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Journal Case Rep Neurol Med

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Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition.

Alisha Khan, Jonathan Hingre, Amit S Dhamoon,

Manganese accumulation in the central nervous system creates clinical symptoms of cognitive dysfunction, behavioral changes, and movement disorders resembling Parkinson's disease. Radiographic features of this rare clinical entity include symmetric T1 hyperintensities in the bilateral globus pallidi, with corresponding hypointensities on T2-weighted images. Total parenteral nutrition (TPN) is an increasingly ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:9484028]

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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study.

Praveen Sripad, Jessica Rosenberg, Frank Boers, Christian P Filss, Norbert Galldiks, Karl-Josef Langen, Ralf Clauss, N Jon Shah, Jürgen Dammers,

In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:8597062]

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Medically Refractory Multiple Sclerosis Is Successfully Treated with Plasmapheresis in a Super Morbidly Obese Pregnant Patient.

Lindsey Dalka, Antoine Harb, Kael Mikesell, Gillian Gordon Perue,

Multiple sclerosis (MS) is a relapse remitting immune-mediated demyelinating neurological disorder that primarily affects women of childbearing age. In most patients, the hormonal changes during pregnancy are protective against MS relapses. When relapses do occur, treatment options are limited to use of intravenous steroids and plasmapheresis rescue therapy. We present ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:4536145]

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A Transforaminal Endoscopic Surgical Technique for Treating Lumbar Disc Herniation in the Setting of Spina Bifida.

Albert E Telfeian, Adetokunbo Oyelese, Jared Fridley, Rohaid Ali, Deus Cielo, Ziya L Gokaslan,

Recent literature suggests that adult patients with spina bifida receive surgery for degenerative disc disease at higher rates than the general population. However, sometimes the complex anatomic features of co-occurring spina bifida and lumbar disc herniation can significantly challenge standard surgical techniques. Here, the technical steps are presented for treating ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:1076847]

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Contrast-Induced Encephalopathy following Cerebral Angiography in a Hemodialysis Patient.

Marija Bender, Gojko Bogdan, Dorijan Radančević, Nataša Pejanović-Škobić,

Contrast-induced encephalopathy (CIE) is a rare complication of contrast media use during angiographic procedures. With the growing use of endovascular interventions, this complication is likely to become more common. We present a case of a 46-year-old woman with hypertension, hypothyroidism, and chronic renal failure. She developed CIE following cerebral angiography ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:3985231]

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Clinical Features of Painful Ophthalmoplegia with a High-Intensity Ring Appearance around the Optic Nerve on MRI: A Case Series.

Yasunobu Nosaki, Ken Ohyama, Maki Watanabe, Takamasa Yokoi, Katsushige Iwai,

Objective:Painful ophthalmoplegia includes nonspecific magnetic resonance imaging (MRI) manifestations and various clinical features including orbital pain and cranial nerve palsies. Treatment for painful ophthalmoplegia remains controversial. The aim of this report was to describe detailed clinical features, MRI findings, treatments, and prognosis of patients with painful ophthalmoplegia. Patients and Methods. ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:6737018]

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Composite Anatomical Variations between the Sciatic Nerve and the Piriformis Muscle: A Nepalese Cadaveric Study.

Ameet Kumar Jha, Prakash Baral,

Piriformis syndrome is a rare syndrome which is one of the main causes of nondiscogenic sciatica causing severe low back pain due to entrapment of sciatic nerve either by the hypertrophy or by inflammation of the piriformis muscle. We have carried out dissection in 20 Nepalese cadavers. Out of 40 ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:7165818]

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Unusual Phenotype and Disease Trajectory in Kearns-Sayre Syndrome.

Josef Finsterer, Michael Winklehner, Claudia Stöllberger, Thomas Hummel,

Objective:To describe unusual course and unusual phenotypic features in an adult patient with Kearns-Sayre syndrome (KSS). Case Report. The patient is a 49-year-old male with KSS, diagnosed clinically upon the core features, namely, onset before the age 20 of years, pigmentary retinopathy, and ophthalmoparesis, and the complementary features, namely, elevated ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:7368527]

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Into a Shaking Limbo: Case Report of a Nonneoplastic Limbic Encephalitis with Faciobrachial Dystonic Seizures and Parkinsonism.

Vijay Renga,

This case report describes a rare but classic presentation of a non-paraneoplastic, antibody-mediated limbic encephalitis. The clinical course did put us in a limbo as it evolved from seizure to Parkinsonism and then from metastasis to stroke, before it finally announced itself by its pathognomonic finding. Knowledge of this rare ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:3796807]

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Immediate Response to Chemotherapy in an Adult Neuroblastoma Patient Presenting with Cord Compression.

Nedal Bukhari, Bachar Harfouch, Majid Shallal Alotaibi, Hulayel Al-Harbi, Omar Chamdine,

We report a case of a 31-year-old female patient with high-risk neuroblastoma (NBL) who presented with a history of static back pain and bilateral lower limb weakness for almost a month. Her primary tumor was located in the right paraspinal region, causing spinal cord compression (SCC). Chemotherapy was administered with ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:6401497]

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A Patient with Combined CADASIL and MTHFR Homozygosity.

Sidonie Ibrikji, Tarek El Halabi, Bassem Yamout,

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds. Homozygosity for the factor Methylenetetrahydrofolate Reductase (MTHFR) is also ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:4980847]

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Bilateral Femoral Neuropathy: A Rare Complication of Drug Overdose due to Prolonged Posturing in Lithotomy Position.

D Tsiptsios, D Daud, K Tsamakis, E Rizos, A Anastadiadis, A Cassidy,

Background:Bilateral femoral neuropathy is an uncommon complication of various surgical and nonsurgical procedures, such as pelvic/abdominal surgery or vaginal delivery. Case Report. We report a case of a 41-year-old male who was found unresponsive against the wall in a "lithotomy-type" position with both knees flexed at approximately 90 degrees and ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:2352850]

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Comment on "CPEO and Mitochondrial Myopathy in a Patient with DGUOK Compound Heterozygous Pathogenetic Variant and mtDNA Multiple Deletions".

Josef Finsterer,

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:5846971]

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Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy.

Jasmine Shimin Koh, James Wei Min Tung, Genevieve Lynn Yu Tan-Yu, Thirugnanam Umapathi,

Chronic immune sensory polyradiculopathy (CISP) is an uncommon and treatable inflammatory disorder of the proximal sensory nerve roots. Patients typically present with severe sensory ataxia, normal motor examination, unsteady gait, and normal nerve conduction studies (NCS). We describe an elderly man who presented with a two-week history of progressive numbness ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:6595086]

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Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies.

Maurizio Benucci, Luciana Tramacere, Maria Infantino, Mariangela Manfredi, Valentina Grossi, Arianna Damiani, Francesca Li Gobbi, Maristella Piccininni, Gaetano Zaccara, Massimo Cincotta,

We report the case of a 64-year-old man who presented with subacute memory, balance impairment, behavioral and mood changes, and epileptic seizures. Magnetic resonance imaging (MRI) showed bilateral hippocampal abnormalities. Brain [18F]-FDG fluorodeoxyglucose positron emission tomography (PET) revealed hypometabolism in both the temporal lobe as well as in the left ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:5697670]

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Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years.

Maria das Dores Medina-Lopes, Luiz Augusto Casulari,

Meningioma treatment includes observation of its growth or surgery with or without associated radiotherapy. However, drug treatment can be used for tumors deemed inoperable because of their size and location. Due to the presence of progesterone receptors, the use of antiprogestin mifepristone is recommended. This study describes a case of ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:5162918]

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Endoscopic Endonasal Resection of Meckel's Cave Epidermoid Cysts: Case Discussion and Literature Review.

Jehad Zakaria, Pravesh Saini, Mariya Yanovskaya, John T Tsiang, Krishnan Ravindran, Stephen Johans, Chirag R Patel, Anand V Germanwala,

Meckel's cave (MC) epidermoid cysts are relatively uncommon lesions. In cases where surgical excision is indicated, resection is often carried out via a frontosphenotemporal craniotomy from an anterolateral approach or a temporal craniotomy with or without a petrosectomy for a lateral corridor; both of these routes are associated with brain ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:7853279]

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Subcutaneous EEG Monitoring Reveals AED Response and Breakthrough Seizures.

Sigge Weisdorf, Ivan C Zibrandtsen, Troels W Kjaer,

Unrecognized seizures are a common problem in temporal lobe epilepsy potentially leading to undertreatment. Objective seizure counting using EEG home monitoring for prolonged periods with a minimally invasive device has not been feasible until now. We present a case in which a novel, subcutaneous EEG device was utilized to provide ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:8756917]

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Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma.

Osmond C Wu, Berje H Shammassian, Arunit J S Chugh, Aparna Harbhajanka, Manish K Kasliwal,

Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:1792582]

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Anti-NMDAR Encephalitis: Higher Suspicious Needed for Earlier Diagnosis (Case Report, Literature Review and Diagnostic Criteria).

Chanaka Amugoda, Noushin Chini Foroush, Hamed Akhlaghi,

Background:Auto-immune mediated anti-NMDA receptor encephalitis is a very common delayed diagnosed encephalitis which predominately affecting young population. Objectives:This encephalitis is relatively unknown amongst emergency physicians and a majority of patients are admitted to psychiatric wards before their diagnosis is confirmed and appropriate treatments are commenced. We reported a case of ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:7476254]

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A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome.

Janet K Lee, Kathleen Murray, Swetha Renati,

Nephrotic syndrome is defined by three characteristic features including proteinuria of >3 g in 24 hours, hypoalbuminemia of less than 3 g/dL, and peripheral edema. Multiple nephropathies can result in nephrotic syndrome. Most commonly, minimal change disease is seen in children under the age of 10, while adults are more commonly found ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:6840240]

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Successful Pallidal Deep Brain Stimulation Treatment in a Case of Generalized Dystonia due to a Novel ANO3 Mutation.

Lizl Lasky, Lindsay Bliss, Christos Sidiropoulos,

Background:Dystonia is a ubiquitous syndrome, with a growing number of genes being continually identified. Mutations in the anoctamin-3 gene have been described to cause dystonia but the management and long-term outcomes are still largely unknown. Methods:We present here a long term, longitudinal follow up of a patient with generalized dystonia, ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:3154653]

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MELAS Missed for Years: Stroke-Like Lesions Are No Indication for Brain Biopsy.

J Finsterer,

A 56-year-old female with a history of chronic alcoholism until age 38 y with a relapse between ages 45 and 46 y developed seizures, psychosis, and hemianopia to the left at age 46 y. Imaging revealed a right parieto-occipital lesion with intralesional bleeding. Five months after the first lesion she developed a second ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:9312451]

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Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands.

Catarina Falcão de Campos, Miguel Oliveira Santos, Rafael Roque, Isabel Conceição, Mamede de Carvalho,

Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in the gene encoding the Thymidine Phosphorylase (TP). It is clinically characterized by severe gastrointestinal dysmotility, cachexia, palpebral ptosis, ophthalmoparesis, sensorimotor polyneuropathy and leukoencephalopathy. The diagnosis is established by the presence of typical clinical and neuroimaging features, ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:5976410]

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Duodenal Neuroendocrine Tumour Presenting as GABA B Receptor Autoimmune Encephalitis.

Dhanashree Peddawad, Manoj K Singh,

GABA B receptor antibody positive autoimmune encephalitis is rarely seen in clinical practice. It is usually associated with small cell lung carcinoma, and occasionally with neuroendocrine tumour (NET) of lung. GABA B receptor antibody can be associated with other autoimmune antibodies like antinuclear antibody and antibody to Glutamic acid decarboxylase. ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:3428918]

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