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Peak Trabecular Bone Microstructure Predicts Rate of Estrogen-Deficiency-Induced Bone Loss in Rats.

Yihan Li, Wei-Ju Tseng, Chantal M J de Bakker, Hongbo Zhao, Rebecca Chung, X Sherry Liu,

Postmenopausal osteoporosis affects a large number of women worldwide. Reduced estrogen levels during menopause lead to accelerated bone remodeling, resulting in low bone mass and increased fracture risk. Both peak bone mass and the rate of bone loss are important predictors of postmenopausal osteoporosis risk. However, whether peak bone mass ... Read more >>

Bone (Bone)
[2021, :115862]

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Bone Densitometry Categories as a Salient Distracting Feature in the Modern Clinical Pathways of Osteoporosis Care: a retrospective 20-year cohort study.

Gregory A Kline, Suzanne N Morin, Lisa M Lix, William D Leslie,

<h4>Background</h4>It is unknown as to what factors typically drive osteoporosis therapy decisions in real-world practice.<h4>Methods</h4>Retrospective, 20-year cohort study within the government health system of Manitoba including all women having bone densitometry (BMD) tests between 1996-2017. Osteoporosis prescription data was linked to registry data on fractures, clinical risk factors and BMD ... Read more >>

Bone (Bone)
[2021, :115861]

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Bisphosphonates impair the onset of bone formation at remodeling sites.

Pia Rosgaard Jensen, Thomas Levin Andersen, Pascale Chavassieux, Jean-Paul Roux, Jean-Marie Delaisse,

Bisphosphonates are widely used anti-osteoporotic drugs targeting osteoclasts. They strongly inhibit bone resorption, but also strongly reduce bone formation. This reduced formation is commonly ascribed to the mechanism maintaining the resorption/formation balance during remodeling. The present study provides evidence for an additional mechanism where bisphosphonates actually impair the onset of ... Read more >>

Bone (Bone)
[2021, :115850]

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Muscular loading affects the 3D structure of both the mineralized rudiment and growth plate at early stages of bone formation.

Maria Pierantoni, Sophie Le Cann, Vivien Sotiriou, Saima Ahmed, Andrew J Bodey, Iwan Jerjen, Niamh C Nowlan, Hanna Isaksson,

Fetal immobilization affects skeletal development and can lead to severe malformations. Still, how mechanical load affects embryonic bone formation is not fully elucidated. This study combines mechanobiology, image analysis and developmental biology, to investigate the structural effects of muscular loading on embryonic long bones. We present a novel approach involving ... Read more >>

Bone (Bone)
[2021, :115849]

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Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling.

Gillian P Johnson, Sean Fair, David A Hoey,

The benefits of physical loading to skeletal mass are well known. The primary cilium has emerged as an important organelle in bone mechanobiology/mechanotransduction, particularly in mesenchymal stem/stromal cells, yet the molecular mechanisms of cilium mechanotransduction are poorly understood. In this study, we demonstrate that Gpr161 is a mechanoresponsive GPCR, that ... Read more >>

Bone (Bone)
[2021, 145:115846]

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Reciprocal effect of microRNA-224 on osteogenesis and adipogenesis in steroid-induced osteonecrosis of the femoral head.

Yuanwu Cao, Chang Jiang, Xinyuan Wang, Hao Wang, Zuoqin Yan, Hengfeng Yuan,

The adverse effects of glucocorticoids (GCs) on bone marrow stromal stem cells (BMSCs) play an important role in steroid-induced osteonecrosis of the femoral head (ONFH). Our previous miRNA microarray analysis indicated that microRNA-224-5p (miR-224-5p) could be a potential regulator; however, the underlying mechanism remains unclear. In the present study, we ... Read more >>

Bone (Bone)
[2021, :115844]

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Erratum to 'Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts'.

Karen Fuller, Kevin M Lawrence, Jade L Ross, Urszula B Grabowska, Masahiro Shiroo, Bertil Samuelsson, Timothy J Chambers,

Bone (Bone)
[2021, :115354]

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Effects of recreational team handball on bone health, postural balance and body composition in inactive postmenopausal women - A randomised controlled trial.

Rita Pereira, Peter Krustrup, Carlo Castagna, Eduardo Coelho, Rute Santos, Eva Wulff Helge, Niklas Rye Jørgensen, José Magalhães, Susana Póvoas,

This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in untrained postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women without previous experience of team handball practice (68.3±6.2 years, stature 156.9±5.8 cm, body ... Read more >>

Bone (Bone)
[2021, :115847]

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GDF5 mutation case report and a systematic review of molecular and clinical spectrum: Expanding current knowledge on genotype-phenotype correlations.

Maria Luce Genovesi, Daniele Guadagnolo, Enrica Marchionni, Agnese Giovannetti, Alice Traversa, Noemi Panzironi, Silvia Bernardo, Pietro Palumbo, Francesco Petrizzelli, Massimo Carella, Tommaso Mazza, Antonio Pizzuti, Viviana Caputo,

<h4>Introduction</h4>Brachydactyly is a bone development abnormality presenting with variable phenotypes and different transmission patterns. Mutations in GDF5 (Growth and Differentiation Factor 5, MIM *601146) account for a significant amount of cases. Here, we report on a three-generation family, where the proband and the grandfather have an isolated brachydactyly with features ... Read more >>

Bone (Bone)
[2021, 144:115803]

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Osteoporosis prevention in an extraordinary hibernating bear.

Seth W Donahue, Samantha J Wojda, Meghan E McGee-Lawrence, Janene Auger, Hal L Black,

Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the ... Read more >>

Bone (Bone)
[2021, 145:115845]

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Mineral and Organic Matrix Composition at Bone Forming Surfaces in Postmenopausal Women with Osteoporosis Treated With Either Teriparatide or Zoledronic Acid.

Eleftherios P Paschalis, David W Dempster, Faye W Chan-Diehl, Sonja Gamsjaeger, Stamatia Rokidi, Norbert Hassler, Wolfgang Brozek, Klaus Klaushofer, Kathleen A Taylor,

The ability of bone to resist fracture is dependent on the composite nature of its mineral and organic matrix content. Teriparatide (TPTD) and zoledronic acid (ZOL) are approved anabolic and antiresorptive therapies, respectively, to reduce fracture risk in women with postmenopausal osteoporosis. In the SHOTZ study, postmenopausal women with osteoporosis ... Read more >>

Bone (Bone)
[2021, :115848]

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Angiotensin II triggers knee joint lesions in experimental osteoarthritis.

Grazielle A de Sá, Anna Clara P M Dos Santos, Júlia M Nogueira, Diogo M Dos Santos, Flávio A Amaral, Erika C Jorge, Marcelo V Caliari, Celso M Queiroz-Junior, Anderson J Ferreira,

<h4>Objectives</h4>This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo.<h4>Methods</h4>Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the ACE inhibitor captopril, ... Read more >>

Bone (Bone)
[2021, 145:115842]

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Leukemia inhibitory factor treatment attenuates the detrimental effects of glucocorticoids on bone in mice.

Sooyeon Lee, Peng Liu, Mubashir Ahmad, Jan P Tuckermann,

Glucocorticoids (GCs) are widely used drugs for the treatment of inflammatory and autoimmune diseases. However, a severe side effect induced by long-term GC therapy is osteoporosis. Leukemia inhibitory factor (LIF) - a glycoprotein 130 (gp130) dependent cytokine and member of the interleukin-6 cytokine family - is an activator protein 1 ... Read more >>

Bone (Bone)
[2021, 145:115843]

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Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.

Vibha Singhal, Nazanin Hazhir Karzar, Amita Bose, Colleen Buckless, Kathryn E Ackerman, Miriam A Bredella, Anne Klibanski, Madhusmita Misra,

<h4>Context</h4>Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol administration in physiologic doses increases BMD in adolescents and adults with FHA. However, ... Read more >>

Bone (Bone)
[2021, 145:115841]

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Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness.

Vanessa D Sherk, Chelsea M Heveran, Rebecca M Foright, Ginger C Johnson, David M Presby, Virginia L Ferguson, Paul S MacLean,

Bone fragility and obesity are both diseases that are multifactorial in etiology and pathology. The contributing role of high fat diet (HFD) versus energy overconsumption on bone health is controversial. Exercise is often prescribed for improving bone health, but it is unclear whether HFD or overconsumption influences skeletal adaptations to ... Read more >>

Bone (Bone)
[2021, 145:115840]

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Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice.

Qiangqiang Li, Haixing Wang, Jiajun Zhang, Alice Pik-Shan Kong, Gang Li, Tsz-Ping Lam, Jack Chun-Yiu Cheng, Wayne Yuk-Wai Lee,

SIRT3 has been speculated to affect osteoclast activity through its important roles in regulating mitochondrial function. It remains unclear whether SIRT3 affects osteoclast activity in female mice which is relevant to postmenopausal osteoporosis. We hypothesized that deletion of SIRT3 could modulate bone remodeling in female mice under physiological aging process ... Read more >>

Bone (Bone)
[2021, 144:115827]

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Non-Endemic Skeletal Fluorosis: Causes And Associated Secondary Hyperparathyroidism (Case Report and Literature Review).

Fiona J Cook, Maighan Seagrove-Guffey, Steven Mumm, Deborah J Veis, William H McAlister, Vinieth N Bijanki, Deborah Wenkert, Michael P Whyte,

Skeletal fluorosis (SF) is endemic primarily in regions with fluoride (F)-contaminated well water, but can reflect other types of chronic F exposure. Calcium (Ca) and vitamin D (D) deficiency can exacerbate SF. A 51-year-old man with years of musculoskeletal pain and opiate use was hypocalcemic with secondary hyperparathyroidism upon manifesting ... Read more >>

Bone (Bone)
[2021, :115839]

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Persistence with osteoporosis treatment in patients from the Lille University Hospital Fracture Liaison Service.

Anthony Delbar, Arnaud Pflimlin, Isabelle Delabrière, Camille Ternynck, Christophe Chantelot, François Puisieux, Bernard Cortet, Julien Paccou,

<h4>Purpose/introduction</h4>A Fracture Liaison Service (FLS) was set up at Lille University Hospital in 2016. The purpose of this study was to assess persistence with osteoporosis treatment in patients from the FLS over a period of 1 year, and to determine predictors of discontinuation.<h4>Methods</h4>The study population comprised adults of both genders, aged ... Read more >>

Bone (Bone)
[2020, 144:115838]

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Transcriptomic and bioinformatic analysis of Clcn7-dependent Autosomal Dominant Osteopetrosis type 2. Preclinical and clinical implications.

Iona Norwood, Denis Szondi, Michela Ciocca, Amélie Coudert, Martine Cohen-Solal, Nadia Rucci, Anna Teti, Antonio Maurizi,

Autosomal Dominant Osteopetrosis type 2 (ADO2) is a rare genetic disease characterized by dense yet fragile bones. To date, the radiological approach remains the gold standard for ADO2 diagnosis. However, recent observations unveiled that ADO2 is a systemic disease affecting various organs beyond bone, including lung, kidney, muscle, and brain. ... Read more >>

Bone (Bone)
[2020, 144:115828]

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Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation.

Sangyong Lee, Hyuk Soon Kim, Myoung Jun Kim, Keun Young Min, Wahn Soo Choi, Jueng Soo You,

Osteoclasts (OCs) have been well-known involved in the exacerbation of bone-related diseases. However, the role of metabolites on osteoclastogenesis has not been well characterized. Herein, we found osteoclastogenesis was negatively regulated by α-ketoglutarate (αKG) in vitro and in vivo (C57BL/6 mouse). Kinetic transcriptome analysis revealed the upregulation of solute carrier ... Read more >>

Bone (Bone)
[2020, 145:115836]

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Postnatal Expression and Possible Function of RANK and RANKL in the Murine Inner Ear.

Shyan-Yuan Kao, Sachiyo Katsumi, Dongjun Han, Argyro J Bizaki-Vallaskangas, Sasa Vasilijic, Lukas D Landegger, Arthur G Kristiansen, Michael J McKenna, Konstantina M Stankovic,

The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG acts as a decoy receptor of receptor activator of nuclear ... Read more >>

Bone (Bone)
[2020, :115837]

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PTCH1 regulates anchorage-independent growth and bone invasion of non-small cell lung cancer cells.

Ji-Yoon Choi, Yun Sun Lee, Da Mi Shim, Sung Wook Seo,

Acquisition of metastatic potential by cancer cells is related to cancer stemness and anchorage-independent growth. The onset and progression of cancer are known to involve Hedgehog (HH) signaling that is activated by the binding of HH to the Patched 1 (PTCH1) receptor. However, the functions and mechanisms of action of ... Read more >>

Bone (Bone)
[2020, 144:115829]

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Risk factors for vertebral fractures and bone loss after denosumab discontinuation: A real-world observational study.

J Everts-Graber, S Reichenbach, B Gahl, H R Ziswiler, U Studer, T Lehmann,

<h4>Background</h4>Denosumab discontinuation without subsequent bisphosphonates (BPs) is associated with bone loss and multiple vertebral fractures.<h4>Objective</h4>Identifying risk factors for bone loss and vertebral fractures after denosumab discontinuation.<h4>Methods</h4>This retrospective study measured the outcome of 219 women with osteoporosis who discontinued denosumab treatment and received subsequent treatment with zoledronate, other BPs or a ... Read more >>

Bone (Bone)
[2020, 144:115830]

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The effect of exercise intensity on bone in postmenopausal women (part 1): A systematic review.

Melanie Kistler-Fischbacher, Benjamin K Weeks, Belinda R Beck,

<h4>Background</h4>Previous systematic reviews and meta-analyses of exercise effects on bone have reported null or modest effect sizes. While animal research has determined that a strong positive relationship exists between load magnitude/intensity and bone adaptation, nevertheless many human exercise interventions have been applied at low intensity. Meta-analytic pooling of exercise interventions ... Read more >>

Bone (Bone)
[2021, 143:115696]

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Coalescing expansile skeletal disease: Delineation of an extraordinary osteopathy involving the IFITM5 mutation of osteogenesis imperfecta type V.

Michael P Whyte, James Aronson, William H McAlister, Robert S Weinstein, Deborah Wenkert, Karen L Clements, Gary S Gottesman, Katherine L Madson, Marina Stolina, Vinieth N Bijanki, Horacio Plotkin, Margaret Huskey, Shenghui Duan, Steven Mumm,

In 2003, we briefly reported the remarkable osteopathy of a 12-year-old boy who at age two months began fracturing his limbs with subsequent hyperplastic callus formation and expansion and fusion of appendicular bones. By age ten years he had coalesced his lumbosacral spine, pelvis, femurs, and leg and foot bones ... Read more >>

Bone (Bone)
[2020, 145:115835]

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