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Low-dose whole-lung radiation for COVID-19 pneumonia: Planned day 7 interim analysis of a registered clinical trial.

Clayton B Hess, Zachary S Buchwald, William Stokes, Tahseen H Nasti, Jeffrey M Switchenko, Brent D Weinberg, James P Steinberg, Karen D Godette, David Murphy, Rafi Ahmed, Walter J Curran, Mohammad K Khan,

BACKGROUND:Individuals of advanced age with comorbidities face a higher risk of death from coronavirus disease 2019 (COVID-19), especially once they are ventilator-dependent. Respiratory decline in patients with COVID-19 is precipitated by a lung-mediated aberrant immune cytokine storm. Low-dose lung radiation was used to treat pneumonia in the pre-antibiotic era. Radiation ... Read more >>

Cancer (Cancer)
[2020, :]

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Trends in screening breast magnetic resonance imaging use among US women, 2006 to 2016.

Karen J Wernli, Katherine A Callaway, Louise M Henderson, Karla Kerlikowske, Janie M Lee, Dennis Ross-Degnan, Jamie K Wallace, J Frank Wharam, Fang Zhang, Natasha K Stout,

BACKGROUND:Supplemental breast cancer screening with breast magnetic resonance imaging (MRI) is recommended for women at high risk of breast cancer. To the authors' knowledge, recent national trends in breast MRI use are unknown. METHODS:The authors used claims data from a large national insurer to calculate screening breast MRI rates from ... Read more >>

Cancer (Cancer)
[2020, :]

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Mining the past to treat the present, ever mindful of the future: Low-dose radiotherapy and COVID-19 pneumonia.

Heath D Skinner,

Cancer (Cancer)
[2020, :]

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Education and communication are critical to effectively incorporating cannabis into cancer treatment.

Kelly T Hughes, David J Casarett,

Cancer (Cancer)
[2020, :]

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Cancer care and well-being in adolescents and young adults during the coronavirus disease 2019 pandemic: A UK sarcoma perspective.

Emma K Lidington, Alannah Smrke, Katrina M Ingley, Sandra J Strauss, Olga Husson, Eugenie Younger,

Cancer (Cancer)
[2020, :]

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Cancer patients' experiences with medicinal cannabis-related care.

Ilana M Braun, Manan M Nayak, Anna Revette, Alexi A Wright, Peter R Chai, Miryam Yusufov, William F Pirl, James A Tulsky,

BACKGROUND:Little is known about medical cannabis (MC)-related care for patients with cancer using MC. METHODS:Semistructured telephone interviews were conducted in a convenience sample of individuals (n = 24) with physician-confirmed oncologic diagnoses and state/district authorization to use MC (Arizona, California, Florida, Illinois, Massachusetts, Oregon, New York, and Washington, DC) from ... Read more >>

Cancer (Cancer)
[2020, :]

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Everolimus plus bevacizumab is an effective first-line treatment for patients with advanced papillary variant renal cell carcinoma: Final results from a phase II trial.

Darren R Feldman, Yasser Ged, Chung-Han Lee, Andrea Knezevic, Ana M Molina, Ying-Bei Chen, Joshua Chaim, Devyn T Coskey, Samuel Murray, Satish K Tickoo, Victor E Reuter, Sujata Patil, Han Xiao, Jahan Aghalar, Arlyn J Apollo, Maria I Carlo, Robert J Motzer, Martin H Voss,

BACKGROUND:We previously reported on a phase 2 study of everolimus plus bevacizumab across various nonclear cell renal cell carcinoma (nccRCC) histologies and observed encouraging activity among patients with papillary RCC (pRCC) and unclassified RCC (uRCC) with a major papillary component. We subsequently expanded the study to enroll additional patients with ... Read more >>

Cancer (Cancer)
[2020, :]

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What happened to the US cancer cooperative groups? A status update ten years after the Institute of Medicine report.

Monica M Bertagnolli, Charles D Blanke, Walter J Curran, Douglas S Hawkins, Robert S Mannel, Peter J O'Dwyer, Mitchell D Schnall, Norman Wolmark,

The US cancer cooperative groups (cooperative groups) were founded in the 1950s to establish a standing infrastructure to conduct multi-institutional cancer clinical trials. Initially funded almost entirely by the US National Cancer Institute (NCI), over the years, the research conducted by the Cooperative Groups has evolved to meet the demands ... Read more >>

Cancer (Cancer)
[2020, :]

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African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States.

Talha Badar, Parameswaran Hari, Omar Dávila, Raphael Fraser, Baldeep Wirk, Binod Dhakal, Cesar O Freytes, Cesar Rodriguez Valdes, Cindy Lee, David H Vesole, Ehsan Malek, Gerhard C Hildebrandt, Heather Landau, Hemant S Murthy, Hillard M Lazarus, Jesus G Berdeja, Kenneth R Meehan, Melhem Solh, Miguel Angel Diaz, Mohamed A Kharfan-Dabaja, Natalie S Callander, Nosha Farhadfar, Qaiser Bashir, Rammurti T Kamble, Ravi Vij, Reinhold Munker, Robert A Kyle, Saurabh Chhabra, Shahrukh Hashmi, Siddhartha Ganguly, Sundar Jagannath, Taiga Nishihori, Yago Nieto, Shaji Kumar, Nina Shah, Anita D'Souza,

BACKGROUND:Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine ... Read more >>

Cancer (Cancer)
[2020, :]

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Age is just a number, the wrong number.

Susan Bal, Luciano J Costa,

Cancer (Cancer)
[2020, :]

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Suicidality among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study.

Margaret M Lubas, Sedigheh Mirzaei Salehabadi, Jeanette Lavecchia, Nicole M Alberts, Kevin R Krull, Matthew J Ehrhardt, Deokumar Srivastava, Leslie L Robison, Melissa M Hudson, Tara M Brinkman,

BACKGROUND:Suicide is a serious public health concern. An increased risk of suicide ideation previously has been reported among survivors of childhood cancer. METHODS:Suicide mortality was assessed for all potentially eligible survivors (those aged ≥18 years who were ≥5 years after their cancer diagnosis; 7312 survivors). Risk factors for acute suicidal ... Read more >>

Cancer (Cancer)
[2020, :]

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The National Clinical Trials Network and the cooperative groups: The road not taken.

Richard L Schilsky,

Cancer (Cancer)
[2020, :]

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Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma.

Pashna N Munshi, David Vesole, Artur Jurczyszyn, Jan Maciej Zaucha, Andrew St Martin, Omar Davila, Vaibhav Agrawal, Sherif M Badawy, Minoo Battiwalla, Saurabh Chhabra, Edward Copelan, Mohamed A Kharfan-Dabaja, Nosha Farhadfar, Siddhartha Ganguly, Shahrukh Hashmi, Maxwell M Krem, Hillard M Lazarus, Ehsan Malek, Kenneth Meehan, Hemant S Murthy, Taiga Nishihori, Rebecca L Olin, Richard F Olsson, Jeffrey Schriber, Sachiko Seo, Gunjan Shah, Melhem Solh, Jason Tay, Shaji Kumar, Muzaffar H Qazilbash, Nina Shah, Parameswaran N Hari, Anita D'Souza,

BACKGROUND:Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. METHODS:The authors investigated the outcomes of AHCT in patients with MM who were aged ≥70 years. The Center for International Blood and Marrow Transplant Research ... Read more >>

Cancer (Cancer)
[2020, :]

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Prognostic impact of t(11;14) in multiple myeloma: Black and white or shades of gray?

Rajshekhar Chakraborty, Suzanne Lentzsch,

Cancer (Cancer)
[2020, :]

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Breast cancer treatment delays by socioeconomic and health care access latent classes in Black and White women.

Marc A Emerson, Yvonne M Golightly, Allison E Aiello, Katherine E Reeder-Hayes, Xianming Tan, Ugwuji Maduekwe, Marian Johnson-Thompson, Andrew F Olshan, Melissa A Troester,

BACKGROUND:Breast cancer mortality is higher for Black and younger women. This study evaluated 2 possible contributors to disparities-time to treatment and treatment duration-by race and age. METHODS:Among 2841 participants with stage I-III disease in the Carolina Breast Cancer Study, we identified groups of women with similar patterns of socioeconomic status ... Read more >>

Cancer (Cancer)
[2020, :]

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Quality reporting in postchemotherapy retroperitoneal lymph node dissection.

Siamak Daneshmand,

Cancer (Cancer)
[2020, :]

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Association between postoperative complications and long-term oncologic outcomes following total laryngectomy: 10-year experience at MD Anderson Cancer Center.

Stefanos Boukovalas, Ryan P Goepfert, J Michael Smith, Elise Mecham, Jun Liu, Mark E Zafereo, Edward I Chang, Amy C Hessel, Matthew M Hanasono, Neil D Gross, Peirong Yu, Jan S Lewin, Carol M Lewis, Eduardo M Diaz, Randal S Weber, Jeffrey N Myers, Anaeze C Offodile,

BACKGROUND:Postoperative complications are an independent predictor of poor survival across several tumors. However, there is limited literature on the association between postoperative morbidity and long-term survival following total laryngectomy (TL) for cancer. METHODS:We conducted a retrospective review of all TL patients at a single institution from 2008 to 2013. Demographic ... Read more >>

Cancer (Cancer)
[2020, :]

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Clinical trial design: Past, present, and future in the context of big data and precision medicine.

Allen Li, Raymond C Bergan,

Clinical trials are fundamental for advances in cancer treatment. The traditional framework of phase 1 to 3 trials is designed for incremental advances between regimens. However, our ability to understand and treat cancer has evolved with the increase in drugs targeting an expanding array of therapeutic targets, the development of ... Read more >>

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[2020, :]

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Intraoperative and early postoperative complications in postchemotherapy retroperitoneal lymphadenectomy among patients with germ cell tumors using validated grading classifications.

Eric C Umbreit, Andrew G McIntosh, Chalairat Suk-Ouichai, Luis A Segarra, Levi C Holland, Bryan M Fellman, Stephen B Williams, Arun Z Thomas, Shi-Ming Tu, Curtis A Pettaway, Louis L Pisters, John F Ward, Christopher G Wood, Jose A Karam,

BACKGROUND:Postchemotherapy retroperitoneal lymphadenectomy (PC-RPLND) is an essential, yet potentially morbid, therapy for the management of patients with advanced germ cell tumors. In the current study, the authors sought to define the complication profile of PC-RPLND using validated grading systems for intraoperative adverse events (iAEs) and early postoperative complications. METHODS:Between 2000 ... Read more >>

Cancer (Cancer)
[2020, :]

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Preservation of spinal accessory and level 2b-sparing neck dissection: The balance beyond oncology and functionality.

Nagarjuna G V Reddy, Abhijeet Singh, Anand Subash,

Cancer (Cancer)
[2020, :]

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Reply to Preservation of spinal accessory and level 2b-sparing neck dissection: The balance beyond oncology and functionality.

Peter T Dziegielewski, Hadi Seikaly,

Cancer (Cancer)
[2020, :]

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Understanding the response of mammography facilities to breast density notification.

Louise M Henderson, Mary W Marsh, Kathryn Earnhardt, Michael Pritchard, Thad S Benefield, Robert P Agans, Sheila S Lee,

BACKGROUND:State-specific breast density notification legislation requires that women undergoing mammography be informed about breast density, with variation among states. Because mammography facilities are among the main points of contact for women undergoing mammography, research is needed to understand how facilities communicate information on breast density, cancer risk, and supplemental screening ... Read more >>

Cancer (Cancer)
[2020, :]

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A prospective study of pediatric and adolescent renal cell carcinoma: A report from the Children's Oncology Group AREN0321 study.

James I Geller, Nicholas G Cost, Yueh-Yun Chi, Brett Tornwall, Mariana Cajaiba, Elizabeth J Perlman, Yeonil Kim, Elizabeth A Mullen, Richard D Glick, Geetika Khanna, Najat C Daw, Peter Ehrlich, Conrad V Fernandez, Jeffrey S Dome, ,

BACKGROUND:To the authors' knowledge, AREN0321 is the first prospective clinical study of pediatric and adolescent renal cell carcinoma (RCC). Goals of the study included establishing epidemiological, treatment, and outcome data and confirming that patients with completely resected pediatric RCC, including lymph node-positive disease (N1), have a favorable prognosis without adjuvant ... Read more >>

Cancer (Cancer)
[2020, :]

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Impact of adjuvant trastuzumab on locoregional failure rates in a randomized clinical trial: North Central Cancer Treatment Group N9831 (alliance) study.

Carlos E Vargas, Cameron S Thorpe, Amylou C Dueck, Kathleen S Tenner, Nancy E Davidson, Silvana Martino, Thomas M Pisansky, E Shelley Hwang, Michele Y Halyard, Barbara A Pockaj, Edith A Perez,

BACKGROUND:The goal of this study was to assess the impact of trastuzumab on locoregional failure. METHODS:The analysis included 2763 patients with HER2-positive (HER2+) breast cancer who were randomly assigned to adjuvant doxorubicin (A), cyclophosphamide (C), paclitaxel (T) and trastuzumab (H) (arm A, AC→T [n = 922]; arm B, AC→T→H [n = 988]; arm C, ... Read more >>

Cancer (Cancer)
[2020, :]

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Hyperthermic intraperitoneal chemotherapy in interval debulking surgery for advanced epithelial ovarian cancer: A single-center, real-life experience.

Valentina Ghirardi, Carlo Ronsini, Rita Trozzi, Chiara Di Ilio, Andrea Di Giorgio, Stefano Cianci, Gaetano Draisci, Giovanni Scambia, Anna Fagotti,

BACKGROUND:An improvement in survival without increasing perioperative morbidity in patients with advanced epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) after interval debulking surgery (IDS) has been recently demonstrated in a randomized controlled trial. This study was aimed at assessing the feasibility and perioperative outcomes of the use of ... Read more >>

Cancer (Cancer)
[2020, :]

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