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Journal Cardiovasc Pathol

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Rac1 mediates Cadherin-11 induced cellular pathogenic processes in aortic valve calcification.

Kiran A Vaidya, Matthew P Donnelly, Ablajan Mahmut, Jae Woong Jang, Terence W Gee, Marine-Ayan Ibrahim Aibo, Robert Bossong, Clare Hall, Sanjay Samb, Jonathan Chen, Jonathan T Butcher,

<h4>Background</h4>-Calcific aortic valve disease (CAVD), a major cause for surgical aortic valve replacement, currently lacks available pharmacological treatments. Cadherin-11 (Cad11), a promising therapeutic target, promotes aortic valve calcification in vivo, but direct Cad11 inhibition in clinical trials has been unsuccessful. Targeting of downstream Cad11 effectors instead may be clinically useful; ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, :107414]

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Hypertrophic cardiomyopathy with a complex clinical course leading to heart transplantatioN.

Uttam Savariya, Maria M Patarroyo Aponte, Sriram Nathan, Bihong Zhao, Rajko Radovancevic, Ismael A Salas de Armas, Biswajit Kar, Igor D Gregoric, L Maximilian Buja,

The purpose of this report is to present clinicopathological features of two cases of hypertrophic cardiomyopathy (HCM) that underwent orthotopic heart transplantation (OHT) because of an unusually complex clinical course. One case is that of a 37-year-old man with HCM who underwent OHT because of a combination of recurrent severe ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 58:107406]

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Perfusion-distention fixation of heart specimens: a key step in immortalizing heart specimens for wax infiltration and generating 3D imaging data sets for reconstruction and printed 3D models.

Takato Yamasaki, Shuhei Toba, Stephen P Sanders, Chrystalle Katte Carreon,

Perfusion-distention fixation by gravity is a fundamental cardiac predissection technique that may be used to preserve the 3D anatomy of a cardiac specimen. The equipment and steps are illustrated, and examples of cardiac specimens preserved in various methods including wet specimens, wax-infiltrated hearts, and 3D-printed models, created after performing this ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 58:107404]

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Remodeling of abdominal aortic aneurysm sac following endovascular aortic repair: association with clinical, surgical, and genetic factors.

Mario D'Oria, Filippo Giorgio Di Girolamo, Cristiano Calvagna, Filippo Gorgatti, Nicola Altamura, Sandro Lepidi, Gianni Biolo, Nicola Fiotti,

After successful endovascular aortic repair (EVAR), abdominal aortic aneurysms (AAA) sac will undergo negative remodeling (i.e., shrinkage) as a measure of successful exclusion. Determinants of shrinkage after EVAR are not fully known. In 84 post-EVAR patients, time course of AAA diameter after repair and occurrence of endoleaks (ELs) have been ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 58:107405]

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A case report of Nocardia asiatica constrictive pericarditis in a patient with Human Immunodeficiency Virus.

Rosemary Griessel, Barend Mitton, Roxanne Rule, Mohamed Said,

Nocardiosis commonly affects the respiratory system and is a rare cause of purulent pericarditis. Invasive nocardial infections occur more frequently in patients with immunosuppression. A misdiagnosis as tuberculosis infection is not uncommon, especially in the context of immunosuppression in high burden tuberculosis settings. The risk factors and clinical features of ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 58:107403]

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Pericardial lymphangioma: a rare benign albeit variably symptomatic tumefactive lesion.

Simona Pichler Sekulic, David M Kalfa, Edward Fenlon, Amee Shah, Jared LaCorte, Miroslav Sekulic,

Primary pericardial-based tumefactive lesions include pericardial cysts, mature teratomas, and lymphangiomas, and while benign they may result in clinical symptomatology that leads to their radiologic detection. We present the case of a 5-year-old boy with a heart murmur who was otherwise healthy and without significant medical history. Transthoracic echocardiogram, computed ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 57:107402]

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A case with two faces: noncompaction or phospholamban cardiomyopathy?

Sip Wijchers, Jan H von der Thüsen, Jan Lukas Robertus, Kadir Caliskan,

Noncompaction cardiomyopathy is a well-known clinical entity, whereas phospholamban gene mutation is a relatively recently known mutation with phenotypes as arrhythmogenic cardiomyopathy and dilated cardiomyopathy. We report the case of a 15-year-old girl that presents with rapid progressive heart failure based on a noncompaction cardiomyopathy as confirmed through cardiovascular imaging. ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 57:107395]

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Unexpected case of chagas disease reactivation in endomyocardial biopsy for evaluation of cardiac allograft rejection.

Madeleine M Hamilton, Michael Sciaudone, Patricia P Chang, Natalie M Bowman, Tessa M Andermann, Luther A Bartelt, Sudha P Jaganathan, Lisa J Rose-Jones, Megan E Andrews, Bart Singer,

Acute Chagas disease reactivation (CDR) after cardiac transplantation is a well-known phenomenon in endemic countries of Central and South America and Mexico, but is rare outside of those countries. In this report, we describe a case of a 49-year-old male who presented 25 weeks after heart transplant with clinical features ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 57:107394]

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An untapped resource: characteristics of thrombus recovered from intermediate or high risk pulmonary embolus patients.

Geoffrey Newcomb, Bennett L Wilson, R James White, Bruce Goldman, Neil A Lachant, Daniel J Lachant,

<h4>Introduction</h4>Response to anticoagulation varies during management of acute hospitalized pulmonary embolism. We aimed to study thrombus histology in pulmonary embolism samples removed during acute surgical embolectomy to evaluate whether thrombus morphology was similar between patients and whether there was an association with duration of symptoms and/or resolution on follow up ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 57:107392]

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The spectrum of macrophage-predominant inflammatory myocardial disease presenting as fulminant heart failure.

Bruce I Goldman, Hae-Yoon Choung, Michele Sainvil, Christa-Whitney Miller,

<h4>Background</h4>Endomyocardial biopsy results are integral for diagnosis and management of myocarditis. Current diagnostic classifications of myocarditis are based on the microscopic and immunochemical characterization of inflammation do not include monocyte/macrophage-predominant (i.e. "histiocytic") myocarditis as a histologic subtype.<h4>Methods</h4>Endomyocardial biopsies from 6 patients with sudden heart failure were reviewed by 3 cardiac ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 57:107393]

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Cardiac sarcoidosis diagnosed after orthotopic heart transplantation and clinically mimicking arrhythmogenic right ventricular cardiomyopathy.

Madiha Makhdumi, Manish D Assar, Dan M Meyer, William C Roberts,

Described herein is a 71-year-old man who underwent orthotopic heart transplant (OHT) for chronic severe heart failure secondary to cardiac sarcoidosis (CS) devoid of non-caseating granulomas but nevertheless characteristic of CS. Clinically, his heart disease had suggested the presence of arrhythmogenic right ventricular cardiomyopathy. ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107390]

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Myocardial fibrosis: morphologic patterns and role of imaging in diagnosis and prognostication.

Carla Giordano, Marco Francone, Giulia Cundari, Annalinda Pisano, Giulia d'Amati,

Myocardial fibrosis is defined as an increased amount of collagen in the myocardium relative to cardiac myocytes. Two main morphologic patterns are recognized: 1) replacement fibrosis, which occurs in response to myocyte necrosis (myocardial scarring); and 2) interstitial fibrosis, which is usually a diffuse process and has been shown to ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107391]

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Autopsy findings of left atrial appendage closure device.

Masaaki Nakase, Masahiko Asami, Kazuyuki Yahagi, Yu Sato, Atsuhito Nakayama, Kai Ninomiya, Tetsu Tanaka, Yu Horiuchi, Hitomi Yuzawa, Kota Komiyama, Jun Tanaka, Jiro Aoki, Renu Virmani, Masaya Mori, Kengo Tanabe,

We report an autopsy case of an 80-year-old woman who underwent left atrial appendage closure with a WATCHMAN (Boston Scientific, St. Paul, MN, USA) device. This is the first report of histologic assessment following left atrial appendage closure with a WATCHMAN device at 3 months. Gross and histopathological examinations revealed ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107384]

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Morphology of the papillary muscles and the chordae tendineae of the ventricles of adult human hearts.

Mamatha Hosapatna, Anne DSouza, Vrinda Hari Ankolekar,

<h4>Introduction</h4>The papillary muscles (PM) play a vital role in atrioventricular (AV) valve function. The PM and their chordae tendineae (CT) regulate the closure of the AV valve during systole. The present study was undertaken to categorize the PM based on their shapes and variant patterns and CT based on their ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107383]

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Post-treatment bacterial endocarditis mimicking fungal organisms: a morphologic comparison and tips for avoiding this diagnostic pitfall.

David A Pacheco, Omar A Saldarriaga, Morgan Killian, Jennifer A Perone, Beilin Wang, Ping Ren, Abe DeAnda, Gal Levy, Vicki J Schnadig, Heather L Stevenson,

<h4>Background</h4>Histopathologic differentiation of bacterial endocarditis from yeast-like fungal endocarditis is usually straightforward; however, an underappreciated phenomenon is the effect of antimicrobial therapy on bacterial size, shape and septa (cross-wall) formation resulting in bacterial forms that mimic yeast-like fungi. In this article we illustrate the alterations that occur in antibiotic-treated Staphylococcus ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107382]

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Cardiac fibroma: A clinicopathologic study of a series of 12 cases.

Fei Teng, Shaomin Yang, Dong Chen, Wei Fang, Jianfeng Shang, Songbo Dong, Yayan Cui, Wen Fu, Menghan Zheng, Yanwei Li, Guoliang Lian,

<h4>Background</h4>Cardiac fibroma (CF) is a rare tumor that has not been widely reported. This study investigated the clinical findings, histologic features, and differential diagnosis of CF.<h4>Methods</h4>A total of 12 CF cases were studied and reviewed using hematoxylin and eosin (H&E), special staining and immunohistochemical staining. The ALK gene was tested ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2022, 56:107381]

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Clinically occult amyloidosis derived from leukocyte chemotactic factor 2 (ALECT 2) with cardiac involvement complicating renal transplantation: case report and literature review.

Olanrewaju Eletta, Mahmoud Ali, Anthony Grieff, Sonika Puri, Kant Matsuda, Advaith Bongu, Billie Fyfe,

<h4>Introduction</h4>Amyloidosis derived from leukocyte chemotactic factor 2 (ALECT2) may be associated with slowly progressive renal failure that is clinically unsuspected at the time of transplantation. While this is typically clinically insignificant, we report a case with extensive systemic ALECT2 amyloidosis that also involved the myocardium, contributing to perioperative death post ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 55:107375]

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The prognostic value of cardiac troponin for 60 day mortality and major adverse events in COVID-19 patients.

Max Ruge, Joanne Michelle D Gomez, Jeanne du Fay de Lavallaz, Alexander Hlepas, Annas Rahman, Priya Patel, Prutha Lavani, Gatha G Nair, Nusrat Jahan, J Alan Simmons, Anupama K Rao, Kim A Williams, Annabelle Santos Volgman, Karolina Marinescu, Tisha Suboc,

<h4>Background</h4>The variability of coronavirus disease 2019 (COVID-19) illness severity has puzzled clinicians and has sparked efforts to better predict who would benefit from rapid intervention. One promising biomarker for in-hospital morbidity and mortality is cardiac troponin (cTn).<h4>Methods</h4>A retrospective study of 1331 adult patients with COVID-19 admitted to the Rush University ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 55:107374]

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Light chain deposition disease presenting as an atrial mass: a case report and review of literature.

Madeline Hudak, Ruhani Sardana, Anil V Parwani, Roger C Mathewson, Christopher G Gibson, P Aryeh Cohen, John J Lazarus, Jarrod T Bruce, Jae H Son, Zofia Tynski,

Light chain deposition disease (LCDD) also known as nonamyloidotic immunoglobulin deposition disease is a rare systemic disorder due to the abnormal deposition of immunoglobulin in multiple organs caused by the clonal proliferation of B lymphocytes and plasma cells. Renal involvement is the most common with cardiac manifestations being the most ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 55:107368]

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Right atrial papillary fibroelastoma arising from the Chiari network detected by echocardiography: a case report and literature review.

Nana Hu, Wenqian Shen, Hairu Li, Qinghua Zhang, Guohua Cai, Yanmei Zhang, Guoqing Du,

<h4>Purpose</h4>To improve our understanding of cardiac papillary fibroelastomaand provide evidence for its treatment and prognosis.<h4>Materials and methods</h4>We report a 54-year-old Chinese male who was hospitalized for a 14-day headache with a previous vertebral aneurysm history. A right atrial mass arising from the Chiari network was detected by echocardiography and complete ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 55:107372]

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The pathology of early failure in Mitroflow pericardial valve bioprosthesis (12A/LX).

Mila Della Barbera, Marialuisa Valente, Cristina Basso, Elena Pettenazzo, Gaetano Thiene,

<h4>Background</h4>Limited mid-term durability of 12A/LX Mitroflow bioprosthesis has been reported. Aim of the study was to ascertain the pathologic substrates and possible mechanisms of structural valve deterioration in explants from animals and humans.<h4>Methods</h4>Nine aortic 12A/LX Mitroflow bioprostheses preserved in hypotonic solution and three aortic 12A/LX bioprostheses, preserved in isotonic solution, ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 55:107373]

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Sengers syndrome: a rare case of cardiomyopathy combined with congenital cataracts in an infant: post-mortem case report.

Nora Fawzy Fnon, Hanan Hosney Hassan, Hazem Mahmoud Ali, Zahraa Khalifa Sobh,

Sengers syndrome is a rare autosomal recessive disorder caused by a mutation in the Acylglycerol Kinase (AGK) gene with subsequent mitochondrial dysfunction. It is a combination of cardiomyopathy, skeletal myopathy, congenital bilateral cataracts, and lactic acidosis following exertion. The current study describes an extremely rare case of Sengers syndrome that ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 54:107371]

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Cardiovascular pathologists in translation research.

Avrum I Gotlieb,

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 54:107369]

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Cardiac pathology in COVID-19: a single center autopsy experience.

Charlie J Sang, Alison Burkett, Brittain Heindl, Silvio H Litovsky, Sumanth D Prabhu, Paul V Benson, Indranee Rajapreyar,

<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is commonly associated with myocardial injury and heart failure. The pathophysiology behind this phenomenon remains unclear, with many diverse and multifaceted hypotheses. To contribute to this understanding, we describe the underlying cardiac findings in fifty patients who died with coronavirus disease 2019 (COVID-19).<h4>Methods</h4>Included ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 54:107370]

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Electrocardiographic changes are strongly correlated with the extent of cardiac inflammation in mice with Coxsackievirus B3-induced viral myocarditis.

Linghe Wu, Linde Woudstra, Tariq A Dam, Tjeerd Germans, Albert C van Rossum, Hans W M Niessen, Paul A J Krijnen,

<h4>Objective</h4>Viral myocarditis (VM) can induce changes in myocardial electrical conduction and arrhythmia. However, their relationship with myocarditis-associated arrhythmic substrates in the heart such as inflammation and fibrosis is relatively unknown. This we have analyzed in the present study.<h4>Methods</h4>C3H mice were infected with 1×10<sup>5</sup> plaque-forming units Coxsackievirus B3 (CVB3, n=68) and ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 54:107367]

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