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Journal Brachytherapy

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Complications of intracavitary brachytherapy for gynecologic cancers and their management: A comprehensive review.

Scott M Glaser, Pranshu Mohindra, Umesh Mahantshetty, Sushil Beriwal,

Intracavitary gynecologic brachytherapy in the form of tandem-based brachytherapy and vaginal cylinder-based brachytherapy represents a fundamental component of the treatment of women with cervical or uterine cancer due to the ability to deliver a therapeutic dose of radiation with sharp dose falloff. This results in highly effective treatment in terms ... Read more >>

Brachytherapy (Brachytherapy)
[2021, :]

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HDR brachytherapy as monotherapy for prostate cancer: A systematic review with meta-analysis.

Gustavo Arruda Viani, Caio Viani Arruda, Antonio Cassio Assis Pellizzon, Ligia Issa De Fendi,

<h4>Purpose</h4>The effectiveness and safety of high dose brachytherapy as monotherapy (HDR-BRT-M) in prostate cancer is limited to retrospective studies. We performed a meta-analysis to summarize existing data and identify trends in biochemical recurrence-free survival (bRFS) and toxicity after HDR-BRT-M in patients with prostate cancer.<h4>Methods and materials</h4>Retrospective, prospective, or randomized clinical ... Read more >>

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[2021, :]

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Automatic optimization of treatment dosimetry to improve visual outcomes in episcleral plaque brachytherapy.

Gawon Han, Matthew Larocque, Ezekiel Weis, Geetha Menon,

<h4>Purpose</h4>The aim of this study was to develop an automated dose optimization algorithm, powered by simulated annealing, for inverse planning of ocular plaque brachytherapy treatments, to improve tumor coverage and critical structure sparing for reduced treatment-related morbidity.<h4>Methods and materials</h4>A simulated annealing based algorithm was built and evaluated by finding variable ... Read more >>

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[2021, :]

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HDR brachytherapy boost using MR-only workflow for intermediate- and high-risk prostate cancer: 8-year results of a pilot study.

Ferenc Lakosi, Gergely Antal, Janos Pall, Andrea Farkas, Tibor Jenei, Denes Nagy, Jozsef Liptak, Istvan Sipocz, Akos Pytel, Melinda Csima, Akos Gulyban, Gabor Toller,

<h4>Purpose</h4>To report 8-year clinical outcome with high-dose-rate brachytherapy (HDRBT) boost using MRI-only workflow for intermediate (IR) and high-risk (HR) prostate cancer (PC) patients.<h4>Methods and materials</h4>Fifty-two patients were treated with 46-60 Gy of 3D conformal radiotherapy preceded and/or followed by a single dose of 8-10 Gy MRI-guided HDRBT. Interventions were performed in a ... Read more >>

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[2021, :]

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Letter to the editor regarding "125I seed implantation for hepatocellular carcinoma with portal vein tumor thrombus: A systematic review and metaanalysis".

Yingxing Guo, Ting Li, Jingxin Yan,

Brachytherapy (Brachytherapy)
[2020, :]

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Review of brachytherapy complications - Upper gastrointestinal tract.

Michael R Folkert, Sujana Gottumukkala, Nhu Tram Nguyen, Amandeep Taggar, Ranjan Kumar Sur,

While brachytherapy applications are not widely used for cancer diagnoses in the upper GI tract (including the esophagus, liver, stomach, and pancreas), they have a clear role in palliation and symptom management and occasionally definitive locoregional treatment. With the increasing use of image-guided techniques, the incidence of side effects and ... Read more >>

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[2020, :]

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Breast brachytherapy.

Vratislav Strnad, Catheryn Yashar,

Accelerated partial breast irradiation with brachytherapy is a treatment method with a very low risk profile. In fact, accelerated partial breast irradiation brachytherapy has been proven in randomized trials to have fewer late side effects than whole-breast irradiation. Notably, Grade 3 late side effects are extremely rare, and excellent to ... Read more >>

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[2020, :]

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A dosimetric and centeredness comparison of the conventional and novel endobronchial applicators: A preliminary study.

Kotaro Iijima, Naoya Murakami, Hiroyuki Okamoto, Satoshi Nakamura, Shie Nishioka, Takahito Chiba, Junichi Kuwahara, Hiroki Nakayama, Mihiro Takemori, Ako Aikawa, Shibata Yoshihiro, Tairo Kashihara, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuko Nakayama, Jun Itami,

<h4>Purpose</h4>This study compared the applicator position relative to the tracheal wall and dosimetric parameters between conventional and novel applicators among patients receiving endobronchial brachytherapy (EBBT) for intratracheal tumors.<h4>Methods and materials</h4>Data from 7 patients who received EBBT for intratracheal tumors were retrospectively analyzed; 4 and 3 patients were treated with conventional ... Read more >>

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[2020, :]

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Brachytherapy for lung cancer.

Bin Qiu, Ping Jiang, Zhe Ji, Xiaodong Huo, Haitao Sun, Junjie Wang,

Brachytherapy (BT) is a minimally invasive anticancer radiotherapeutic modality where the tumor is directly irradiated via a radioactive source that is precisely implanted in or adjacent to the tumor. BT for lung cancer may be conducted in the form of endobronchial BT and radioactive seed implantation (RSI-BT), mainly for nonsmall ... Read more >>

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[2020, :]

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Benchmarking failure mode and effects analysis of electronic brachytherapy with data from incident learning systems.

Jeremy D P Hoisak, Ryan Manger, Irena Dragojević,

<h4>Purpose</h4>Failure modes and effects analysis (FMEA) is a prospective risk assessment tool for identifying failure modes in equipment or processes and informing the design of quality control systems. This work aims to benchmark the performance of FMEAs for electronic brachytherapy (eBT) of the skin and for breast by comparing predicted ... Read more >>

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[2020, :]

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Comparison of TG43 and Hounsfield Unit-based TG186 brachytherapy dose metrics in Oncentra Brachy for 100 patients receiving interstitial partial breast irradiation.

Andrew Howie, Joel Poder, Ryan Brown, Kristine Schreiber, Andrej Bece, Peter Graham, Yaw Sinn Chin,

<h4>Purpose</h4>The aim of the study was to conduct a retrospective analysis of 100 patients who received interstitial accelerated partial breast irradiation at a single institution, comparing the standard American Association of Physicists in Medicine Task Group (TG) 43 dose calculation algorithm to the model-based dose calculation algorithms (MBDCAs) available in ... Read more >>

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[2020, :]

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Do air gaps with image-guided vaginal cuff brachytherapy impact failure rates in patients with high-intermediate risk FIGO Stage I endometrial cancer?

Adam H Richman, Ankur K Patel, Joshua L Rodríguez-López, Andrew Keller, John A Vargo, Hayeon Kim, Paniti Sukumvanich, Jessica L Berger, Michelle M Boisen, Robert Edwards, Sarah E Taylor, Madeleine B Courtney-Brooks, Alexander Olawaiye, Brian C Orr, Jamie L Lesnock, Sushil Beriwal,

<h4>Purpose</h4>The aim of this study was to assess the impact of air gaps at the cylinder surface on the rate of vaginal cuff failure (VCF) after image-guided adjuvant vaginal cuff brachytherapy (VCBT) in the treatment of high-intermediate risk (HIR) FIGO (Fédération Internationale de Gynécologie et d'Obstétrique (International Federation of Gynecology ... Read more >>

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[2020, :]

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Toxicity and outcomes associated with high-dose rate brachytherapy for medically inoperable endometrial cancer.

Alexander Yaney, Erin Healy, Patrick Wald, Meghan Olsen, Xueliang Pan, Douglas Martin, Allison Quick,

<h4>Purpose</h4>To evaluate toxicity in inoperable endometrial cancer (EC) treated with definitive radiation therapy (RT).<h4>Materials and methods</h4>Patients treated with definitive RT for EC were retrospectively reviewed. EQD2 values were calculated for bladder, rectum, and sigmoid. Acute and late toxicities were retrospectively graded. Descriptive statistical analysis was performed.<h4>Results</h4>Fifty-one patients were included. The ... Read more >>

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[2020, :]

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Management of ductal carcinoma in situ with accelerated partial breast irradiation brachytherapy: Implications for guideline expansion.

Matthew N Mills, Nicholas W Russo, Ronica H Nanda, Jason P Wilson, Taghrid A Altoos, Debra L Caldwell, Lisa L Stout, Scott Dube, Peter W Blumencranz, Kathleen G Allen, Roberto Diaz,

<h4>Purpose</h4>Accelerated partial breast irradiation (APBI) for patients with ductal carcinoma in situ (DCIS) is controversial, and the suitability criteria from the American Brachytherapy Society (ABS), American Society of Therapeutic Radiology and Oncology (ASTRO), and the European Society for Radiotherapy and Oncology (GEC-ESTRO) have important differences.<h4>Methods and materials</h4>This is a single-institution ... Read more >>

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[2020, :]

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Surgery combined with iodine-125 interstitial brachytherapy for treatment of parotid adenoid cystic carcinoma: A single-institution experience.

Ya Gao, Lei Zheng, Jian-Guo Zhang, Shu-Ming Liu, Jian-Yun Zhang, Shuang Dong,

<h4>Purpose</h4>The purpose of this study was to analyze the effectiveness and safety of the combination of surgery plus postoperative iodine-125 interstitial brachytherapy for treatment of adenoid cystic carcinoma (ACC) of the parotid.<h4>Methods and materials</h4>This study included a retrospective analysis of the data of patients who underwent postoperative iodine-125 interstitial brachytherapy ... Read more >>

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[2020, :]

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An iodine-125 seed strand combined with a metal stent versus a metal stent alone for obstructive jaundice caused by pancreatic ductal adenocarcinoma.

Junhao Li, Tianzhu Yu, Li Zhang, Minjie Yang, Shanshan Gao, Ning Pu, Changyu Li, Chenggang Wang, Gaoquan Gong, Jiemin Cheng, Liangwen Wang, Guoping Li, Xiaolin Wang, Yi Chen,

<h4>Purpose</h4>The purpose of this study was to assess the efficacy of an iodine-125 (<sup>125</sup>I) seed strand combined with a metal stent compared with a metal stent for treatment of obstructive jaundice caused by pancreatic ductal adenocarcinoma (PDAC).<h4>Methods and materials</h4>A retrospective analysis was carried out of patients who were referred to ... Read more >>

Brachytherapy (Brachytherapy)
[2020, :]

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A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review.

Raquel Dávila Fajardo, Bradley R Pieters, Jim C H Wilde, Hugo A Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M C Mavinkurve-Groothuis, Anne Smets, Petra S Kroon, An Van Damme, Kees P van de Ven, Ronald R de Krijger, Marc R Lilien, Marc H Wijnen, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Purpose</h4>To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.<h4>Results (methods and case description)</h4>Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and ... Read more >>

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[2020, :]

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Dosimetric consequences of seed placement accuracy in permanent breast seed implant brachytherapy.

Alexandra Guebert, Michael Roumeliotis, Elizabeth Watt, Tyler Meyer, Sarah Quirk,

<h4>Purpose</h4>This study quantifies the dosimetric impact of implant accuracy and derives a quantitative relationship relating implant accuracy to target dosimetry.<h4>Methods and materials</h4>A framework was developed to simulate multiple implants for error combinations. Spherical clinical target volumes (CTVs) were modeled with volumes 1.4 cm<sup>3</sup>, 9.2 cm<sup>3</sup>, and 20.6 cm<sup>3</sup>, representing the range seen clinically. ... Read more >>

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[2020, :]

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Brachytherapy-based radiotherapy is associated with improved survival for newly diagnosed metastatic cervical cancer.

Lin Ding, Zhuofei Bi, Zihao Pan, Xiaoli Yu, Xiaohui Zhao, Shoumin Bai, Herui Yao, Yimin Liu,

<h4>Purpose</h4>The purpose of this study was to explore the value of brachytherapy (BT) in metastatic cervical cancer, as it has not been well evaluated before.<h4>Methods and materials</h4>We analyzed 2391 patients with Stage IVB cervical cancer from 2004 to 2015 by using data from the Surveillance, Epidemiology, and End Results registry. ... Read more >>

Brachytherapy (Brachytherapy)
[2020, :]

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Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy.

Emily Draeger, Daniel W Pinkham, Zhe Jay Chen, Christopher J Tien,

<h4>Purpose</h4>Multiple dwell positions ("multidwell") within a Leipzig-style applicator can be used to increase dose uniformity and treatment area. Model-based dose calculation algorithms (MBDCAs) are necessary for accurate calculations involving these applicators because of their nonwater equivalency and complex geometry. The purpose of this work was to create template plans from ... Read more >>

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[2020, :]

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Mammographically guided noninvasive breast brachytherapy: Preoperative partial breast radiotherapy markedly improves targeting accuracy and decreases irradiated volume.

Kara L Leonard, David E Wazer, Matthew Listo, Jaroslaw T Hepel,

<h4>Purpose</h4>Mammographically based noninvasive image-guided breast brachytherapy (NIBB) partial breast irradiation (PBI) is ideally suited for preoperative treatment. We hypothesize that delivering NIBB PBI to the preoperative tumor volume compared with the postoperative lumpectomy bed would simplify target identification and allow for a reduction in irradiated volume along each orthogonal axis.<h4>Methods ... Read more >>

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[2020, :]

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An in silico study on the effect of host tissue at brachytherapy dose enhancement by gold nanoparticles.

Samaneh Hashemi, Seyed Mahmoud Reza Aghamiri, Ramin Jaberi, Zahra Siavashpour,

<h4>Purpose</h4>Iridium-192 brachytherapy dose enhancement by gold nanoparticles was investigated in five different tumor tissues to observe the tissue-related differences as an effective environmental factor in the applications of nanoparticles as radio-enhancer agents.<h4>Methods and materials</h4>The brachytherapy high-dose-rate source of BEBIG Ir-192, a tumor volume with five different tissues including water, Plexiglas, ... Read more >>

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[2020, :]

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A comparison of treatment planning techniques for low-dose-rate (LDR) prostate brachytherapy.

David Connolly, Gordon Sands, Helen Winter, Mark J Foley, Christoph Kleefeld,

<h4>Purpose</h4>The purpose of this study was to compare low-dose-rate prostate brachytherapy treatment plans created using three retrospectively applied planning techniques with plans delivered to patients.<h4>Methods and materials</h4>Treatment plans were created retrospectively on transrectal ultrasound (TRUS) scans for 26 patients. The technique dubbed 4D Brachytherapy was applied, using TRUS and MRI ... Read more >>

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[2020, :]

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Risk factors for urethral stricture following external beam radiotherapy and HDR brachytherapy for prostate cancer.

Nicki Groom, Yatman Tsang, Gerry Lowe, Peter Hoskin,

<h4>Purpose</h4>A potential late side effect of high-dose-rate (HDR) prostate brachytherapy combined with external beam radiotherapy (EBRT) is urethral stricture. The purpose of this study was to evaluate dosimetric parameters possibly contributing to stricture development, including dose to bladder base and D2cc(Gy) within 10 mm of prostatic urethra (D2cc <sub>10 mm</sub>), which has, ... Read more >>

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[2020, :]

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Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors.

Örs Ferenczi, Tibor Major, Hironori Akiyama, Georgina Fröhlich, Ferenc Oberna, Mónika Révész, Márton Poósz, Csaba Polgár, Zoltán Takácsi-Nagy,

<h4>Purpose</h4>The purpose of this study was to describe the results of postoperative sole interstitial brachytherapy (BT) in patients with resectable floor of mouth tumors.<h4>Methods and materials</h4>Between January 1998 and December 2017, 44 patients with squamous cell histology, stage T1-3N0-1M0 floor of mouth tumor were treated by excision of the primary ... Read more >>

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[2020, :]

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