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Journal Cancer Cell Int

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Addition of chemoradiotherapy to palliative chemotherapy in de novo metastatic nasopharyngeal carcinoma: a real-world study.

Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia,

<h4>Background</h4>To determine whether concurrent chemotherapy is necessary during locoregional radiotherapy (RT) after palliative chemotherapy (PCT) in patients with de novo metastatic nasopharyngeal carcinoma (mNPC).<h4>Methods</h4>A total of 746 patients with mNPC from 2000 to 2017 at our hospital were retrospectively reviewed. Among them, 355 patients received PCT followed by RT. Overall ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):36]

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Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression.

Jiaan Xu, Xiujuan Xiao, Bo Yan, Qiang Yuan, Xiaoqiao Dong, Quan Du, Jin Zhang, Letian Shan, Zhishan Ding, Li Zhou, Thomas Efferth,

<h4>Background</h4>Theabrownin (TB) is a bioactive component of tea and has been reported to exert effects against many human cancers, but its efficacy and mechanism on hepatocellular carcinoma (HCC) with different p53 genotypes remains unclarified.<h4>Methods</h4>MTT assay, DAPI staining, flow cytometry and SA-β-gal staining were applied to evaluate the effects of TB ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):39]

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A novel prognostic model based on single-cell RNA sequencing data for hepatocellular carcinoma.

Juan Lu, Yanfei Chen, Xiaoqian Zhang, Jing Guo, Kaijin Xu, Lanjuan Li,

<h4>Background</h4>The tumour heterogeneous make-up of immune cell infiltrates is a key factor for the therapy response and prognosis of hepatocellular carcinoma (HCC). However, it is still a major challenge to comprehensively understand the tumour immune microenvironment (TIME) at the genetic and cellular levels.<h4>Methods</h4>HCC single-cell RNA sequencing (scRNA-seq) data were downloaded ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):38]

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Retraction Note to: Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells.

Shiwei Liu, Jingchao Li, Liang Kang, Yueyang Tian, Yuan Xue,

Cancer Cell Int (Cancer cell international)
[2022, 22(1):37]

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Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p.

Ying Gao, Zheng Yin, Yunling Qi, Hong Peng, Wenbin Ma, Ruizhi Wang, Wen Li,

<h4>Background</h4>Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role in the cancer-associated intercellular signaling communication has not yet been explored. This study aimed at exploring whether GOLPH3 regulates angiogenesis and sorafenib resistance via exosomal mechanisms in hepatocellular carcinoma (HCC).<h4>Methods</h4>In vivo ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):35]

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Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.

Chaojian Xu, Ziyue Wang, Long Zhang, Yi Feng, Jia Lv, Zhuangzhuang Wu, Rong Yang, Taiyong Wu, Jian Li, Ruhao Zhou, Zhi Tian, Junjun Bai, Huadong Zhang, Yanping Lan, Zhi Lv,

<h4>Background</h4>Silencing of the periostin gene (POSTN) can inhibit the biological process of several different cancers, and this inhibition may be related to down-regulation of PI3K/AKT signaling. However, the effect of POSTN on the progression, proliferation, and invasion of osteosarcoma (OS) remain unclear.<h4>Methods</h4>We used the Gene Expression Omnibus (GEO) database to ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):34]

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Construction of a risk prediction model using m6A RNA methylation regulators in prostate cancer: comprehensive bioinformatic analysis and histological validation.

Yongjun Quan, Xiaodong Zhang, Hao Ping,

<h4>Background</h4>Epigenetic reprogramming reportedly has a crucial role in prostate cancer (PCa) progression. RNA modification is a hot topic in epigenetics, and N6-methyladenosine (m6A) accounts for approximately 60% of RNA chemical modifications. The aim of this study was to evaluate the m6A modification patterns in PCa patients and construct a risk ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):33]

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4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Wei Li, Bai-Sheng Huang, Yuan-Yuan Xiong, Li-Jian Yang, Li-Xiang Wu,

<h4>Background</h4>Glioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety of tumors. This study explored the therapeutic effect of LSD1 inhibition on glioblastoma cell lines and the possible underlying mechanisms.<h4>Methods</h4>The MTT assay was utilized to screen for the sensitivity ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):32]

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Immune-related lncRNA classification of head and neck squamous cell carcinoma.

Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng, Juan Xia,

<h4>Background</h4>Long noncoding RNAs (lncRNAs) play a critical role in innate and adaptive immune responses. Thus, we aimed to identify ideal subtypes for head and neck squamous cell carcinoma (HNSCC) based on immune-related lncRNAs.<h4>Methods</h4>TCGA HNSCC cohort was divided into two datasets (training and validation dataset), and 960 previously characterized immune-related lncRNAs ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):25]

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MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma.

Zijian Ma, Ganyi Chen, Yiqian Chen, Zizhang Guo, Hao Chai, Yu Tang, Lin Zheng, Ke Wei, Chunfeng Pan, Zhifei Ma, Yang Xia, Aiping Zhang,

<h4>Background</h4>Non-small cell lung cancer (NSCLC) is still one of the diseases with the highest mortality and morbidity, and lung adenocarcinoma (LUAD) accounts for more than half of all NSCLC cases in most countries. miRNA can be used as a potential biological marker and treatment for lung adenocarcinoma. However, the effect ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):31]

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The functions and prognostic value of Krüppel-like factors in breast cancer.

Ke-Yun Zhu, Yao Tian, Ying-Xi Li, Qing-Xiang Meng, Jie Ge, Xu-Chen Cao, Ti Zhang, Yue Yu,

<h4>Background</h4>Krüppel-like factors (KLFs) are zinc finger proteins which participate in transcriptional gene regulation. Although increasing evidence indicate that KLFs are involved in carcinogenesis and progression, its clinical significance and biological function in breast cancer are still limited.<h4>Methods</h4>We investigated all the expression of KLFs (KLF1-18) at transcriptional levels by using Oncomine ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):23]

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Application of artificial intelligence in a real-world research for predicting the risk of liver metastasis in T1 colorectal cancer.

Tenghui Han, Jun Zhu, Xiaoping Chen, Rujie Chen, Yu Jiang, Shuai Wang, Dong Xu, Gang Shen, Jianyong Zheng, Chunsheng Xu,

<h4>Background</h4>Liver is the most common metastatic site of colorectal cancer (CRC) and liver metastasis (LM) determines subsequent treatment as well as prognosis of patients, especially in T1 patients. T1 CRC patients with LM are recommended to adopt surgery and systematic treatments rather than endoscopic therapy alone. Nevertheless, there is still ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):28]

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Correction to: NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.

Shu Liu, Yewei Zhang, Shien Cui, Dajiang Song, Bo Li, Qian Chen, Guangyu Yao, Bin Gong,

Cancer Cell Int (Cancer cell international)
[2022, 22(1):26]

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Development and validation of a novel 3-gene prognostic model for pancreatic adenocarcinoma based on ferroptosis-related genes.

Jihua Yang, XiaoHong Wei, Fang Hu, Wei Dong, Liao Sun,

<h4>Background</h4>Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma (PAAD) patients. Analysis of the ferroptosis-related genes may provide novel potential targets for the prognosis and treatment of PAAD.<h4>Methods</h4>RNA-sequence and clinical data of PAAD was downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):21]

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SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma.

Xin Zhang, Hongwei Zhang, Zhibin Liao, Jiacheng Zhang, Huifang Liang, Weixing Wang, Jia Yu, Keshuai Dong,

<h4>Background</h4>The Src homology and collagen 4 (SHC4) is an important intracellular adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma. However, the biological function and detailed mechanisms of SHC4 in hepatocellular carcinoma progression are unclear. This study aimed to evaluate the potential prognostic and ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):24]

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The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis.

Baibei Li, Huachu Deng, Ziyan Zhou, Bo Tang,

<h4>Background</h4>In recent years, the Fibrinogen to pre-albumin ratio (FPR) has been reported in many studies to be significantly associated with the prognosis of various cancers. This systematic review and meta-analysis aimed to investigate the prognostic value of FPR in malignant tumors of the digestive system based on available evidence.<h4>Methods</h4>The relevant ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):22]

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Correction to: Attenuated expression of SNF5 facilitates progression of bladder cancer via STAT3 activation.

Hua Ding, Yaqin Huang, Jiazhong Shi, Liwei Wang, Sha Liu, Baixiong Zhao, Yuting Liu, Jin Yang, Zhiwen Chen,

Cancer Cell Int (Cancer cell international)
[2022, 22(1):20]

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LncRNA TP73-AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes.

Hongchao Yao, Linli Tian, Bingrui Yan, Like Yang, Yushan Li,

<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellular communication. Thus, the aim of this study was to identify the functional lncRNAs in NPC and its relevant mechanisms.<h4>Methods</h4>Data from public ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):16]

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miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy.

Yang Zhou, Chunyan Wang, Jinye Ding, Yingying Chen, Yaoqi Sun, Zhongping Cheng,

<h4>Background</h4>Accumulating evidence has revealed that aberrant microRNA (miRNA) expression can affect the development of chemotherapy drug resistance by modulating the expression of relevant target proteins. Emerging evidence has demonstrated that miR-133a participates in the tumorigenesis of various cancers. However, whether miR-133a is associated with cisplatin resistance in ovarian cancer remains ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):15]

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Identification and validation of the high expression of pseudogene TCAM1P in cervical cancer via integrated bioinformatics analysis.

Yuanhang Zhu, Chenchen Ren, Li Yang, Zhenan Zhang, Meiyuan Gong, Kebing Chen,

<h4>Background</h4>HPV as the main cause of cervical cancer has long been revealed, but the detailed mechanism has not yet been elucidated. The role of testis/cancer antigen in cervical cancer has been revealed. However, there are no reports about the statement of testis/cancer-specific non-coding RNA. In this study, we first proposed ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):17]

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PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A-mediated cell cycle progression.

Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin,

<h4>Background</h4>The roles of Polypyrimidine tract-binding protein 3 (PTBP3) in regulating lung squamous cell carcinoma (LUSC) cells progression is unclear. The aim of this study was to investigate the role of PTBP3 in LUSC.<h4>Methods</h4>Expression and survival analysis of PTBP3 was firstly investigated using TCGA datasets. Quantitative reverse transcription PCR and Western ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):19]

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Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.

Wang Zhi, Suting Li, Yuting Wan, Fuwen Wu, Li Hong,

<h4>Background</h4>Short-term starvation (STS) has gradually been confirmed as a treatment method that synergistically enhances the effect of chemotherapy on malignant tumours. In clinical applications, there are still some limitations of poly (ADP-ribose) polymerase inhibitors (PARPi), including understanding their effectiveness and side effects. Here, we sought to investigate the effect and ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):18]

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METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification.

Yiming Xu, Dandan Lv, Chao Yan, Hua Su, Xue Zhang, Yangfeng Shi, Kejing Ying,

<h4>Background</h4>N6-methyladenosine (m<sup>6</sup>A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear. Here, we explored the biological function and underlying mechanism of methyltransferase-like 3 (METTL3), the main catalyst of m<sup>6</sup>A, in LUAD progression.<h4>Methods</h4>The expression of m<sup>6</sup>A, METTL3, YTHDF1 and ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):11]

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Induction and application of ferroptosis in cancer therapy.

Qing Nie, Yue Hu, Xiao Yu, Xiao Li, Xuedong Fang,

At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway. In the past few years, ferroptosis has been shown to induce tumor cell death, providing new ideas ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):12]

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Systematic analysis of the role of SLC52A2 in multiple human cancers.

Lilong Zhang, Man Li, Zhoujun Cui, Dongqi Chai, Yongjun Guan, Chen Chen, Weixing Wang,

<h4>Background</h4>In humans, riboflavin must be obtained through intestinal absorption because it cannot be synthesized by the body. SLC52A2 encodes a membrane protein belonging to the riboflavin transporter protein family and is associated with a variety of diseases. Here, we systematically explore its relevance to multiple human tumors.<h4>Methods</h4>We analyzed the association ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):8]

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