Jiajun Zhang, Yujia Wang, Ka-Lo Cheng, Kayee Cheuk, Tsz-Ping Lam, Alec L H Hung, Jack C Y Cheng, Yong Qiu, Ralph Müller, Patrik Christen, Wayne Y W Lee,
OBJECTIVE:Emerging evidence suggest abnormal bone metabolism and defective bone qualities are associated to etipathogenesis of Adolescent Idiopathic Scoliosis (AIS). Systemic low bone mass is important prognosticator to predict risk of curve progression in AIS. The underlying mechanism is still unclear. We hypothesize that aberrant bone turnover correlates with bone qualities ... Read more >>
Bone (Bone)
[2020, :115655]
Cited: 0 times
Rasmus Klose-Jensen, Louise Brøndt Hartlev, Jesper Skovhus Thomsen, Jens Randel Nyengaard, Lene Warner Thorup Boel, Mogens Laursen, Trine Bay Laurberg, Kristian Stengaard-Pedersen, Ellen-Margrethe Hauge,
OBJECTIVE:Calcified cartilage is suggested to be involved in the pathogenesis of osteoarthritis (OA) by facilitating endochondral ossification at the bone-cartilage unit. Therefore, the objective was to quantify the volume and surface area of the calcified cartilage in the femoral head in OA patients and healthy subjects. MATERIALS AND METHODS:We used ... Read more >>
Bone (Bone)
[2020, :115660]
Cited: 0 times
Meshail Okla, Moustapha Kassem,
Bone marrow adipose tissue (MAT) is a unique fat depot located in proximity to bone surfaces and exerts regulatory functions in the skeleton. Recent studies have demonstrated that MAT responds to changes in whole-body energy metabolism, such as in obesity and anorexia nervosa, where MAT expands, resulting in deleterious effects ... Read more >>
Bone (Bone)
[2020, :115658]
Cited: 0 times
Andre J van Wijnen, Leila Bagheri, Amr A Badreldin, A Noelle Larson, Amel Dudakovic, Roman Thaler, Christopher R Paradise, Zhong Wu,
Epigenetic regulatory proteins support mammalian development, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment, senescence, aging, and cancer in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes that support the formation of inaccessible heterochromatin and suppress expression ... Read more >>
Bone (Bone)
[2020, :115659]
Cited: 0 times
Layne N Raborn, Kristen S Pan, Edmond J FitzGibbon, Michael T Collins, Alison M Boyce,
BACKGROUND:Fibrous dysplasia (FD) is a rare disorder of expansile fibro-osseous lesions that may be associated with extraskeletal features as part of McCune-Albright syndrome (MAS). Optic disc edema is a potentially serious ophthalmologic finding that has been rarely reported in patients with FD/MAS. The purpose of this study was to investigate ... Read more >>
Bone (Bone)
[2020, :115661]
Cited: 0 times
Jing-Jing Ni, Xiao-Lin Yang, Hong Zhang, Qian Xu, Xin-Tong Wei, Gui-Juan Feng, Min Zhao, Yu-Fang Pei, Lei Zhang,
Recent studies have demonstrated the important role played by gut microbiota in regulating bone development, but the evidence of such causal relationship is still sparse in human population. The aim of this study is to assess the causal relationship from gut microbiota to bone development and to identify specific causal ... Read more >>
Bone (Bone)
[2020, :115652]
Cited: 0 times
L L Loundagin, A J Pohl, W B Edwards,
The fatigue life of cortical bone can vary several orders of magnitude, even in identical loading conditions. A portion of this variability is likely related to intracortical microarchitecture and the role of vascular canals as stress concentrators. The size, spatial distribution, and density of canals determine the peak magnitude and ... Read more >>
Bone (Bone)
[2020, :115647]
Cited: 0 times
Se Hwa Kim, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim,
PURPOSE:To estimate the incidence of osteonecrosis of the jaw (ONJ) in patients treated with bisphosphonates (BPs) and to identify clinical risk factors that increase the risk for ONJ in Korean osteoporosis patients. METHODS:We used data acquired from the Korean National Health Insurance Service. Among 2,140,149 participants with osteoporosis in 2012, ... Read more >>
Bone (Bone)
[2020, :115650]
Cited: 0 times
Anjali Haikerwal, Lex W Doyle, George Patton, Suzanne M Garland, Michael M Cheung, John D Wark, Jeanie L Y Cheong,
BACKGROUND:Most infants born extremely preterm (EP; <28 weeks' gestation) or extremely low birthweight (ELBW; <1000 g birthweight) in the post surfactant era (early 1990s) are now surviving into adulthood. Preterm birth/low birthweight are risk factors for reduced bone growth and mineralisation in infants and children. However, little is known about ... Read more >>
Bone (Bone)
[2020, :115648]
Cited: 0 times
Katsutoshi Hirose, Takuya Ishimoto, Yu Usami, Sunao Sato, Kaori Oya, Takayoshi Nakano, Toshihisa Komori, Satoru Toyosawa,
Bone (Bone)
[2020, :115635]
Cited: 0 times
Akito Makino, Tomoka Hasegawa, Hideko Takagi, Yoshimasa Takahashi, Naoki Hase, Norio Amizuka,
Abaloparatide (ABL) is a novel 34-amino acid peptide analog of parathyroid hormone-related protein. In clinical studies, although ABL showed a greater bone mineral density (BMD) increase than teriparatide (TPTD, human parathyroid hormone 1-34), the responses of ABL to bone formation and resorption markers were weaker, making it difficult to understand ... Read more >>
Bone (Bone)
[2020, :115651]
Cited: 0 times
Veena Ekbote, Raja Padidela, Vaman Khadilkar, Vijay Ramanan, Ankita Maheshwari, Zulf Mughal, Eleni P Kariki, Nicola Crabtree, Anuradha Khadilkar,
INTRODUCTION:In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta thalassemia major. METHODS:We studied 179 patients ... Read more >>
Bone (Bone)
[2020, :115649]
Cited: 0 times
Nethmi Abeynayake, Agnieszka Arthur, Stan Gronthos,
Emerging evidence in the literature describes a physical and functional association between the neural and skeletal systems that forms a neuro-osteogenic network. This communication between bone cells and neural tissues within the skeleton is important in facilitating bone skeletal growth, homeostasis and repair. The growth and repair of the skeleton ... Read more >>
Bone (Bone)
[2020, :115645]
Cited: 0 times
Paul Köhli, Jessika Appelt, Ellen Otto, Denise Jahn, Anke Baranowsky, Alina Bahn, Cordula Erdmann, Judith Müchler, Michael Mülleder, Serafeim Tsitsilonis, Johannes Keller,
The neuropeptide calcitonin gene-related peptide (CGRP) and its receptor, calcitonin receptor-like receptor (CLR) complexing with receptor activity-modifiying protein 1 (RAMP1), have been shown to be crucially involved in the pathogenesis of migraine. However, CGRP also plays a pivotal role in regulating bone turnover and was suggested to contribute to the ... Read more >>
Bone (Bone)
[2020, :115646]
Cited: 0 times
Daniel G Whitney, Andrea I Alford, Maureen J Devlin, Ying Li, Michelle S Caird,
BACKGROUND:Lipidomics, a branch of metabolomics, is an attractive technique to characterize bone marrow lipid composition, which may be associated with skeletal acquisition and homeostasis. However, the reliability of lipidomics-derived lipid composition of the bone marrow is unknown, especially for pediatric populations with bone fragility. The purpose of this study was ... Read more >>
Bone (Bone)
[2020, :115633]
Cited: 0 times
Amelia E Moore, EunJi Kim, Dwight Dulnoan, A Louise Dolan, Kieran Voong, Imtiaz Ahmad, Renata Gorska, Dominic J Harrington, Geeta Hampson,
PURPOSE:Vitamin K may play a potential role in bone metabolism, although further evidence is needed. The mechanisms behind its skeletal effects and optimum intake for maintaining bone health remain poorly defined. To elucidate these two issues, we investigated the association between circulating vitamin K1 (phylloquinone) concentrations with fracture risk, bone ... Read more >>
Bone (Bone)
[2020, :115630]
Cited: 0 times
Corinne E Metzger, Elizabeth A Swallow, Alexander J Stacy, Samantha P Tippen, Max A Hammond, Neal X Chen, Sharon M Moe, Matthew R Allen,
PURPOSE:Chronic kidney disease (CKD) patients have a high incidence of fracture due in part to cortical porosity. The goal of this study was to study cortical pore infilling utilizing two rodent models of progressive CKD. METHODS:Exp 1: Female C57Bl/6J mice (16-week-old) were given dietary adenine (0.2%) to induce CKD for ... Read more >>
Bone (Bone)
[2020, :115632]
Cited: 0 times
Chang-Chin Wu, Chi-Kang Wang, An-Ming Yang, Chia-Sheng Lu, Chien-Yu Lin,
Selenium is an essential trace mineral element for humans. Although previous in vitro and animal studies have reported the vital role of selenium in bone, the results of the relationship between the selenium status and bone health were inconsistent in epidemiological studies. The risk of selenium deficiency is negligible for ... Read more >>
Bone (Bone)
[2020, :115631]
Cited: 0 times
Stamatia Rokidi, Vicente F C Andrade, Victoria Borba, Elizabeth Shane, Adi Cohen, Jochen Zwerina, Eleftherios P Paschalis, Carolina A Moreira,
Type 2 diabetes mellitus (T2DM) patients are at an increased risk of fracture despite normal to high bone mineral density (BMD) values. In this cross-sectional study we establish bone compositional properties in tetracycline labeled iliac crest biopsies from premenopausal women diagnosed with T2DM (N = 26). Within group comparisons were made as ... Read more >>
Bone (Bone)
[2020, :115634]
Cited: 0 times
Slobodan Vukicevic, Kuber T Sampath, Frank P Luyten,
Bone (Bone)
[2020, :115622]
Cited: 0 times
Jean-Marie Delaisse, Thomas Levin Andersen, Helene Bjoerg Kristensen, Pia Rosgaard Jensen, Christina Møller Andreasen, Kent Søe,
Proper bone remodeling necessarily requires that osteoblasts reconstruct the bone that osteoclasts have resorbed. However, the cellular events connecting resorption to reconstruction have remained poorly known. The consequence is a fragmentary understanding of the remodeling cycle where only the resorption and formation steps are taken into account. New tools have ... Read more >>
Bone (Bone)
[2020, :115628]
Cited: 0 times
Maria Enlund-Cerullo, Helena Hauta-Alus, Saara Valkama, Jenni Rosendahl, Sture Andersson, Outi Mäkitie, Elisa Holmlund-Suila,
BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months, in healthy children, participating in a randomized vitamin D ... Read more >>
Bone (Bone)
[2020, :115629]
Cited: 0 times
Jane Taylor, Anna E Saw, Richard Saw, Kevin Sims, Alex Kountouris,
OBJECTIVES:1) Quantify the intensity of bone marrow oedema (BMO) present in the lumbar vertebrae of asymptomatic elite adult fast bowlers; 2) relate the intensity of BMO to bowling workload and lumbar bone stress injury (LBSI), and; 3) evaluate the utility of MRI screening to reduce the risk of LBSI. METHODS:Thirty-eight ... Read more >>
Bone (Bone)
[2020, :115626]
Cited: 0 times
Miya Kang, Chun-Chieh Huang, Yu Lu, Sajjad Shirazi, Praveen Gajendrareddy, Sriram Ravindran, Lyndon F Cooper,
Multiple local and systemic factors including inflammation influence bone regeneration. Several lines of evidence demonstrate that macrophages contribute to the immunological regulation of MSC and osteoblast function during bone regeneration. Recent studies demonstrate that macrophage polarization influences this regulatory process. In this manuscript, we investigated the paracrine functional role of ... Read more >>
Bone (Bone)
[2020, :115627]
Cited: 0 times
Kathryn M Thrailkill, R Clay Bunn, Sasidhar Uppuganti, Philip Ray, Iuliana Popescu, Evangelia Kalaitzoglou, John L Fowlkes, Jeffry S Nyman,
Higher fracture risk in type 2 diabetes (T2D) is attributed to disease-specific deficits in micro-structural and material properties of bone, although the primary cause is not yet established. The TallyHO (TH) mouse is a polygenic model of early-onset T2D and obesity analogous to adolescent-onset T2D in humans. Due to incomplete ... Read more >>
Bone (Bone)
[2020, :115625]
Cited: 0 times