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A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy.

Yi Guo, Lang Chen, Dongmei Wu, Liang Yu, Hongbin Sun, Qiong Zhu,

<h4>Aims</h4>Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy. This study is aimed at evaluating the effects of VPA and OXC on sexual function, sperm quality, and sex hormones in ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6624101]

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Comprehensive Profile Analysis of Differentially Expressed circRNAs in Glucose Deprivation-Induced Human Nucleus Pulposus Cell Degeneration.

Hongze Chang, Hongzhang Wang, Xiaolong Yang, Kemin You, Mingwei Jiang, Feng Cai, Yan Zhang, Liang Liu, Hui Liu, Xiaodong Liu,

Nucleus pulposus (NP) is the core substance to maintain the homeostasis of intervertebral disc and stability of biomechanics. The insufficient supply of nutrition (especially glucose) is an important factor that leads to the degeneration of NP cells. circRNAs play an important role in the process of intervertebral disc degeneration (IDD) ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:4770792]

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FCGR2A Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma.

Yongmei Dai, Wenhan Chen, Junpeng Huang, Tongjian Cui,

<h4>Objective</h4>We aim to investigate the correlation between <i>FCGR2A</i> mRNA level and prognosis of head and neck squamous cancer (HNSC) in public databases. In addition, we investigated the correlation between <i>FCGR2A</i> expression and clinicopathological characteristics and tumor-infiltrating immune cells in HNSC patients.<h4>Methods</h4><i>FCGR2A</i> mRNA expression in multiple cancers was analyzed based on ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:8874578]

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Identification and Validation of Potential Biomarkers and Pathways for Idiopathic Pulmonary Fibrosis by Comprehensive Bioinformatics Analysis.

Weibin Qian, Xinrui Cai, Qiuhai Qian, Xinying Zhang,

<h4>Objective</h4>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, high-mortality lung disease, but its pathogenesis is still unclear. Our purpose was to explore potential genes and molecular mechanisms underlying IPF.<h4>Methods</h4>IPF-related data were obtained from the GSE99621 dataset. Differentially expressed genes (DEGs) were identified between IPF and controls. Their biological functions ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:5545312]

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PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.

Guang Li, Xuefeng Wang, Guobing Liu,

<h4>Background</h4>PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear.<h4>Methods</h4>PLOD2 expression and CESC patients' survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:5512340]

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Intraoperative Blood Loss and Postoperative Pain in the Sagittal Split Ramus Osteotomy and Intraoral Vertical Ramus Osteotomy: A Literature Review.

Kun-Tsung Lee, Shiu-Shiung Lin, Kun-Jung Hsu, Chi-Yu Tsai, Yi-Hao Lee, Yu-Jen Chang, Te-Ju Wu,

<h4>Purpose</h4>The purpose of the present study was to review the literature regarding the blood loss and postoperative pain in the isolated sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO).<h4>Materials and methods</h4>Investigating the intraoperative blood loss and postoperative pain, articles were selected from 1970 to 2021 in the ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:4439867]

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Impact of Adenosine Analogue, Adenosine-5'-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells.

Mansour Haddad,

<h4>Materials and methods</h4>Rat L6 skeletal muscle cells were cultured in 25 cm<sup>2</sup> flasks. These differentiated cells were treated, and then, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) (probe-based) was used to measure the relative mRNA expression level for metabolic, inflammatory, and nuclear receptor genes including peroxisome proliferator-activated receptor gamma (PGC-1<i>α</i>), carnitine palmitoyl ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9979768]

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N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1α Pathway.

Xiaopeng Liu, Zhixiong Hu, Haiying Zhou,

<h4>Introduction</h4>This study was aimed to investigate the effects of N-acetylcysteine (NAC) on chronic obstructive pulmonary disease (COPD) and the change of Th17/Treg cytokine imbalance. <i>Material and Methods</i>. A total of 121 patients with stable COPD at the stage of C or D were consecutively enrolled and randomly divided into 2 ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6372128]

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Lineage Contribution of PDGFRα-Expressing Cells in the Developing Mouse Eye.

Deyi Zhuo, Yumei Diao, Xiaoqi Li, Yifei Huang, Liqiang Wang,

PDGFR<i>α</i> signaling is critically important in ocular development. Previous data on PDGFR<i>α</i> lacks an expression map with high spatial and temporal resolution and lineage information. In this study, we aim to present a detailed PDGFR<i>α</i> expression and lineage map from early embryogenesis to adulthood. PDGFR<i>α</i>-CreER; mT/mG reporter mice were analyzed. ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:4982227]

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Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring.

Abdelmalek Hakmaoui, Faisal Khan, Abdelhamid Liacini, Amanjot Kaur, Yacine Berka, Safaa Machraoui, Hafid Soualhine, Noureddine Berka, Hanane Rais, Brahim Admou,

Real-time genome monitoring of the SARS-CoV-2 pandemic outbreak is of utmost importance for designing diagnostic tools, guiding antiviral treatment and vaccination strategies. In this study, we present an accurate method for temporal and geographical comparison of mutational events based on GISAID database genome sequencing. Among 42523 SARS-CoV-2 genomes analyzed, we ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:5553173]

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Comparative Analyses of the Subgingival Microbiome in Chronic Periodontitis Patients with and without Gingival Erosive Oral Lichen Planus Based on 16S rRNA Gene Sequencing.

Haohao Liu, Huiwen Chen, Yue Liao, Huxiao Li, Linjun Shi, Yiwen Deng, Xuemin Shen, Zhongchen Song,

The aim of the study was to compare the microbiota composition and bacterial diversity of subgingival plaque in chronic periodontitis patients with and without gingival erosive oral lichen planus. The subgingival plaque samples of 20 chronic periodontitis patients with gingival erosive oral lichen planus (CP-OLP group) and 19 chronic periodontitis ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9995225]

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An Ultrastructural Study on the Effect of High Temperatures on Teeth and Restorative Materials That Aids in the Identification of Human Remains.

V Yashoda, Manay Srinivas Munisekhar, S Shylaja, Krishna A Rao, Sharath Kumar Reddy, Farahnaz Muddebihal, Mohammad Khursheed Alam,

<h4>Introduction</h4>In most disasters, teeth are the only means of positive identification of an otherwise unrecognizable body, as there has been tremendous increase in the use of dental restorations that have different resistance to prolonged high temperature which is an important aid in identifying burned victims. Application of SEM/EDS in forensics ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6629560]

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Artificial Intelligence Techniques: Analysis, Application, and Outcome in Dentistry-A Systematic Review.

Naseer Ahmed, Maria Shakoor Abbasi, Filza Zuberi, Warisha Qamar, Mohamad Syahrizal Bin Halim, Afsheen Maqsood, Mohammad Khursheed Alam,

<h4>Objective</h4>The objective of this systematic review was to investigate the quality and outcome of studies into artificial intelligence techniques, analysis, and effect in dentistry.<h4>Materials and methods</h4>Using the MeSH keywords: artificial intelligence (AI), dentistry, AI in dentistry, neural networks and dentistry, machine learning, AI dental imaging, and AI treatment recommendations and ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9751564]

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Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells.

Hao Xu, Yuan Ding, Xiangying Yang,

<h4>Objective</h4>The abnormal expression of LncRNA H19 and miR-140-5p has been linked to ovarian cancer (OC). Whether H19 directly regulates miR-140-5p in ovarian cancer cells has been unclear. In this study, we deeply explored the relationship between H19 and miR-140-5p in ovarian cancer and the mechanism of action in regulating OC ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6619730]

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Identification of Macrophage Polarization-Related Genes as Biomarkers of Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analyses.

Yalin Zhao, Meihua Li, Yanxia Yang, Tao Wu, Qingyuan Huang, Qinghua Wu, Chaofeng Ren,

<h4>Objectives</h4>Chronic obstructive pulmonary disease (COPD) is characterized by lung inflammation and remodeling. Macrophage polarization is associated with inflammation and tissue remodeling, as well as immunity. Therefore, this study attempts to investigate the diagnostic value and regulatory mechanism of macrophage polarization-related genes for COPD by bioinformatics analysis and to provide a ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9921012]

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Astragalus Polysaccharides Enhance the Immune Response to OVA Antigen in BALB/c Mice.

Yumei Zhou, Yuhan Zong, Zihao Liu, Haihong Zhao, Xiaoshan Zhao, Ji Wang,

Vaccination has been identified as one of the most effective ways to prevent the transmission of infectious diseases in humans and animals. One of the most critical steps in vaccine development is the selection of a suitable adjuvant. Although various adjuvant candidates have been evaluated in the past few decades, ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9976079]

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Body Mass Index Is Associated with the Severity and All-Cause Mortality of Acute Kidney Injury in Critically Ill Patients: An Analysis of a Large Critical Care Database.

Benji Wang, Diwen Li, Yuqiang Gong, Binyu Ying, Bihuan Cheng, Laifang Sun,

<h4>Background</h4>Acute kidney injury (AKI) is a common clinical syndrome carrying high morbidity and mortality. Body mass index (BMI) is a common health indicator, and a high BMI value-obesity has been shown to be associated with the outcomes of several diseases. However, the relationship between different BMI categories and mortality in ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6616120]

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Chemical Composition Analysis Using HPLC-UV/GC-MS and Inhibitory Activity of Different Nigella sativa Fractions on Pancreatic α-Amylase and Intestinal Glucose Absorption.

Mohammed Dalli, Nour Elhouda Daoudi, Salah-Eddine Azizi, Hind Benouda, Mohamed Bnouham, Nadia Gseyra,

<i>Nigella sativa</i> (NS) is a well-known plant for its various benefits and multiuse in traditional medicine. This study is aimed at investigating the chemical composition of the different <i>NS</i> fractions by using GC-MS for the esterified fatty acids or HPLC-UV for organic fraction and at evaluating the inhibitory effect on ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9979419]

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The Effects of Nonnutritive Sweeteners on the Cariogenic Potential of Oral Microbiome.

Jianhui Zhu, Jiaxin Liu, Zhengyi Li, Ranhui Xi, Yuqing Li, Xian Peng, Xin Xu, Xin Zheng, Xuedong Zhou,

Nonnutritive sweeteners (NNSs) are sugar substitutes widely used to reduce the negative health effects of excessive sugar consumption. Dental caries, one of the most prevalent chronic diseases globally, results from a pathogenic biofilm with microecological imbalance and frequent exposure to sugars. Some research has shown that certain NNSs possess less ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9967035]

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Blood Plasma Metabolic Profile of Newborns with Hypoxic-Ischaemic Encephalopathy by GC-MS.

Yanjuan Jia, Xiaoni Jia, Hui Xu, Lan Gao, Chaojun Wei, Yonghong Li, Xia Liu, Xiaoling Gao, Li Wei,

<h4>Background</h4>Early diagnosis of hypoxic-ischaemic encephalopathy (HIE) is crucial in preventing neurodevelopmental disabilities and reducing morbidity and mortality. The study was to investigate the plasma metabolic signatures in the peripheral blood of HIE newborns and explore the potential diagnostic biomarkers.<h4>Method</h4>In the present study, 24 newborns with HIE and 24 healthy controls ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6677271]

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The Effect of Combined Oral Contraceptive Pills on Beclin-1 and LC3B Transcript Levels in Ovarian Endometrioma.

Wanwisa Waiyaput, Ongarj Bovornsakulvong, Srithean Lertvikool, Areepan Sophonsritsuk,

<h4>Background</h4>Autophagy is likely altered in patients with endometriosis. Ovarian steroid hormones seem to affect this changing of the autophagic process.<h4>Objective</h4>To study the effect of combined oral contraceptive (COC) pills on the expression of autophagic-related gene <i>BECN1</i> and <i>LC3B</i> in the ectopic and eutopic endometria of patients with endometriosis. <i>Material and ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:5519538]

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Patient Recovery from COVID-19 Infections: Follow-Up of Hair, Nail, and Cutaneous Manifestations.

Rattapon Thuangtong, Nasikarn Angkasekwinai, Charussri Leeyaphan, Daranporn Triwongwaranat, Kanchalit Thanomkitti, Kanyalak Munprom, Kanokvalai Kulthanan,

<h4>Background</h4>COVID-19 is a pandemic disease worldwide. Although cutaneous manifestations may present in affected patients, there have been limited studies on the cutaneous findings and hair and nail abnormalities after discharge.<h4>Objective</h4>To establish the cutaneous manifestations, hair and scalp disorders, and nail abnormalities in patients who recovered from COVID-19 infections.<h4>Methods</h4>A retrospective chart ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:5595016]

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Whole-Genome Sequence Data Analysis of Anoxybacillus kamchatkensis NASTPD13 Isolated from Hot Spring of Myagdi, Nepal.

Punam Yadav, Shikha Sharma, Tribikram Bhattarai, Lakshmaiah Sreerama, Gandham S Prasad, Girish Sahni, Jyoti Maharjan,

<i>Anoxybacillus kamchatkensis</i> NASTPD13 isolated from Paudwar hot spring of Myagdi, Nepal, upon morphological and biochemical analysis revealed to be Gram-positive, straight or slightly curved, rod-shaped, spore-forming, catalase, and oxidase-positive facultative anaerobes. It grows over a wide range of pH (5.0-11) and temperature (37-75°C), which showed growth in different reduced carbon ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:1869748]

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Intensity-Modified Recreational Volleyball Training Improves Health Markers and Physical Fitness in 25-55-Year-Old Men.

Goran Vasić, Nebojša Trajković, Draženka Mačak, Tine Sattler, Peter Krustrup, Nikola Starčević, Goran Sporiš, Špela Bogataj,

The present study is aimed at determining the effects of intensity-modified recreational volleyball training on health markers and physical fitness in healthy middle-aged men. Thirty-four healthy untrained men aged 25-55 years were randomized to either a modified recreational volleyball group (MRV, <i>n</i> = 17) or a recreational volleyball group (RV, ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9938344]

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Phylogeny and Comparative Analysis for the Plastid Genomes of Five Tulipa (Liliaceae).

Juan Li, Megan Price, Dan-Mei Su, Zhen Zhang, Yan Yu, Deng-Feng Xie, Song-Dong Zhou, Xing-Jin He, Xin-Fen Gao,

Species of <i>Tulipa</i> (Liliaceae) are of great horticultural importance and are distributed across Europe, North Africa, and Asia. The Tien Shan Mountain is one of the primary diversity centres of <i>Tulipa</i>, but the molecular studies of <i>Tulipa</i> species from this location are lacking. In our study, we assembled four <i>Tulipa</i> ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6648429]

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