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Journal Case Rep Hematol

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Fatal Retroperitoneal Hematoma in a Patient Receiving Enoxaparin for Bilateral Pulmonary Emboli.

Jordan Sexe, Robin McCarthy, Navid Dara, Lyon Brown, Gaurav Dutta,

Venous thromboembolism occurs when a deep vein thrombosis travels to the lungs and forms a pulmonary embolism. Low-molecular-weight heparins are a mainstay in the treatment and prevention of venous thromboembolism and should be initiated promptly due to substantial morbidity and mortality. A rare side effect of low-molecular-weight heparins is major ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4805967]

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Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia.

G F Cittolin-Santos, S Khalil, J K Bakos, K Baker,

A 28-year-old Caucasian male with Hashimoto's disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8697493]

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Hereditary Hyperferritinemia-Cataract Syndrome in 3 Generations of a Family in East Tennessee.

Heidi A Worth, Zachary Marlette, David Aljadir, Ronald Lands,

Hereditary hyperferritinemia and cataracts syndrome (HHCS) without iron overload is a syndrome first identified less than 3 decades ago. While investigators have dissected the gene where several responsible mutations reside, it remains a relatively unknown genetic disorder to clinicians. The result is often an expensive, invasive evaluation for iron overload, ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:2837573]

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CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor.

Kazuaki Teshima, Masaaki Kume, Yasushi Kawaharada, Takashi Saito, Ko Abe, Sho Ikeda, Hideaki Ohyagi, Megumi Zuguchi, Masashi Zuguchi, Yosuke Kubota, Yoshitaka Enomoto, Masahito Miura, Satsuki Takahashi, Masahiro Saito, Ken Saito, Naoto Takahashi,

We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:1514729]

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Two Consecutive Episodes of Severe Delayed Hemolytic Transfusion Reaction in a Sickle Cell Disease Patient.

Clarisse Mpinganzima, Alf Haaland, Anne Guro Vreim Holm, Swee Lay Thein, Geir Erland Tjønnfjord, Per Ole Iversen,

Patients with sickle cell disease (SCD) suffer from anemia and painful vaso-occlusive crisis (VOC) and sometimes need blood transfusions. Delayed hemolytic transfusion reaction (DHTR) is a rare life-threatening complication observed in SCD and mimics VOC. We describe a female SCD patient undergoing three surgical procedures during which DHTR developed following ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:2765012]

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Reactivation of Epstein-Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment.

Anthony J Febres-Aldana, Christopher A Febres-Aldana, Kathrin Dvir, Gliceida Galarza-Fortuna, Michael Schwartz, Ana M Medina, Vathany Sriganeshan,

Epstein-Barr virus infection is most commonly asymptomatic in the acute setting, where the end result of infection is the adoption of a viral latency phenotype. The virus can reactivate later in life leading to the abnormal proliferation of the infected B, T, or NK cells. Hereby, we report a 71-year-old ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3641813]

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Spontaneous Spinal Epidural Hematoma in a Patient on Apixaban for Nonvalvular Atrial Fibrillation.

Ahmad El Alayli, Logeswari Neelakandan, Hicham Krayem,

Background:With the rise in the use of direct oral anticoagulants (DOACs), more hemorrhagic complications are being encountered. Since the first description of a case of spontaneous spinal epidural hematoma (SSEH) related to the utilization of DOACs in 2012, there have been few reports describing a similar association. However, no cases ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:7419050]

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Primary Bone Lymphoma: A Case Series and Review of Literature.

Poorva Bindal, Aakash Desai, Lukas Delasos, Sudhanshu Mulay, James Vredenburgh,

Primary bone lymphoma (PBL) is a subtype of lymphoma that exclusively affects skeletal tissue. Despite the relatively common involvement of skeletal structures as a manifestation of non-Hodgkin's lymphoma (NHL), primary and exclusive involvement of the skeletal system is rare. The prevalence of PBL is estimated to be 3-7% amongst primary ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4254803]

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Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report.

H G C S Karunathilaka, D P Chandrasiri, P Ranasinghe, V Ratnamalala, A H N Fernando,

Drug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of DIIHA due to co-amoxiclav. A 53-year-old male being treated for left-sided pyelonephritis with intravenous co-amoxiclav developed symptoms and signs of anaemia on the third day of treatment. He was found to have evidence of haemolysis with ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:9841097]

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Orbital Mucosa-Associated Lymphoid Tissue Lymphoma and Primary Cutaneous Classical Hodgkin Lymphoma: A Rare Case Report and Review of the Literature.

Nicole Yun, James Coggan, Ira Miller, Parameswaran Venugopal,

A 60-year-old woman was diagnosed with isolated mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa and treated with two years of weekly rituximab for eight doses followed by rituximab maintenance. After nearly two years of maintenance therapy, she developed a tender, indurated mass on the left neck. Biopsy results ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:1945058]

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A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab.

Ikuo Inoue, Yasuhiro Takenaka, Yoshitora Kin, Satoshi Yamazaki, Yuichi Ikegami, Daigo Saito, Akira Shimada,

A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3281626]

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Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn's Disease: Case Vignette and Systematic Literature Review.

Raisa Epistola, Tiffanie Do, Ritika Vankina, Daniel Wu, James Yeh, Michael W Fleischman, Jennifer M Lee,

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn's disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4785759]

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Ibrutinib-Associated Cardiac Tamponade with Concurrent Antiplatelet Therapy.

Jennifer L Miatech, John H Hughes, Dillon K McCarty, M Patrick Stagg,

Ibrutinib is approved for the first-line treatment of chronic lymphocytic leukemia (CLL). A well-known side effect of ibrutinib therapy is increased bleeding risk, which ranges from mild mucocutaneous bleeding to rarely life-threatening hemorrhage. The increased bleeding tendency associated with ibrutinib is thought to be related to its effect on several ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4282486]

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Non-Nodal CD5-Negative Mantle Cell Lymphoma with Secondary TP53 Deletion.

Robert K McCall, Changlee S Pang, Mark J Pettenati,

Mantle cell lymphoma is a non-Hodgkin lymphoproliferative neoplasm with several clinical and morphologic variants linked, primarily, through genetic derangement of the cyclin D1 locus. Aberrant phenotypes have been described, though prognostic data in such cohorts are limited due to a paucity of cases. We report a case of mantle cell ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:9185432]

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Patient-Initiated Discontinuation of Tyrosine Kinase Inhibitor for Chronic Myeloid Leukemia.

Stephen E Langabeer, Rehman Faryal, Michael O'Dwyer, Sorcha Ní Loingsigh,

The introduction of tyrosine kinase inhibitors (TKI) has revolutionised the management of patients with chronic myeloid leukemia (CML) over the last twenty years, but despite significant improvements in survival, patients exhibit long-term side effects that impact on quality of life. A major advance in CML management has been the ability ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:9571691]

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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman.

Claire Cochet, Marion Simonet, Julie Cattin, Jean-Patrick Metz, Ana Berceanu, Eric Deconinck, Etienne Daguindau, Françoise Schillinger, Pierre Fenaux, Nicolas Mottet, Yohan Desbrosses,

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3686584]

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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax.

Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova,

Myelodysplastic syndromes are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow. They are a group of heterogeneous clonal stem cell malignancies with a high risk to progress to acute myeloid leukemia. Currently, there are no curative FDA-approved medications for myelodysplastic syndromes. Hematopoietic cell transplantation is ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:9031067]

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Surgery in a Patient with Haemophilia A and Lymphoma.

M S Cruz, J Santillan, J Lesser, J Ortiz, L Forzani, P Plaza,

An increased incidence of haematologic malignancies and other cancer types among patients with haemophilia compared with matched controls has been reported in several longitudinal studies. Tumours initially misdiagnosed as haematomas and conversely haematomas mistaken for tumours have been reported. Here, we describe the case of a 43-year-old man with severe ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4852428]

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Atypical Hemolytic Uremic Syndrome following Acute Type A Aortic Dissection.

Eigo Ikushima, Manabu Hisahara, Takuya Nishijima, Hikaru Uchiyama, Tatsushi Onzuka, Yoshie Ochiai, Tsuyoshi Muta, Shigehiko Tokunaga,

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)-related disease that manifests as a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) and is caused by uncontrolled activation of the complement system. We report the case of a 61-year-old woman with acute type A aortic dissection ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:2467953]

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Addressing the Challenges to Diagnose Neonatal Hemolytic Anemia's Aetiologies in Low Ressources Countries: A Case Report.

Lydie Ocini Ngolet, Josue Simo Louokdom, Nelly Guembo, Ocko Ngokaba Thibault,

Background. The diagnosis of neonatal hemolysis is an easy exercise. However, the diagnosis of its etiology can be very challenging especially in low ressources countries where laboratory capacities are limited. We report the case of hemolytic anemia episodes that started in the neonatal period, for which the trigger factor, infectious ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3247127]

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A Curious Case of Pseudothrombocytopenia due to In Vitro Agglutination.

Le Zhong, Juskaran Chadha, Ali Ameri,

Pseudothrombocytopenia (PTCP) is a laboratory phenomenon that can occur in hospitalized patients, with approximately 0.1 to 0.2% due to ethylenediaminetetraacetic acid (ETDA). The EDTA-dependent mechanism of PTCP occurs due to a conformational change of platelet surface glycoprotein IIb/IIIa (GPIIb/IIIa) caused by EDTA, which allows natural IgM or IgG auto-antibodies to ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:6236350]

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Use of KRD-PACE as Salvage Therapy in Aggressive, Relapsed/Bortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review.

Ricardo D Parrondo, Vivek Roy, Taimur Sher, Victoria Alegria, Asher A Chanan-Khan, Sikander Ailawadhi,

Extramedullary multiple myeloma is defined by the presence of plasma cell infiltration outside of the bone marrow. It is associated with a poor prognosis and resistance to therapy and is often associated with high-risk cytogenetics. Aggressive relapsed and refractory extramedullary multiple myeloma is often treated with salvage infusional chemotherapy to ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:4360926]

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Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis.

Vaibhav Agrawal, Bryan J Brinda, Sherif S Farag,

Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:8124137]

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Multiple Myeloma in a Young Female Presenting with Neurological Symptoms.

Matthew Lee, Xinmin Zhang, Vinh Nguyen, Monique Hartley-Brown,

Background:Multiple myeloma is overall the 14th most common malignancy but is rarely seen in those younger than 35 years. Those in the younger age group have been shown to have a more aggressive course but reportedly have had similar responses to treatment compared to older cohorts. Extramedullary plasmacytomas are discrete ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:1375174]

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A Case Report with Severe Thrombocytopenia Induced by Axitinib.

Ulkuhan I Koksal, Janeiro Goffin, Brian Lewis, Oliver A Sartor, Elizaveta Belyaeva, Francisco Socola, Pedro C Barata,

Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is associated with a safety profile very similar to other ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:7520783]

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