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Journal Br J Haematol

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CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.

Stephen Fitter, Alanah L Bradey, Chung Hoow Kok, Jacqueline E Noll, Vicki J Wilczek, Nicola C Venn, Tamara Law, Sakrapee Paisitkriangkrai, Colin Story, Lynda Saunders, Luciano Dalla Pozza, Glenn M Marshall, Deborah L White, Rosemary Sutton, Andrew C W Zannettino, Tamas Revesz,

Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machine-learning approach to identify B-ALL blast-secreted factors that are associated with poor survival outcomes. Using this approach, we ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Conditioning intensity before allogeneic haematopoietic stem cell transplantation: a quality control audit.

Alois Gratwohl, Jakob Passweg, Helen Baldomero, Kim Orchard, Nicolaus Kröger, John A Snowden, ,

Br J Haematol (British journal of haematology)
[2021, :]

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Correspondence in reference to the previously published Epub manuscript: "Peter Hokland, et al. How I treat advanced Hodgkin lymphoma - a global view. British Journal of Haematology 2020; 190: 837-850." - RESPONSE.

Judith Trotman, Peter Hokland,

Br J Haematol (British journal of haematology)
[2021, :]

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MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study.

Andrés J M Ferreri, Teresa Calimeri, Paolo Lopedote, Ilaria Francaviglia, Rita Daverio, Chiara Iacona, Cristina Belloni, Sara Steffanoni, Alessandro Gulino, Elena Anghileri, Angelo Diffidenti, Annamaria Finardi, Filippo Gagliardi, Nicoletta Anzalone, Alessandro Nonis, Roberto Furlan, Daniela De Lorenzo, Maria R Terreni, Vittorio Martinelli, Marianna Sassone, Marco Foppoli, Piera Angelillo, Elena Guggiari, Andrea Falini, Pietro Mortini, Massimo Filippi, Vittoria Tarantino, Marica Eoli, Fabio Ciceri, Claudio Doglioni, Claudio Tripodo, Massimo Locatelli, Maria Giulia Cangi, Maurilio Ponzoni,

Reliable biomarkers are needed to avoid diagnostic delay and its devastating effects in patients with primary central nervous system (CNS) lymphoma (PCNSL). We analysed the discriminating sensitivity and specificity of myeloid differentiation primary response (88) (MYD88) L265P mutation (mut-MYD88) and interleukin-10 (IL-10) in cerebrospinal fluid (CSF) of both patients with ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Limited-stage diffuse large B-cell lymphoma: current management and challenges.

Xiao-Yin Zhang, Graham P Collins, David J Cutter, Toby A Eyre,

Twenty-five to thirty per cent of diffuse large B-cell lymphoma (DLBCL) presents as limited stage (I-II). Prognosis is generally excellent with four to six cycles of R-CHOP alone (rituximab, cyclophosphamide, vincristine, doxorubicin, prednisolone) or combined-modality therapy with three or four cycles and involved-site radiotherapy (RT). There is growing interest in ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Cancer is not a single disease: is it safe to extrapolate evidence from trials of direct oral anticoagulants in cancer-associated venous thromboembolism to patients with haematological malignancies?

Richard J Buka, Deepak Chandra, David J Sutton,

Br J Haematol (British journal of haematology)
[2021, :]

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Phase I study of F16IL2 antibody-cytokine fusion with very low-dose araC in acute myeloid leukaemia relapse after allogeneic stem cell transplantation.

Christoph Schliemann, Torsten Kessler, Andrew F Berdel, Teresa Hemmerle, Linus Angenendt, Bianca Altvater, Claudia Rossig, Jan-Henrik Mikesch, Georg Lenz, Michael Schäfers, Dario Neri, Matthias Stelljes, Wolfgang E Berdel,

Br J Haematol (British journal of haematology)
[2021, :]

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Low-dose fludarabine and cyclophosphamide combined with rituximab in the first-line treatment of elderly/comorbid patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL): long-term results of project Q-lite by the Czech CLL Study Group.

Lukáš Smolej, Yvona Brychtová, Eduard Cmunt, Michael Doubek, Martin Špaček, David Belada, Martin Šimkovič, Lukáš Stejskal, Irena Zygulová, Renata Urbanová, Martin Brejcha, Jana Zuchnická, Heidi Móciková, Tomáš Kozák, ,

Therapeutic options used to be very limited for treatment-naïve elderly/comorbid patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) before the introduction of chemo-immunotherapy. Because dose-reduced fludarabine-based regimens yielded promising results, the Czech CLL Study Group initiated a prospective observational study to assess safety and efficacy of low-dose fludarabine and cyclophosphamide ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Flow cytometric immunophenotypic alterations of persistent clonal haematopoiesis in remission bone marrows of patients with NPM1-mutated acute myeloid leukaemia.

Sanam Loghavi, Courtney D DiNardo, Ken Furudate, Koichi Takahashi, Tomoyuki Tanaka, Nicholas J Short, Tapan Kadia, Marina Konopleva, Rashmi Kanagal-Shamanna, Noushin R Farnoud, Sherry Pierce, Joseph D Khoury, Jeffrey L Jorgensen, Keyur P Patel, Naval Daver, Musa Yilmaz, L Jeffrey Medeiros, Hagop Kantarjian, Farhad Ravandi, Sa A Wang,

Clonal haematopoiesis (CH) in patients with acute myeloid leukaemia (AML) may persist beyond attaining complete remission. From a consecutive cohort of 67 patients with nucleophosmin 1-mutated (NPM1<sup>mut</sup> ) AML, we identified 50 who achieved NPM1<sup>mut</sup> clearance and had parallel multicolour flow cytometry (MFC) and next generation sequencing (NGS). In total, ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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MgSO4 anticoagulant prevents pseudothrombocytopenia by preserving the integrity of the platelet GPIIb-IIIa complex.

Mariangela Scavone, Elena Bossi, Gian M Podda, Marco Cattaneo,

Br J Haematol (British journal of haematology)
[2021, :]

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Extramedullary pericardial haematopoiesis as a presenting feature of chronic myeloid leukaemia.

Louisa Shackleton, Julie McCarthy, Vitaliy Mykytiv,

Br J Haematol (British journal of haematology)
[2021, :]

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Ibrutinib for mantle cell lymphoma at first relapse: a United Kingdom real-world analysis of outcomes in 211 patients.

Rory McCulloch, David Lewis, Nicola Crosbie, Toby A Eyre, Simon Bolam, Anita Arasaretnam, Thomas Creasey, Harshita Goradia, Annabel McMillan, Safia Dawi, Samuel Harrison, Oliver Miles, Andrew Robinson, David Dutton, Matthew R Wilson, Pam McKay, George Follows, Neil Phillips, Russell Patmore, Jonathan Lambert, Mark Bishton, Wendy Osborne, Rosalynd Johnston, Amy A Kirkwood, Simon Rule,

Ibrutinib is an established treatment for relapsed/refractory (R/R) mantle cell lymphoma (MCL) and clinical trial data supports use at second line compared to later relapse. We aimed to investigate outcomes and tolerability for ibrutinib when given second line in a real-world setting. Our multicentre retrospective analysis included 211 R/R MCL ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Soluble PD-L1 is a promising disease biomarker but does not reflect tissue expression in classic Hodgkin lymphoma.

Johanna Veldman, Zainab N D Alsada, Anke van den Berg, Wouter J Plattel, Arjan Diepstra, Lydia Visser,

Individually, tissue and soluble markers involved in the programmed cell death protein 1/programmed death-ligand (PD-1/PD-L) axis have been described as biomarkers with clinical value in classical Hodgkin lymphoma (cHL). In the context of the success of immune checkpoint blockade therapy in cHL, it is interesting to discover whether plasma levels ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Safety and efficacy of obinutuzumab alone or with chemotherapy in previously untreated or relapsed/refractory chronic lymphocytic leukaemia patients: Final analysis of the Phase IIIb GREEN study.

Stephan Stilgenbauer, Francesc Bosch, Osman Ilhan, Jens Kisro, Béatrice Mahé, Eva Mikuskova, Dzhelil Osmanov, Gianluigi Reda, Sue Robinson, Eugen Tausch, Mehmet Turgut, Marcin Wójtowicz, Sebastian Böttcher, Thomas Perretti, Peter Trask, Marlies Van Hoef, Véronique Leblond, Robin Foà,

The manageable toxicity profile of obinutuzumab (GA101; G) alone or with chemotherapy in first-line (1L; fit and non-fit) and relapsed/refractory (R/R) patients with chronic lymphocytic leukaemia (CLL) was established in the primary analysis of the Phase IIIb GREEN trial (Clinicaltrials.gov: NCT01905943). The final analysis (cut-off, 31 January 2019) is reported ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Flow cytometry reveals the nuances of clonal haematopoiesis.

Robert P Hasserjian,

Br J Haematol (British journal of haematology)
[2021, :]

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Eltrombopag second-line therapy in adult patients with primary immune thrombocytopenia in an attempt to achieve sustained remission off-treatment: results of a phase II, multicentre, prospective study.

Elisa Lucchini, Francesca Palandri, Stefano Volpetti, Nicola Vianelli, Giuseppe Auteri, Elena Rossi, Andrea Patriarca, Giuseppe Carli, Wilma Barcellini, Melania Celli, Ugo Consoli, Federica Valeri, Cristina Santoro, Enrico Crea, Marco Vignetti, Francesca Paoloni, Casimiro Luca Gigliotti, Elena Boggio, Umberto Dianzani, Ilaria Giardini, Monica Carpenedo, Francesco Rodeghiero, Renato Fanin, Francesco Zaja, ,

Up to 30% immune thrombocytopenia (ITP) patients achieve a sustained remission off-treatment (SROT) after discontinuation of thrombopoietin receptor agonists (TPO-RAs). Factors predictive of response are lacking. Patients aged ≥18 years with newly diagnosed or persistent ITP were treated with eltrombopag for 24 weeks. Primary end-point was SROT: the proportion of responders that ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Primary plasma cell leukaemia presenting with flower-shaped nuclei.

Carlos De Miguel Sánchez, Diego Robles de Castro, Carlos Pisón Herrero, Ernesto Pérez Persona, Laura Salcedo Cuesta, José M Guinea de Castro,

Br J Haematol (British journal of haematology)
[2021, :]

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Towards ecosystem integration for a better understanding of aggressiveness of B-cell lymphomas.

David Chiron,

Br J Haematol (British journal of haematology)
[2021, :]

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Drop metastases in multiple myeloma.

Rachel Fisken, Arieff Abuhassan, Dean Smith,

Br J Haematol (British journal of haematology)
[2021, :]

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Unusual morphological abnormality of neutrophils in a patient with SARS-CoV-2 infection.

Praveen Sharma, Shano Naseem, Neelam Varma, Pankaj Malhotra,

Br J Haematol (British journal of haematology)
[2021, :]

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Care of haematology patients in an overwhelmed healthcare system.

John Willan, Andrew King, Nicola Bienz, Graham P Collins,

Br J Haematol (British journal of haematology)
[2021, :]

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Genome-wide DNA methylation analysis along the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type.

Rucha Dugge, Rabea Wagener, Peter Mӧller, Thomas F E Barth,

Extra-nodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small-cell morphology (SC-MZBL) and often arises in the background of Helicobacter pylori-induced gastritis. In some cases, a clonal malignant progression to large-cell morphology (LC-MZBL) is observed. Here, ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Prognostic value of minimal residual disease measured by fusion-gene transcript in infants with KMT2A-rearranged acute lymphoblastic leukaemia treated according to the MLL-Baby protocol.

Grigory Tsaur, Alexander Popov, Tatiana Riger, Anatoly Kustanovich, Alexander Solodovnikov, Egor Shorikov, Anna Demina, Tatiana Verzhbitskaya, Olga Streneva, Olga Makarova, Elena Lapotentova, Olga Aleinikova, Natalia Miakova, Elmira Boichenko, Konstantin Kondratchik, Natalia Ponomareva, Alexander Karachunskiy, Alexander Roumiantsev, Larisa Fechina,

The prognostic value of minimal residual disease (MRD) measured by fusion-gene transcript (FGT) detection was investigated in 76 infants (aged ≤1 year) with acute lymphoblastic leukaemia (ALL) with lysine methyltransferase 2A (KMT2A) rearrangements. Either at the end of induction or at later time-points, FGT-MRD-positivity was associated with poor outcome. FGT-MRD-positivity after ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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Atezolizumab-induced pure red cell aplasia.

Rory Bennett, Anna Ruskova,

Br J Haematol (British journal of haematology)
[2021, :]

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Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study.

Caspar da Cunha-Bang, Klaus Rostgaard, Michael A Andersen, Emelie C Rotbain, Kirsten Grønbaek, Henrik Frederiksen, Carsten U Niemann, Henrik Hjalgrim,

Patients with chronic lymphocytic leukaemia (CLL) have an increased risk of new malignancies. However, limited data have been published about the impact of CLL treatment on this risk. Here we followed a Danish population-based cohort of CLL patients for risks of new malignancies. Patients in the Danish CLL registry (2008-2017) ... Read more >>

Br J Haematol (British journal of haematology)
[2021, :]

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