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Journal Case Rep Hematol

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Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review.

Salimah Valliani, Mir Ali, Omar Mahmoo, Sanjay Hinduja, Calvin K Chen, Lloyd Damon, Haifaa Abdulhaq,

Primary plasma cell leukemia (pPCL) is an uncommon disease. IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases. IgM pPCL is quite rare with only a few cases published to date. We describe a case of a patient with IgM pPCL ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8823877]

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Prolonged Response of a Patient with Relapsed Acute Myeloid Leukemia to a Novel Oral Bromodomain Extraterminal Inhibitor (BETi).

Meilen Chang Muñoz, Jennifer A Murphy, Johannes E Wolff, Brian A Jonas,

Acute myeloid leukemia (AML) is an aggressive clonal bone marrow cancer characterized by high rates of relapse and mortality. A middle-aged woman with AML relapsed twice after achieving complete remission with induction therapy and subsequent salvage therapy. She was then enrolled in a clinical trial with the bromodomain extraterminal inhibitor ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8830123]

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Myeloid Disease with the CSF3R T618I Mutation after CLL.

Maria Eduarda Couto, Susana Bizarro, Domingos Sousa, Nelson Domingues, Isabel Oliveira, Gabriela Martins, Manuel R Teixeira, Mário Mariz,

Chronic lymphocytic leukemia (CLL) is frequently an indolent diagnosis, with most of the patients being under surveillance for long time. There is an increased risk of a second neoplasia in CLL, rarely hematological (in the myeloid lineage is even rarer). A 58-year-old male was diagnosed with CLL in 2012, remaining ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:6670965]

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Rapid Response in a Patient with Relapsed/Refractory Multiple Myeloma Treated with BRAF/MEK Inhibitors.

Steve Biko Otieno, Syed Nasir, Alva Weir, Robert Johnson,

Patients with relapsed and refractory multiple myeloma have a poor prognosis. The mitogen-activated protein kinase (MAPK) pathway has been implicated in the pathogenesis of multiple myeloma. Several mutations in this pathway can lead to its constitutive activation leading to oncogenesis. One such mutation is BRAFV600E which is a therapeutic target ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8821415]

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Double-Hit Primary Plasma Cell Leukemia with IGH/MYC and IGH/CCND1 Translocations.

Masato Yasumi, Takaya Endo, Hiroshi Sata, Takahiro Karasuno,

Primary plasma cell leukemia (pPCL) is an aggressive variant of multiple myeloma (MM). Immunoglobulin heavy chain (<i>IgH</i>) translocations are found in a majority of pPCL cases, supporting a central relation to pathogenesis of pPCL. However, two independent <i>IgH</i> translocations are barely detected at the onset of pPCL, and their significance ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8811114]

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An Incidental Finding of Gastric Mucosa-Associated Lymphoma (MALToma) in a Sleeve Gastrectomy with Literature Review.

Brenda Mai, Michaelangelo Friscia, Pamela Younes, Jaiyeola Thomas-Ogunniyi, Lei Chen,

Mucosal-associated lymphoid tissue (MALT) lymphoma can typically be identified as a mass lesion or nodularity endoscopically and macroscopically. We report an incidental finding of a <i>Helicobacter pylori</i> gastric mucosal-associated lymphoid tissue (MALT) lymphoma in a sleeve gastrectomy specimen with no gross examination findings. ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8855127]

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Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma.

Norisato Hashimoto, Tomoki Ueda, Shinichiro Hiraiwa, Takuma Tajiri, Naoya Nakamura, Kenji Yokoyama,

Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma. Although it was first described in HIV- (human immunodeficiency virus-) infected patients, PBL has been diagnosed in patients with other immunodeficiencies as well as in immunocompetent patients. PBL immunohistochemically expresses plasmacytic markers and lacks pan B-cell markers. The cells of origin of ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8876567]

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Hemorrhagic Cystitis Secondary to Adenovirus and BK Virus Infection in a Diffuse Large B-Cell Lymphoma Patient with Recent CAR T-Cell Therapy.

Abdul Moiz Khan, Zainub Ajmal, Fatima Tuz Zahra, Ananthakrishnan Ramani, Ira Zackon,

Patients who undergo chimeric antigen receptor T-cell therapy (CAR T-cell therapy) are immunosuppressed due to multiple factors. While adenovirus and BK virus are well-known pathogens in the context of hematopoietic stem cell transplant, there are no detailed reports of these infections in the setting of CAR T-cell therapy. We describe ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:6621967]

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Acute Iatrogenic Agranulocytosis: A Rare and Dire Case of an Adverse Drug Reaction to Be Aware.

Diogo André, Mónica Caldeira, Fabiana Gouveia, Rafael Nascimento, António Chaves, Maria Braza O,

<h4>Background</h4>Iatrogenic agranulocytosis (IA), by nonchemotherapeutic drugs, is a rare adverse event, resulting in a neutrophil count under 0.5 × 10<sup>9</sup> cells/L with fever or other suggestive signs of infection.<h4>Methods</h4>This paper discusses the possible mechanisms responsible for agranulocytosis induced by nonchemotherapeutic drugs. It also describes three cases as well as potential ways to handle ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:6125626]

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Clinical Presentation of Acute Pulmonary Embolism in Patients with Coronavirus Disease 2019 (COVID-19).

Nonso Osakwe, Douglas Hart,

The clinical management of severely ill patients with COVID-19-related acute respiratory distress syndrome (ARDS) presents significant challenges. Many COVID-19 patients with ARDS also present with laboratory findings significant for derangement in coagulation function. In this report, we describe acute pulmonary embolism in three patients with COVID-19. We assessed the role ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8855957]

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Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature.

William Forehand Iii, Germame Ajebo, Michael Toscano, Anand Jillella, Paul Dainer,

Lenalidomide is indicated in the front-line management of multiple myeloma. More recently, it has been introduced for use in treating other hematologic malignancies. Although the drug is known to cause myelosuppression, there have been rare reports of lenalidomide-associated immune thrombocytopenia (ITP). Here, we review the literature on lenalidomide-associated ITP and ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8825618]

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Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections.

Jorge Labrador, Gerardo J Hermida, Rodolfo Alvarez, Victor Anso, Pilar de Vicente, Mercedes Goñi, Tomas Jose Gonzalez-Lopez,

Blast crisis (BC) continues to be the major challenge in the treatment of chronic myeloid leukemia. Best results have been observed in a few patients who were successfully transplanted after returning to chronic phase. Recent studies focus on the combination of chemotherapy with imatinib, but results remain unsatisfactory. Since dasatinib ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8867461]

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A Rare CD4-CD8+ Adult T-Cell Leukemia/Lymphoma with Unique Molecular Mutations: A Case Report with Literature Review.

Jui Choudhuri, Leah Geiser Roberts, Yan Zhang, Yanhua Wang, Yanan Fang,

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm caused by infection of the human T-cell lymphotropic virus type 1 (HTLV-1). Most ATLL cases are CD4-positive and CD8-negative. Though rare, there are a few dual negative (CD4-CD8-), dual positive (CD4+CD8+), and CD4-CD8+ cases reported in literature. ATLL is associated with ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8890502]

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EF Bart's Disease with Coinheritance of Gγ-XmnI and Aγ-Globin Polymorphisms: A Case of Nontransfusion-Dependant Thalassemia.

Kane M Laks, Cara Hirner, Barbara Gruner, Jared Coberly, Katsiaryna Laziuk, Bindu Kanathezhath Sathi,

EF Bart's disease is a rare form of nontransfusion-dependant thalassemia (NTDT) due to the coinheritance of homozygous hemoglobin <i>E</i> (<i>β</i> <sup>E</sup>/<i>β</i> <sup>E</sup>) genotype with hemoglobin H disease. These individuals are routinely found to have thalassemia intermedia with moderate anemia, increased hemoglobin Bart's and hemoglobin F on electrophoresis. The contribution of ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8869335]

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Nonimmunoglobulin Crystal-Storing Histiocytosis (CSH): Case Report and Literature Review.

Manuel Beltran, Sharad Khurana, Yennifer Gil, Jason T Lewis, Rohit Kumar, James M Foran,

Crystal-storing histiocytosis (CSH) is an uncommon condition in which histiocytes accumulate a crystalline matter within their cytoplasm. Generally, those crystals are composed of either monoclonal or polyclonal immunoglobulin chains, which have a strong association with an underlying lymphoproliferative or plasma cell disorder (LP-PCD). Rarely, CSH has been reported as local ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8856411]

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Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation.

Rūta Čepulytė, Andrius Žučenka, Valdas Pečeliūnas,

Multiple myeloma (MM) is an incurable plasma cell neoplasia characterized by relapsed and/or refractory (R/R) disease course, which poses a major therapeutic challenge. New therapies, including BRAF V600E mutation targeting, may become a new treatment option for R/R MM. In combination with mitogen-activated protein kinase inhibitors (MEKi), BRAF inhibitors (BRAFi) ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8894031]

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IgA Monoclonal Gammopathy of Undetermined Significance and Complication of Streptococcus mitis Bacteremia.

Jennifer Paterno, Alessandra Petrillo, David Samuel Dicapua Siegel, Chinwe Ogedegbe,

This case presents a patient with bacteremia of an unusual organism with a history of monoclonal gammopathy of undetermined significance (MGUS). MGUS is typically thought to be asymptomatic until potential progression of the disease. This case reports a patient with a history of MGUS who does not show disease progression, ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8823908]

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Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region.

S A Touré, M Seck, A B Diallo, E H D Niang, M Keita, M F Dabo, B F Faye, S Diop,

Angioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic malignancy recognized in the WHO 2016 classification as a clinical and histological entity. It is a very poorly described disease in Africa due to its rarity and diagnostic difficulties, particularly differential diagnosis with tuberculosis. Here, we report a 57-year-old man who presented ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8824843]

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Venetoclax and Decitabine for T/Myeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS).

Heather Klocke, Zhao Ming Dong, Craig O'Brien, Nicholas Burwick, Robert E Richard, Daniel Y Wu, Thomas R Chauncey, Solomon A Graf,

T/myeloid mixed-phenotype acute leukemia not otherwise specified (MPAL NOS) is an uncommon and aggressive leukemia without well-established treatment guidelines, particularly when relapsed. Venetoclax plus a hypomethylating agent offers a promising option in this situation since studies support its use in both acute myeloid and, albeit with fewer data to date, ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8811673]

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Sevoflurane-Induced Thrombocytopenia in Post-Robotic-Assisted Paraesophageal Hernia Repair.

Sara Alhaj, James Tran, Muhammad Nazim, Praveen Tumula, Hassan Ahmed,

<h4>Background</h4>Transient transaminitis is an expected outcome from liver retraction after foregut surgeries. However, severe thrombocytopenia is usually not a sequela of that. We present a case in which sevoflurane is suspected of inducing thrombocytopenia as it was the only newly introduced medication to the patient during the hospital course. Thrombocytopenia ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8851687]

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Cerebral Venous Thrombosis in the Setting of Malignancy: Case Report and Review of the Literature.

Constantine N Logothetis, Charles Pizanis,

Cerebral venous thrombosis (CVT) is a rare condition that can be difficult to diagnose due to its vague and nonspecific symptoms. It is even more unusual to identify CVT in association with malignancy. Given the rarity of this disease, treatment and management of CVT in the setting of malignancy is ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8849252]

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Acute Laryngeal Dyspnea as the First Presentation of Mantle Cell Lymphoma: A Case Report and Review of the Literature.

Mounir Ababou, Hicham El Maaroufi, Adnane Hammani, Selim Jennane, El Mehdi Mahtat, Mohammed Mikdame, Kamal Doghmi,

<h4>Introduction</h4>Acute laryngeal dyspnea is a life-threatening emergency, and the causes in adults are most often laryngeal tumors or inflammatory edema. Lymphoma of the larynx and especially the mantle cell type is extremely rare. <i>Case Presentation</i>. We report a case of a 43-year-old woman with no particular pathological history. She presented ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8818270]

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PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia.

Stephanie Wolanin, Robert K McCall, Mark J Pettenati, Michael W Beaty, Giovanni Insuasti-Beltran, Bayard L Powell, Stacey S O'Neill,

Promyelocytic blast crisis arising from chronic myeloid leukemia (CML) is rare. We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the <i>t</i>(15;17) and <i>t</i>(9;22) translocations in the leukemic cells. Preserved nucleic acids from routine <i>BCR-ABL1</i> testing provided a unique ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8830595]

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Rivaroxaban Treatment for Heparin-Induced Thrombocytopenia: A Case Report and a Review of the Current Experience.

Mohamed Aon, Omar Al-Shammari,

Heparin-induced thrombocytopenia is a life-threatening complication of exposure to heparin. Heparin-induced thrombocytopenia results from an autoantibody directed against platelet factor 4 in complex with heparin. Heparin-induced thrombocytopenia is traditionally treated with bivalirudin, argatroban, danaparoid, or fondaparinux. Recently, direct oral anticoagulants administration to treat heparin-induced thrombocytopenia has been reported. Direct oral ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8885256]

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Corrigendum to "An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase".

S Kartthik, Prakas K Mandal, Souren Pal, Saleh Mohammed Abdullah,

[This corrects the article DOI: 10.1155/2019/5674193.]. ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:2194247]

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