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Journal Biochem Pharmacol

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Cordycepin prevents and ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte infiltration and reducing neuroinflammation.

Ying-Chyi Song, Chuan-Teng Liu, Hui-Ju Lee, Hung-Rong Yen,

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease characterized by multifocal perivascular infiltration of immune cells in the central nervous system (CNS). Cordycepin (3'-deoxyadenosine), an adenosine analogue initially extracted from the fungus Cordyceps militarisa, is one of the candidates that has multiple actions. We investigated that crdycepin attenuated the activation ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114918]

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Targeting hippocampal amyloidogenesis with SV2A protein modulator levetiracetam.

Ludmila A Kasatkina, Vitaliy P Gumenyuk, Olha O Lisakovska, Irene O Trikash,

Cerebral amyloid β (Aβ) proteostasis is compromised under neuronal overexcitation, long-term neuroinflammation and brain aging. Using the animal model of LPS-induced neuroinflammation we demonstrated that treatment with levetiracetam, a specific modulator of synaptic vesicle glycoprotein SV2A, rescues abnormal synaptic vesicle (SV) fusion and neurotransmitter release, decreasing elevated hippocampal APP levels ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114927]

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The druggability of bitter taste receptors for the treatment of neurodegenerative disorders.

Ana Catarina Duarte, Ana Raquel Costa, Isabel Gonçalves, Telma Quintela, Robert Preissner, Cecília R A Santos,

The delivery of therapeutic drugs to the brain remains a major pharmacology challenge. A complex system of chemical surveillance to protect the brain from endogenous and exogenous toxicants at brain barriers hinders the uptake of many compounds with significant in vitro and ex vivo therapeutic properties. Despite the advances in ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114915]

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Selective stabilization of the intermediate inactivated Na+channelby new-generation anticonvulsant rufinamide.

Yun-Chu Lin, Yi-Chen Lai, Tien-Hung Lin, Ya-Chin Yang, Chung-Chin Kuo,

Na<sup>+</sup> channels undergo multiple inactivated states with different kinetics, which set the refractory period of neuronal discharges, but isolating the intermediate inactivated state has been challenging. Most classical Na<sup>+</sup>channel-inhibiting anticonvulsants bind to the fast inactivated state to reduce Na<sup>+</sup>currents and cellular excitability. The slow binding kinetics necessitates long depolarization for ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114928]

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Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?

Gurleen Kour, Rupali Choudhary, Sobia Anjum, Asha Bhagat, B K Bajaj, Zabeer Ahmed,

Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent studies have shown JAK/STAT signaling pathway as potential target for the treatment of RA. Novel JAK/STAT inhibitors viz tofacitinib and baricitinib have been recently approved by ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114929]

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Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition.

Aya Hasan Alshammari, Yusuke Masuo, Ken-Ichi Fujita, Kazuhiro Shimada, Noriho Iida, Tomohiko Wakayama, Yukio Kato,

Tyrosine kinase inhibitors (TKIs) are molecular-targeted anticancer drugs. Their benefits are limited by dermal toxicities, including hand-foot skin reaction (HFSR), which is commonly found in skin areas subjected to friction. The present study aimed to explain the incidence of HFSR in patients treated with TKIs by focusing on keratinocyte toxicity ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114914]

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Ganciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina.

Jianhong Zhou, Xiangxiang Lin, Huiping Shang, Yutuo Zhu, Jinrun Chen, Mengyun Deng, Mali Dai, Dan Lin, Serhii Vakal, Yuqin Wang, Xingyi Li,

Noninfectious (autoimmune and immune-mediated) uveitis is one of the primary diseases leading to blindness in the world. Due to the limitation of current first-line drugs for clinical uveitis, novel drugs and targets against uveitis are urgently needed. Ganciclovir (GCV), an FDA-approved antiviral drug, is often used to treat cytomegalovirus-induced retinitis ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, :114917]

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The gut microbiota can be a potential regulator and treatment target of bone metastasis.

Kelly F Contino, Hariom Yadav, Yusuke Shiozawa,

The gut microbiota, an often forgotten organ, have a tremendous impact on human health. It has long been known that the gut microbiota are implicated in cancer development, and more recently, the gut microbiota have been shown to influence cancer metastasis to distant organs. Although one of the most common ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114916]

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Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.

Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He,

The roots of Glycine tabacina are used to treat rheumatoid arthritis (RA) and joint infection in folk medicine. Glytabastan B (GlyB), a newly reported coumestan isolated from this species, was found to significantly attenuate IL-1β-induced inflammation in SW982 human synovial cells at 3 and 6 μM, as evidenced by the decreased ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114912]

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Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes.

Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Niu,

Nitazoxanide and related thiazolides are a novel class of anti-infectious agents against protozoan parasites, bacteria and viruses. In recent years, it is demonstrated that thiazolides can also induce cell cycle arrest and apoptotic cell death in cancer cells. Due to their fast proliferating nature, cancer cells highly depend on the ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114913]

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Vascular endotheliitis associated with infections: Its pathogenetic role and therapeutic implication.

Yuichi Hattori, Kohshi Hattori, Takuji Machida, Naoyuki Matsuda,

Vascular endothelial cells are major participants in and regulators of immune responses and inflammation. Vascular endotheliitis is regarded as a host immune-inflammatory response of the endothelium forming the inner surface of blood vessels in association with a direct consequence of infectious pathogen invasion. Vascular endotheliitis and consequent endothelial dysfunction can ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114909]

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Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation.

Tao Su, Teng Wang, Nasha Zhang, Yue Shen, Wenwen Li, Huaixin Xing, Ming Yang,

Phosphorylation of proteins is one of the most extensively investigated post-translational protein modifications. Threonine, serine and tyrosine in proteins are the most commonly phosphorylated amino acids. Dysregulated cancer-related signaling pathways due to aberrant phosphorylation status of the key protein(s) in these pathways exist in most malignancies. Intensive studies in the ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114907]

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Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis.

Richard C Chang, Chloe S Thangavelu, Erika M Joloya, Angela Kuo, Zhuorui Li, Bruce Blumberg,

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid found in the Cannabis sativa plant. Human exposure to CBD can be through recreational marijuana use, commercially available CBD-containing products, and medical treatments. Previous studies found that cannabidiol may activate the master regulator of adipogenesis, peroxisome proliferator activated receptor gamma (PPARγ). Here we investigated ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114910]

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Identification of ritanserin analogs that display DGK isoform specificity.

Mitchell E Granade, Laryssa C Manigat, Michael C Lemke, Benjamin W Purow, Thurl E Harris,

The diacylglycerol kinase (DGK) family of lipid enzymes catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Both DAG and PA are lipid signaling molecules that are of notable importance in regulating cell processes such as proliferation, apoptosis, and migration. There are ten mammalian DGK enzymes that appear to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114908]

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Screening approaches and therapeutic targets: The two driving wheels of tuberculosis drug discovery.

Summaya Perveen, Rashmi Sharma,

Tuberculosis (TB) is an infectious disease, infecting a quarter of world's population. Drug resistant TB further exacerbates the grim scenario of the drying TB drug discovery pipeline. The limited arsenal to fight TB presses the need for thorough efforts for identifying promising hits to combat the disease. The review highlights ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114906]

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Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells.

Diego Colombo, Laura Gatti, Linda Sjöstrand, Nives Carenini, Matteo Costantino, Elisabetta Corna, Noemi Arrighetti, Marco Zuccolo, Michelandrea De Cesare, Stig Linder, Pádraig D'Arcy, Paola Perego,

Deubiquitinases (DUBs) mediate the removal of ubiquitin from diverse proteins that participate in the regulation of cell survival, DNA damage repair, apoptosis and drug resistance. Previous studies have shown an association between activation of cell survival pathways and platinum-drug resistance in ovarian carcinoma cell lines. Among the strategies available to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114900]

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Bisphenol-A analogs induce lower urinary tract dysfunction in male mice.

J L Nguyen, E A Ricke, T T Liu, R Gerona, L MacGillivray, Z Wang, B G Timms, D E Bjorling, F S Vom Saal, W A Ricke,

Bisphenol-A (BPA), an estrogenic endocrine disrupting chemical, significantly impacts numerous diseases and abnormalities in mammals. Estrogens are known to play an important role in the biology of the prostate; however, little is known about the role of bisphenols in the etiology of prostate pathologies, including benign prostate hyperplasia (BPH) and ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114889]

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Immuno-modulatory biomaterials as anti-inflammatory therapeutics.

Roisin I Lynch, Ed C Lavelle,

Biocompatible and biodegradable biomaterials are used extensively in regenerative medicine and serve as a tool for tissue replacement, as a platform for regeneration of injured tissue, and as a vehicle for delivery of drugs. One of the key factors that must be addressed in developing successful biomaterial-based therapeutics is inflammation. ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2022, 197:114890]

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A synthetic resveratrol analog termed Q205 reactivates latent HIV-1 through activation of P-TEFb.

Taizhen Liang, Ziyao Wu, Yibin Li, Chao Li, Kangni Zhao, Xinman Qiao, Heng Duan, Xuanxuan Zhang, Shuwen Liu, Baomin Xi, Lin Li,

The persistence of HIV-1 latent reservoir creates the major obstacle toward an HIV-1 cure. The "shock and kill" strategy aims to reverse HIV-1 proviral latency using latency-reversing agents (LRAs), thus boosting immune recognition and clearance to residual infected cells. Unfortunately, to date, none of these tested LRA candidates has been ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114901]

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Role of nitric oxide in type 1 diabetes-induced osteoporosis.

Sajad Jeddi, Nasibeh Yousefzadeh, Khosrow Kashfi, Asghar Ghasemi,

Type 1 diabetes (T1D)-induced osteoporosis is characterized by decreased bone mineral density, bone quality, rate of bone healing, bone formation, and increased bone resorption. Patients with T1D have a 2-7-fold higher risk of osteoporotic fracture. The mechanisms leading to increased risk of osteoporotic fracture in T1D include insulin deficiency, hyperglycemia, ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114888]

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Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments.

Sepideh Saeb, Jeanne Van Assche, Thomas Loustau, Olivier Rohr, Clémentine Wallet, Christian Schwartz,

Suicide Gene Therapy (SGT) aims to introduce a gene encoding either a toxin or an enzyme making the targeted cell more sensitive to chemotherapy. SGT represents an alternative approach to combat pathologies where conventional treatments fail such as pancreatic cancer or the high-grade glioblastoma which are still desperately lethal. We ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114893]

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Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.

H Cui, S Norrbacka, T T Myöhänen,

The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the intermediates formed during the aggregation process to be toxic to cells. Current PD treatments only ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114899]

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The potential value of amlexanox in the treatment of cancer: Molecular targets and therapeutic perspectives.

Christian Bailly,

Amlexanox (AMX) is an azoxanthone drug used for decades for the treatment of mouth aphthous ulcers and now considered for the treatment of diabetes and obesity. The drug is usually viewed as a dual inhibitor of the non-canonical IκB kinases IKK-ɛ (inhibitor-kappaB kinase epsilon) and TBK1 (TANK-binding kinase 1). But ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114895]

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Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions.

Chrishan S Samuel, Robert G Bennett,

Fibrosis refers to the scarring and hardening of tissues, which results from a failed immune system-coordinated wound healing response to chronic organ injury and which manifests from the aberrant accumulation of various extracellular matrix components (ECM), primarily collagen. Despite being a hallmark of prolonged tissue damage and related dysfunction, and ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114884]

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Pyrroloquinoline quinone attenuated benzyl butyl phthalate induced metabolic aberration and a hepatic metabolomic analysis.

Jian Zhang, Catherine Powell, Sunitha Meruvu, Ravi Sonkar, Mahua Choudhury,

Benzyl butyl phthalate (BBP) has recently been implicated as an obesogen. Our recent study demonstrated that BBP can exacerbate high fat diet (HFD) induced diabesity in male mice. Here, we explored if pyrroloquinoline quinone (PQQ), a natural antioxidant andphytochemical, can attenuate metabolic aberrations induced by HFD or HFD-BBPcombination. C57Bl/6 male ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 197:114883]

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