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Edaravone improves intermittent hypoxia-induced cognitive impairment and hippocampal damage in rats.

Jizu Ling, Qin Yu, Yuning Li, Xinhui Yuan, Xiaoya Wang, Weiying Liu, Ting Guo, Yanni Duan, Lifang Li,

Oxidative stress plays an essential role in obstructive sleep apnea-hypopnea syndrome-induced cognitive dysfunction in children. This study investigated the effects of edaravone, a potent free radical scavenger, on intermittent hypoxia (IH)-induced oxidative damage and cognition impairment in a young rat model of IH. IH rats were treated with edaravone for ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer.

Mayako Uchida, Yuki Yamaguchi, Syuhei Hosomi, Hiroaki Ikesue, Yasuhiro Mori, Nami Maegawa, Aoi Takano, Yuki Sato, Keiko Hosohata, Nobuyuki Muroi, Keisuke Tomii, Toru Hashida, Tsutomu Nakamura,

We retrospectively obtained data of patient background and pretreatment characteristics from medical records and identified the predictive factors of febrile neutropenia (FN) in patients with non-small cell lung cancer (NSCLC) treated with docetaxel alone or in combination with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab.Patients were eligible for inclusion ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Adenosine A2A Receptor Agonist PSB-0777 Modulates Synaptic Proteins and AMPA Receptor Expression in A Dose- and Time-Dependent Manner in Rat Primary Cortical Neurons.

Shaolei Luo, Yangyang Hou, Yaping Zhang, Tengfei Ma, Wenping Shao, Chunjie Xiao,

Regulating synaptic formation and transmission is critical for the physiology and pathology of psychiatric disorders. The adenosine A2A receptor subtype has attracted widespread attention as a key regulator of neuropsychiatric activity, neuroprotection and injury. In this study, we systematically investigated the regulatory effects of a novel A2A receptor agonist, PSB-0777, ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Latifolin inhibits oxidative stress-induced senescence via upregulation of SIRT1 in human dermal fibroblasts.

Seok-Hee Lim, Bing Si Li, Ri Zhe Zhu, Jae-Ho Seo, Byung-Min Choi,

Latifolin, a natural flavonoid found in Dalbergia odorifera T. Chen, has been reported to exhibit anti-inflammatory and anticarcinogenic activities in vitro. However, the anti-aging effects of latifolin are unknown. In this study, we selected a model in vitro system, hydrogen peroxide (H2O2)-induced senescence in human dermal fibroblasts (HDFs), to examine ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.

Mingzhi Luo, Peili Yu, Kai Ni, Yang Jin, Lei Liu, Jingjing Li, Yan Pan, Linhong Deng,

Excessive contraction of airway smooth muscle cells (ASMCs) is a hallmark feature of asthma. Intriguing, the activation of bitter taste receptor (TAS2R) in ASMCs can relax ASMCs. However, there is a lack of potent TAS2R agonists that can be used in asthma therapies since those tested agonists cannot relax ASMCs ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Reduction in the doses of direct oral anticoagulants and risk of ischemic stroke events: A hospital survey.

Aya Ueda, Shinji Toki, Chisato Kitayama, Manabu Akazawa,

Inappropriately reduced doses (IRDs) of direct oral anticoagulants (DOACs) are common in clinical practice. We performed a retrospective review using electronic medical records of St. Marianna University School of Medicine Hospital (a 1200-bed teaching hospital in Japan) to address the prevalence of IRDs and patient-related factors that result in IRDs. ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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The application of the in-situ hyperthermia emission from acoustic nanodroplets for theranostic dual-imaging and antitumor modalities.

Rodi Abdalkader, Johan Unga, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida,

In this study, we have developed a theranostic nanocarrier that can emit heat upon the exposure to ultrasound (US) irradiation as well as the generation of a contrast signal that can be detected with ultrasonography. The prepared acoustic nanodroplets (NDs) made with liquid perfluporopentane (PFPn) had an average size of ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Beta-asarone alleviates myocardial ischemia-reperfusion injury by inhibiting inflammatory response and NLRP3 inflammasome mediated pyroptosis.

Bin Xiao, Xiaobo Huang, Qian Wang, Yanchuan Wu,

Beta-asarone(β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting the central nervous system. However, the effect of β-Asarone on myocardial ischemia-reperfusion injury (I/R) injury is not yet clear. This study used a rat model with 45minutes ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Three-Dimensional Culture of Umbilical Cord Mesenchymal Stem Cells Effectively Promotes Platelet Recovery in Immune Thrombocytopenia.

Xiangcui Gong, Di Sun, Zhenghao Li, Qing Shi, Dong Li, Xiuli Ju,

Mesenchymal stem cells (MSCs) can effectively regulate immune cell functions and therefore are promising for the treatment of autoimmune disorders, such as immune thrombocytopenia (ITP). Recent research has shown that three-dimensional (3D) culture method have many advantages over conventional culture with respect to MSC secretion and immunogenicity. In this study, ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Increased Vancomycin Clearance in Patients with Solid Malignancies.

Tomohiro Izumisawa, Nobuyuki Wakui, Tomoyoshi Kaneko, Masakazu Soma, Masahiko Imai, Daisuke Saito, Hideo Hasegawa, Tetsuya Horino, Noriko Takahashi,

Vancomycin (VAN) is an anti-microbial agent used to treat a number of bacterial infections, which has a high incidence of nephrotoxicity. We examined the pharmacokinetics of VAN retrospectively based on trough concentrations at large scale and identified pharmacokinetic differences between Japanese patients having solid malignancy and non-malignancy patients. Data were ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, :]

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Induction of PD-L1 by Nitric Oxide via JNK Activation in A172 Glioblastoma Cells.

Yoshimitsu Kiriyama, Anna Tani, Minako Kadoya, Ryoko Okamoto, Hiromi Nochi,

Glioblastoma comprises 54% of all the gliomas derived from glial cells and are lethally malignant tumors of the central nervous system (CNS). Glioma cells disrupt the blood-brain barrier, leading to access of circulating immune cells to the CNS. Blocking the interaction between programmed cell death 1 (PD-1) and programmed cell ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):1020-1022]

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L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice.

Yong Chen, Fang Lian, Qiang Lu, Shengliang Peng, Jiahao Li, Song Huang, Xiaohong Du,

The neurodevelopmental toxicity of isoflurane has been proved by many studies, which makes it essential to explore the underline mechanisms and search for protective agents to attenuate its neurotoxcity. Accumulating evidence showed that L-theanine had neuroprotective effects on injured neurons and the developing brain. The present study was designed to ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):938-945]

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Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation.

Fangmei Chen, Xiaoying Yin, Yanqing Wang, Yixin Lv, Si Sheng, Sheng Ouyang, Youquan Zhong,

Cytisine N-methylene-(5,7-dihydroxy-4'-methoxy)-isoflavone (CNF2) is a new compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary pharmacodynamic studies demonstrated its activity in inhibiting breast cancer cell metastasis. This study examined the pharmacokinetics, absolute bioavailability, and tissue distribution of CNF2 in rats, and combined computer-aided technology to predict the druggability of ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(6):976-984]

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Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of Candida krusei.

Chiho Yanai, Hiroaki Tanaka, Noriko N Miura, Ken-Ichi Ishibashi, Daisuke Yamanaka, Hiroaki Ohnishi, Naohito Ohno, Yoshiyuki Adachi,

Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as the hot water extract of C. albicans (CADS) and Candida water-soluble fraction (CAWS), induced coronary vasculitis similar to KD in mice. An increasing proportion of deep-seated candidiasis cases are ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):848-858]

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Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels.

Ali Parlar, Seyfullah Oktay Arslan, Saliha Ayşenur Çam,

Inflammation, and the pain that accompanies it, is a natural response of the body. The licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous, and anti-nociceptive effects of its extracts. The effective ingredient remains unidentified; however, one possibility is the unique isoflavone glabridin. The anti-nociceptive, and anti-inflammatory effects of glabridin and ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):884-897]

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Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT2B Receptor Blockade in the Rat Formalin Test.

Takato Nikaido, Chikashi Maruyama, Minako Hamanaka, Chiharu Yamaguchi, Yukiko Fujimaru, Yutaka Nakanishi, Toshiki Asano, Akiko Takaoka,

Ethenzamide (ETZ), an antipyretic analgesic categorized as a non-steroidal anti-inflammatory drug (NSAID), is widely used as an OTC drug in combination with other NSAIDs. However, its site of action and mechanism underlying its analgesic action have not yet been fully elucidated. In this study, we performed in vitro pharmacological assays ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):839-847]

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Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs.

Honglei Xu, Kun He, Yi Li, Yulong Tao, Chunfang Xu, Zhenlin Hu, Tingfang Wang, Chuan Zhang,

Ischemic heart disease (IHD) is one of the most common cardiovascular diseases with high morbidity and mortality. Danshensu (DSS) is widely used in the treatment of coronary heart disease. In this study, the carboxy group of DSS was esterified with edaravone to synthesize the novel DSS derivative DEX-018 to achieve ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):801-809]

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A Sensitive and Simple Enzyme-Linked Immunosorbent Assay Using Polymer as Carrier.

Long Liu, Aihong Zhang, Xinghe Wang,

In this study, a new and sensitive enzyme-linked immunosorbent assay (ELISA) was developed by introducing a polymer as a reaction carrier. The results suggest that the newly developed ELISA method is more convenient than the existing paper-based ELISA method and applicable to a wider range of environments. In addition, the ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):757-761]

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Frequency of Clinical Monitoring of Serum Concentrations of Digoxin, Potassium, and Creatinine, and Recording of Electrocardiograms in Digoxin-Treated Patients: A Japanese Claims Database Analysis.

Nobuhiro Ooba, Ayaka Sente, Megumi Abe, Fumiyuki Watanabe, Daisuke Tsutsumi, Kiminobu Nakamura, Toshimitsu Nakayama, Koichi Kimura, Noriyasu Fukuoka,

Guidelines for cardiovascular drug therapy recommend monitoring serum digoxin concentration (SDC) in patients receiving digoxin treatment, especially those with renal dysfunction and hypokalemia. However, only a few studies have reported the prevalence of SDC monitoring and laboratory testing in clinical practice. Therefore, the aim of this study was to describe ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):913-916]

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Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats.

Feng Zhang, Mengting Zhai, Qian Wu, Xiaoyi Jia, Yan Wang, Ning Wang,

Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classic traditional Chinese medicine prescription for treating cerebral ischemia. The purpose of this study was to investigate the effect of TQHXD on intervening inflammatory response of ischemic stroke by regulating intestinal flora and repairing the intestinal barrier. A rat model of cerebral ischemia was established ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):788-800]

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Possibility for Dose Optimization of Pazopanib from Its Plasma Concentration in Japanese Patients with Cancer.

Hiroyuki Tanaka, Hiroaki Hiraga, Yoh Takekuma, Toru Harabayashi, Satoshi Nagamori, Masayuki Endo, Mitsuru Sugawara,

The currently approved dose of pazopanib (800 mg) is being re-examined owing to its adverse effects. The aim of this study was to evaluate the relationships among starting or maintenance doses of pazopanib, estimated pazopanib Cmin, and other clinical factors, including albumin and α-1 acid glycoprotein levels, in soft-tissue sarcoma and ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):762-766]

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MiR-140-3p Ameliorates the Progression of Osteoarthritis via Targeting CXCR4.

Tiantian Ren, Peng Wei, Qinghua Song, Zhaohui Ye, Yangjian Wang, Lixin Huang,

Osteoarthritis is a common disease character with progressive destruction of cartilage. MicroRNA (miR)-140-3p was validated as a biomarker for osteoarthritis. However, the mechanism by which miRNA-140-3p regulates osteoarthritis remains unclear. Thus, this study aims to evaluate the potential function of miRNA-140-3p during the pathogenesis of osteoarthritis. MiRNA-140-3p expression in tissue ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(5):810-816]

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Effect of Obesity on Hematotoxicity Induced by Carboplatin and Paclitaxel Combination Therapy in Patients with Gynecological Cancer.

Yosuke Ando, Takahiro Hayashi, Hideyo Shiouchi, Chihiro Tanaka, Kaori Ito, Seira Nishibe, Nanaho Miyata, Ruri Horiba, Hisano Yanagi, Takuma Fujii, Kenji Kawada, Yoshiaki Ikeda, Shigeki Yamada,

Despite in vivo studies suggesting that obesity increases carboplatin (CBDCA) bone marrow toxicity, the American Society of Clinical Oncology recommends that full weight-based cytotoxic chemotherapy doses be used to treat obese patients with cancer. Accordingly, the present study retrospectively investigated the effect of body mass index (BMI) on bone marrow ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(4):669-674]

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Suppression of Malignant Potentials of A549 Human Lung Cancer Cell Line by Downregulation of the β4-Galactosyltransferase 1 Gene Expression.

Saeka Kinouchi, Miku Sato, Haruna Furukawa, Takeshi Sato,

Our previous study demonstrated that downregulation of transcription factor Specificity protein (Sp) 1 suppresses the malignant potentials of A549 human lung cancer cell line with the reduced β4-galactosylation of highly branched N-glycans on cell surface glycoproteins. The reduced β4-galactosylation was brought about by the decreased expression of the β4-galactosyltransferase 1 ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(4):747-751]

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Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation in Vitro and Modulates Downstream Pathogenesis in Vivo.

Haruka Fujikawa, Taise Kawakami, Ryunosuke Nakashima, Aoi Nasu, Shunsuke Kamei, Hirofumi Nohara, Yuka Eto, Keiko Ueno-Shuto, Toru Takeo, Naomi Nakagata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto,

Epithelial sodium channel (ENaC) is an amiloride-sensitive sodium ion channel that is expressed in epithelial tissues. ENaC overexpression and/or hyperactivation in airway epithelial cells cause sodium over-absorption and dysregulated ciliary movement for mucus clearance; however, the agents that suppress constitutive airway ENaC activation are yet to be clinically available. Here, ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(4):725-730]

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