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A novel five-gene signature predicts overall survival of patients with hepatocellular carcinoma.

Zhigang Wang, Leyu Pan, Deliang Guo, Xiaofeng Luo, Jie Tang, Weihua Yang, Yuxian Zhang, Anni Luo, Yang Gu, Yuxuan Pan,

Hepatocellular carcinoma (HCC) is one of the most common public health challenges, worldwide. Because of molecular complexity and tumor heterogeneity, there are no effective predictive models for prognosis of HCC. This underlines the unmet need for accurate prognostic models for HCC. Analysis of GSE14520 data from gene omnibus (GEO) database ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Comprehensive mutational analysis of background mucosa in patients with Lugol-voiding lesions.

Naoki Akizue, Kenichiro Okimoto, Makoto Arai, Yosuke Hirotsu, Kenji Amemiya, Hirotaka Oura, Tatsuya Kaneko, Mamoru Tokunaga, Kentaro Ishikawa, Yuki Ohta, Takashi Taida, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Tomoo Nakagawa, Motoi Nishimura, Tetsuhiro Chiba, Kazuyuki Matsushita, Hitoshi Mochizuki, Osamu Yokosuka, Masao Omata, Naoya Kato,

Somatic mutations including the background mucosa in patients with Lugol-voiding lesions (LVLs) are still not well known. The aim of this study was to evaluate the somatic mutations of the background mucosa in patients with LVLs (Squamous cell carcinoma (SCC), intraepithelial neoplasia (IN), and hyperplasia). Twenty-five patients with LVLs (9 ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Hospital-level compliance with the commission on cancer's quality of care measures and the association with patient survival.

Daniel P Nussbaum, Christel N Rushing, Zhifei Sun, Babatunde A Yerokun, Mathias Worni, Robert S Saunders, Mark B McClellan, Donna Niedzwiecki, Rachel A Greenup, Dan G Blazer,

<h4>Background</h4>Quality measurement has become a priority for national healthcare reform, and valid measures are necessary to discriminate hospital performance and support value-based healthcare delivery. The Commission on Cancer (CoC) is the largest cancer-specific accreditor of hospital quality in the United States and has implemented Quality of Care Measures to evaluate ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial-mesenchymal transition and angiogenesis.

Yan Zhao, Jiajia Gao, Xiufeng Xie, Peng Nan, Fang Liu, Yulin Sun, Xiaohang Zhao,

Metastasis to regional lymph nodes or distal organs predicts the progression of the disease and poor prognosis in esophageal squamous cell carcinoma (ESCC). Previous studies demonstrated that BTB and CNC homology 1 (BACH1) participates in various types of tumor metastasis. However, the function of BACH1 in ESCC was rarely reported. ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Real-world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B-cell lymphoma.

Gloria Iacoboni, Guillermo Villacampa, Nuria Martinez-Cibrian, Rebeca Bailén, Lucia Lopez Corral, Jose M Sanchez, Manuel Guerreiro, Ana Carolina Caballero, Alberto Mussetti, Juan-Manuel Sancho, Rafael Hernani, Pau Abrisqueta, Carlos Solano, Anna Sureda, Javier Briones, Alejandro Martin Garcia-Sancho, Mi Kwon, Juan Luis Reguera-Ortega, Pere Barba, ,

Tisagenlecleucel (tisa-cel) is a second-generation autologous CD19-targeted chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Sputum cell-free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR-TKIs.

Zheng Wang, Xiaoguang Li, Lin Zhang, Yan Xu, Mengzhao Wang, Li Liang, Peng Jiao, Yuanming Li, Shurong He, Jun Du, Lei He, Min Tang, Mingjun Sun, Li Yang, Jing Di, Guanshan Zhu, Lin Li, Dongge Liu,

<h4>Background</h4>Sputum cell-free DNA (cfDNA) is a valuable surrogate sample for assessing EGFR-sensitizing mutations in patients with advanced lung adenocarcinoma. Detecting EGFR exon 20 p.T790 M (p.T790 M) is much more challenging due to its limited availability in tumor tissues. Exploring sputum cfDNA as an alternative for liquid-based sample type in detecting p.T790 M ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Surgery shows survival benefit in patients with primary intestinal diffuse large B-cell lymphoma: A population-based study.

Moran Wang, Shengling Ma, Wei Shi, Yuanyuan Zhang, Shanshan Luo, Yu Hu,

<h4>Background</h4>The clinical characteristics and prognosis of primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) are rarely reported. We aimed to explore the role of surgery in patients with PI-DLBCL.<h4>Methods</h4>Adult PI-DLBCL patients were included from the Surveillance, Epidemiology, and End Results database. The effect of surgery was evaluated by Kaplan-Meier and Cox ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Trametinib therapy for children with neurofibromatosis type 1 and life-threatening plexiform neurofibroma or treatment-refractory low-grade glioma.

Rebecca Ronsley, Celine D Hounjet, Sylvia Cheng, Shahrad Rod Rassekh, Walter J Duncan, Christopher Dunham, Jane Gardiner, Arvindera Ghag, Jeffrey P Ludemann, David Wensley, Wingfield Rehmus, Michael A Sargent, Juliette Hukin,

<h4>Purpose</h4>To describe a series of children with extensive PNF or treatment refractory PLGG treated on a compassionate basis with trametinib.<h4>Methods</h4>We report on six patients with NF-1 treated with trametinib on a compassionate basis at British Columbia Children's Hospital since 2017. Data were collected retrospectively from the patient record. RAPNO and ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Investigating the association between serum human papillomavirus type 16 E7 antibodies and risk of head and neck cancer.

Cheng-Chih Huang, Yu-Chu Su, Chan-Chi Chang, Wei-Ting Lee, Chun-Yen Ou, Yuan-Hua Wu, Shang-Yin Wu, Yu-Hsuan Lai, Jehn-Shyun Huang, Ken-Chung Chen, Wei-Ting Hsueh, Sen-Tien Tsai, Chia-Jui Yen, Jang-Yang Chang, Mei-Ling Tsai, Chen-Lin Lin, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jenn-Ren Hsiao, Jeffrey S Chang,

Human papillomavirus (HPV) is recognized as a major cause of oropharyngeal cancer (OPC) in Western countries. Less is known regarding its contribution to the OPC occurring in Asia. The current study aimed to investigate the association between antibody responses to HPV16 E7 and head and neck cancer (HNC) risk in ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor-infiltrating immune cell analysis.

Yi Wan, Xin Wang, Ting Liu, Tianyu Fan, Zugui Zhang, Bin Wang, Bei Zhang, Zibin Tian, Tao Mao, Zheng Gong, Li Zhang,

<h4>Background</h4>Prognostic indicators in lung adenocarcinoma (LUAD) have been seeking under database analysis, and remarkable advance is on the way.<h4>Methods</h4>This study calculated the scores of stromal and immune components of the tumor microenvironment (TME) in 551 LUAD samples using the ESTIMATE algorithm on The Cancer Genome Atlas (TCGA) database. R package ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Data mining of an acoustic biomarker in tongue cancers and its clinical validation.

Yudong Xiao, Tao Wang, Wei Deng, Le Yang, Bin Zeng, Xiaomei Lao, Sien Zhang, Xiangqi Liu, Daiqiao Ouyang, Guiqing Liao, Yujie Liang,

The promise of speech disorders as biomarkers in clinical examination has been identified in a broad spectrum of neurodegenerative diseases. However, to the best of our knowledge, a validated acoustic marker with established discriminative and evaluative properties has not yet been developed for oral tongue cancers. Here we cross-sectionally collected ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Establishment of a prognostic model of four genes in gastric cancer based on multiple data sets.

Liqiang Zhou, Shi H Li, You Wu, Lin Xin,

Gastric cancer (GC) is a kind of malignancy with a high mortality and recurrence. An effective prediction model based on ideal biomarkers to assess prognosis could benefit patients for optimization of treatment. Bioinformatics has played an increasingly important role in the study of cancer diseases. Therefore, this study started with ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Health care access and utilization among adult cancer survivors: Results from the National Institutes of Health "All of Us" Research Program.

Steven S Coughlin, Jie Chen, Jorge E Cortes,

<h4>Background</h4>Many cancer survivors face financial difficulties that prevent them from receiving appropriate health care. Racial/ethnic disparities in receipt of health care have been reported among cancer survivors, but recent data for important racial/ethnic subgroups of the US population are lacking.<h4>Methods</h4>To learn more about barriers to healthcare access faced by cancer ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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DNA methylome analysis identifies BMI-related epigenetic changes associated with non-small cell lung cancer susceptibility.

Guyanan Li, Hua Meng, Yansen Bai, Wei Wei, Yue Feng, Mengying Li, Hang Li, Meian He, Xiaomin Zhang, Sheng Wei, Yangkai Li, Huan Guo,

<h4>Background</h4>Body mass index (BMI) has been reported to be inversely associated with incident risk of non-small cell lung cancer (NSCLC). However, the underlying mechanism is still unclear. This study aimed to investigate the role of DNA methylation in the relationship between BMI and NSCLC.<h4>Methods</h4>We carried out a genome-wide DNA methylation ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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First-line therapy of bevacizumab plus chemotherapy versus cetuximab plus chemotherapy for metastatic colorectal cancer patients with mucinous adenocarcinoma or mucinous component.

Yu-Wen Zhou, Yi-Xiu Long, Ye Chen, Ji-Yan Liu, Dan Pu, Jia-Yan Huang, Feng Bi, Qiu Li, Hong-Feng Gou, Meng Qiu,

<h4>Background</h4>To compare the efficacy of first-line bevacizumab plus chemotherapy with cetuximab plus chemotherapy based on the stratification of metastatic colorectal cancer (mCRC) patients with mucinous adenocarcinoma (MA) or mucinous component (MC).<h4>Methods</h4>A retrospective study involving all mCRC patients receiving first-line bevacizumab-based or cetuximab-based chemotherapy at our hospital from September 2013 to ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Recent improvement in survival outcomes and reappraisal of prognostic factors in hepatoblastoma.

Kyung-Nam Koh, Jung-Man Namgoong, Hee Mang Yoon, Young Ah Cho, Se Hoon Choi, Juhee Shin, Sung Han Kang, Jin Kyung Suh, Hyery Kim, Seak Hee Oh, Kyung Mo Kim, Dae Yeon Kim, Ho Joon Im,

<h4>Background</h4>Prognostic factors in hepatoblastoma need to be reevaluated considering the advances in treatment modalities. The study aimed to evaluate current outcomes of hepatoblastoma and reappraise the association of prognostic factors, including pre-treatment extent of tumor (PRETEXT) stage with annotation factors and Children's Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system, with ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Surgical strategies for hepatocellular carcinoma located in the left lateral lobe: A propensity score-matched and prognostic nomogram study.

Jingwen Zou, Shaohua Li, Qiaoxuan Wang, Jie Mei, Lianghe Lu, Wenping Lin, Yuhua Wen, Yuechao Li, Wei Wei, Rongping Guo,

<h4>Purpose</h4>For hepatocellular carcinoma (HCC) located in the left lateral lobe, the optimal surgical procedure is still controversial. This study aimed to optimize surgical strategies and to construct a nomogram to predict the postoperative survival of patients with HCC.<h4>Methods</h4>Between 1 January 2005 and 30 September 2018, a total of 493 patients ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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TNF-α/NF-κB signaling epigenetically represses PSD4 transcription to promote alcohol-related hepatocellular carcinoma progression.

Jia'ning Shi, Shupeng Song, Shuangxing Li, Kaili Zhang, Yinghua Lan, Yongguo Li,

<h4>Background</h4>Chronic alcohol consumption is more frequently associated with advanced, aggressive hepatocellular carcinoma (HCC) tumors. Alcohol adversely impacts ER/Golgi membrane trafficking and Golgi protein N-glycosylation in hepatocytes; these effects have been attributed (in part) to dysregulated adenosine diphosphate-ribosylation factor (ARF) GTPase signaling. Here, we investigated the role of the ARF GTPase ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells.

Haojun Shi, Yisi Yang,

Immune checkpoint blockade (ICB) has become one of the most promising approaches to activating antitumor immunity. However, only a small subset of patients with breast cancer benefit from ICB treatment. To improve the therapeutic effect in the clinic, precision immunotherapy is proposed to accurately eliminate cancer stem cells that contribute ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Haematologic malignancies with unfavourable gene mutations benefit from donor lymphocyte infusion with/without decitabine for prophylaxis of relapse after allogeneic HSCT: A pilot study.

Rui Zhang, Lili Wang, Peng Chen, Xiaoning Gao, Shuhong Wang, Fei Li, Liping Dou, Chunji Gao, Yan Li, Daihong Liu,

Relapse is the main cause of treatment failure for leukaemia patients with unfavourable gene mutations who receive allogeneic haematopoietic stem cell transplantation (allo-HSCT). There is no consensus on the indication of donor lymphocyte infusion (DLI) for prophylaxis of relapse after allo-HSCT. To evaluate the tolerance and efficacy of prophylactic DLI ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Patient perspectives on chemotherapy de-escalation in breast cancer.

Gabrielle B Rocque, Courtney P Williams, Courtney Andrews, Timothy C Childers, Kimberly D Wiseman, Kathleen Gallagher, Nadine Tung, Alan Balch, Valerie M Lawhon, Stacey A Ingram, Thelma Brown, Tara Kaufmann, Mary L Smith, Angela DeMichele, Antonio C Wolff, Lynne Wagner,

<h4>Background</h4>Given excellent survival outcomes in breast cancer, there is interest in de-escalating the amount of chemotherapy delivered to patients. This approach may be of even greater importance in the setting of the COVID-19 pandemic.<h4>Methods</h4>This concurrent mixed methods study included (1) interviews with patients and patient advocates and (2) a cross-sectional ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.

Zhongbo Zhang, Yuanhong Xu, Chenghai Zhao,

Mining databases and data obtained from assays on human specimens had shown that Fzd7 is closely associated with Wnt7b, that Fzd7/Wnt7b expression is upregulated in pancreatic cancer tissues compared with normal tissues, and its expression is negatively correlated with survival. Fzd7/Wnt7b knockdown in Capan-2 and Panc-1 cells reduced the proliferative ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Corrigendum.

Cancer Med (Cancer medicine)
[2021, :]

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MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer.

Haoya Xu, Ruoyao Zou, Feifei Li, Jiyu Liu, Nannan Luan, Shengke Wang, Liancheng Zhu,

<h4>Purpose</h4>To analyze the role of six human epididymis protein 4 (HE4)-related mitochondrial ribosomal proteins (MRPs) in ovarian cancer and selected MRPL15, which is most closely related to the tumorigenesis and prognosis of ovarian cancer, for further analyses.<h4>Methods</h4>Using STRING database and MCODE plugin in Cytoscape, six MRPs were identified among genes ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma.

Shiqi Ren, Wei Wang, Chenlin Zhang, Yidan Sun, Mengjing Sun, Yingjing Wang, Xiaojing Zhang, Bing Lu, Lanlan Yao,

A primary factor in tumor morbidity and mortality, lung adenocarcinoma (LUAD) is known to be a major subtype of lung cancer, having the lowest survival rate among all other cancers. Using The Cancer Genome Atlas (TCGA) database the relationship between the immune infiltrate and the NUP62CL was explored and the ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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