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Journal Biomed. Pharmacother.

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Corrigendum to "Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway" [Biomed. Pharmacother. 117 (2019) 109194].

Jing Gong, Ying-Nan Ju, Xue-Ting Wang, Jing-Li Zhu, Zhe-Hao Jin, Wei Ga,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, :110760]

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Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates.

Eszter Fliszár-Nyúl, Violetta Mohos, Rita Csepregi, Přemysl Mladěnka, Miklós Poór,

Polyphenolic compounds (including flavonoids, chalcones, phenolic acids, and furanocoumarins) represent a common part of our diet, but are also the active ingredients of several dietary supplements and/or medications. These compounds undergo extensive metabolism by human biotransformation enzymes and the microbial flora of the colon. CYP2D6 enzyme metabolizes approximately 25% of ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110732]

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Cardioprotection by triiodothyronine following caloric restriction via long noncoding RNAs.

Viswanathan Rajagopalan, Mateusz Gorecki, Clifford Costello, Emily Schultz, Youhua Zhang, A Martin Gerdes,

Severe caloric-restriction compromises thyroid hormone (TH) status, apparently to save energy and proteins for enduring stress stimulus. However, a persistent decrease in TH levels may compromise heart function. We hypothesized that supplementation of low dose active TH or targeting hypoxia-inducible factor-1-alpha, HIF-1α (a strong activator of deiodinase enzyme that degrades ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110657]

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Protective effect of picroside I against hepatic fibrosis in mice via sphingolipid metabolism, bile acid biosynthesis, and PPAR signaling pathway.

Kai Xiong, Mengge Shi, Tong Zhang, Han Han,

Picroside I, a hepatoprotectant isolated from Picrorhiza kurroa Royle ex Benth and P. scrophulariiflora Pennell, can reduce liver injury in humans and animals. However, its anti-fibrosis effect remains elusive. This work aimed to explore the mechanism underlying the hepatoprotective effect of picroside I against hepatic fibrosis. Male mice (12 mice ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110683]

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Small molecule compounds promote the proliferation of chondrocytes and chondrogenic differentiation of stem cells in cartilage tissue engineering.

Tian Li, Bingzhang Liu, Kang Chen, Yingyue Lou, Yuhan Jiang, Duo Zhang,

The application of tissue engineering to generate cartilage is limited because of low proliferative ability and unstable phenotype of chondrocytes. The sources of cartilage seed cells are mainly chondrocytes and stem cells. A variety of methods have been used to obtain large numbers of chondrocytes, including increasing chondrocyte proliferation and ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110652]

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Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibiting VEGF production.

Zhenzhen Yang, Jiacheng Guo, Kang Cui, Yabing Du, Huan Zhao, Lili Zhu, Lanling Weng, Wenxue Tang, Jiancheng Guo, Tengfei Zhang, Xiaojing Shi, Hong Zong, Shuiling Jin, Wang Ma,

BACKGROUND:Thymosin alpha-1 (TA) has been reported to inhibit tumor growth as an immunomodulator. However, its mechanism of action in immunosuppressive cells is unclear. The purpose of this study was to investigate whether TA can reshape the immune microenvironment by inhibiting the function of myeloid-derived suppressor cells (MDSCs) in non-small cell ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110740]

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Therapeutic potential of ALKB homologs for cardiovascular disease.

Ming-Zhu Xiao, Jia-Ming Liu, Cui-Ling Xian, Keng-Yu Chen, Zhong-Qiu Liu, Yuan-Yuan Cheng,

Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation. These functions may regulate the physiological and pathological processes of CVDs, including inflammation, oxidative ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110645]

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Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells.

Fei Zhou, Fei Liu, Juan Liu, Yu-Lin He, Qin-Mei Zhou, Li Guo, Cheng Peng, Liang Xiong,

Stachydrine is a main active component of Leonurus japonicus (Chinese motherwort), which has traditionally been used to promote postpartum recovery and alleviate myocardial and cerebral ischemic injuries due to its pro-angiogenic effect. Our prior study demonstrated that stachydrine increased angiogenesis in zebrafish embryos, but its pro-angiogenic effect and underlying mechanisms ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110724]

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Novel cellular immunotherapy using NKG2D CAR-T for the treatment of cervical cancer.

Yan Zhang, Xing Li, Jun Zhang, Lin Mao,

Cellular immunotherapy, including chimeric antigen receptor (CAR) modified T cell therapy, has been regarded as one of the most potential antineoplastic drugs for hematological malignancies and solid tumor. However, due to lacking the suitable target, there is no CAR-T drug had been appoved by FDA for the treatment of cervical ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110562]

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Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor.

Xionghua Sun, Xinjian Cui, Xihua Chen, Xiaogang Jiang,

Although we have reported that baicalein ameliorated bleomycin-induced pulmonary fibrosis in rats and inhibited fibroblast-to-myofibroblast differentiation, the mechanisms of the capability of baicalein to suppress the production of type I collagen in fibroblasts remains unclear. Here, we showed that baicalein suppressed transforming growth factor β1 (TGF β1)-stimulated the production of ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110744]

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A novel time-dimension and circadian rhythm-dependent strategy for pharmacodynamic evaluation of Uncaria in the regulation of neurotransmitter circadian metabolic homeostasis in spontaneously hypertensive rats.

Mengjia Sun, Huanjun Wang, Lili Gong, Dongmei Qi, Xiaoming Wang, Yunlun Li, Haiqiang Jiang,

In the present study, we aimed to use metabolomics platforms to examine circadian-regulated neurotransmitters across a 24-h day and the effects of Uncaria administration on daily rhythmicity in order to establish a strategy for evaluating the spatiotemporal efficacy evaluation strategy of Uncaria. By using targeted ultrahigh performance liquid chromatography-mass spectrometry ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110704]

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In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves.

Cristina Rey-Blanes, Yalina Pérez-Portero, Humberto J Morris-Quevedo, Virginia Casas, Roberto Abdala, Ana R Quesada, Beatriz Martínez-Poveda, Miguel Ángel Medina,

The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110716]

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Polymer-hybrid nanoparticles: Current advances in biomedical applications.

Daniel Crístian Ferreira Soares, Stephanie Calazans Domingues, Daniel Bragança Viana, Marli Luiza Tebaldi,

The unique properties of polymer-hybrid nanosystems enable them to play an important role in different fields such as biomedical applications. Hybrid materials, which are formed by polymer and inorganic- or organic-base systems, have been the focus of many recently published studies whose results have shown outstanding improvements in drug targeting. ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110695]

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Principles of RNA methylation and their implications for biology and medicine.

Yujia Zhou, Ying Kong, Wenguo Fan, Tao Tao, Qin Xiao, Na Li, Xiao Zhu,

RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds of RNA modifications have been identified. They are widely distributed in messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), noncoding small RNA (sncRNA) and long-chain non-coding RNA (lncRNA). In recent years, with the discovery of ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110731]

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Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment.

Feng Cao, Le Zhu, Jing Zhang, Pawin Pongkorpsakol, Wei-Ting Kuo, Jerrold R Turner, Qing Zhou, Yuan Wang, Feihu Chen, Yehai Liu, Li Zuo,

Hypopharyngeal cancer is squamous cell carcinoma (SCC) with the worst prognosis among the head and neck cancers. Overall, the 5-year survival rate remains poor although diagnostic imaging, radiation, chemotherapy, and surgical techniques have been improved. The mortality of patients with hypopharyngeal cancer is partly due to an increased likelihood of ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110665]

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Corrigendum to "Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway" [Biomed. Pharmacother. 128 (2020) 110216].

Lihua Cui, Caixia Li, Yuzhen Zhuo, Lei Yang, Naiqiang Cui, Yuhong Li, Shukun Zhang,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, :110685]

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Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Ahmed Abdeen, Afaf Abdelkader, Dina Elgazzar, Mohamed Aboubakr, Omnia A. Abdulah, Khaled Shoghy, Mohamed Abdel-Daim, Hamed A. El-Serehy, Agnieszka Najda, Amany El-Mleeh,

Highlights • PM produced oxidative stress in gastric, liver, and kidney tissue.• PM-induced toxicity was mediated by ROS and mitochondrial dysfunction.• PM enhanced the activated caspase-3 expression.• CoQ10 alleviates PM-induced gastropathy and hepato-renal damage.• CoQ10 might be effective in COVID-19 treatment regimen. Piroxicam (PM) is an oxicam-NSAID commonly recommended for ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 130:110627-110627]

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Retraction notice to "Baicalein inhibits proliferation and migration of bladder cancer cell line T24 by down-regulation of microRNA-106" [Biomed. Pharmacother. 107 (2018) 1583-1590].

Liangzhen Jiang, Haibin Song, Hongbo Guo, Chao Wang, Zhanpeng Lu,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, :110634]

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Retraction notice to "Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling" [Biomed Pharmacother. 107 (2018) 243-253].

Bo Liu, Shuo Yu,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, :110635]

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Corrigendum to "Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration" [Biomed. Pharmacother. 2020 (128) 110366].

Yangyang Guo, Hengyue Zhu, Min Weng, Bicheng Chen, Cheng Wang, Linxiao Sun,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, :110631]

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SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia

Wei Chen, Jie Zhang, Xijian Qin, Weixiao Wang, Miaomiao Xu, Lin-Fa Wang, Chuanjun Xu, Shuangshuang Tang, Pei Liu, Libo Zhang, Xuan Liu, Yongchen Zhang, Changhua Yi, Zhiliang Hu, Yongxiang Yi,

Highlights • Neutralizing antibody evaluation helps to assess the risk of re-infection.• Some COVID-19 patients may not develop neutralizing antibody after recovery.• SARS-CoV-2 neutralizing antibody levels are correlated with COVID-19 disease severity. The emerging coronavirus disease 2019 (COVID-19) has become a serious global public health threat. With more and more ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 130:110629-110629]

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Role of oncogenic REGγ in cancer.

Maolei Shen, Qinzhang Wang, Shuaijun Xu, Guang Chen, Hao Xu, Xin Li, Shankun Zhao,

Cancer is a critical global health-care problem with limited therapeutic options. Since cancers are life-threatening illnesses, the identification of a promising oncotarget and its clinical correlates are relevant. Mounting evidence has emerged indicating that REG gamma (REGγ), a member of the 11S proteasome activators, plays a pivotal role in the ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 130:110614]

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Corrigendum to "Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1" [Biomed. Pharmacother. 101 (2018) 14-23].

Ze Zhang, Feng Liu, Fan Yang, Yahui Liu,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 129:110598]

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Corrigendum to "Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124" [Biomed. Pharmacother. 126 (2020) 109786].

Wei Miao, Yong Yan, Tian-Hao Bao, Wen-Ji Jia, Fei Yang, Ying Wang, Yu-Hong Zhu, Mei Yin, Jian-Hong Han,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 129:110597]

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Relationship between antofloxacin concentration and QT prolongation and estimation of the possible false-positive rate.

Li-Yu Liang, Ying-Chun He, Yun-Fei Li, Juan Yang, Feng-Yan Xu, Lu-Jin Li, Ji-Han Huang, Kun Wang, Qing-Shan Zheng,

PURPOSE:To elucidate the relationship between antofloxacin (AT) plasma concentration and QT interval prolongation, compare the effects of different correction and analytical methods on conclusions, and estimate the possible false-positive rate in thorough QT (TQT) studies. METHODS:Twenty-four healthy Chinese volunteers from a four-period crossover TQT study orally received 200 mg/d AT, 400 mg/d ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 130:110619]

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