Full Text Journal Articles in
Journal Bioengineered

Advertisement

Find full text journal articles






Testis developmental related gene 1 promotes non-small-cell lung cancer through the microRNA-214-5p/Krüppel-like factor 5 axis.

Xudong Lu, Nian Zhao, Guangjun Duan, Zhiyong Deng, Yimin Lu,

[Formula: see text]. ... Read more >>

Bioengineered (Bioengineered)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models.

Yuanxing Cai, Jing Xu, Qinghao Cheng,

Chronic neuroinflammation is an important factor in the development of neuropathic pain (NP). Excess microglia activation releases a mass of pro-inflammatory cytokines during neuroinflammation process, leading to a constant painful irritation of the sensory nerve. Src belongs to a non-receptor tyrosine kinase associated with sarcoma, whereas the role of Src ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):11390-11398]

Cited: 0 times

View full text PDF listing >>



Advertisement

Integrative analysis of prognostic value and immune infiltration of spindle and kinetochore-associated family members in breast cancer.

Jianfeng Ding, Xiaobo He, Jinkun Wang, Guodong Cao, Sihan Chen, Liping Yuan, Bo Chen, Maoming Xiong,

Spindle and kinetochore associated (SKA) complex subunit, which maintains the stability of mitotic metaphase, with emerging research implying its effect as a carcinogenic regulator in cancer. However, its potential role in BC has not been fully elucidated. ONCOMINE, UALCAN, GEPIA, Kaplan-Meier Plotter, cBioPortal and TIMER databases were performed to analyze ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10905-10923]

Cited: 0 times

View full text PDF listing >>



Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based on TCGA, RT‑qPCR, Western blotting, and immunohistochemistry.

Di Han, Zhongjie Yu, Hong Zhang, Haipeng Liu, Bin Wang, Donmeng Qian,

Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors worldwide. The clinical treatment of ccRCC is strongly associated with the tumor microenvironment (TME). Identifying potential markers of ccRCC is important to improve prognosis. Therefore, in the present study, the levels of immune/stromal components and the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10891-10904]

Cited: 0 times

View full text PDF listing >>



Effect of chromogranin A N-terminal fragment vasostatin-1 nano-carrier transfection on abdominal aortic aneurysm formation.

Pingshan Wang, Wei Wang, Xingxing Peng, Fugui Ruan, Shiyao Yang,

The effects of transfection of N-terminal fragment of chromogranin A Vasostatin-1 (VS-1) nanocarriers on formation of abdominal aortic aneurysm (AAA) were discussed, and its mechanism was analyzed. Nanoparticles containing VS-1 genes were prepared by emulsion solvent evaporation method, and property of nanoparticles was examined. A total of 30 male SD ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):11018-11029]

Cited: 0 times

View full text PDF listing >>



Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway.

Jinfeng Liu, Liang Ning,

We aimed to explore the effects of emodin on the energy metabolism of myocardial cells in rats with post-myocardial infarction (MI) heart failure (HF) and the extracellular signal-regulated kinase (ERK) pathway. The model of MI was established by ligation of the left anterior descending branch. After 4 weeks, the rats ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10246-10253]

Cited: 0 times

View full text PDF listing >>



Ubiquitin-associated protein 2 like (UBAP2L) enhances growth and metastasis of gastric cancer cells.

Sihan Lin, Zhiyong Yan, Qiaofei Tang, Shuang Zhang,

Ubiquitin-proteasome pathway has emerged as therapeutic targets for cancer. GEPIA database analysis showed that the expression of ubiquitin-associated protein 2 like (UBAP2L) in gastric cancer specimens was significantly higher than that in non-tumor tissue, and its high expression is associated with poor survival of gastric cancer patients. This study aims ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10232-10245]

Cited: 0 times

View full text PDF listing >>



LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer.

Mingkun Zhang, Liu Yang, Lan Hou, Xueyuan Tang,

The long-non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is a known cause of tumorigenesis. Nevertheless, it's yet unclear how lncRNA SNHG1 influences breast cancer. Herein, we explored the mechanisms through which SNHG1 modulates breast cancer tumor progression. Our findings demonstrated that SNHG1 is significantly upregulated in breast ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9239-9250]

Cited: 0 times

View full text PDF listing >>



Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway.

Xingming Zhong, Yong Cai,

Glioblastoma (GBM) is the most lethal type of brain cancer. An increasing number of studies suggest that long non-coding RNAs (lncRNAs) are implicated in tumor progression. LncRNA HOXD-AS2 was reported to be highly expressed in glioma and associated with glioma grade and poor prognosis. However, the molecular mechanism remains to ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9113-9127]

Cited: 0 times

View full text PDF listing >>



N6-Methyladenosine-regulated LINC00675 suppress the proliferation, migration and invasion of breast cancer cells via inhibiting miR-513b-5p.

Shenglan Fan, Liping Wang,

Breast cancer (BC) is the most common cancer among women. LINC00675 and miR-513b-5p has been reported to be abnormally expressed in multiple types of cancers and modulate malignant phenotypes of cancer cells. However, to date, the functional role and underlying regulatory mechanism of LINC00675 and miR-513b-5p in BC remains largely ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10690-10702]

Cited: 0 times

View full text PDF listing >>



MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.

Qiang Zhu, Yun Li, Lina Li, Mingxue Guo, Chenxi Zou, Yi Xu, Zhen Yang,

Dysregulated microRNAs (miRNAs) are common in human cancers and are involved in the proliferation, promotion, and metastasis of tumor cells. Therefore, the aim of this study was to evaluate the expression and biological function of miR-889-3p in lung cancer (LC). MiR-889-3p and Homeodomain-interacting protein kinase 1 (HIPK1) expression was detected ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10945-10958]

Cited: 0 times

View full text PDF listing >>



Uncovering potential single nucleotide polymorphisms, copy number variations and related signaling pathways in primary Sjogren's syndrome.

Xuan Qi, Xi-Qin Wang, Lu Jin, Li-Xia Gao, Hui-Fang Guo,

Primary Sjogren's syndrome (pSS) is a complex systemic autoimmune disease, which is difficult to accurately diagnose due to symptom diversity in patients, especially at earlier stages. We tried to find potential single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and related signaling pathways. Genomic DNA was extracted from peripheral blood ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9313-9331]

Cited: 0 times

View full text PDF listing >>



Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer.

Jingzhi Chang, Yuxia Zhang, Xin Ye, Hui Guo, Kun Lu, Qing Liu, Yli Guo,

Long non-coding RNA (lncRNA)-microRNA-mRNA signaling axes have recently been shown to have a key role in the development of breast cancer (BC). In this study, we investigated how the cancer susceptibility candidate 9 (CASC9) gene affects the cell growth, invasion, migration, and apoptosis of BC cells. The levels of microRNA-590-3p ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8709-8723]

Cited: 0 times

View full text PDF listing >>



Biofuel production from Macroalgae: present scenario and future scope.

Godvin Sharmila V, Dinesh Kumar M, Arulazhagan Pugazhendi, Amit Kumar Bajhaiya, Poornachander Gugulothu, Rajesh Banu J,

The current fossil fuel reserves are not sufficient to meet the increasing demand and very soon will become exhausted. Pollution, global warming, and inflated oil prices have led the quest for renewable energy sources. Macroalgae (green, brown, and red marine seaweed) is gaining popularity as a viable and promising renewable ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9216-9238]

Cited: 0 times

View full text PDF listing >>



Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p.

Yue Zhao, Rui Yao,

Increasing evidence demonstrated long non-coding RNAs (lncRNAs) play important roles in the occurrence and development of oral squamous cell carcinoma (OSCC). This study aimed to explore the role and molecular mechanism of lncRNA HOXA-AS3 in the progression of OSCC. Here, we found that <b>t</b>he expression of lncRNA HOXA-AS3 was upregulated ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8724-8737]

Cited: 0 times

View full text PDF listing >>



Long non-coding RNA FENDRR inhibits the stemenss of colorectal cancer cells through directly binding to Sox2 RNA.

Xin Zhao, Jincheng Wu, Yongwen Li, Feng Ye, Chunyue Wang,

Cancer stem cells (CSCs) contribute to malignant features. Long non-coding RNA (LncRNA) <i>FENDRR</i> has been shown to regulate tumor proliferation, migration, and invasion. However, the effects of <i>FENDRR</i> on the CSC-like traits of colorectal cancer cells remain to be elucidated. Here, we identified that lncRNA <i>FENDRR</i> level was remarkably lower ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8698-8708]

Cited: 0 times

View full text PDF listing >>



MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.

Weihong Xu, Lu Ye, Huaxiang Wu,

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is increasing in incidence worldwide. RA is regulated by a variety of microRNAs (miRNAs/miR). Moreover, analysis of public data has revealed that miR-4423-3p is significantly downregulated in peripheral blood mononuclear cells of RA patients. This study investigated the role of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9411-9423]

Cited: 0 times

View full text PDF listing >>



Up-regulation of microRNA miR-101-3p enhances sensitivity to cisplatin via regulation of small interfering RNA (siRNA) Anti-human AGT4D and autophagy in non-small-cell lung carcinoma (NSCLC).

Dong Cui, Yu Feng, Rulin Qian,

The emergence of drug resistance hinders the treatment of malignant tumors, and autophagy plays an important role in tumor chemotherapy resistance. However, its mechanism in non-small cell lung cancer (NSCLC) has not been well-researched. We aim to investigate the role of miR-101-3p in cisplatin-resistant via regulation of autophagy-related protein 4D ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8435-8446]

Cited: 0 times

View full text PDF listing >>



Tranilast inhibits angiotensin II-induced myocardial fibrosis through S100A11/ transforming growth factor-β (TGF-β1)/Smad axis.

Youquan Chen, Ming Huang, Yi Yan, Dequan He,

Tranilast has an ameliorative effect on myocardial fibrosis (MF), but the specific mechanism has not been studied. S100A11 is a key regulator of collagen expression in MF. In this paper, we will study the regulatory roles of Tranilast and S100A11 in MF. After the introduction of angiotensin II (AngII) to ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8447-8456]

Cited: 0 times

View full text PDF listing >>



Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis.

Qiong Jiang, Xianfeng Dong, Danqing Hu, Lejun Chen, Yukun Luo,

Myocardial injury caused by ischemia-reperfusion is the main pathological manifestation of coronary artery disease (CAD), which is characterized by high mortality and morbidity. Thus, there's an urgent need to develop efficacious strategies and elucidate the underlying mechanisms to prevent or alleviate myocardial ischemia-reperfusion injury to improve the clinical outcomes in ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):9021-9030]

Cited: 0 times

View full text PDF listing >>



MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1).

Guang-Lin Song, Ming Xiao, Xiao-Ya Wan, Jun Deng, Jun-Da Ling, Ying-Guo Tian, Min Li, Jie Yin, Ren-Ying Zheng, Yi Tang, Gui-Yuan Liu,

The microRNA miR-130a-3p (miR-130a-3p) has anti-tumor activity against numerous cancer types. Further, miR-130a-3p may target Wnt signaling, which is a critical pathway regulating tumorigenesis. Functions of miR-130a-3p in colorectal cancer (CRC) and contributions of Wnt1 pathway modulation, however, have not been examined, hence the exploration on these two aspects. In ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8407-8418]

Cited: 0 times

View full text PDF listing >>



Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9.

Luo Qiong, Jun Yin,

Orosomucoid 1 (ORM1) has been shown to be upregulated in the serum of breast cancer patients; however, the expression and function of ORM1 in breast cancer remains unknown. We measured the expression of ORM1 in breast cancer tissues and cell lines using qRT-PCR. A colony formation assay was done to ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8822-8832]

Cited: 0 times

View full text PDF listing >>



Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5'-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner.

Cuiyun Zhou, Xiaoqiong Huang, Xia Li, Yan Xiong,

Apoptosis of lens epithelial cells contributed to the formation of age-related cataract (ARC), and previous data revealed that circular RNA (circRNA) was responsible for the underneath mechanism. The study was organized to explore the role of circular RNA erythrocyte membrane protein band 4.1 (circ_EPB41) in ultraviolet (UV) irradiation-induced apoptosis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8953-8964]

Cited: 0 times

View full text PDF listing >>



Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells.

Yishan Ge, Wenwu Liu, Wei Yin, Xuebin Wang, Jie Wang, Xiaoqing Zhu, Shengkai Xu,

Atherosclerosis (AS) is an inflammatory disease caused by multiple factors. Multiple circRNAs are involved in the development of AS. The present study focusses on delineating the role of circ_0090231 in AS. Human aortic endothelial cells (HAECs) were treated with oxidized low-density lipoprotein (ox-LDL) to construct an <i>in vitro</i> AS model. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):10837-10848]

Cited: 0 times

View full text PDF listing >>



Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma.

Ziyou Tao, Chao Lu, Shuai Gao, Peng Zhang, Yuan Chen, Yuanguo Wang, Zhaoyu Yang, Kai Xiong, Yuxin Liu, Peng Zhang,

Thymoma is the most common primary mass in anterior mediastinum. Although associated with low malignancy, it is often accompanied by myasthenia gravis resulting in poor prognosis. Due to the dual factors of tumor immune tolerance and autoimmune reaction, it is urgent to understand the immune status of MG with thymoma. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5004-5016]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

0.8373 s