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SARS-CoV-2 infection: Understanding the immune system abnormalities to get an adequate diagnosis.

Karen Medina-Quero, Omar Barreto-Rodriguez, Voltaire Mendez-Rodriguez, Anahí Sanchez-Moncivais, Ivette Buendia-Roldan, Leslie Chavez-Galan,

COVID-19 is the current pandemic caused by the novel coronavirus, SARS-CoV-2, that emerged from China at the end of December 2019. The scientific community is making extraordinary efforts to understand the virus structure and the pathophysiology and immunological processes activated in the host, in order to identify biomarkers, diagnostic tools, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study.

Yunting Cai, Yan Xie, Yanli Xiong, Wei Guan, Yu Pu, Dong Wang, Mingfang Xu, Shenglan Meng,

Lung signet ring cell carcinoma (LSRCC) is a very rare type of lung cancer, the clinical characteristics, and prognosis of which remain to be clarified. In order to explore the clinicopathological and survival-related factors associated with LSRCC, we performed a large population-based cohort analysis of data included in the Surveillance, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Predictive performance of CT for adverse outcomes among COVID-19 suspected patients: a two-center retrospective study.

Begümhan Baysal, Mahmut Bilal Dogan, Mutlu Gulbay, Mine Sorkun, Murathan Koksal, Aliye Bastug, Sumeyye Kazancioglu, Bahadir Orkun Ozbay, Sacit Icten, Ferhat Arslan, Yasemin Cag, Hurrem Bodur, Haluk Vahaboglu,

To compare the performance of various CT reporting tools, including Zonal CT Visual Score (ZCVS), the number of involved lobes, and Radiological Society of North America (RSNA) categorization in predicting adverse outcomes among patients hospitalized due to lower respiratory symptoms during the COVID-19 pandemic. A total of 405 patients admitted ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Extreme lateral interbody fusion (XLIF) in a consecutive series of 72 patients.

Mirza Pojskic, Benjamin Saβ, Benjamin Völlger, Christopher Nimsky, Barbara Carl,

Extreme lateral interbody fusion (XLIF) has become the standard of minimally invasive lumbar segmental scoliosis treatment. Our objective is to determine the safety and efficacy of XLIF in spinal canal stenosis (SCS) and spondylodiscitis (SD). Patients treated with XLIF in our department between 2012 and 2018 were retrospectively analyzed. Patient ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Phylogenetic pattern of SARS-CoV-2 from COVID-19 patients from Bosnia and Herzegovina: lessons learned to optimize future molecular and epidemiological approaches.

Teufik Goletic, Rijad Konjhodzic, Nihad Fejzic, Sejla Goletic, Toni Eterovic, Adis Softic, Aida Kustura, Lana Salihefendic, Maja Ostojic, Maja Travar, Visnja Mrdjen, Nijaz Tihic, Sead Jazic, Sanjin Musa, Damir Marjanovic, Mirsada Hukic,

This is the first report of molecular and epidemiology findings from Bosnia and Herzegovina related to ongoing SARS-CoV-2 epidemic. Whole Genome Sequence of four samples from COVID-19 outbreaks was done in two laboratories in Bosnia and Herzegovina (Veterinary Faculty Sarajevo and Alea Genetic Center). All four BiH sequences cluster mainly ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Efficacy of chemotherapeutics in classic and non-classic Kaposi sarcoma: A single-center retrospective real-world data.

Sibel Oyucu Orhan, Ahmet Bilgehan Sahin, Erdem Cubukcu, Adem Deligonul, Birol Ocak, Bedrettin Orhan, Turkkan Evrensel,

Kaposi sarcoma is a rare disease and there is a gap in the literature about which chemotherapeutics should be applied, especially for the classical type. We aimed to present our institutional data on the demographic characteristics, treatment, and treatment efficacy in 16 Kaposi sarcoma (KS) patients treated with chemotherapy. We ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Targeting HER2 expression in cancer: New drugs and new indications.

Semir Vranić, Semir Bešlija, Zoran Gatalica,

Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. This has been best documented in the context of HER2 gene amplification in breast and gastric/gastroesophageal junction carcinomas for which ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):1-4]

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Asymptomatic neurotoxicity of amyloid β-peptides (Aβ1-42 and Aβ25-35) on mouse embryonic stem cell-derived neural cells.

Nur Izzati Mansor, Carolindah Makena Ntimi, Noraishah Mydin Abdul-Aziz, King-Hwa Ling, Aishah Adam, Rozita Rosli, Zurina Hassan, Norshariza Nordin,

One of the strategies in the establishment of in vitro oxidative stress models for neurodegenerative diseases, such as Alzheimer's disease (AD), is to induce neurotoxicity by amyloid beta (Aβ) peptides in suitable neural cells. Presently, data on the neurotoxicity of Aβ in neural cells differentiated from stem cells are limited. ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):98-110]

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Vancomycin-releasing cross-linked collagen sponges as wound dressings.

Jan Miroslav Hartinger, Peter Lukáč, Petr Mitáš, Mikuláš Mlček, Michaela Popková, Tomáš Suchý, Monika Šupová, Jan Závora, Václava Adámková, Hana Benáková, Ondřej Slanař, Martin Šíma, Martin Bartoš, Hynek Chlup, Tomáš Grus,

The study presents a novel vancomycin-releasing collagen wound dressing derived from Cyprinus carpio collagen type I cross-linked with carbodiimide which retarded the degradation rate and increased the stability of the sponge. Following lyophilization, the dressings were subjected to gamma sterilization. The structure was evaluated via scanning electron microscopy images, micro-computed ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):61-70]

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Dose-dependent effects of adalimumab in neonatal rats with hypoxia/reoxygenation-induced intestinal damage.

Halil Kocamaz, Özmert Ma Özdemir, Nilay Şen Türk, Yaşar Enli, Barbaros Şahin, Hacer Ergin,

Tumor necrosis factor-alpha (TNF-α) has an important role in hypoxia/reoxygenation (H/R)-induced intestinal damage. It was shown that blocking TNF-α with infliximab has beneficial effects on experimental necrotizing enterocolitis and hypoxic intestinal injury. However, there is no data about the effect of adalimumab on H/R-induced intestinal damage. Therefore, we aimed to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):33-38]

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Association of miRNA-145 with the occurrence and prognosis of hydrosalpinx-induced defective endometrial receptivity.

Qingli Wang, Haiquan Ai, Xia Li, Haiqing Tian, Bingxue Ning, Meng Zhang, Xiaolin La,

MiR-145 is reported to facilitate inflammation and is also associated with unsuccessful embryonic implantation. Whether miR-145 mediates inflammatory response underlying hydrosalpinx-induced defective endometrial receptivity (ER) remains unclear, and this study attempted to clarify this point. Endometrium samples were collected from hydrosalpinx patients (case, n = 243) and patients with tubal ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):81-92]

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MicroRNA-126 enhances the biological function of endothelial progenitor cells under oxidative stress via PI3K/Akt/GSK3β and ERK1/2 signaling pathways.

Qinqin Wu, Benling Qi, Xiaoyu Duan, Xiaoyan Ming, Fengqin Yan, Yingxia He, Xiaofen Bu, Shan Sun, Hong Zhu,

Endothelial progenitor cell (EPC) transplantation is a safe and effective method to treat acute myocardial infarction (AMI). However, oxidative stress leads to the death of a large number of EPCs in the early stage of transplantation, severely weakening the therapeutic effect. Previous studies demonstrated that microRNAs regulate the biological function ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):71-80]

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Cross-sectional imaging and cytologic investigations in the preoperative diagnosis of parotid gland tumors - An updated literature review.

Sebastian Stoia, Grigore Băciuț, Manuela Lenghel, Radu Badea, Csaba Csutak, Georgeta Mihaela Rusu, Mihaela Băciuț, Tiberiu Tamaș, Emil Boțan, Gabriel Armencea, Simion Bran, Cristian Dinu,

An accurate preoperative diagnosis of parotid tumors is essential for the selection and planning of surgical treatment. Various modern cross-sectional imaging and cytologic investigations can support the differential diagnosis of parotid tumors. The aim of this study was to achieve a comprehensive and updated review of modern imaging and cytologic ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):19-32]

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Rapid, multimodal, critical care knowledge-sharing platform for COVID-19 pandemics.

Amra Sakusic, Dragana Markotic, Yue Dong, Emir Festic, Vladimir Krajinovic, Zoran Todorovic, Alan Sustic, Natasa Milivojevic, Milka Jandric, Srdjan Gavrilovic, Alexander Niven, Pedja Kovacevic, Ognjen Gajic,

In many areas of the world, critical care providers caring for COVID-19 patients lacked specific knowledge and were exposed to the abundance of new and unfiltered information. With support from the World Health Organization, we created a multimodal tele-education intervention to rapidly share critical care knowledge related to COVID-19 targeting ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):93-97]

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SARS-CoV-2 virus outbreak and the emergency public health measures in Bosnia and Herzegovina: January - July, 2020.

Mirsada Hukic, Mirza Ponjavic, Emin Tahirovic, Almir Karabegovic, Elvir Ferhatbegovic, Maja Travar, Fadila Serdarevic,

Between March 5th and July 25th, 2020, the total number of SARS-CoV-2 confirmed cases in Bosnia and Herzegovina (BH) was 10,090, corresponding to a cumulative incidence rate of 285.7/100,000 population. Demographic and clinical information on all the cases along with exposure and contact information were collected using a standardized case ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):111-116]

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Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer.

Jun Tang, Fei Huang, Hui Wang, Feng Cheng, Yaping Pi, Juanjuan Zhao, Zhihong Li,

Long non-coding RNAs are considered to be critical regulators of tumor progression. Tumor protein translationally controlled 1 antisense RNA 1 (TPT1-AS1) was shown to have an oncogenic role in cervical and ovarian cancer. The clinical significance and biological function of TPT1-AS1 in gastric cancer (GC) are not clear. In this ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):39-46]

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Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer.

Chenhui Ma, ZeLong Cui, YiChao Wang, Lei Zhang, JunYe Wen, HuaiBin Guo, Na Li, WanXing Zhang,

Pancreatic cancer (PCC) is a common malignant tumor of the digestive system that is resistant to traditional treatments and has an overall 5-year survival rate of <7%. Transcriptomics research provides reliable biomarkers for diagnosis, prognosis, and clinical precision treatment, as well as the identification of molecular targets for the development ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):47-60]

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The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review.

Mislav Glibo, Alan Serman, Valentina Karin-Kujundzic, Ivanka Bekavac Vlatkovic, Berivoj Miskovic, Semir Vranic, Ljiljana Serman,

Glycogen synthase kinase 3 (GSK3) is a monomeric serine-threonine kinase discovered in 1980 in a rat skeletal muscle. It has been involved in various cellular processes including embryogenesis, immune response, inflammation, apoptosis, autophagy, wound healing, neurodegeneration, and carcinogenesis. GSK3 exists in two different isoforms, GSK3α and GSK3β, both containing seven ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):5-18]

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Lessons learned from COVID-19 pandemic in Italy - A commentary.

Antonio Minni, Massimo Ralli, Francesca Candelori, Fabrizio Cialente, Lucia Ercoli, Claudio Parlapiano, Antonio Greco, Marco De Vincentiis,

Since the COVID-19 outbreak, Italy has been one of the most affected countries in Europe and the second for number of deaths. In this commentary, we discuss some lessons that we learned as health-care providers working in a large public hospital during the pandemic, with a special focus on the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, 21(1):117-119]

Cited: 3 times

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Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.

Jernej Letonja, Matej Završnik, Jana Makuc, Maja Šeruga, Ana Peterlin, Ines Cilenšek, Danijel Petrovič,

The global prevalence for diabetes mellitus nearly doubled from 4.7% in 1980 to 8.5% in 2014. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that is expressed in a variety of tissues. It modifies proteins that participate in DNA repair, stress, and inflammatory response. The aim of the study was to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Recent advances of targeted therapy in relapsed/refractory acute myeloid leukemia.

Jiale Ma, Zheng Ge,

Despite advances in the understanding of disease pathobiology, treatment for relapsed or refractory acute myeloid leukemia (R/R AML) remains challenging. The prognosis of R/R AML remains extremely poor despite chemotherapy and bone marrow transplants. Discoveries on recurrent and novel genetic mutations, such as FLT3-ITD and IDH1/IDH2, critical signaling pathways, and ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Development and validation of nomograms for predicting survival of elderly patients with stage I small-cell lung cancer.

Yaji Yang, Shusen Sun, Yuwei Wang, Feng Xiong, Yin Xiao, Jing Huang,

There is a lack of predictive models to determine the prognosis of elderly patients diagnosed with stage I small-cell lung cancer (SCLC). The purpose of this study was to establish a useful nomogram to predict cancer-specific survival (CSS) in this patient population. Based on the Surveillance, Epidemiology, and End Results ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma.

Ivan Lerotić, Petra Vuković, Davor Hrabar, Zvonimir Misir, Ivan Kruljac, Tajana Pavić, Jelena Forgač, Petra Ćaćić, Monika Ulamec,

Gastric cancer is related to high mortality rates and advanced disease stage at the time of diagnosis. Its carcinogenesis is extensively studied and is associated with genetic and epigenetic changes, changed the interaction between tumor and adjacent stromal cells, and changes in the microenvironment molecule status. Neural precursor cell-expressed developmentally ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2021, :]

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Machine learning as the new approach in understanding biomarkers of suicidal behavior.

Alja Videtič Paska, Katarina Kouter,

In psychiatry, compared to other medical fields, the identification of biological markers that would complement current clinical interview, and enable more objective and faster clinical diagnosis, implement accurate monitoring of treatment response and remission, is grave. Current technological development enables analyses of various biological marks in high throughput scale at ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Significance of chromogranin A and synaptophysin in medullary thyroid carcinoma.

Tatsuo Tomita,

Medullary thyroid carcinoma (MTC) is a relatively rare thyroid carcinoma of C-cell deviation and produces and secrete calcitonin (CT) and chromogranin A (CgA) into the blood. Thus, both CT and CgA are immunohistochemical and serum markers for MTCs. MTC occurs in both sporadic and inheritable cases and the hallmark of ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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