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Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines.

Joni Järvenpää, Minna Rahnasto-Rilla, Maija Lahtela-Kakkonen, Jenni Küblbeck,

Alterations in epigenetic marking, due to changes in expression or activity of epigenetic regulators, may affect cancer development and progression and thus, targeting epigenetic regulators provides potential avenues for cancer treatment. Bromodomain and extra terminal domain (BET) proteins, epigenetic readers recognizing histone acetylation, and Sirtuins (SIRT1-7), histone deacetylases or erasers, ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112652]

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High on-treatment platelet reactivity to aspirin in patients after myocardial infarction.

Wioleta Stolarek, Michał Kasprzak, Joanna Sikora, Emilia Siemińska, Grzegorz Grześk,

Aspirin (ASA) is widely used as an antiplatelet therapeutic drug in secondary prevention. Last years brought many reports on ASA resistance or high on-treatment platelet reactivity (HTPR) to aspirin.This study is a post-hoc prospective analysis with 30 patients evaluated during follow up on average of 6.3 years after hospitalization from ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112618]

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Saponin-rich extract of Tribulus terrestris alleviates systemic inflammation and insulin resistance in dietary obese female rats: Impact on adipokine/hormonal disturbances.

Yousra Abdel-Mottaleb, Howaida S Ali, Mohamed K El-Kherbetawy, Amany Y Elkazzaz, Mohamed H ElSayed, Amr Elshormilisy, Amira H Eltrawy, Sally Y Abed, Asma M Alshahrani, Abdullah A Hashish, Eman Saad Alamri, Sawsan A Zaitone,

Tribulus terrestris saponins (TTS) have been longley used as an overall tonic and recent studies showed they influence inflammatory conditions. We examined the ameliorative effect of a commercial formula of a saponin-rich extract of TT in a model of dietary obesity in female rats focusing on their ability to control ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112639]

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Clinical use of N-acetyl cysteine during liver transplantation: Implications of oxidative stress and inflammation as therapeutic targets.

Yonela Ntamo, Khanyisani Ziqubu, Nireshni Chellan, Bongani B Nkambule, Tawanda M Nyambuya, Sithandiwe E Mazibuko-Mbeje, Kwazikwakhe B Gabuza, Patrick Orlando, Luca Tiano, Phiwayinkosi V Dludla,

Currently, liver transplantation is considered as the definitive treatment option for individuals with complete liver failure. However, the detrimental effects of oxidative stress and inflammation remain the predominant feature that drives hepatic ischemia-reperfusion injury during liver transplantation. As such, therapeutic drugs that hinder oxidative stress and attenuate inflammation, have become ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112638]

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Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells.

Liu Liu, Xi Chen, Yi Lu, Xiao-Ying Sun, Kan Ze, Ya-Qiong Zhou, Wei Li, Xin Li, Hong-Jin Li, Bin Li,

<h4>Background</h4>Psoriasis is an autoimmune disease mediated by T cells. However, treatment remains a clinical challenge because of its frequent recurrence. Celastrol (Cel), the main active ingredient in Tripterygium wilfordii Hook F, is efficacious in treating autoimmune diseases such as psoriasis.<h4>Objective</h4>To investigate the effect and mechanism of topical Cel in imiquimod ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112644]

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CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer.

Jean-Baptiste Delhorme, Emilie Bersuder, Chloé Terciolo, Ourania Vlami, Marie-Pierrette Chenard, Elisabeth Martin, Serge Rohr, Cécile Brigand, Isabelle Duluc, Jean-Noël Freund, Isabelle Gross,

Most patients affected with colorectal cancers (CRC) are treated with 5-fluorouracil (5-FU)-based chemotherapy but its efficacy is often hampered by resistance mechanisms linked to tumor heterogeneity. A better understanding of the molecular determinants involved in chemoresistance is critical for precision medicine and therapeutic progress. Caudal type homeobox 2 (CDX2) is ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112630]

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The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy.

Ziqi Yan, Qiong Shi, Xumei Liu, Jinghua Li, Vidula Ahire, Shenqiu Zhang, Jing Zhang, Dun Yang, Thaddeus D Allen,

Plants are a rich source for bioactive compounds. However, plant extracts can harbor a mixture of bioactive molecules that promote divergent phenotypes and potentially have confounding effects in bioassays. Even with further purification and identification, target deconvolution can be challenging. Corynoline and acetylcorynoline, are phytochemicals that were previously isolated through ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112645]

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A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction.

Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song,

Sarcopenia characterized by reduced skeletal muscle mass and decreased muscle strength is increasing in prevalence globally. The pathophysiology of sarcopenia is related to various factors including hormonal imbalance, increased intracellular oxidative stress, reduction of food intake, advanced age, low body mass index, and low physical activity. Recently, sarcopenia has been ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112636]

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The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.

Devin Kepchia, Ling Huang, Antonio Currais, Zhibin Liang, Wolfgang Fischer, Pamela Maher,

J147 is a novel drug candidate developed to treat neurological dysfunction. Numerous studies have demonstrated the beneficial effects of J147 in cellular and animal models of disease which has led to the transitioning of the compound into human clinical trials. However, no biomarkers for its target engagement have been identified. ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112648]

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ANKRD22 is a novel therapeutic target for gastric mucosal injury.

Rui Wang, Youhe Wu, Yue Zhu, Sheng Yao, Yongliang Zhu,

Ankyrin repeat domain 22 (ANKRD22) is a nuclear-encoded mitochondrial membrane protein that is highly expressed in normal gastric mucosal epithelial cells and activated macrophages. As a regulator of mitochondrial Ca<sup>2+</sup>, ANKRD22 could help repair damaged gastric mucosa by promoting the mobilization of LGR5<sup>+</sup> gastric epithelial cells via the upregulation of ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112649]

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Decursin prevents melanogenesis by suppressing MITF expression through the regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β cascades.

Hyungyeong Choi, Jeong-Hyun Yoon, Kumju Youn, Mira Jun,

Abnormal melanin synthesis upon UV exposure causes excessive oxidative stress, which leads to skin hyperpigmentation disorders such as freckles, melisma, and age spots. The present study investigated the anti-melanogenic effects of decursin and the underlying mechanism using multiple approaches. Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112651]

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Protective role of activating PPARγ in advanced glycation end products-induced impairment of coronary artery vasodilation via inhibiting p38 phosphorylation and reactive oxygen species production.

Bing Hua, Qingbo Liu, Side Gao, Weiping Li, Hongwei Li,

Advanced glycation end products (AGEs) can damage voltage-gated K<sup>+</sup> (Kv) channels and attenuate coronary artery vasodilation, but the underlying mechanisms remain unclear. The aim of this study was to investigate the role and potential mechanism of PPARγ in AGEs-induced Kv 1 channels impairment. We used both primary rat coronary smooth ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112641]

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The effect of trehalose administration on vascular inflammation in patients with coronary artery disease.

Tannaz Jamialahmadi, Farshad Emami, Ramin Khameneh Bagheri, Hedieh Alimi, Fabio Bioletto, Simona Bo, Behzad Aminzadeh, Mohammad Ali Ansari, Faezeh Ehsani, Omid Rajabi, Shiva Ganjali, Maciej Banach, Amirhossein Sahebkar,

<h4>Background</h4>In recent years, several trials investigated the role of anti-inflammatory agents in reducing cardiovascular events. Trehalose is a natural disaccharide able to reduce inflammation by enhancing macrophage autophagic activity. This action has been demonstrated to attenuate atherosclerotic plaque development in various pro-atherogenic animal models. However, at present, no data about ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112632]

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Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.

Ana Virseda-Berdices, David Rojo, Isidoro Martínez, Juan Berenguer, Juan González-García, Oscar Brochado-Kith, Amanda Fernández-Rodríguez, Cristina Díez, Víctor Hontañon, Leire Pérez-Latorre, Rafael Micán, Coral Barbas, Salvador Resino, María Angeles Jiménez-Sousa, ,

<h4>Background</h4>A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting antivirals (DAAs) therapy and their association with liver disease scores in HIV/HCV-coinfected patients with ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112623]

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Osteoprotective effect of the marine alkaloid norzoanthamine on an osteoporosis model in ovariectomized rat.

Patricia García-García, Ricardo Reyes, Carmen Évora, Araceli Delgado, José J Fernández, Antonio Hernández Daranas,

Norzoanthamine (NZ), an alkaloid that has been isolated from the marine cnidiaria Zoanthus sp., has been shown an interesting anti-osteoporotic activity. Although its mechanism of action is not yet clear, it seems that it is different from those of currently used drugs making it particularly interesting. Previous studies have been ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112631]

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Retraction notice to "Ginkgolides B alleviates hypoxia-induced PC-12 cell injury by up-regulation of PLK1" [Biomed. Pharmacother. 115 (2019) 108885].

Jian Gao, Mingyang Kang, Yingying Han, Tuo Zhang, Hui Jin, Chunyang Kang,

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, :112624]

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Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance.

Yarigui Bao, Jing Peng, Kai-Li Yang, Chang-Hai Wang, Yu-Fei Guo, Zi-Shuo Guo, Shou-Ying Du,

Chinese medicine Di-Long, the dried body of Pheretima vulgaris (Chen) has been used for the treatment of joint inflammation, arthralgia and numbness of limbs for many years. This study was to investigate the anti-rheumatoid arthritis (RA) effects of Di-Long and to explore its possible mechanisms. The identification and quantification of ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112643]

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Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective.

Chetna Hemrajani, Poonam Negi, Arun Parashar, Gaurav Gupta, Niraj Kumar Jha, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua,

Atopic dermatitis (AD) is an inflammatory disorder centered around loss of epidermal barrier function, and T helper 2 (Th2) immune responses. The current understanding of disease heterogeneity and complexity, limits the rational use of existing topical, systemic therapeutic agents, but paves way for development of advanced therapeutic agents. Additionally, advanced ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112633]

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Effect of Lycium barbarum polysaccharides on cell signal transduction pathways.

Youchao Qi, Guozhen Duan, Guanghui Fan, Ning Peng,

Lycium barbarum polysaccharide (LBP), is a major active ingredient Lycium barbarum (LB), which exhibits several beneficial effects through NF-κB, PI3K-Akt-mTOR, p38-MAPK, Wnt-β-catenin, PI3K-Akt-GSK-3β, and MyD88 signal pathway, including anti-oxidation, and anti-aging, hypolipidemic and hypoglycemic, radiation, anti-tumor, and neuroprotection. Today, many researching papers are published on the LBP in physiology and ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112620]

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Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis.

Seon-A Jang, Youn-Hwan Hwang, Hyun Yang, Jin Ah Ryuk, Dong Ryun Gu, Hyunil Ha,

Pyrrosia lingua (Thunb.) Farw is a common plant that has been widely used as a traditional herbal medicine in China and Korea to treat patients suffering from pain, vaginal bleeding and urolithiasis. However, the pharmacological effects of P. lingua on bone remain unknown. We investigated the anti-osteoporotic effects of an ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112640]

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The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury.

Eslam E Abd El-Fattah, Sameh Saber, Ahmed A E Mourad, Eman El-Ahwany, Noha A Amin, Simona Cavalu, Galal Yahya, Ahmed S Saad, Mansour Alsharidah, Ahmed Shata, Haidy M Sami, Mohamed M Y Kaddah, Amal M H Ghanim,

Acute lung injury (ALI) is one the most common causes of morbidity and mortality in critically ill patients. In this study, we examined for first time the role of dapagliflozin (DPGZ) in lipopolysaccharide (LPS)-induced ALI in rats and determined the underlying molecular mechanisms by evaluating the effects of DPGZ on ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112628]

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Retraction notice to "Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1" [Biomed. Pharmacother. 92 (2017) 451-458].

Qinggang Wang, Yunyun Jiang, Renle Guo, Rongbin Lv, Tingting Liu, Hongji Wei, Hanxin Ming, Xingsong Tian,

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, :112625]

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Retraction notice to "Kaempferol protects lipopolysaccharide-induced inflammatory injury in human aortic endothelial cells (HAECs) by regulation of miR-203" [Biomed. Pharmacother. 115 (2019) 108888].

Shuxian Cui, Jianmin Tang, Shanshan Wang, Ling Li,

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, :112627]

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Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation.

Yan-Yan Yu, Xiang-Qian Li, Wen-Peng Hu, Shi-Chao Cu, Jia-Jia Dai, Ya-Nan Gao, Yi-Ting Zhang, Xiao-Yi Bai, Da-Yong Shi,

Sepsis-induced acute kidney injury (AKI) and acute lung injury (ALI) have high morbidity and mortality, with no effective clinically available drugs. Anti-inflammation is effective strategy in the therapy of AKI and ALI. NF-κB is a target for the development of anti‑inflammatory agents. The purpose of the study is to evaluate ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 147:112615]

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Retraction notice to "Alkannin inhibits proliferation, migration and invasion of hepatocellular carcinoma cells via regulation of miR-92a" [Biomed. Pharmacother. 114 (2019) 108782].

Baozhen Sun, Jingzhe Zhang, Meihan Liu, Lianyue Guan,

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, :112626]

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