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Bionformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer.

Chenhui Ma, ZeLong Cui, YiChao Wang, Lei Zhang, JunYe Wen, HuaiBin Guo, Na Li, WanXing Zhang,

Pancreatic cancer (PCC) is a common malignant tumor of the digestive system that is resistant to traditional treatments and has an overall 5-year survival rate of less than 7%. Transcriptomics research provides reliable biomarkers for diagnosis, prognosis and clinical precision treatment, as well as the identification of molecular targets for ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? A commentary.

Cihan Bedel, Mustafa Korkut, Hamit Hakan Armağan,

This letter comments the article DOI: https://doi.org/10.17305/bjbms.2019.4445. ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Epigenetically inactivated RASSF1A as a tumor biomarker.

Dora Raos, Monika Ulamec, Ana Katusic Bojanac, Floriana Bulic-Jakus, Davor Jezek, Nino Sincic,

RASSF1A represents one of the eight isoforms of the RASSF1 gene. RASSF1A is a tumor suppressor gene whose inactivation influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated by mutations, loss of heterozygosity and, most commonly, by promoter hypermethylation. As epigenetic inactivation of RASSF1A was detected in various ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Immunohistochemical study of dental pulp cells with 3D collagen type I gel in demineralized dentin tubules in vivo.

Sultan Zeb Khan, Sana Mirza, Samina Karim, Takashi Inoue, Mohammed S Bin-Shuwaish, Laila Al Deeb, Khold Al Ahdal, Rana S Al-Hamdan, Ahmed M Maawadh, Fahim Vohra, Tariq Abduljabbar,

Dental pulp cells (DPCs) represent good candidates for the regeneration of dental tissue. This study aimed to evaluate the growth and differentiation potential of DPCs cultured inside demineralized dentin tubules in vivo. Six green fluorescent protein-transgenic rats (body weight 100 g each) and thirty-two Sprague-Dawley (SD) male rats (body weight ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):438-444]

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DNA methylation of AHCY may increase the risk of ischemic stroke.

Lei Zhao, Xiaosheng Chen, Shengjun Zhou, Zhiqing Lin, Xi Yu, Yi Huang,

Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):471-476]

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Human brucellosis in pregnancy - an overview.

Mile Bosilkovski, Jurica Arapović, Fariba Keramat,

Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):415-422]

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Chronic maxillary sinusitis of dental origin and oroantral fistula: The results of combined surgical approach in an Italian university hospital.

Massimo Galli, Giulia De Soccio, Fabrizio Cialente, Francesca Candelori, Francesca Romana Federici, Massimo Ralli, Marco De Vincentiis, Antonio Minni,

Unilateral chronic maxillary sinusitis is a possible complication of odontogenic disease or dental treatment and is mainly due to the development of an oroantral fistula (OAF). The management of chronic maxillary sinusitis of dental origin (CMSDO) requires a combined treatment via endoscopic sinus surgery (ESS) and intraoral surgical treatment of ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):524-530]

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Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.

Gulmira Kulmambetova, Ivan Shtefanov, Akbota Aitkulova, Meruyert Imanbekova, Aisha Iskakova, Abay Makishev, Yerlan Ramankulov,

The emerging evidence indicates that single nucleotide polymorphisms (SNPs) of the tumor necrosis factor (TNF), interleukin 10 (IL10), tumor protein p53 (TP53), and cluster of differentiation 14 (CD14) genes may determine individual susceptibility to gastric cancer (GC). We aimed to investigate the associations for polymorphisms of the TNF, IL10, TP53, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):539-546]

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Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms.

Davorka Herman Mahečić, Maja Cigrovski Berković, Vanja Zjačić-Rotkvić, Tamara Čačev, Sanja Kapitanović, Monika Ulamec,

Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells and their signal molecules can influence all stages of tumor progression, as well as therapeutic intervention. Proinflammatory cytokines are known triggers of growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we explored ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):445-450]

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Can telomere length predict bone health? A review of current evidence.

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):423-429]

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Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? Author's reply on commentary.

Nuri Kose, Tarık Yıldırım, Fatih Akın, Seda Elçim Yıldırım, Ibrahim Altun,

This letter is answer to the commentary DOI: 10.17305/bjbms.2020.5236. ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Shan Xu, Qianping Shi, Bo Li, Liyuan Han, Guodong Xu, Xiaolin Peng, Hongen Chen, Shuhong Dai, Wancheng Ma, Changyi Wang, Jianping Ma,

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):477-486]

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Upper limb principal arteries variations: A cadaveric study with terminological implication.

Marek Konarik, Vladimir Musil, Vaclav Baca, David Kachlik,

Although the variability of the upper limb arteries is a clinically important problem, the prevalence is varying across the existing studies and classification is rather complicated, not well established and sometimes even unclear for simple and direct understanding and usage. Multiple case reports appearing in the last years apply incorrect, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):502-513]

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Endothelial loss during the surgical procedure in saphenous veins harvested by open and endoscopic techniques in coronary artery bypass surgery.

Aleksandra Milutinović, Ruda Zorc-Pleskovič,

The patency of the vein graft in coronary artery bypass grafting could be dependent on the conventional open (vsO) or endoscopic (vsE) harvesting and on the hypoxic damage of endothelial cells. We aimed to evaluate both surgical techniques according to endothelial loss that occurs in the time between harvesting and ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):451-458]

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Percutaneous coronary intervention assisted by invasive mechanical ventilation and intra-aortic balloon pump for acute myocardial infarction with cardiogenic shock: Retrospective cohort study and meta-analyses.

Yin Liu, Chang-Ping Li, Peng-Ju Lu, Xu-Ying Wang, Jian-Yong Xiao, Ming-Dong Gao, Ji-Xiang Wang, Xiao-Wei Li, Nan Zhang, Chun-Jie Li, Jun Ma, Jing Gao,

There is little evidence to recommend the optimal invasive mechanical ventilation (IMV) modes and ideal positive end-expiratory pressure stress levels for acute myocardial infarction-cardiogenic shock (AMI-CS) patients. The aim of this study was to compare the mortality outcome in patients with AMI-CS who were treated with percutaneous coronary intervention (PCI) ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):514-523]

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Rapid, multimodal, critical care knowledge-sharing platform for COVID-19 pandemics.

Amra Sakusic, Dragana Markotic, Yue Dong, Emir Festic, Vladimir Krajinovic, Zoran Todorovic, Alan Sustic, Natasa Milivojevic, Milka Jandric, Srdjan Gavrilovic, Alexander Niven, Pedja Kovacevic, Ognjen Gajic,

In many areas of the world, critical care providers caring for COVID-19 patients lacked specific knowledge and were exposed to the abundance of new and unfiltered information. With support from the World Health Organization, we created a multimodal tele-education intervention to rapidly share critical care knowledge related to COVID-19 targeting ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China.

Shu-Hua Lu, Zhen-Wen Qian, Pei-Pei Mou, Lian Xie,

Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species over 3 years in two tertiary general hospitals in China. In this retrospective study, a total of 27 Nocardia species were isolated from ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):531-538]

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Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells.

Yong Zhang, Hongxia Cao,

C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the production of atherosclerosis-re-lated factors in cultured human coronary artery endothelial ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):487-494]

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Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Xu Guo, Haozhe Piao, Ye Zhang, Peixin Sun, Bing Yao,

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. In recent years, microRNAs have received considerable attention due to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):459-470]

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SARS-CoV-2 virus outbreak and the emergency public health measures in Bosnia and Herzegovina: January - July, 2020.

Mirsada Hukic, Mirza Ponjavic, Emin Tahirovic, Almir Karabegovic, Elvir Ferhatbegovic, Maja Travar, Fadila Serdarevic,

Between March 5th and July 25th, 2020, the total number of SARS-CoV-2 confirmed cases in Bosnia and Herzegovina (BH) was 10,090, corresponding to a cumulative incidence rate of 285.7/100,000 population. Demographic and clinical information on all the cases along with exposure and contact information were collected using a standardized case ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Tranexamic acid is associated with decreased transfusion, hospital length of stay, and hospital cost in simultaneous bilateral total knee arthroplasty.

Ryan D'Souza, Christopher Duncan, Daniel Whiting, Michael Brown, Matthew Warner, Hugh Smith, Hilal Kremers, Thomas Stewart,

Tranexamic acid (TXA) reduces blood loss and transfusion rates in unilateral total knee arthroplasty (TKA), but there is limited data regarding its efficacy in bilateral TKA. This study reports the impact TXA has on clinical outcomes and hospital cost of care in simultaneous, primary bilateral TKA. The 449 patients were ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans.

Deligonul Adem, Serkan Yazici, Mine Ozsen, Sibel Kahraman Cetintas, Ulviye Yalcinkaya, Ahmet Bilgehan Şahin, Ozgur Tanrıverdi, Sibel Oyucu Orhan, Birol Ocak, Erdem Cubukcu, Ramazan Kahveci, Turkkan Evrensel,

Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Because morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis.

Xu Feng, En-Shi Xu,

Most advanced non-small cell lung cancer (NSCLC) patients are accompanied by brain metastasis which is the major cause of increased mortality. The fusion rearrangement of anaplastic lymphoma kinase (ALK) gene is an important feature of brain metastasis in lung cancer. The novel ALK inhibitors alectinib and lorlatinib are shown to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Microsurgical resection of giant T11/T12 conus cauda equina schwannoma.

Alisa Arnautovic, Mirza Pojskic, Kenan Arnautovic,

In this video, we highlight the anatomy involved with microsurgical resection of a giant T11/T12 conus cauda equina schwannoma. Spinal schwannoma remains the third most common intradural spinal tumor. Tumors undergoing gross total resection usually do not recur. To our knowledge, this is the first video case report of giant ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Kawasaki-like disease and acute myocarditis in the SARS-CoV-2 pandemic - reports of three adolescents.

Stasa Krasic, Sergej Prijic, Predrag Minic, Gordana Petrovic, Dejan Nesic, Aleksandra Paripovic, Milena Vasiljevic, Borko Gobeljic, Vladislav Vukomanovic,

The novel coronavirus disease (COVID-19) may induce multisystem inflammatory syndrome in children, which may be associated with Kawasaki-like disease, and cardiac injury. In this study, we presented three male adolescents with multisystem inflammatory syndrome and myocardial injury admitted to the hospital during the peak of COVID-19 pandemic. All of the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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