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Journal Cancer Biomark

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Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cell.

Ming Ni, Qin Yan, Hui Xue, Yanfang Du, Shuangdan Zhao, Zhiming Zhao,

BACKGROUND:The dysregulation of microRNA-802 (miR-802) has crucial roles in cancer progression. Nevertheless, the bio-function of miR-802 in cervical cancer remains unclear. OBJECTIVE:Hence, we illuminated the potential roles of miR-802 in cervical cancer cell growth, migration, and invasion. METHODS:The levels of miR-802 and myosin regulatory light chain interacting protein (MYLIP) were ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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TRIP13 promotes lung cancer cell growth and metastasis through AKT/mTORC1/c-Myc signaling.

Weiyang Cai, Wei Ni, Yin Jin, Yanyan Li,

BACKGROUNDS:Lung adenocarcinoma (LUAD) is a primary cause of cancer-patient mortality throughout the world. Thyroid hormone receptor interactor 13 (TRIP13) is a gene that expresses a protein involved in cell division, including tumorigenesis. Its expression is high in various human tumors; however, its role in LUAD cells remains undetermined. OBJECTIVE:To investigate ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Bone mesenchymal stem cells derived extracellular vesicles promotes TRAIL-related apoptosis of hepatocellular carcinoma cells via the delivery of microRNA-20a-3p.

Lu Deng, Chang Wang, Chao He, Li Chen,

OBJECTIVE:Bone mesenchymal stem cells (BMSCs) have been widely researched in cancer treatment, including hepatocellular carcinoma (HCC). This study intended to discuss the mechanism of miR-20a-3p in BMSCs-extracellular vesicles (EVs) in HCC apoptosis. METHODS:BMSCs were isolated and identified. EVs derived from BMSCs were extracted and identified. After overexpressing or inhibiting miR-20a-3p ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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New insights to the clinical implication of HOXA5 as prognostic biomarker in patients with colorectal cancer.

Hamza Yaiche, Haifa Tounsi-Kettiti, Nadia Ben Jemii, Amira Jaballah Gabteni, Najla Mezghanni, Monia Ardhaoui, Emna Fehri, Afifa Maaloul, Sonia Abdelhak, Samir Boubaker,

BACKGROUND:Homeobox A5 (HOXA5) is a member of the HOX protein family which is involved in several pathways of carcinogenesis, and is dysregulated in many types of cancers. However, its expression and function in human colorectal cancer (CRC) is still largely unknown. OBJECTIVE:This study, aimed to evaluate HOXA5 expression in Tunisian ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LncRNA HOTAIR promotes breast cancer progression through regulating the miR-129-5p/FZD7 axis.

Dongdi Wu, Jia Zhu, Ying Fu, Chenqin Li, Biao Wu,

Breast cancer is the most common malignancies worldwide. LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to promote progression and metastasis of various cancers, including breast cancer. This reasearch aimed to investigate the downstream regulatory pathways of HOTAIR in breast cancer. The levels of HOTAIR and miR-129-5p were ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Upregulated CNTN1 is associated with lymph node metastasis and poor prognosis of colorectal cancer.

Guangyao Li, Zhengjun Zhang, Guochao Ge, Ke Fang, Jianyu Zhu,

BACKGROUND:Contactin1 (CNTN1), a member of the immunoglobulin superfamily, is known to correlate with tumor development and progression. Although recent studies have found that elevated CNTN1 has been demonstrated in some types of cancers, the expression and prognosis of CNTN1 in colorectal cancer (CRC) are unclear. Here, we aimed to determine ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis.

Daqing Shen, Jing Xu, Xiande Cao, Xianxiang Cao, Hailin Tan, Huanghao Deng,

BACKGROUND:Long noncoding RNA (lncRNA) are critical regulators of tumor progression. OBJECTIVE:To determine how the lncRNA membrane associated guanylate kinase, WW and PDZ domain-containing 2 (MAG12) antisense RNA 3 (MAGI2-AS3) and the phosphatase and tensin homolog (PTEN) gene function in regulating bladder cancer (Bca) progression. METHODS:Total RNA from 80 and 30 ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Mining database for the therapeutic targets and prognostic biomarkers among STAT family in glioblastoma.

Chenglin Li, Yanfei Zhou, Hanshun Deng, Yuanshen Ye, Shuizhen Zhao, Shangnan Liang, Shirong Cai, Jincai Lin, Yaolong Tang, Yanyu Wu,

BACKGROUND:Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor with a high mortality rate. Aberrant activation of signal transducers and activators of transcription (STAT) signaling results in tumor pathogenesis and progression by regulating cell cycle, cell survival and immune response. METHODS:Therapeutic targets and prognostic biomarkers within the ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p/DEK axis.

Dengguo Fan, Changjiang Wang, Deyuan Wang, Ning Zhang, Tao Yi,

BACKGROUND:Circular RNA (circRNA) is a class of non-coding RNA that is vital for regulating gene expression and biological functions. Mounting studies demonstrate that circRNA is crucial for human cancer development. However, the role of circ_0000039 in gastric cancer (GC) remains uncertain. METHODS:Normal human gastric tissues and GC tissue samples were ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Overexpression of FADD and Bcl-XS proteins as novel prognostic biomarkers for surgically resected non-small cell lung cancer.

Lingjiao Chen, Guiyuan Xie, Juan Feng, Qiuyuan Wen, Hongjing Zang, Junmi Lu, Yuting Zhan, Songqing Fan,

BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most widespread cancer with increasing morbidity and mortality. FAS-associated protein with death domain (FADD) is considered as an essential instrument in cell death, whereas Bcl-XS promotes apoptosis through inhibiting the activity of Bcl-2 and Bcl-XL. OBJECTIVE AND METHODS:We detected the expression ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LncRNA-SNHG7 interferes with miR-34a to de-sensitize gastric cancer cells to cisplatin.

Li-Juan Pei, Peng-Jun Sun, Kui Ma, Yan-Yan Guo, Ling-Yan Wang, Fei-De Liu,

Gastric cancer (GC) remains poor prognosis and survival issues due to the resistance of chemotherapies, such as cisplatin. The long non-coding RNA small nucleolar RNA host gene 7 (lncRNA-SNHG7) is known as an oncogenic molecule in diverse cancers. Here, we demonstrate that SNHG7 was significantly upregulated in gastric cancer and ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LncRNA testis-specific transcript, Y-linked 15 (TTTY15) promotes proliferation, migration and invasion of colorectal cancer cells via regulating miR-29a-3p/DVL3 axis.

Xiao-Ying Zheng, Ming-Zheng Cao, Ying Ba, Yue-Feng Li, Jun-Ling Ye,

BACKGROUND:Long non-coding RNA testis-specific transcript, Y-linked 15 (TTTY15) is oncogenic in prostate cancer, however its expression and function in colorectal cancer remain largely unknown. METHODS:Paired colorectal cancer samples/adjacent tissues were collected, and the expression levels of TTTY15, miR-29a-3p and disheveled segment polarity protein 3 (DVL3) were examined by quantitative real-time ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Prognostic value of circulating Bcl-2 and anti-p53 antibodies in patients with breast cancer: A long term follow-up (17.5 years).

Maja Sirotković-Skerlev, Natalija Dedić Plavetić, Filip Sedlić, Sanja Kusačić Kuna, Damir Vrbanec, Borislav Belev, Stjepko Pleština, Zdenko Kovač, Ana Kulić,

BACKGROUND:Apoptosis inhibition is a major tumorigenic factor. Bcl-2 dysregulation and TP53 mutation status, which may correlate with autoantibody generation, contribute to impaired apoptosis. OBJECTIVE:This study aimed to investigate the prognostic value of circulating Bcl-2 and anti-p53 antibodies (p53Abs) in a 17.5-year follow-up of breast cancer patients. We also analyzed the ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.

Qingwen Zeng, Leyan Li, Zongfeng Feng, Lianghua Luo, Jianbo Xiong, Zhigang Jie, Yi Cao, Zhengrong Li,

BACKGROUND:Previous studies have identified LCP1 as a diagnostic and prognostic marker in several cancers. However, the role of LCP1 in gastric cancer (GC) and its effect on tumor immune infiltration remain unclear. OBJECTIVE:The aim was to explore the role of LCP1 in GC and its effect on tumor immune infiltration. ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.

Yaoxiang Tang, Yang Yang, Jiadi Luo, Sile Liu, Yuting Zhan, Hongjing Zang, Hongmei Zheng, Yuting Zhang, Juan Feng, Songqing Fan, Qiuyuan Wen,

BACKGROUND:HSP60 and its partner HSP10 are members of heat shock proteins (HSPs) family, which help mitochondrial protein to fold correctly. Mcl-1 a member of the Bcl-2 family, plays a crucial role in regulation of cell apoptosis. Aberrant expression of HSP10 HSP60 and Mcl-1 is involved in the development of many ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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An integrative pan-cancer analysis of COPB1 based on data mining.

Heyan Chen, Kunlong Li, Yijun Li, Peilin Xie, Jianjun He, Huimin Zhang,

BACKGROUND:Cancer will become the leading cause of death worldwide in the 21st century, meanwhile, immunotherapy is the most popular cancer treatment methods in recent years. COPI Coat Complex Subunit Beta 1 (COPB1) relates to human innate immunity. However, the role of COPB1 in pan-cancer remains unclear. OBJECTIVE:The purpose of this ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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First evaluation of Neighbor of Punc E11 (NOPE) as a novel marker in human hepatocellular carcinoma.

Susanne Zweerink, Senait Mesghenna, Vera Mueck, Sigrid Schulte, Fabian Kuetting, Alexander Quaas, Tobias Goeser, Dirk Nierhoff,

BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide and the search for clinically useful biomarkers is ongoing. Neighbor of Punc E11 (NOPE) is an established biomarker of murine HCC that remains undetectable in normal liver and at preneoplastic stages. OBJECTIVE:The aim of our study was ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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MCM5 urine expression (ADXBLADDER) is a reliable biomarker of high-risk non- muscle-invasive bladder cancer recurrence: A prospective matched case-control study.

Łukasz Białek, Katarzyna Czerwińska, Łukasz Fus, Wojciech Krajewski, Anna Sadowska, Piotr Radziszewski, Jakub Dobruch, Piotr Kryst, Sławomir Poletajew,

BACKGROUND:Mini Chromosome Maintenance 5 (MCM5) is considered as a urinary biomarker of bladder cancer. ADXBLADDER is a commercially available test to detect MCM5 antibodies. OBJECTIVE:External validation of ADXBLADDER test as a urinary biomarker of histopathologically confirmed non-muscle invasive bladder cancer (NMIBC) recurrence. METHODS:The study enrolled 119 consecutive patients with a ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LINC00893 inhibits papillary thyroid cancer by suppressing AKT pathway via stabilizing PTEN.

Shujing Li, Yanyan Zhang, Jian Dong, Ruihuan Li, Bo Yu, Wenjun Zhao, Jing Liu,

Long non-coding RNAs (lncRNAs) are important to the occurrence and advancement of human cancers. We found through GEPIA that LINC00893 was lowly expressed in thyroid carcinoma (THCA) tissues, whereas the specific functions of LINC00893 has never been reported in PTC. In the current study, we confirmed that LINC00893 was expressed ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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LncRNA SNHG17 promotes the progression of oral squamous cell carcinoma by modulating miR-375/PAX6 axis.

Fei Tong, Jun Guo, Zhanqi Miao, Zhihua Li,

BACKGROUND:The prognosis of patients with recurrent and/or metastatic oral squamous cell carcinoma (OSCC) remains poor, and its incidence is especially high in developing countries. Multiple long non-coding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumor suppressors. This study aimed to probe into the role of lncRNA small ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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UNIVmAb reactive albumin associated hyaladherin as a potential biomarker for colorectal cancer.

Srinivasa Prasad Kolapalli, Sunil B Kumaraswamy, Karuna Kumar Martha, Anil Thomas, Shib Das Banerjee,

Colorectal cancer (CRC) is the third most common cancer; cancer biomarker discovery is important for disease detection and management. It is known that hyaluronic acid and its receptors are ubiquitously expressed in almost all human tissues. Earlier we have shown that a monoclonal antibody H11B2C2, presently known as UNIVmAb, reactive ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling.

Yuwen Ning, Zhengfa Bai,

Osteosarcoma (OS) is one of the most primary bone malignancies, often occurring in adolescents or children. Numerous scientific findings have introduced that long noncoding RNAs (lncRNAs) can be involved in tumor occurrence and development. Although DSCAM-AS1 has been studied in several cancers, its role and mechanism in OS are poorly ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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MicroRNA profiling in serum: Potential signatures for breast cancer diagnosis.

Xuan Zou, Tiansong Xia, Minghui Li, Tongshan Wang, Ping Liu, Xin Zhou, Zebo Huang, Wei Zhu,

BACKGROUND:Circulating microRNAs (miRNAs) prove to be potential non-invasive indicators of cancers. The purpose of this study is to profile serum miRNA expression in breast cancer (BC) patients to find potential biomarkers for BC diagnosis. METHODS:The miRNA expression patterns of serum samples from 216 BC patients and 214 normal control subjects ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

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Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.

Iulia V Iancu, Anca Botezatu, Adriana Plesa, Irina Huica, Alina Fudulu, Adrian Albulescu, Marinela Bostan, Mirela Mihaila, Camelia Grancea, Dana Alice Manda, Ruxandra Dobrescu, Susana Vilma Vladoiu, Gabriela Anton, Corin Virgil Badiu,

PURPOSE:DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local DNA methylation status and to establish the levels of important DNA methylation regulators (TET family and DNMT1) in thyroid tumours: follicular adenoma-FA, papillary thyroid carcinoma-PTC (classic papillary ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, 28(2):255-268]

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Prognostic value of miR-892a in gastric cancer and its regulatory effect on tumor progression.

Jingjing Lv, Haitao Zhang, Zhimei Gao, Xinyan Zhang, Xin Huang, Xiaojuan Jia,

BACKGROUND:Gastric cancer is a prevalent malignant around the world. Aberrantly expression of microRNAs (miRNAs) contributes to the progression of tumors. The aim of this study was to investigate the expression and role of miR-892a in gastric cancer. METHODS:A total of 119 gastric cancer patients were enrolled in this study. And ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, 28(2):247-254]

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