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Journal Cancer

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American Indian and Alaska Native populations face a higher risk of many types of cancer.

Carrie Printz,

Cancer (Cancer)
[2020, 126(5):921]

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First person profile: Dennis J. Slamon, MD, PhD: Dr. Slamon's pioneering work helped lead to the breakthrough breast cancer drug trastuzumab, which has saved and extended the lives of millions of patients.

Carrie Printz,

Cancer (Cancer)
[2020, 126(5):919-920]

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Hematopoietic stem cell transplantation for blood cancers in the era of precision medicine and immunotherapy.

Steven M Bair, Joshua D Brandstadter, Emily C Ayers, Edward A Stadtmauer,

Hematopoietic stem cell transplantation (HCT) has been an integral component in the treatment of many hematologic malignancies. Since the development of HCT nearly 50 years ago, the role of this modality has evolved as newer treatment approaches have been developed and integrated into the standard of care. In the last decade, ... Read more >>

Cancer (Cancer)
[2020, :]

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A randomized phase 2 network trial of tivantinib plus cetuximab versus cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma.

Sara E Kochanny, Francis P Worden, Douglas R Adkins, Dean W Lim, Julie E Bauman, Stephanie A Wagner, Ryan J Brisson, Theodore G Karrison, Walter M Stadler, Everett E Vokes, Tanguy Y Seiwert,

BACKGROUND:MET signaling is a well described mechanism of resistance to anti-EGFR therapy, and MET overexpression is common in head and neck squamous cell carcinomas (HNSCCs). In the current trial, the authors compared the oral MET inhibitor tivantinib (ARQ197) in combination with cetuximab (the TC arm) versus a control arm that ... Read more >>

Cancer (Cancer)
[2020, :]

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The 5-year relative survival of older patients with prostate cancer is insignificantly different from the 5-year survival of all men of a similar age.

Steven Lehrer, Peter H Rheinstein,

Cancer (Cancer)
[2020, :]

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Reply to Helping patients to understand terrifying news: Addressing the inner lives of physicians and extending beyond what we know.

Gavin Paul Campbell, Eli Rowe Abernethy, Rebecca D Pentz,

Cancer (Cancer)
[2020, :]

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Helping patients to understand terrifying news: Addressing the inner lives of physicians and extending beyond what we know.

Kah Poh Loh, Supriya G Mohile, Ronald M Epstein, Paul R Duberstein,

Cancer (Cancer)
[2020, :]

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Validation of a subclassification for high-risk prostate cancer in a prospective cohort.

Santino S Butler, Edward C Dee, Nayan Lamba, Sybil T Sha, Brandon A Mahal, Amanda Whitbeck, Rishi Makkar, Janet Wangoe, Kent W Mouw, Paul L Nguyen, Vinayak Muralidhar,

BACKGROUND:A subgroup of men with favorable high-risk prostate cancer (T1c with either a Gleason score of 4 + 4 = 8 and a prostate-specific antigen [PSA] level <10 ng/mL or a Gleason score of 6 and a PSA level >20 ng/mL) has been associated with improved outcomes in comparison with other standard high-risk patients. This study ... Read more >>

Cancer (Cancer)
[2020, :]

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How to focus our efforts in improving prognostic disclosure in oncology.

Hanny Al-Samkari, Arpan A Patel,

Cancer (Cancer)
[2020, :]

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Reply to The 5-year relative survival of older patients with prostate cancer is insignificantly different from the 5-year survival of all men of a similar age.

Minh-Phuong Huynh-Le, Tyler M Seibert,

Cancer (Cancer)
[2020, :]

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Outcomes of rituximab-BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation.

Deepa Jagadeesh, Navneet S Majhail, Yizeng He, Kwang W Ahn, Carlos Litovich, Sairah Ahmed, Mahmoud Aljurf, Ulrike Bacher, Sherif M Badawy, Nelli Bejanyan, Mitchell Cairo, Jan Cerny, Narendranath Epperla, Nosha Farhadfar, César O Freytes, Robert Peter Gale, Bradley Haverkos, Nasheed Hossain, David Inwards, Rammurti T Kamble, Vaishalee P Kenkre, Hillard M Lazarus, Aleksandr Lazaryan, Lazaros Lekakis, Matthew Mei, Hemant S Murthy, Alberto Mussetti, Sunita Nathan, Taiga Nishihori, Richard F Olsson, Praveen Ramakrishnan Geethakumari, Bipin N Savani, Jean A Yared, Timothy S Fenske, Mohamed A Kharfan-Dabaja, Anna Sureda, Mehdi Hamadani,

BACKGROUND:Although rituximab-based high-dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto-HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab-based conditioning on auto-HCT outcomes in patients who have DLBCL. METHODS:Using the Center for International Blood ... Read more >>

Cancer (Cancer)
[2020, :]

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State of palliative care services at US cancer centers: An updated national survey.

David Hui, Allison De La Rosa, Joseph Chen, Seyedeh Dibaj, Marvin Delgado Guay, Yvonne Heung, Diane Liu, Eduardo Bruera,

BACKGROUND:This study examined the changes in outpatient palliative care services at US cancer centers over the past decade. METHODS:Between April and August 2018, all National Cancer Institute (NCI)-designated cancer centers and a random sample of 1252 non-NCI-designated cancer centers were surveyed. Two surveys used previously in a 2009 national study ... Read more >>

Cancer (Cancer)
[2020, :]

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More evidence suggesting that 1-dose human papillomavirus vaccination may be effective.

Julia M L Brotherton, Karin Sundström,

Cancer (Cancer)
[2020, :]

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Comparison of the long-term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study.

Ana M Rodriguez, Burak Zeybek, Micah Vaughn, Jordan Westra, Sapna Kaul, Jane R Montealegre, Yu-Li Lin, Yong-Fang Kuo,

BACKGROUND:Human papillomavirus (HPV)-related disease remains a significant source of morbidity and mortality, and this underscores the need to increase HPV vaccination to reduce the burden of the disease. The objective of this study was to examine the association between the number of HPV vaccine doses and the risk of histologically ... Read more >>

Cancer (Cancer)
[2020, :]

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Extracapsular extension of neck nodes and absence of human papillomavirus 16-DNA are predictors of impaired survival in p16-positive oropharyngeal squamous cell carcinoma.

Josefine Freitag, Theresa Wald, Thomas Kuhnt, Tanja Gradistanac, Marlen Kolb, Andreas Dietz, Susanne Wiegand, Gunnar Wichmann,

BACKGROUND:Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinomas (OPSCCs) demonstrate superior outcome compared with HPV-negative OPSCCs. The eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor, lymph node, metastasis (TNM) classification (TNM 2017) modifies OPSCC staging based on p16 positivity as a surrogate for HPV-driven ... Read more >>

Cancer (Cancer)
[2020, :]

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Patients with adenoid cystic carcinomas of the salivary glands treated with lenvatinib: Activity and quality of life.

Laura D Locati, Donata Galbiati, Giuseppina Calareso, Salvatore Alfieri, Susanne Singer, Stefano Cavalieri, Cristiana Bergamini, Paolo Bossi, Ester Orlandi, Carlo Resteghini, Francesca Platini, Roberta Granata, Pasquale Quattrone, Moela Mancinelli, Luigi Mariani, Salvatore Lo Vullo, Lisa F Licitra,

BACKGROUND:The treatment of patients with recurrent and/or metastatic (R/M) salivary gland adenoid cystic carcinoma (ACC) remains an unmet need. METHODS:Patients with R/M disease with a history of clinical or symptomatic disease progression within 6 months and a maximum of 1 previous line of chemotherapy or a multiple kinase inhibitor received oral ... Read more >>

Cancer (Cancer)
[2020, :]

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National cancer screening program for gastric cancer in Korea: Nationwide treatment benefit and cost.

Yun-Suhk Suh, Joonki Lee, Hyeongtaek Woo, Dongwook Shin, Seong-Ho Kong, Hyuk-Joon Lee, Aesun Shin, Han-Kwang Yang,

BACKGROUND:The purpose of this study was to evaluate the nationwide benefit and cost of the national cancer screening program (NCSP) for gastric cancer treatment. METHODS:For this nationwide, population-based study, the Korean National Health Insurance Big Data Base, which included gastric cancer-related treatment information and the costs for all patients with ... Read more >>

Cancer (Cancer)
[2020, :]

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The golden rule: Do not do to others what you do not want done to yourself.

Takeshi F Takahashi,

Cancer (Cancer)
[2020, :]

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Reply to Obesity and aggressive prostate cancer and the golden rule: Do not do to others what you do not want done to yourself.

Shreyas S Joshi, Christopher P Filson,

Cancer (Cancer)
[2020, :]

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Pain in older survivors of hematologic malignancies after blood or marrow transplantation: A BMTSS report.

Naveed Farrukh, Lindsey Hageman, Yanjun Chen, Jessica Wu, Emily Ness, Michelle Kung, Liton Francisco, Mariel Parman, Wendy Landier, Mukta Arora, Saro Armenian, Smita Bhatia, Grant R Williams,

BACKGROUND:Blood or marrow transplantation (BMT) is increasingly offered to older adults with hematologic malignancies; however, their risk for severe pain is poorly understood. Using the Bone Marrow Transplant Survivor Study, the current study investigated the prevalence and predictors of pain after BMT (allogeneic or autologous) as well as its association ... Read more >>

Cancer (Cancer)
[2020, :]

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Examining the use of pre-operative radiation therapy in addition to perioperative chemotherapy: National Cancer Data Base vs. Surveillance, Epidemiology, and End Results.

Sibo Tian, Renjian Jiang, Pretesh R Patel,

Cancer (Cancer)
[2020, :]

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Downgrading of grade group 2 intermediate-risk prostate cancer from biopsy to radical prostatectomy: Comparison of outcomes and predictors to identify potential candidates for active surveillance.

Zhuo T Su, Hiten D Patel, Jonathan I Epstein, Christian P Pavlovich, Mohamad E Allaf,

BACKGROUND:A proportion of men with grade group (GG) 2 intermediate risk (IR) prostate cancer are downgraded to GG1 or harbor favorable pathology (FP, defined as GG1 or GG2 with <5% Gleason pattern 4) at radical prostatectomy (RP). Prediction of downgrading or FP may help identify potential active surveillance candidates within ... Read more >>

Cancer (Cancer)
[2020, :]

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Obesity and aggressive prostate cancer.

Steven P Lehrer,

Cancer (Cancer)
[2020, :]

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Evaluating the impact of smoking on disease-specific survival outcomes in patients with human papillomavirus-associated oropharyngeal cancer treated with transoral robotic surgery.

Dylan F Roden, Kealan Hobelmann, Swar Vimawala, Tony Richa, Christopher E Fundakowski, Richard Goldman, Adam Luginbuhl, Joseph M Curry, David M Cognetti,

BACKGROUND:When treated nonsurgically with definitive chemoradiation, smokers with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a worse prognosis compared with their nonsmoking counterparts. To the authors' knowledge, the prognostic significance of smoking in surgically treated patients is unknown. METHODS:The current study is a retrospective case series of patients ... Read more >>

Cancer (Cancer)
[2020, :]

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Reply to Obesity and aggressive prostate cancer and the golden rule: Do not do to others what you do not want done to yourself.

Santino S Butler, Brandon A Mahal,

Cancer (Cancer)
[2020, :]

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