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Rosmarinic acid protects mice from Concanavalin A-induced hepatic injury through AMPK signaling.

Yangyang Wang, Jie Meng, Lu Men, Boran An, Xiaoxu Jin, Wenjuan He, Sucai Lu, Na Li,

Rosmarinic acid (RA) is extensively utilized in herbal medicine in China. The adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling can be activated by RA and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C (CC). The objective of this study was to investigate the role of AMPK signaling involving the protective ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis via the PI3K/Akt, Bax/Bcl-2, and Wnt/β-catenin Pathway in LX-2 Cells.

Yuanguo Xiong, Hao Lu, Hanlin Xu,

Hepatic fibrosis (HF) is a common disease, with currently no available treatment. Galangin, a natural flavonoid extracted from Alpinia officinaruim Hance, has multiple effects demonstrated in previous studies. The aim of the present study was to explore the anti-fibrogenic effect of galangin in vitro, and research its potential molecular mechanisms. ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Sinomenine inhibited Interleukin-1β-induced matrix metalloproteinases levels via SOCS3 up-regulation in SW1353 cells.

Wei Qi, Yongfu Gu, Zhen Wang, Weimin Fan,

Matrix metalloproteinases (MMPs) are required for collagen degradation which play a key pathological role in arthritis progression. Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1β)-induced MMPs production and its underlying mechanism were explored in SW1353 cells. The MTT assay showed that 200 and 400 µM SN significantly ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Cigarette smoke extract and its cytotoxic factor acrolein inhibit nitric oxide production in human vascular endothelial cells.

Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa,

Acrolein (ACR), a highly reactive α,β-unsaturated aldehyde, is a major cytotoxic factor in nicotine- and tar-free cigarette smoke extract (CSE). There are conflicting results regarding endothelial functions despite the fact that both CSE and ACR cause cellular damage. Several lines of evidence indicate that CSE impairs endothelium-derived nitric oxide (NO)-dependent ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Olsalazine sodium increases renal urate excretion by modulating urate transporters in hyperuricemic animals.

Yanfen Niu, Pingfen Yang, Hongjian Li, Qiang Li, Hua Lin, Lihui Gao, Ling Li,

Hyperuricemia is mainly the result of relative underexcretion of urate. Urate is mainly eliminated by kidney and several important transporters expressed on the membrane of renal tubular cells involved in urate excretion. Olsalazine sodium was screened from 3167 authorized small compounds/drugs, targeting xanthine oxidoreductase. In previous study, we reported that ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Risk Factors for Skin Toxicities Associated with Bendamustine-Based Chemotherapy in Patients with Non-Hodgkin Lymphoma.

Mayako Uchida, Yasuhiro Mori, Kenta Akiba, Moena Miyasaka, Tatsuya Hirano, Hiroaki Ikesue, Yuki Yamaguchi, Aoi Takano, Nami Maegawa, Yoshimitsu Shimomura, Keiko Hosohata, Nobuyuki Muroi, Takayuki Ishikawa, Tohru Hashida, Tsutomu Nakamura,

Bendamustine plays an especially important role as a treatment for non-Hodgkin lymphoma (NHL). However, patients administered bendamustine alone or in combination with rituximab (BR) may experience drug-associated skin toxicities that can profoundly impact their health-related QOL through both physical discomfort and psychological distress. Moreover, worsening skin symptoms may lead to ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(10):1577-1582]

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Development of a Diagnostic Screening Strategy for Niemann-Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine.

Anna Iwahori, Masamitsu Maekawa, Aya Narita, Akie Kato, Toshihiro Sato, Jiro Ogura, Yu Sato, Masafumi Kikuchi, Atsuko Noguchi, Katsumi Higaki, Torayuki Okuyama, Tsutomu Takahashi, Yoshikatsu Eto, Nariyasu Mano,

Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this study, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(9):1398-1406]

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Evaluation of Daptomycin-Induced Cellular Membrane Injury in Skeletal Muscle.

Takehiro Yamada, Shuhei Ishikawa, Nobuhisa Ishiguro, Masaki Kobayashi, Ken Iseki,

Daptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms and is especially effective against methicillin-resistant Staphylococcus aureus. Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed mechanisms underlying these adverse drug reactions in skeletal muscle are unclear. This study aimed ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(9):1338-1345]

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Low Viability of Cholera Toxin-Producing Vibrio cholerae O1 in the Artificial Low Ionic Strength Aquatic Solution.

Subha Sankar Paul, Eizo Takahashi, Goutam Chowdhury, Shin-Ichi Miyoshi, Tamaki Mizuno, Asish K Mukhopadhyay, Shanta Dutta, Keinosuke Okamoto,

It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we could ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(8):1288-1291]

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Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats.

Jizu Ling, Qin Yu, Yuning Li, Xinhui Yuan, Xiaoya Wang, Weiying Liu, Ting Guo, Yanni Duan, Lifang Li,

Oxidative stress plays an essential role in obstructive sleep apnea-hypopnea syndrome-induced cognitive dysfunction in children. This study investigated the effects of edaravone, a potent free radical scavenger, on intermittent hypoxia (IH)-induced oxidative damage and cognition impairment in a young rat model of IH. IH rats were treated with edaravone for ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(8):1196-1201]

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Adenosine A2A Receptor Agonist PSB-0777 Modulates Synaptic Proteins and AMPA Receptor Expression in a Dose- and Time-Dependent Manner in Rat Primary Cortical Neurons.

Shaolei Luo, Yangyang Hou, Yaping Zhang, Tengfei Ma, Wenping Shao, Chunjie Xiao,

Regulating synaptic formation and transmission is critical for the physiology and pathology of psychiatric disorders. The adenosine A2A receptor subtype has attracted widespread attention as a key regulator of neuropsychiatric activity, neuroprotection and injury. In this study, we systematically investigated the regulatory effects of a novel A2A receptor agonist, PSB-0777, ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(8):1159-1171]

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Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer.

Mayako Uchida, Yuki Yamaguchi, Syuhei Hosomi, Hiroaki Ikesue, Yasuhiro Mori, Nami Maegawa, Aoi Takano, Yuki Sato, Keiko Hosohata, Nobuyuki Muroi, Keisuke Tomii, Tohru Hashida, Tsutomu Nakamura,

We retrospectively obtained data of patient background and pretreatment characteristics from medical records and identified the predictive factors of febrile neutropenia (FN) in patients with non-small cell lung cancer (NSCLC) treated with docetaxel alone or in combination with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab. Patients were eligible for ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(8):1235-1240]

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Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.

Mingzhi Luo, Peili Yu, Kai Ni, Yang Jin, Lei Liu, Jingjing Li, Yan Pan, Linhong Deng,

Excessive contraction of airway smooth muscle cells (ASMCs) is a hallmark feature of asthma. Intriguing, the activation of bitter taste receptor (TAS2R) in ASMCs can relax ASMCs. However, there is a lack of potent TAS2R agonists that can be used in asthma therapies since those tested agonists cannot relax ASMCs ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1027-1034]

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Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts.

Seok-Hee Lim, Bing Si Li, Ri Zhe Zhu, Jae-Ho Seo, Byung-Min Choi,

Latifolin, a natural flavonoid found in Dalbergia odorifera T. Chen, has been reported to exhibit anti-inflammatory and anticarcinogenic activities in vitro. However, the anti-aging effects of latifolin are unknown. In this study, we selected a model in vitro system, hydrogen peroxide (H2O2)-induced senescence in human dermal fibroblasts (HDFs), to examine ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1104-1110]

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Reduction in the Doses of Direct Oral Anticoagulants and Risk of Ischemic Stroke Events: A Hospital Survey.

Aya Ueda, Shinji Toki, Chisato Kitayama, Manabu Akazawa,

Inappropriately reduced doses (IRDs) of direct oral anticoagulants (DOACs) are common in clinical practice. We performed a retrospective review using electronic medical records of St. Marianna University School of Medicine Hospital (a 1200-bed teaching hospital in Japan) to address the prevalence of IRDs and patient-related factors that result in IRDs. ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1135-1140]

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The Application of the in-Situ Hyperthermia Emission from Acoustic Nanodroplets for Theranostic Dual-Imaging and Antitumor Modalities.

Rodi Abdalkader, Johan Unga, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida,

In this study, we have developed a theranostic nanocarrier that can emit heat upon the exposure to ultrasound (US) irradiation as well as the generation of a contrast signal that can be detected with ultrasonography. The prepared acoustic nanodroplets (NDs) made with liquid perfluporopentane (PFPn) had an average size of ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1141-1145]

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Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis.

Bin Xiao, Xiaobo Huang, Qian Wang, Yanchuan Wu,

Beta-asarone (β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting the central nervous system. However, the effect of β-Asarone on myocardial ischemia-reperfusion (I/R) injury is not yet clear. This study used a rat model with 45 min ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1046-1051]

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Three-Dimensional Culture of Umbilical Cord Mesenchymal Stem Cells Effectively Promotes Platelet Recovery in Immune Thrombocytopenia.

Xiangcui Gong, Di Sun, Zhenghao Li, Qing Shi, Dong Li, Xiuli Ju,

Mesenchymal stem cells (MSCs) can effectively regulate immune cell functions and therefore are promising for the treatment of autoimmune disorders, such as immune thrombocytopenia (ITP). Recent research has shown that three-dimensional (3D) culture method have many advantages over conventional culture with respect to MSC secretion and immunogenicity. In this study, ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1052-1060]

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Increased Vancomycin Clearance in Patients with Solid Malignancies.

Tomohiro Izumisawa, Nobuyuki Wakui, Tomoyoshi Kaneko, Masakazu Soma, Masahiko Imai, Daisuke Saito, Hideo Hasegawa, Tetsuya Horino, Noriko Takahashi,

Vancomycin (VAN) is an anti-microbial agent used to treat a number of bacterial infections, which has a high incidence of nephrotoxicity. We examined the pharmacokinetics of VAN retrospectively based on trough concentrations at large scale and identified pharmacokinetic differences between Japanese patients having solid malignancy and non-malignancy patients. Data were ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1081-1087]

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Induction of PD-L1 by Nitric Oxide via JNK Activation in A172 Glioblastoma Cells.

Yoshimitsu Kiriyama, Anna Tani, Minako Kadoya, Ryoko Okamoto, Hiromi Nochi,

Glioblastoma comprises 54% of all the gliomas derived from glial cells and are lethally malignant tumors of the central nervous system (CNS). Glioma cells disrupt the blood-brain barrier, leading to access of circulating immune cells to the CNS. Blocking the interaction between programmed cell death 1 (PD-1) and programmed cell ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):1020-1022]

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Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation.

Fangmei Chen, Xiaoying Yin, Yanqing Wang, Yixin Lv, Si Sheng, Sheng Ouyang, Youquan Zhong,

Cytisine N-methylene-(5,7-dihydroxy-4'-methoxy)-isoflavone (CNF2) is a new compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary pharmacodynamic studies demonstrated its activity in inhibiting breast cancer cell metastasis. This study examined the pharmacokinetics, absolute bioavailability, and tissue distribution of CNF2 in rats, and combined computer-aided technology to predict the druggability of ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):976-984]

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L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice.

Yong Chen, Fang Lian, Qiang Lu, Shengliang Peng, Jiahao Li, Song Huang, Xiaohong Du,

The neurodevelopmental toxicity of isoflurane has been proved by many studies, which makes it essential to explore the underline mechanisms and search for protective agents to attenuate its neurotoxcity. Accumulating evidence showed that L-theanine had neuroprotective effects on injured neurons and the developing brain. The present study was designed to ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):938-945]

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Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of Candida krusei.

Chiho Yanai, Hiroaki Tanaka, Noriko N Miura, Ken-Ichi Ishibashi, Daisuke Yamanaka, Hiroaki Ohnishi, Naohito Ohno, Yoshiyuki Adachi,

Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as the hot water extract of C. albicans (CADS) and Candida water-soluble fraction (CAWS), induced coronary vasculitis similar to KD in mice. An increasing proportion of deep-seated candidiasis cases are ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):848-858]

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Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels.

Ali Parlar, Seyfullah Oktay Arslan, Saliha Ayşenur Çam,

Inflammation, and the pain that accompanies it, is a natural response of the body. The licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous, and anti-nociceptive effects of its extracts. The effective ingredient remains unidentified; however, one possibility is the unique isoflavone glabridin. The anti-nociceptive, and anti-inflammatory effects of glabridin and ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):884-897]

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Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT2B Receptor Blockade in the Rat Formalin Test.

Takato Nikaido, Chikashi Maruyama, Minako Hamanaka, Chiharu Yamaguchi, Yukiko Fujimaru, Yutaka Nakanishi, Toshiki Asano, Akiko Takaoka,

Ethenzamide (ETZ), an antipyretic analgesic categorized as a non-steroidal anti-inflammatory drug (NSAID), is widely used as an OTC drug in combination with other NSAIDs. However, its site of action and mechanism underlying its analgesic action have not yet been fully elucidated. In this study, we performed in vitro pharmacological assays ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):839-847]

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