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Journal Cancer Manag Res

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Magnetic Resonance Diffusion Kurtosis Imaging versus Diffusion-Weighted Imaging in Evaluating the Pathological Grade of Hepatocellular Carcinoma.

Guang-Zhi Wang, Ling-Fei Guo, Gui-Hua Gao, Yao Li, Xi-Zhen Wang, Zhen-Guo Yuan,

PurposeTo investigate the diagnostic efficacy of diffusion kurtosis imaging (DKI) and conventional diffusion-weighted imaging (DWI) for pathological grading.MethodsFrom December 2015 to January 2017, consecutive patients suspected of having hepatocellular carcinoma (HCC) without prior treatment were prospectively enrolled in this study. MRI examinations were performed before surgical treatment. HCC patients confirmed ... Read more >>

Cancer Manag Res (Cancer Management and Research)
[2020, 12:5147-5158]

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Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses.

Yong Wu, Lingfang Xia, Qinhao Guo, Jun Zhu, Yu Deng, Xiaohua Wu,

PurposeHigh-grade serous ovarian cancer (HGSOC) is the leading cause of death among gynecological malignancies. This is mainly attributed to its high rates of chemoresistance. To date, few studies have investigated the molecular mechanisms underlying this resistance to treatment in ovarian cancer patients. In this study, we aimed to explore these ... Read more >>

Cancer Manag Res (Cancer Management and Research)
[2020, 12:5213-5223]

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Clinical Significance of Red Cell Distribution Width and Circulating Tumor Cells with an Epithelial–Mesenchymal Transition Phenotype in Lung Adenocarcinoma.

Huajian Peng, Xiang Tan, Yongyong Wang, Lei Dai, Guanbiao Liang, Jianji Guo, Mingwu Chen,

ObjectiveTo determine the prognostic value of red cell distribution width (RDW) and circulating tumor cells with epithelial–mesenchymal transition phenotype (M-CTC) in lung adenocarcinoma (LUAD).Patients and MethodsClinical and laboratory data of 60 patients with LUAD were collected. CTCs were isolated from their peripheral blood using the CanPatrolTM CTC enrichment method. The ... Read more >>

Cancer Manag Res (Cancer Management and Research)
[2020, 12:5105-5117]

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Lidocaine Suppresses Cell Proliferation and Aerobic Glycolysis by Regulating circHOMER1/miR-138-5p/HEY1 Axis in Colorectal Cancer.

Juan Du, Liying Zhang, Hongzhong Ma, Yang Wang, Pengpeng Wang,

Background:Increasing evidence has uncovered the anticancer activity of lidocaine in many cancers. However, the role and the underlying molecular mechanism of lidocaine in colorectal cancer (CRC) remain poorly understood. Materials and Methods:Cell viability and apoptosis were measured by cell counting kit-8 assay and flow cytometry. Western blot was used to ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:5009-5022]

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Down-Regulation of Ribosomal Protein RPS21 Inhibits Invasive Behavior of Osteosarcoma Cells Through the Inactivation of MAPK Pathway.

Tao Wang, Zhi-Yong Wang, Ling-Yuan Zeng, Yao-Zu Gao, Yu-Xin Yan, Quan Zhang,

Objective:The goal of our present study was to explore the expression level, biological function, and underlying molecular mechanism of ribosomal protein s21 (RPS21) in human osteosarcoma (OS). Methods:Firstly, we evaluated the expression of RPS21 in OS tissue samples based on the Gene Expression Omnibus (GEO) datasets and also measured the ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4949-4955]

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A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.

Zhongjing Lv, Kun Wu, Xing Qin, Jian Yuan, Ming Yan, Jianjun Zhang, Lizhen Wang, Tong Ji, Wei Cao, Wantao Chen,

Background:In our previous study, serine protease inhibitor Kazal-type 5 (SPINK5), which encodes the product of serine protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) was found to be down-regulated in head and neck squamous cell carcinoma (HNSCC) using oligonucleotide microarrays. However, the function and clinical implications of SPINK5/LEKTI remain obscure in HNSCC. ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4855-4869]

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MiR-34a Inhibits Cell Proliferation and Induces Apoptosis in Human Nasopharyngeal Carcinoma by Targeting lncRNA MCM3AP-AS1.

Piyun Sun, Yuchen Feng, Hui Guo, Rong Li, Peng Yu, Xingguang Zhou, Zhige Pan, Yanyan Liang, Bihan Yu, Yanyi Zheng, Yu Shi, Lingbo Wen, Minmei Wei, Yanhua Chen,

Introduction:MCM3AP-AS1 has been characterized as an oncogenic lncRNA in several types of cancer, while its role in nasopharyngeal carcinoma (NPC) is unknown. This study aimed to investigate the role of MCM3AP-AS1 in NPC. Patients and Methods:Paired NPC tissues and non-tumor tissues were collected from 55 NPC patients. Expression of MCM3AP-AS1 ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4799-4806]

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Chinese Cancer Research in 2009-18 and the Disease Burden.

Aihua Li, Grant Lewison,

Objective:We investigated the correlation of cancer research in China with its disease burden and national or provincial wealth. We also compared China's research output with that of other Asian countries. Methods:Chinese publications on cancer research for 2009-18 were retrieved from the Web of Science with a special filter giving high ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:5031-5040]

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Knockdown of lncRNA HCP5 Suppresses the Progression of Colorectal Cancer by miR-299-3p/PFN1/AKT Axis.

Ni Bai, Ying Ma, Jia Zhao, Bo Li,

Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system. The lncRNA HCP5 has been reported to affect the progression of tumor in several types of cancer. Here, in this research, we focus on the role and function of lncRNA HCP5 in human colorectal cancer. ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4747-4758]

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CircRNA SMARCC1 Sponges MiR-140-3p to Regulate Cell Progression in Colorectal Cancer.

Miao-Sheng Chen, Cui-Hong Lin, Ling-Yan Huang, Xiao-Ming Qiu,

Purpose:Our objective was to investigate the effect of circSMARCC1 on the developmental and biological behavior of colorectal cancer (CRC). Materials and Methods:The expression of circSAMRCC1 and miR-140-3p in CRC tissues and cell lines (SW620, HCT116, HT29 and SW480) and a normal cell line (NCM460) was detected using qRT-PCR. The expression ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4899-4910]

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Erratum: Validation of the Chinese Version of the Shame and Stigma Scale in Patients with Head and Neck Cancer [Corrigendum].

[This corrects the article DOI: 10.2147/CMAR.S228843.]. ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4957]

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Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer.

Xing-Chen Li, Yang-Yang Dong, Yuan Cheng, Jing-Yi Zhou, Xiao Yang, Bo-Qiang Shen, Xiao-Tong Wu, Xiao-Ping Li, Jian-Liu Wang,

Purpose:The early predictive values of diagnostic markers for lymph node metastasis (LNM) in endometrial cancer (EC) are still unclear at present. The purpose of this study is to explore the relationship between serum calcium and LNM in EC. Methods:We identified all patients with EC who underwent surgery between January 2012 ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:5023-5030]

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Nosocomial Infections in Gastrointestinal Cancer Patients: Bacterial Profile, Antibiotic Resistance Pattern, and Prognostic Factors.

Ai-Min Jiang, Na Liu, Rim Ali Said, Meng-Di Ren, Huan Gao, Xiao-Qiang Zheng, Xiao Fu, Xuan Liang, Zhi-Ping Ruan, Yu Yao, Tao Tian,

Background:Cancers of the gastrointestinal (GI) tract and its associated excretory glands are one of the most common causes of cancer-related death worldwide, and these patients are more likely to developing nosocomial infections due to immunodeficiency. Objective:To explore the bacterial profile, antibiotic resistance pattern, and prognostic factors of nosocomial infections in ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4969-4979]

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Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma.

Jinghua Fan, Xiaoxiao Kang, Limin Zhao, Yan Zheng, Jun Yang, Di Li,

Background:Melanoma is aggressive and lethal melanocytic neoplasm, and its incidence has increased worldwide in recent decades. Accumulating evidence has showed that various long noncoding RNAs (lncRNAs) participated in occurrence of malignant tumors, including melanoma. The present study was designed to investigate function of lncRNA colon cancer-associated transcript-1 (CCAT1) in melanoma. ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4699-4714]

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Information Seeking Behavior About Cancer and Associated Factors Among University Students, Ethiopia: A Cross-Sectional Study.

Adugna Gedefaw, Tesfahun Melese Yilma, Berhanu Fikadie Endehabtu,

Introduction:Cancer is among the leading cause of death in sub-Saharan Africa over the last few years, putting a tremendous physical, emotional, and financial strain on individuals, families, and health systems. Many health systems in sub-Saharan Africa are least prepared to manage this burden, and a large number of individuals do ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4829-4839]

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Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib.

Xiaowen Chen, Zhenqi Huang, Wei Wu, Ruixiang Xia,

Introduction:Skp2 is an E3 ubiquitin ligase that plays an important role in modulating tumor progression. The mechanisms underlying Skp2 in the promotion of proliferation and its function in the primary resistance to tyrosine kinase inhibitors (TKIs) in human CML remain to be determined. This study aimed to investigate the function ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4777-4787]

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Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade.

Qian Yang, Laichao Ni, Saber Imani, Zhangqiang Xiang, Rui Hai, Ruilin Ding, Shaozhi Fu, Jing Bo Wu, Qinglian Wen,

Background:Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good anti-tumor activity against a variety of solid tumors. However, its effect on colorectal cancer (CRC) is not yet clearly understood. The objective of this study was to investigate the anti-tumor effect and underlying mechanism of anlotinib in the ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4937-4948]

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CD56 Expression Is Associated with Biological Behavior of Pancreatic Neuroendocrine Neoplasms.

Xin Chen, Chuangen Guo, Wenjing Cui, Ke Sun, Zhongqiu Wang, Xiao Chen,

Purpose:CD56 is a neural cell adhesion molecule that plays a role in the cohesiveness of neuroendocrine cells. The aim of this study was to explore the biological values of CD56 expression in pancreatic neuroendocrine neoplasms (PNENs) and its role in predicting PNENs grades. Patients and Methods:A total of 138 patients ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4625-4631]

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Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma.

Xingyuan Wang, Zeyu Chen, Shi Qiu, Dehong Cao, Kun Jin, Jin Li, Bo Chen, Yin Huang, Yige Bao, Liangren Liu, Qiang Wei,

Objective:To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS). Patients and Methods:In the Surveillance Epidemiology and End Results (SEER) database (2006-2016), people with TS were enrolled in our research. Multivariable logistic regression models were constructed to compare the impact of cryptorchidism on CS. Results:This research ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4883-4888]

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Localization of Nuclei in Breast Cancer Using Whole Slide Imaging System Supported by Morphological Features and Shape Formulas.

Anil Kumar, Manish Prateek,

Purpose:Cancer rates are exponentially increasing worldwide and over 15 million new cases are expected in the year 2020 according to the World Cancer Report. To support the clinical diagnosis of the disease, recent technical advancements in digital microscopy have been achieved to reduce the cost and increase the efficiency of ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4573-4583]

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Mitochondrial Stress-Mediated Targeting of Quiescent Cancer Stem Cells in Oral Squamous Cell Carcinoma.

Tajindra Singh Saluja, Vijay Kumar, Monika Agrawal, Abhilasha Tripathi, Rajesh Kumar Meher, Kamini Srivastava, Anurag Gupta, Anjana Singh, Arun Chaturvedi, Satyendra Kumar Singh,

Introduction:Despite improved therapeutics in oral squamous cell carcinoma (OSCC), tumor cells that are either quiescent and/or endowed with stem cell-like attributes usually survive treatment and recreate tumor load at relapse. Through this study, we aimed strategically to eliminate these stem cell-like cancer cells using a combination drug approach. Methods:Primary cultures ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4519-4530]

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Overexpression of lncRNA MT1JP Mediates Apoptosis and Migration of Hepatocellular Carcinoma Cells by Regulating miR-24-3p.

Qiu-Li Shan, Ning-Ning Chen, Gui-Zhi Meng, Fan Qu,

Objective:This study aimed to determine the effects of the long non-coding (lnc) RNA MT1JP on the apoptosis and migration of hepatocellular carcinoma cells. Patients and Methods:Patients with liver cancer admitted to the Second People's Hospital of Liaocheng were included in this study. We transfected hepatocellular carcinoma cells with MT1JP and ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4715-4724]

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Icotinib as Adjuvant Treatment for Stage II-IIIA Lung Adenocarcinoma Patients with EGFR Mutation (ICWIP Study): Study Protocol for a Randomised Controlled Trial.

Yu-Tao Liu, Xue-Zhi Hao, De-Ruo Liu, Gang Cheng, Shu-Cai Zhang, Wen-Hua Xiao, Yi Hu, Jun-Feng Liu, Ming He, Cui-Min Ding, Li Zhang, Jun Wang, Hui Li, Gui-Lan Dong, Xiu-Yi Zhi, Jian Li, Yuan-Kai Shi,

The efficacy and possible role of epidermal growth factor receptor tyrosine kinase inhibitors in treating early-stage non-small-cell lung cancer have yet to be established. Therefore, we aimed to explore the efficacy and safety of icotinib in completely resected EGFR-mutant stage II-IIIA lung adenocarcinoma patients who underwent standard chemotherapy. This is ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4633-4643]

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Regulation of Autophagy by Non-Steroidal Anti-Inflammatory Drugs in Cancer.

Xiangjie Fu, Tan Tan, Peijun Liu,

Cancer is the leading cause of death, placing a substantial global health burden. The development of the most effective treatment regimen is the unmet clinical need for cancer. Inflammation plays a role in tumorigenesis and progression, and anti-inflammation may be a promising option for cancer management and prevention. Emerging studies ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4595-4604]

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CFTR Regulates the Proliferation, Migration and Invasion of Cervical Cancer Cells by Inhibiting the NF-κB Signalling Pathway.

Zhao Wu, Jinke Li, Yi Zhang, Lina Hu, Xue Peng,

Background:The cystic fibrosis transmembrane conductance regulator (CFTR) and nuclear factor κB (NF-κB) signalling pathways are currently regarded as co-regulators of the occurrence of cervical cancer. However, the detailed mechanism of CFTR- and NF-κB-mediated effects in cervical cancer remains to be elucidated. This study aimed to investigate the mechanism by which ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:4685-4697]

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