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Journal Card Electrophysiol Clin

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Preface: Arrhythmic and Vascular Complications of Coronavirus Disease 2019

Domenico G. Della Rocca, Giovanni B. Forleo, Andrea Natale,

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Preface.

Eric N Prystowsky, Benzy J Padanilam,

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):xv-xvi]

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Systemic Diseases and Heart Block.

Syed Rafay A Sabzwari, Wendy S Tzou,

Systemic diseases can cause heart block owing to the involvement of the myocardium and thereby the conduction system. Younger patients (<60) with heart block should be evaluated for an underlying systemic disease. These disorders are classified into infiltrative, rheumatologic, endocrine, and hereditary neuromuscular degenerative diseases. Cardiac amyloidosis owing to amyloid fibrils ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):721-740]

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Left Bundle Branch Block: Characterization, Definitions, and Recent Insights into Conduction System Physiology.

Margarida Pujol-López, José M Tolosana, Gaurav A Upadhyay, Lluís Mont, Roderick Tung,

Left bundle branch block (LBBB) is not just a simple electrocardiogram alteration. The intricacies of this general terminology go beyond simple conduction block. This review puts together current knowledge on the historical concept of LBBB, clinical significance, and recent insights into the pathophysiology of human LBBB. LBBB is an entity ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):671-684]

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Congenital Heart Block.

Leonard Steinberg,

Congenital complete heart block (CCHB) defines atrioventricular conduction abnormalities diagnosed in utero or within the first 27 days of life. Maternal autoimmune disease and congenital heart defects are most commonly responsible. Recent genetic discoveries have highlighted our understanding of the underlying mechanism. Hydroxychloroquine shows promise in preventing autoimmune CCHB. Patients ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):691-702]

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Cardiac Conduction System Disorders.

Ranjan K Thakur, Andrea Natale,

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):xiii]

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Anatomy and Pathology of the Cardiac Conduction System.

Roshan Karki, Anvi Raina, Fatima M Ezzeddine, Melanie C Bois, Samuel J Asirvatham,

The cardiac conduction system is formed of histologically and electrophysiologically distinct specialized tissues uniquely located in the human heart. Understanding the anatomy and pathology of the cardiac conduction system is imperative to an interventional electrophysiologist to perform safe ablation and device therapy for the management of cardiac arrhythmias and heart ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):569-584]

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Prevalence and Clinical Implications of COVID-19 Myocarditis

Cristina Chimenti, Michele Magnocavallo, Federico Ballatore, Federico Bernardini, Maria Alfarano, Domenico Giovanni Della Rocca, Paolo Severino, Carlo Lavalle, Fedele Francesco, Andrea Frustaci,

Synopsis The clinical manifestations of COVID-19 are widely variable and may involve several districts. Although the clinical course is mostly characterized by respiratory involvement, up to 30% of hospitalized patients have evidence of myocardial injury due to acute coronary syndrome, cardiac arrhythmias, myocarditis, and cardiogenic shock. In particular, myocarditis is ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Electrophysiology and Interventional Cardiology Procedure Volumes During the COVID-19 Pandemic

Naga Venkata K. Pothineni, Pasquale Santangeli,

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Echocardiography in COVID-19 pandemic: clinical findings and the importance of emerging technology

Alberto Barosi, Luca Bergamaschi, Ignazio Cusmano, Alessio Gasperetti, Marco Schiavone, Elisa Gherbesi,

SYNOPSIS Coronavirus disease 2019 (COVID-19) could have a direct or indirect effect on the cardiovascular system. To detect cardiac involvement, trans-thoracic echocardiography (TTE), as a widely available and cost-effective tool, is highly recommended and can provide important information that can affect the clinical management of COVID-19 patients. Despite that, considering ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Role of Digital Health During COVID-19 Pandemic and Future Perspectives

Adnan Ahmed, Rishi Charate, Naga Venkata K. Pothineni, Surya Kiran Aedma, Rakesh Gopinathannair, Dhanunjaya Lakkireddy,

Abstract: The Coronavirus disease (COVID-19) revolutionized the digital health care. This pandemic was the catalyst for not only a sudden but also widespread paradigm shift in patient care, with nearly 80% of the U.S. population indicating they have used one form of digital health. Cardiac electrophysiology took the initiative to ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Clinical Features and Management of COVID-19 Associated Hypercoagulability

Gianluca Massaro, Dalgisio Lecis, Eugenio Martuscelli, Gaetano Chiricolo, Giuseppe Massimo Sangiorgi,

Synopsis Covid-19 is an acute respiratory disease of viral origin caused by Sars-Cov2. This disease is associated with a hypercoagulable state resulting in arterial and venous thrombotic events. The latter are more frequent, especially in patients who develop a severe form of the disease and are associated with an increased ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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COVID-19, Acute Myocardial Injury and Infarction

Armando Del Prete, Francesca Conway, Domenico Giovanni Della Rocca, Giuseppe Biondi-Zoccai, Francesco De Felice, Carmine Musto, Marco Picichè, Eugenio Martuscelli, Andrea Natale, Francesco Versaci,

Synopsis SARS-CoV-2 can affect the cardiovascular system yielding a wide range of complications, including acute myocardial injury. The myocardium can be damaged by direct viral invasion or indirect mechanisms, sustained by systemic inflammation, immune-mediated response and dysregulation of the renin-angiotensin system. Myocardial injury affects about one-quarter of patients with COVID-19, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Imaging Findings of COVID-19-Related Cardiovascular Complications

Eleni Nakou, Estefania De Garate, Kate Liang, Matthew Williams, Dudley J. Pennell, Chiara Bucciarelli-Ducci,

Other than respiratory disease, patients with coronavirus disease 2019 (COVID-19) commonly have cardiovascular manifestations, which are recognised as significant risk factors for increased mortality. COVID-19 patients may present with a wide spectrum of clinical presentations ranging from asymptomatic heart disease detected incidentally by cardiac investigations (troponin, BNP, imaging) to cardiogenic ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Arrhythmogenic Risk and Mechanisms of QT Prolonging Drugs to Treat COVID-19

Marco Schiavone, Alessio Gasperetti, Elisa Gherbesi, Luca Bergamaschi, Roberto Arosio, Gianfranco Mitacchione, Maurizio Viecca, Giovanni B. Forleo,

While looking for a “magic bullet” to treat COVID-19, the massive off-label use of several of drugs in COVID-19, including repurposed antimalarial drugs, immunosuppressive agents, anti-virals and antibacterial agents, have generated concerns in the early phase of the pandemic due a possible arrhythmogenic effects in relation to QTc interval prolongation. ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Prevalence, Outcomes, and Management of Ventricular Arrhythmias in COVID-19 Patients

Nicola Tarantino, Domenico G. Della Rocca, Fengwei Zou, Aung Lin, Andrea Natale, Luigi Di Biase,

Synopsis We review the current data on epidemiology, the clinical significance, the pathophysiologic mechanisms, and the treatment of VAs in the setting of COVID-19. VAs prevail in 0.15-8% of in hospitalized patients, but only sustained and rapid tachyarrhythmias are purportedly associated with a significant increase in mortality. Multiple factors can ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Iatrogenic Atrioventricular Block.

Christopher C Cheung, Shumpei Mori, Edward P Gerstenfeld,

Iatrogenic atrioventricular (AV) block can occur in the context of cardiac surgery, percutaneous transcatheter, or electrophysiologic procedures. In cardiac surgery, patients undergoing aortic and/or mitral valve surgery are at the highest risk for developing perioperative AV block requiring permanent pacemaker implantation. Similarly, patients undergoing transcatheter aortic valve replacement are also ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):711-720]

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Pacing of Specialized Conduction System.

Santosh K Padala, Kenneth A Ellenbogen,

Right ventricular pacing for bradycardia remains the mainstay of pacing therapy. Chronic right ventricular pacing may lead to pacing-induced cardiomyopathy. We focus on the anatomy of the conduction system and the clinical feasibility of pacing the His bundle and/or left bundle conduction system. We review the hemodynamics of conduction system ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):755-784]

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Epidemiology and Outcomes Associated with PR Prolongation.

Larry R Jackson, Francis Ugowe,

PR prolongation is defined primarily as delayed conduction through the AV node, but can also signify delayed electrical impulse propagation through any part of the conduction system. The prevalence of PR prolongation ranges from 1% to 5% in patients younger than 50 years, with increasing prevalence, after the sixth decade ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):661-669]

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Atrioventricular Conduction: Physiology and Autonomic Influences.

Eric N Prystowsky, Jasen L Gilge,

Atrioventricular (AV) nodal conduction is decremental and very prone to alterations in autonomic tone. Conduction through the His-Purkinje system (HPS) is via fast channel tissue and typically not that dependent on autonomic perturbations. Applying these principles, when the sinus rate is stable and then heart block suddenly occurs preceded by ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):585-598]

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Physiologic Variants of Cardiac Conduction (Aberration, Gap, Supernormal Conduction).

William M Miles, Philip George,

Wide QRS complexes during supraventricular rhythms can be caused by fixed bundle branch block, functional (intermittent) bundle branch block, preexcitation, or toxic/metabolic causes. Functional bundle branch block can be caused by long-short aberrancy (usually physiologic), or acceleration/deceleration dependent aberrancy (usually pathologic). Electrocardiogram criteria have been proposed to differentiate aberration from ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):607-624]

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Electrocardiography of Atrioventricular Block.

Bradley A Clark, Eric N Prystowsky,

Delayed atrioventricular (AV) conduction most commonly occurs in the AV node, resulting from AH prolongation on an intracardiac electrocardiogram and PR prolongation on a surface electrocardiogram. AV conduction may be blocked in a 2:1 manner, with a normal PR interval and wide QRS suggesting infranodal disease, whereas a prolonged PR ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):599-605]

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Pacing-Induced Cardiomyopathy.

Shaan Khurshid, David S Frankel,

Right ventricular (RV) pacing-induced cardiomyopathy (PICM) is typically defined as left ventricular systolic dysfunction resulting from electrical and mechanical dyssynchrony caused by RV pacing. RV PICM is common, occurring in 10-20% of individuals exposed to frequent RV pacing. Multiple risk factors for PICM have been identified, including male sex, wider ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):741-753]

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Bilateral Bundle Branch Block.

Jasen L Gilge, Benzy J Padanilam,

Left bundle branch block (LBBB) and right bundle branch block (RBBB) are classic manifestations of bundle branch conduction disorders. However, a third form that is uncommon and underrecognized may exist that has features and pathophysiology of both: bilateral bundle branch block (BBBB). This unusual form of bundle branch block exhibits ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):685-689]

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