson, Mirvat El-Sibai,

BACKGROUND:Lung cancer is the second most commonly occurring cancer. The ability to metastasize and spread to distant locations renders the tumor more aggressive. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in the regulation of the actin cytoskeleton and in cancer cell migration and ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):144]

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Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells.

Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P Acker, Syed M Qadri,

BACKGROUND:Thrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD47, orchestrates a wide array of cellular functions including cytoskeletal organization, migration, cell-cell interaction, cell proliferation, autophagy, and apoptosis. In the present ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):155]

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Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.

Ping Yin, Yu Bai, Zhuo Wang, Yu Sun, Jian Gao, Lei Na, Zhongbo Zhang, Wei Wang, Chenghai Zhao,

Mesenchymal-like stemness is characterized by epithelial-mesenchymal transition (EMT). Breast cancer (BC) cell mesenchymal-like stemness is responsible for distal lung metastasis. Interrogation of databases showed that Fzd7 was closely associated with a panel of mesenchymal-related genes and a panel of stemness-related genes. Fzd7 knockdown in mesenchymal-like MDA-MB-231 and Hs578T cells reduced ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):143]

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Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.

Xiuman Zhou, Jiangfeng Du, Hongfei Wang, Chunxia Chen, Ling Jiao, Xiangrui Cheng, Xiaowen Zhou, Shaomeng Chen, Shanshan Gou, Wenshan Zhao, Wenjie Zhai, Junhui Chen, Yanfeng Gao,

BACKGROUND:Inhibitors targeting immune checkpoint were proved effective in cancer immunotherapy, such as PD-1/PD-L1 blockade. The novel immune checkpoint TIGIT/PVR plays critical roles in suppressing the anti-tumor effects of CD8+ T and NK cells, and dual blockade of TIGIT/PVR and PD-1/PD-L1 by antibody can elicit synergistic effects in tumor models and ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):142]

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Rabies virus phosphoprotein P5 binding to BECN1 regulates self-replication by BECN1-mediated autophagy signaling pathway.

Juan Liu, Min Liao, Yan Yan, Hui Yang, Hailong Wang, Jiyong Zhou,

BACKGROUND:Rabies virus (RABV) is reported to encode five phosphoproteins (P), which are involved in viral genomic replication, axonal transport, oxidative stress, interferon antagonism, and autophagy induction. However, the functions of the different P proteins are poorly understood. METHODS:Immunofluorescence staining and western blot were performed to detect the autophagy activity, the ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):153]

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CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.

Hang Li, Jun Che, Mian Jiang, Ming Cui, Guoxing Feng, Jiali Dong, Shuqin Zhang, Lu Lu, Weili Liu, Saijun Fan,

INTRODUCTION:Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) is involved in the progression of non-small cell lung cancer (NSCLC), however, the role of ERβ in the response to radiotherapy in lung cancer remains elusive. In the present study, we ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):152]

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miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators.

Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira, Veronica Huber, Michele Del Vecchio, Marialuisa Sensi, Biagio Eugenio Leone, Mario Santinami, Licia Rivoltini, Monica Rodolfo, Viviana Vallacchi,

BACKGROUND:Targeted therapy with BRAF and MEK inhibitors has improved the survival of patients with BRAF-mutated metastatic melanoma, but most patients relapse upon the onset of drug resistance induced by mechanisms including genetic and epigenetic events. Among the epigenetic alterations, microRNA perturbation is associated with the development of kinase inhibitor resistance. ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):156]

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G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone.

Xiao-Fan Zhao,

G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands. Recent studies have suggested that GPCRs transmit animal steroid hormone signals. Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):146]

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Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer.

Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren, Tasneem Bawa-Khalfe,

BACKGROUND:Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease. Hence, ET-resistant (ET-R) HR+ BCa presents a therapeutic challenge. Previous studies show elevated androgen receptor (AR) that supports resistance to ET ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):154]

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AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.

Yameng Si, Jiadong Huang, Xiang Li, Yu Fu, Rongyao Xu, Yifei Du, Jie Cheng, Hongbing Jiang,

BACKGROUND:Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth muscle cells (SMCs) coverage. However, the underlying mechanism of interaction between ECs and SMCs responsible for VMs has not been fully ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):139]

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Calcineurin.

Trevor P Creamer,

The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to, transcription factors, receptors and channels, proteins associated with mitochondria, and proteins associated with microtubules. Calcineurin is activated by increases in intracellular calcium concentrations, ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):137]

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Orchestration of signaling by structural disorder in class 1 cytokine receptors.

Pernille Seiffert, Katrine Bugge, Mads Nygaard, Gitte W Haxholm, Jacob H Martinsen, Martin N Pedersen, Lise Arleth, Wouter Boomsma, Birthe B Kragelund,

BACKGROUND:Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes such as proliferation, differentiation, immunity and growth through long disordered intracellular domains (ICDs), but without having intrinsic kinase activity. Despite these key roles, ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):132]

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Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation.

Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Han,

BACKGROUND:Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, closely associated with the pathogenesis of neurodegeneration. However, how calcium regulates this process in neuronal cells is poorly understood. Therefore, the present study ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):123]

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The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy.

Dongfang Liu, Saiaditya Badeti, Gianpietro Dotti, Jie-Gen Jiang, He Wang, James Dermody, Patricia Soteropoulos, Deanna Streck, Raymond B Birge, Chen Liu,

Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation. In recent clinical trials, the adoptive transfer of CAR-modified immune cells (including CAR-T and CAR-NK cells) into patients has been remarkably successful in treating multiple ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):134]

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Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.

Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M Saadiq, Kyra L Jordan, Alfonso Eirin, Lilach O Lerman,

BACKGROUND:The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may induce senescence in mesenchymal stem/stromal cells (MSC) and impact their micro-RNA (miRNA) content. We hypothesized that MetS also alters senescence-associated (SA) miRNAs in MSC-derived extracellular vesicles (EVs), and interferes with their ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):124]

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Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions.

Ioannis Skalidis, Christian Tüting, Panagiotis L Kastritis,

Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical species of reactions catalyzed by highly abundant, gigantic enzymatic complexes, dubbed as "metabolons", have broad "nonmetabolic" signaling functions. Conserved unstructured regions within metabolons determine the yield of these metabolites. ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):136]

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Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma.

Chuanzong Zhao, Ben Wang, Enyu Liu, Zongli Zhang,

BACKGROUND:Metabolic reprogramming, in which energetic metabolism changes from oxidative phosphorylation to glycolysis, is well-accepted as a hallmark of cancers including hepatocellular carcinoma (HCC). A growing body of evidence suggests the involvement of oncogenes and tumor suppressor genes in the control of metabolic reprogramming. In this study, we attempt to investigate ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):131]

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Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis.

Amir B Ghaemmaghami, Maryam Mahjoubin-Tehran, Ahmad Movahedpour, Korosh Morshedi, Amirhossein Sheida, Seyed Pouya Taghavi, Hamed Mirzaei, Michael R Hamblin,

Malignant gliomas are the most common and deadly type of central nervous system tumors. Despite some advances in treatment, the mean survival time remains only about 1.25 years. Even after surgery, radiotherapy and chemotherapy, gliomas still have a poor prognosis. Exosomes are the most common type of extracellular vesicles with a ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):120]

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Role of tyrosine kinases in bladder cancer progression: an overview.

Amir Sadra Zangouei, Amir Hossein Barjasteh, Hamid Reza Rahimi, Majid Mojarrad, Meysam Moghbeli,

BACKGROUND:Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases are diagnosed after macroscopic clinical symptoms, it is required to find efficient markers for the early detection. Receptor tyrosine-kinases ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):127]

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Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia.

Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi,

BACKGROUND:Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain. Previously, Ser216 was found to be phosphorylated in neutrophils infiltrating into the mouse uterus and to ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):117]

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RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression.

Mei Wang, Yanyan Zhang, Zhi Xu, Peipei Qian, Wenbo Sun, Xiumei Wang, Zhang Jian, Tiansong Xia, Yong Xu, Jinhai Tang,

BACKGROUND:The activation of the NF-κB pathway plays a crucial role in the progression of breast cancer (BCa) and also involved in endocrine therapy resistance. On the contrary to the canonical NF-κB pathway, the effect of the noncanonical NF-κB pathway in BCa progression remains elusive. METHODS:BCa tumor tissues and the corresponding ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):128]

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