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Journal Biofactors

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Cyanidin-3-O-glucoside attenuates endothelial cell dysfunction by modulating miR-204-5p/SIRT1-mediated inflammation and apoptosis.

Zhihong Wang, Min Zhang, Zhong Wang, Zongjun Guo, Zongqiu Wang, Qun Chen,

Endothelial cell (EC) dysfunction is a major symptom associated with the initiation of atherosclerosis (AS). Cyanidin-3-O-glucoside (C3G) has the potentials to attenuate AS symptoms. In the current study, the mechanism driving the effects of C3G on AS rabbits and injured ECs were explored by focusing on the changes in miR-204-5p/SIRT1 ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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POTEE stimulates the proliferation of pancreatic cancer by activating the PI3K/Akt/GSK-3β/β-catenin signaling.

Qingya Hao, Lihua Gao, Wenyang Niu, Liang Chen, Peng Zhang, Zhong Chen,

To explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK-3β inhibitor, proliferative ... Read more >>

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[2020, :]

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Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.

Wei Cui, Jun Xue,

BACKGROUND:Both circular RNA DOCK1 (circDOCK1) and microRNA-124 (miR-124) are implicated in carcinogenesis, but functional association between these two molecules remains uncharacterized. Here, we aimed to ascertain the role of circDOCK1-miR-124 node in thyroid cancer cells. METHODS:circDOCK1 in thyroid cancer specimens from 25 patients was quantified by qRT-PCR. FTC-133 and TPC-1 ... Read more >>

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[2020, :]

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LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells.

Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia,

Rheumatoid arthritis (RA) is a common chronic autoimmune disease in women. This research aims to disclose the probable function of lncRNA H19 in MH7A cells. The influences of tumor necrosis factor-α (TNF-α) on cell viability, apoptosis, and inflammatory factor expression were, respectively, detected through cell counting kit-8 (CCK-8), flow cytometry, ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma.

Fangxian Liu, Qijin Pan, Liangliang Wang, Shijiang Yi, Peng Liu, Wenjun Huang,

Calycosin is a naturally occurring phytoestrogen, and it has the anti-nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti-NPC targets and therapeutic mechanisms played ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors.

Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii, Mehdi Yousefi,

As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves ... Read more >>

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[2020, :]

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Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.

Roberta Ricciarelli, Angelo Azzi, Jean-Marc Zingg,

Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress-induced premature senescence, SIPS). With the acquisition of the senescence-associated secretory phenotype (SASP), cells release several molecules ... Read more >>

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[2020, :]

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The roles of melatonin on kidney injury in obese and diabetic conditions.

Sasivimon Promsan, Anusorn Lungkaphin,

Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney ... Read more >>

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[2020, :]

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Dicer and Drosha expression in patients with nephrotic syndrome.

Seyyedeh Mina Hejazian, Yalda Rahbar Saadat, Zahra Bahmanpour, Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan, Sepideh Zununi Vahed,

Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer/Drosha knockout mice indicate the importance of Dicer, ... Read more >>

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[2020, :]

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High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.

Perinur Bozaykut, Ruchan Ekren, Osman Ugur Sezerman, Vadim N Gladyshev, Nesrin Kartal Ozer,

Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress-related ... Read more >>

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[2020, :]

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COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin.

Theoharis C Theoharides,

Biofactors (BioFactors (Oxford, England))
[2020, 46(3):306-308]

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A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices.

Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A Ferns, Majid Ghayour-Mobarhan,

Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta-analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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Challenges in redox biology.

Bato Korac, Francesco Galli,

Biofactors (BioFactors (Oxford, England))
[2020, 46(2):191-192]

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Plasmatic lipocalin-2 levels in chronic low-grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency.

Diego Currò, Edoardo Vergani, Carmine Bruno, Simone Comi, Claudia D'Abate, Antonio Mancini,

Lipocalin-2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross-sectional study was to compare LCN2 plasmatic levels in these clinical settings, whereas the secondary objective was ... Read more >>

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[2020, :]

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Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-β1/α-SMA/Col I and III pathway.

Linlin Bai, Aimin Li, Cuike Gong, Xuecong Ning, Zhihua Wang,

Lung fibrosis is a progressive fatal lung disorder with significantly high mortality rates. Bleomycin (BLM) is one of the most commonly used chemotherapeutic agents for the treatment of several carcinomas. The most severe adverse effect of BLM is lung toxicity; therefore, BLM has been repeatedly reported to be considered amongst ... Read more >>

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[2020, :]

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Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a.

Jing Cui, Hao Li, Ying Wang, Tian Tian, Chao Liu, Yanan Wang, Shukai Sun, Baisui Feng,

Baicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.

Xiaofeng Shi, Wei Ma, Yongqi Li, Han Wang, Shuang Pan, Yongquan Pan, Caiming Xu, Lei Li,

The aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS)-induced HK2 cell injury and its mechanism. The circPRKCI level was identified in serum samples from patients with urosepsis and healthy subjects, as well as LPS-treated HK2 cells by qRT-PCR. Cell viability, apoptosis, ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, 46(3):475-486]

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Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.

Pengxin Zhao, Zhigang Hu, Weiyuan Ma, Leilei Zang, Zhisheng Tian, Qian Hou,

Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L-thyroxin (LT4)-induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and ... Read more >>

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[2020, :]

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6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance.

Iqra Sarfraz, Azhar Rasul, Ghulam Hussain, Muhammad Ajmal Shah, Ameer Fawad Zahoor, Muhammad Asrar, Zeliha Selamoglu, Xin-Ying Ji, Şevki Adem, Satyajit D Sarker,

Reprogrammed metabolism is key biochemical characteristic of malignant cells, which represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation on oxidative pentose phosphate pathway (PPP) enzymes as potential therapeutic hits due to their affiliation with tumor metabolism. 6-Phosphogluconate dehydrogenase (6PGD), third oxidative decarboxylase of PPP, has ... Read more >>

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[2020, :]

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LncRNA TTN-AS1 acts as sponge for miR-15b-5p to regulate FBXW7 expression in ovarian cancer.

Sheng Miao, Jia Wang, Lili Xuan, Xiaojun Liu,

Emerging evidence showed that long noncoding RNA (lncRNA) plays crucial roles in regulating various cancer biological behaviors. Titin-antisense RNA1 (TTN-AS1) has been reported to have crucial roles in cancers but its role in ovarian cancer remains unknown. The levels of TTN-AS1, microNRA-15b-5p (miR-15b-5p), and F-box and WD repeat domain containing ... Read more >>

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[2020, :]

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Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer.

Xiaoyu Chen, Youjun Wu, Junzhao Gu, Ping Liang, Meizhen Shen, Jiaxi Xi, Jian Qin,

Colorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti-CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2020, :]

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Circular RNA-0072309 has antitumor influences in Hep3B cell line by targeting microRNA-665.

Qiuyun Yu, Jinhua Dai, Ming Shu,

Liver cancer is a malignant tumor that occurs in the liver and has a high mortality rate. We strived to detect the role and mechanism of circRNA-0072309 in liver cancer. Hep3B cell line was transfected with pc-circ and si-circ for viability, colony formation, apoptosis, migration, and invasion tests, which were ... Read more >>

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[2020, :]

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Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II.

Jaap van Doorn,

Insulin-like growth factor (IGF)-II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF-I and proinsulin. At least in vitro, IGF-II actions are mediated through the IGF-I receptor and to a lesser extent the insulin receptor. After birth, the function of IGF-II ... Read more >>

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[2020, :]

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MicroRNA-31 weakens cisplatin resistance of medulloblastoma cells via NF-κB and PI3K/AKT pathways.

Hui Ma, Wei Cao, Meili Ding,

BACKGROUND:Medulloblastoma (MB) is a malignant intracranial tumor. Cisplatin is a broad-spectrum antitumor drug. It is important to study the cisplatin resistance of MB cells for the treatment of MB. In this article, we preliminarily studied the cisplatin resistance of microRNA (miR)-31 and the possible mechanism in DAOY and UW228 cells, ... Read more >>

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[2020, :]

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Dysfunction of thioredoxin triggers inflammation through activation of autophagy in chicken cardiomyocytes.

Jie Yang, Yafan Gong, Jingzeng Cai, Qi Liu, Yuan Zhang, Yingying Zheng, Dahai Yu, Ziwei Zhang,

Thioredoxin (Txn) is a hydrogen carrier protein and exists widely in organism. Txn deficiency implicates cardiomyocytes injury has been proven. However, the exact mechanism remains unclear. To understand the mechanistic response of cardiomyocytes subsequent to Txn suppression, we established the model of Txn dysfunction by employing gene interference technology (siRNA) ... Read more >>

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[2020, :]

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