Full Text Journal Articles in
Journal Biomaterials

Advertisement

Find full text journal articles






Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials.

Eric C Hobson, Weiping Li, Benjamin A Juliar, Andrew J Putnam, Jan P Stegemann, Cheri X Deng,

Resonant Acoustic Rheometry (RAR) is a new, non-contact technique to characterize the mechanical properties of soft and viscoelastic biomaterials, such as hydrogels, that are used to mimic the extracellular matrix in tissue engineering. RAR uses a focused ultrasound pulse to generate a microscale perturbation at the sample surface and tracks ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120676]

Cited: 0 times

View full text PDF listing >>



Corrigendum to "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells" [Biomaterials 236 (2020) 119,802].

Heyong Yin, Franziska Strunz, Zexing Yan, Jiaju Lu, Christoph Brochhausen, Stefanie Kiderlen, Hauke Clausen-Schaumann, Xiumei Wang, Manuela E Gomes, Volker Alt, Denitsa Docheva,

Biomaterials (Biomaterials)
[2021, 269:120617]

Cited: 0 times

View full text PDF listing >>



Advertisement

Cryopreservation and CO2-independent culture of 3D cardiac progenitors for spaceflight experiments.

Antonio Rampoldi, Rajneesh Jha, Jordan Fite, Gene Boland, Chunhui Xu,

Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved cultures of cardiomyocytes being loaded and cultivated in ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120673]

Cited: 0 times

View full text PDF listing >>



Self-assembled peptide nanorod vaccine confers protection against influenza A virus.

Ximena Zottig, Soultan Al-Halifa, Mélanie Côté-Cyr, Cynthia Calzas, Ronan Le Goffic, Christophe Chevalier, Denis Archambault, Steve Bourgault,

Proteinaceous nanostructures have emerged as a promising strategy to develop safe and efficient subunit vaccines. The ability of synthetic β-sheet self-assembling peptides to stabilize antigenic determinants and to potentiate the epitope-specific immune responses have highlighted their potential as an immunostimulating platform for antigen delivery. Nonetheless, the intrinsic polymorphism of the ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120672]

Cited: 0 times

View full text PDF listing >>



Corrigendum to "A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect" [Biomaterials 253 (2020) 120095].

Dan Lin, Bolei Cai, Le Wang, Lisha Cai, Zihao Wang, Jirong Xie, Qian-Xin Lv, Yuan Yuan, Changsheng Liu, Steve Gf Shen,

Biomaterials (Biomaterials)
[2021, 269:120618]

Cited: 0 times

View full text PDF listing >>



Resorbable additively manufactured scaffold imparts dimensional stability to extraskeletally regenerated bone.

C Vaquette, J Mitchell, T Fernandez-Medina, S Kumar, S Ivanovski,

Dimensionally stable vertical bone regeneration outside of the existing bony envelope is a major challenge in the field of orofacial surgery. In this study, we demonstrate that a highly porous, resorbable scaffold fabricated using additive manufacturing techniques enables reproducible extra-skeletal bone formation and prevents bone resorption. An additively manufactured medical ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120671]

Cited: 0 times

View full text PDF listing >>



Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling.

Kelsey G DeFrates, Daniela Franco, Ellen Heber-Katz, Phillip B Messersmith,

Historically, the field of regenerative medicine has aimed to heal damaged tissue through the use of biomaterials scaffolds or delivery of foreign progenitor cells. Despite 30 years of research, however, translation and commercialization of these techniques has been limited. To enable mammalian regeneration, a more practical approach may instead be ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120646]

Cited: 0 times

View full text PDF listing >>



Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold.

Eoghan M Cunnane, Niall F Davis, Connor V Cunnane, Katherine L Lorentz, Alan J Ryan, Jochen Hess, Justin S Weinbaum, Michael T Walsh, Fergal J O'Brien, David A Vorp,

This study addresses a crucial gap in the literature by characterising the relationship between urethral tissue mechanics, composition and gross structure. We then utilise these data to develop a biomimetic urethral scaffold with physical properties that more accurately mimic the native tissue than existing gold standard scaffolds; small intestinal submucosa ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120651]

Cited: 0 times

View full text PDF listing >>



3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts.

Zuyan Lu, Shiny Amala Priya Rajan, Qianqian Song, Yu Zhao, Meimei Wan, Julio Aleman, Aleksander Skardal, Colin Bishop, Anthony Atala, Baisong Lu,

Generating microliver tissues to recapitulate hepatic function is of increasing importance in tissue engineering and drug screening. But the limited availability of primary hepatocytes and the marked loss of phenotype hinders their application. Human induced hepatocytes (hiHeps) generated by direct reprogramming can address the shortage of primary hepatocytes to make ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120668]

Cited: 0 times

View full text PDF listing >>



Valve endothelial-interstitial interactions drive emergent complex calcific lesion formation in vitro.

Terence W Gee, Jennifer M Richards, Ablajan Mahmut, Jonathan T Butcher,

<h4>Objective</h4>Calcific aortic valve disease (CAVD) is an actively regulated degenerative disease process. Clinical lesions exhibit marked 3D complexity not represented in current in vitro systems. We here present a unique mechanically stressed 3D culture system that recapitulates valve interstitial cell (VIC) induced matrix calcification through myofibroblastic activation and osteoblastic differentiation. ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120669]

Cited: 0 times

View full text PDF listing >>



Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles.

Babita Shashni, Yuji Nishikawa, Yukio Nagasaki,

In cancer, angiogenesis is a critical phenomenon of nascent blood vessel development to facilitate the oxygen and nutrient supply prerequisite for tumor progression. Therefore, targeting tumors at the angiogenesis step may be significant to prevent their advanced progression and metastasis. Although angiogenesis inhibitors can limit the further growth of tumors, ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120645]

Cited: 0 times

View full text PDF listing >>



In situ poly I:C released from living cell drug nanocarriers for macrophage-mediated antitumor immunotherapy.

Haimei Zhou, Huamei He, Ruijing Liang, Hong Pan, Ze Chen, Guanjun Deng, Shengping Zhang, Yifan Ma, Lanlan Liu, Lintao Cai,

Immunotherapy is one of the most promising approaches to inhibit tumor growth and metastasis by activating host immune functions. However, the arising problems such as low immune response caused by complex tumor microenvironment and extremely systemic immune storm still limit the clinical applications of immunotherapy. Here, we construct Poly I: ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120670]

Cited: 0 times

View full text PDF listing >>



Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model.

Fabio Magarotto, Alberto Sgrò, Agner Henrique Dorigo Hochuli, Marina Andreetta, Michele Grassi, Mattia Saggioro, Leonardo Nogara, Anna Maria Tolomeo, Riccardo Francescato, Federica Collino, Giuseppe Germano, Federico Caicci, Edoardo Maghin, Martina Piccoli, Marcin Jurga, Bert Blaauw, Piergiorgio Gamba, Maurizio Muraca, Michela Pozzobon,

Biological scaffolds derived from decellularized tissues are being investigated as a promising approach to repair volumetric muscle losses (VML). Indeed, extracellular matrix (ECM) from decellularized tissues is highly biocompatible and mimics the original tissue. However, the development of fibrosis and the muscle stiffness still represents a major problem. Intercellular signals ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120653]

Cited: 0 times

View full text PDF listing >>



Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages.

Claire E Witherel, Kimheak Sao, Becky K Brisson, Biao Han, Susan W Volk, Ryan J Petrie, Lin Han, Kara L Spiller,

Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function. While macrophages are known regulators of fibroblast behavior, how their phenotype influences ECM assembly and the progression of the foreign ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120667]

Cited: 0 times

View full text PDF listing >>



Multiphoton microfabrication and micropatterning (MMM) - An all-in-one platform for engineering biomimetic soluble cell niches.

Xinna Wang, Bo Gao, Barbara P Chan,

Engineered biomimetic cell niches represent a valuable in vitro tool for investigating physiological and pathological cellular activities, while developing an all-in-one technology to engineer cell niches, particularly soluble cell niche factors, with retained bioactivities, remains challenging. Here, we report a mask-free, non-contact and biocompatible multiphoton microfabrication and micropatterning (MMM) technology ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120644]

Cited: 0 times

View full text PDF listing >>



Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment.

Xiaoli Wu, Han Yang, Xingmeng Chen, Junxiao Gao, Yue Duan, Daohe Wei, Jinchao Zhang, Kun Ge, Xing-Jie Liang, Yuanyu Huang, Sizhou Feng, Rongli Zhang, Xi Chen, Jin Chang,

A variety of therapies have been developed and used for the treatment of colon cancer, however, the high mortality rate remains high and more effective strategies are still in urgent needs. In this study, an immunotherapy approach that is composed of innate immune activator Astragaloside III (As) and the photodynamic ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120654]

Cited: 0 times

View full text PDF listing >>



Photodynamic/ photothermal therapy enhances neutrophil-mediated ibrutinib tumor delivery for potent tumor immunotherapy: More than one plus one?

Qiujun Qiu, Cong Li, Xinyang Yan, Hongxia Zhang, Xiang Luo, Xin Gao, Xinrong Liu, Yanzhi Song, Yihui Deng,

Neutrophil-mediated drug-delivery systems have gained widespread attention owing to their superior efficacy in cancer therapy. Neutrophils, the most abundant white cells in peripheral blood, are known to migrate to inflamed tumors. Here, we elaborate on a novel strategy to enhance tumor infiltration of neutrophils by photodynamic/photothermal therapy (PDT/PTT) to deliver ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120652]

Cited: 0 times

View full text PDF listing >>



Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy.

Jinsheng Huang, Zecong Xiao, Yongcheng An, Shisong Han, Wei Wu, Yong Wang, Yu Guo, Xintao Shuai,

Although a combination with photodynamic therapy (PDT) is a potential means to improve the immune checkpoint blockade (ICB)-based anticancer immunotherapy, this strategy is subjected to the extremely poor light penetration in melanoma. Herein, we develop a lipid (LP)-based micellar nanocarrier encapsulating sonosensitizer chlorin e6 (Ce6) in the core, conjugating anti-PD-L1 ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120636]

Cited: 0 times

View full text PDF listing >>



Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers.

Qi Sun, Zhenzhen Yang, Meng Lin, Yiwei Peng, Rudong Wang, Yitian Du, Yu Zhou, Jiajia Li, Xianrong Qi,

Phototherapy and immunogenic cell death (ICD) are powerful strategies to fight cancer. However, their therapeutic outcomes are diminished by immunosuppressive and hypoxia microenvironment. Herein, a photo-based, immunomodulating and hypoxia-alleviated nanosystem, [email protected], is proposed to achieve the synergism between phototherapy and immunotherapy. Catalase (CAT) and anti-GITR antibody (DTA-1) are loaded to ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120648]

Cited: 0 times

View full text PDF listing >>



Elastin-like hydrogel stimulates angiogenesis in a severe model of critical limb ischemia (CLI): An insight into the glyco-host response.

Grazia Marsico, Chunseng Jin, Sunny A Abbah, Eva M Brauchle, Dilip Thomas, Ana Lúcia Rebelo, Doriana Orbanić, Sandrine Chantepie, Paolo Contessotto, Dulce Papy-Garcia, Carlos Rodriguez-Cabello, Michelle Kilcoyne, K Schenke-Layland, N G Karlsson, Karl J A McCullagh, Abhay Pandit,

Critical limb ischemia (CLI) is characterized by the impairment of microcirculation, necrosis and inflammation of the muscular tissue. Although the role of glycans in mediating inflammation has been reported, changes in the glycosylation following muscle ischemia remains poorly understood. Here, a murine CLI model was used to show the increase ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120641]

Cited: 0 times

View full text PDF listing >>



D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy.

Chuanchao Du, Mengxue Zhou, Fei Jia, Lifo Ruan, Huiru Lu, Jiayu Zhang, Bin Zhu, Xiaoguang Liu, Jun Chen, Zhifang Chai, Yi Hu,

Osteosarcoma is a common type of bone cancers with a high rate of pulmonary recurrence. High-dose radiation therapy is useful for the ablation of unresectable osteosarcoma. However, it may cause severe adverse effects. To address this problem, we developed D-arginine-loaded metal-organic frameworks (MOF) nanoparticles for improving the radiosensitivity of osteosarcoma. ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120642]

Cited: 0 times

View full text PDF listing >>



Rheological characterization, compression, and injection molding of hydroxyapatite-silk fibroin composites.

Stephanie L McNamara, Ethan M McCarthy, Daniel F Schmidt, Stephen P Johnston, David L Kaplan,

Traditional bone fixation devices made from inert metal alloys provide structural strength for bone repair but are limited in their ability to actively promote bone healing. Although several naturally derived bioactive materials have been developed to promote ossification in bone defects, it is difficult to translate small-scale benchtop fabrication of ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120643]

Cited: 0 times

View full text PDF listing >>



Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer.

Huaqing Chen, Lanlan Liu, Aiqing Ma, Ting Yin, Ze Chen, Ruijing Liang, Yuzhi Qiu, Mingbin Zheng, Lintao Cai,

Sonodynamic therapy (SDT) is a promising approach for tumor treatment because of the noninvasion, and future would be perfect while it activates systemic immune responses through deep penetration to effectively avoid tumor recurrence. Here, a multifunctional nanosonosensitizer system (FA-MnPs) is designed by encapsulating manganese-protoporphyrin (MnP) into folate-liposomes. The nanoparticles of ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120639]

Cited: 0 times

View full text PDF listing >>



A near-infrared light-responsive extracellular vesicle as a "Trojan horse" for tumor deep penetration and imaging-guided therapy.

Zeng Xu, Huabei Huang, Xiang Xiong, Xiaoqing Wei, Xing Guo, Jingya Zhao, Shaobing Zhou,

How to make the nanoparticles evade immune surveillance and deeply penetrate the tumor tissues is of great importance to maximize the therapeutic efficacy of nanomedicines. Here, a near-infrared (NIR) light-responsive extracellular vesicle as a nanoplatform is developed to realize long circulation in blood, deep penetration in tumor tissues and rapid ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120647]

Cited: 0 times

View full text PDF listing >>



A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration.

Rebecca Rothe, Yong Xu, Alvin Kuriakose Thomas, Sebastian Meister, Yixin Zhang, Jens Pietzsch, Sandra Hauser,

Biomaterials with attenuated adverse host tissue reactions, and meanwhile, combining biocompatibility with mimicry of mechanical and biochemical cues of native extracellular matrices (ECM) to promote integration and regeneration of tissues are important for many biomedical applications. Further, the materials should also be tailorable to feature desired application-related functions, like tunable ... Read more >>

Biomaterials (Biomaterials)
[2020, 269:120637]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9994 s