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Experts say that cervical cancer could be eliminated worldwide with screening, human papillomavirus vaccine.

Carrie Printz,

Cancer (Cancer)
[2020, 126(15):3387]

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Researchers explore new prognostic, predictive tools for cancer: Easily attainable markers and measurements may help to better inform treatment decision making.

Carrie Printz,

Cancer (Cancer)
[2020, 126(15):3385-3386]

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Determining the impact of Medicaid expansion on cancer burden.

Hala T Borno, Tracy K Lin, Rajaie S Batniji,

Cancer (Cancer)
[2020, :]

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The effect of Medicaid expansion among adults from low-income communities on stage at diagnosis in those with screening-amenable cancers.

Uriel Kim, Siran Koroukian, Abby Statler, Johnie Rose,

BACKGROUND:Several states have opted to expand Medicaid under the Patient Protection and Affordable Care Act (ACA), which offers insurance coverage to low-income individuals up to 138% of the federal poverty level. This expansion of Medicaid to a medically vulnerable population potentially can reduce cancer outcome disparities, especially among patients with ... Read more >>

Cancer (Cancer)
[2020, :]

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Novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Andrej Ozaniak, Zuzana Strizova, Pavel Hladik, Robert Lischke,

Cancer (Cancer)
[2020, :]

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Physical activity, health-related quality of life, and adjuvant endocrine therapy-related symptoms in women with hormone receptor-positive breast cancer.

Vanessa B Sheppard, Chiranjeev Dash, Sarah Nomura, Arnethea L Sutton, Robert Lee Franco, Alexander Lucas, Masey Ross, Lucile Adams-Campbell,

BACKGROUND:Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET). METHODS:Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related ... Read more >>

Cancer (Cancer)
[2020, :]

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Reply to Incidence of extrameningeal solitary fibrous tumors and novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Rick L M Haas, Annalisa Trama, Silvia Stacchiotti,

Cancer (Cancer)
[2020, :]

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When a global pandemic complicates cancer care: Although oncologists and their patients are accustomed to fighting tough battles against a lethal disease, Coronavirus Disease 2019 (COVID-19) has posed an unprecedented challenge.

Carrie Printz,

Cancer (Cancer)
[2020, 126(14):3171-3173]

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Incidence of extrameningeal solitary fibrous tumors.

Connor J Kinslow, Tony J C Wang,

Cancer (Cancer)
[2020, :]

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Women with inherited genetic mutations for breast cancer do not always receive treatment according to guidelines.

Carrie Printz,

Cancer (Cancer)
[2020, 126(13):2955]

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Measuring financial toxicity incurred after treatment of head and neck cancer: Development and validation of the Financial Index of Toxicity questionnaire.

Katrina Hueniken, Catriona M Douglas, Ashok R Jethwa, Maryam Mirshams, Lawson Eng, Andrew Hope, Douglas B Chepeha, David P Goldstein, Jolie Ringash, Aaron Hansen, Rosemary Martino, Madeline Li, Geoffrey Liu, Wei Xu, John R de Almeida,

BACKGROUND:The treatment of head and neck cancer (HNC) may cause significant financial toxicity to patients. Herein, the authors have presented the development and validation of the Financial Index of Toxicity (FIT) instrument. METHODS:Items were generated using literature review and were based on expert opinion. In item reduction, items with factor ... Read more >>

Cancer (Cancer)
[2020, :]

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New guidance for treating patients with lung cancer and COVID-19.

Carrie Printz,

Cancer (Cancer)
[2020, 126(14):3173]

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First person profile: Raymond Sawaya, MD: The founding chair of the neurosurgery department at The University of Texas MD Anderson Cancer Center, Dr. Sawaya has nurtured a generation of specialists and helped to advance the field.

Carrie Printz,

Cancer (Cancer)
[2020, 126(13):2953-2954]

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Research notes largest yearly decline in melanoma deaths.

Carrie Printz,

Cancer (Cancer)
[2020, 126(14):3173]

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Vaping prevention program targets students.

Carrie Printz,

Cancer (Cancer)
[2020, 126(13):2955]

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Biomarker-driven phase 2 umbrella trial study for patients with recurrent small cell lung cancer failing platinum-based chemotherapy.

Sehhoon Park, Joonho Shim, Peter G S Mortimer, Simon A Smith, Robert E Godin, Simon J Hollingsworth, Hee-Jung Kim, Hyun Ae Jung, Jong-Mu Sun, Woong-Yang Park, Jin Seok Ahn, Myung-Ju Ahn, Se-Hoon Lee, Keunchil Park,

BACKGROUND:A high percentage of small cell lung cancer (SCLC) cases harbor cell cycle-related gene mutations and RICTOR amplification. Based on underlying somatic mutations, the authors have conducted a phase 2 biomarker-driven, multiarm umbrella study. METHODS:The SCLC Umbrella Korea StudiES (SUKSES) is an adaptive platform trial that undergoes continual modification according ... Read more >>

Cancer (Cancer)
[2020, :]

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Slicing and dicing small cell lung cancer to improve trial outcomes.

Asrar AlAhmadi, Afshin Dowlati,

Cancer (Cancer)
[2020, :]

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Survival in older women with early stage breast cancer receiving low-dose bisphosphonates or denosumab.

Maria E Suarez-Almazor, Raul Herrera, Xiudong Lei, Mariana Chavez-MacGregor, Hui Zhao, Sharon H Giordano,

BACKGROUND:Bisphosphonates and denosumab, as adjuvant therapy in breast cancer, have been associated in some studies with improved cancer outcomes. The potential benefits of these drugs used at the lower doses commonly given for osteoporosis have not been established. The objective of this study was to investigate the association between therapy ... Read more >>

Cancer (Cancer)
[2020, :]

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Oncological outcomes for patients with locally advanced prostate cancer treated with neoadjuvant endocrine and external-beam radiation therapy followed by adjuvant continuous/intermittent endocrine therapy in an open-label, randomized, phase 3 trial.

Kazuto Ito, Mikio Kobayashi, Motokiyo Komiyama, Seiji Naito, Kazuo Nishimura, Junji Yonese, Katsuyoshi Hashine, Shiro Saito, Gaku Arai, Mitsuru Shinohara, Naoya Masumori, Nobuaki Shimizu, Takefumi Satoh, Atsushi Yamauchi, Tatsuo Tochigi, Yutaka Takezawa, Hiroyuki Fujimoto, Akira Yokomizo, Ken-Ichi Kakimoto, Iwao Fukui, Katsuyuki Karasawa, Taiji Tsukamoto, Miwako Nozaki, Masaru Hasumi, Hiromichi Ishiyama, Mikinobu Ohtani, Masaaki Kuwahara, Masaoki Harada, Yasuo Ohashi, Toshihiko Kotake, Tadao Kakizoe, Kazuhiro Suzuki, Hidetoshi Yamanaka, ,

BACKGROUND:To date, research has not determined the optimal procedure for adjuvant androgen deprivation therapy (ADT) in patients with locally advanced prostate cancer (PCa) treated for 6 months with neoadjuvant ADT and external-beam radiation therapy (EBRT). METHODS:A multicenter, randomized, phase 3 trial enrolled 303 patients with locally advanced PCa between 2001 and ... Read more >>

Cancer (Cancer)
[2020, :]

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Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China.

Hongyan Zhang, Linwei Wang, Yuanyuan Chen, Qiuji Wu, Gaili Chen, Xiaokun Shen, Qun Wang, Youqin Yan, Yi Yu, Yahua Zhong, Xinghuan Wang, Melvin L K Chua, Conghua Xie,

BACKGROUND:Patients with cancer have a higher risk of coronavirus disease 2019 (COVID-19) than noncancer patients. The authors conducted a multicenter retrospective study to investigate the clinical manifestations and outcomes of patients with cancer who are diagnosed with COVID-19. METHODS:The authors reviewed the medical records of hospitalized patients who were treated ... Read more >>

Cancer (Cancer)
[2020, :]

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Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.

Caitlin A McIntyre, Sharon A Lawrence, Allison L Richards, Joanne F Chou, Winston Wong, Marinela Capanu, Michael F Berger, Mark T A Donoghue, Kenneth H Yu, Anna M Varghese, David P Kelsen, Wungki Park, Vinod P Balachandran, T Peter Kingham, Michael I D'Angelica, Jeffrey A Drebin, William R Jarnagin, Christine A Iacobuzio-Donahue, Peter J Allen, Eileen M O'Reilly,

BACKGROUND:KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated with clinical outcomes for individuals who undergo resection. METHODS:Eligible individuals were those who underwent ... Read more >>

Cancer (Cancer)
[2020, :]

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Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis.

Shilpa Grover, Michael Dougan, Kevin Tyan, Anita Giobbie-Hurder, Steven M Blum, Jeffrey Ishizuka, Taha Qazi, Rawad Elias, Kruti B Vora, Alex B Ruan, William Martin-Doyle, Michael Manos, Lauren Eastman, Meredith Davis, Maria Gargano, Rizwan Haq, Elizabeth I Buchbinder, Ryan J Sullivan, Patrick A Ott, F Stephen Hodi, Osama E Rahma,

BACKGROUND:There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of this study was to identify potential factors associated with development of ICI colitis. METHODS:We performed a retrospective analysis of melanoma patients at Dana-Farber Cancer Institute who ... Read more >>

Cancer (Cancer)
[2020, :]

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Tipifarnib in recurrent, metastatic HRAS-mutant salivary gland cancer.

Glenn J Hanna, Jeffrey P Guenette, Nicole G Chau, Cyrus M Sayehli, Christian Wilhelm, Robert Metcalf, Deborah J Wong, Marcia Brose, Mohammad Razaq, Elisabeth Pérez-Ruiz, Ezra E W Cohen, Rahul Aggarwal, Catherine Scholz, Antonio Gualberto, Alan L Ho,

BACKGROUND:To the authors' knowledge, there are no approved therapies for recurrent, metastatic (R/M) salivary gland carcinoma (SGC), but molecularly targeted therapies warrant ongoing investigation. In the current study, the authors have reported on the efficacy of tipifarnib in patients with aggressive HRAS-mutant, R/M SGC. METHODS:The current prospective, nonrandomized, multicenter, international ... Read more >>

Cancer (Cancer)
[2020, :]

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Cancer surveillance and distress among adult pathogenic TP53 germline variant carriers in Germany: A multicenter feasibility and acceptance survey.

Nathalie Rippinger, Christine Fischer, Markus W Haun, Kerstin Rhiem, Sabine Grill, Marion Kiechle, Friedrich W Cremer, Karin Kast, Huu P Nguyen, Nina Ditsch, Christian P Kratz, Julia Vogel, Dorothee Speiser, Simone Hettmer, Hanno Glimm, Stefan Fröhling, Dirk Jäger, Stephan Seitz, Andrea Hahne, Imad Maatouk, Christian Sutter, Rita K Schmutzler, Nicola Dikow, Sarah Schott,

BACKGROUND:Li-Fraumeni syndrome (LFS) is a high-risk cancer predisposition syndrome caused by pathogenic germline variants of TP53. Cancer surveillance has noted a significant survival advantage in individuals with LFS; however, little is known about the feasibility, acceptance, and psychosocial effects of such a program. METHODS:Pathogenic TP53 germline variant carriers completed a ... Read more >>

Cancer (Cancer)
[2020, :]

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The microbiome in pediatric oncology.

Seth J Rotz, Christopher E Dandoy,

The human microbiome comprises a diverse set of microorganisms, which play a mostly cooperative role in processes such as metabolism and host defense. Next-generation genomic sequencing of bacterial nucleic acids now can contribute a much broader understanding of the diverse organisms composing the microbiome. Emerging evidence has suggested several roles ... Read more >>

Cancer (Cancer)
[2020, :]

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