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Journal Basic Res. Cardiol.

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Remote ischemic preconditioning reduces myocardial ischemia-reperfusion injury through unacylated ghrelin-induced activation of the JAK/STAT pathway.

Yasuaki Sawashita, Naoyuki Hirata, Yusuke Yoshikawa, Hirofumi Terada, Yasuyuki Tokinaga, Michiaki Yamakage,

Remote ischemic preconditioning (RIPC) offers cardioprotection against myocardial ischemia-reperfusion injury. The humoral factors involved in RIPC that are released from parasympathetically innervated organs have not been identified. Previous studies showed that ghrelin, a hormone released from the stomach, is associated with cardioprotection. However, it is unknown whether or not ghrelin ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):50]

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Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis.

Dorothy E Vatner, Marko Oydanich, Jie Zhang, Denis Babici, Stephen F Vatner,

Our hypothesis is that Secreted Frizzled-Related Protein 2 (sFPR2) is an important mechanism mediating ischemic cardioprotection, since it is the most upregulated gene in the third window of ischemic preconditioning. One week after permanent coronary artery occlusion (CAO), sFRP2 TG mice exhibited a 49% higher LV ejection fraction and a ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):48]

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Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.

Ann-Kathrin Vlacil, Jutta Schuett, Volker Ruppert, Muhidien Soufi, Raghav Oberoi, Kinan Shahin, Christian Wächter, Thomas Tschernig, Yu Lei, Fan Liu, Uwe J F Tietge, Bernhard Schieffer, Harald Schuett, Karsten Grote,

Atherosclerosis is crucially fueled by inflammatory pathways including pattern recognition receptor (PRR)-related signaling of the innate immune system. Currently, the impact of the cytoplasmic PRRs nucleotide-binding oligomerization domain-containing protein (NOD) 1 and 2 is incompletely characterized. We, therefore, generated Nod1/Nod2 double knockout mice on a low-density lipoprotein receptor (Ldlr)-deficient background ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):47]

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Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling.

Satadru K Lahiri, Ann P Quick, Benoit Samson-Couterie, Mohit Hulsurkar, Ies Elzenaar, Ralph J van Oort, Xander H T Wehrens,

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Patients with HF exhibit a loss of junctophilin-2 (JPH2), a structural protein critical in forming junctional membrane complexes in which excitation-contraction takes place. Several mechanisms have been proposed to mediate the loss of JPH2, one being cleavage by ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):49]

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Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.

Vaithinathan Selvaraju, Mahesh Thirunavukkarasu, Mandip Joshi, Babatunde Oriowo, Inam A Shaikh, Muhammad Tipu Rishi, Leonidas Tapias, Vladimir Coca-Soliz, Ibnalwalid Saad, Jacob Campbell, Seetur R Pradeep, Santosh Swaminathan, Siu-Pok Yee, David W McFadden, J Alexander Palesty, Nilanjana Maulik,

INTRODUCTION:In the present study, we aimed to explore the functional role of Pellino-1 (Peli1) in inducing neovascularization after myocardial infarction (MI) and hindlimb ischemia (HLI) using Peli1 global knockout mice (Peli1-/-). Recently we have shown that Peli1, an E3 ubiquitin ligase, induce angiogenesis and improve survivability, with decreased necrosis of ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):45]

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The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner.

Camilla Schinner, Silvana Olivares-Florez, Angela Schlipp, Sebastian Trenz, Manouk Feinendegen, Heinrich Flaswinkel, Ellen Kempf, Desalegn Tadesse Egu, Sunil Yeruva, Jens Waschke,

Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as "positive adhesiotropy", was demonstrated to be a function of sympathetic signaling and to be relevant for a sufficient inotropic response. We used the inotropic agent digitoxin to investigate the ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):46]

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Interplay of the red blood cell and vascular endothelial nitric oxide synthase system to combat cardiac complications of anemia.

Andreas Daiber, Thomas Münzel,

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):44]

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Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.

Nadine Lubos, Svenja van der Gaag, Muhammed Gerçek, Sebastian Kant, Rudolf E Leube, Claudia A Krusche,

Arrhythmogenic cardiomyopathy (AC) is an incurable genetic disease, whose pathogenesis is poorly understood. AC is characterized by arrhythmia, fibrosis, and cardiodilation that may lead to sudden cardiac death or heart failure. To elucidate AC pathogenesis and to design possible treatment strategies of AC, multiple murine models have been established. Among ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):42]

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Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia.

Patricia Wischmann, Viktoria Kuhn, Tatsiana Suvorava, Johanna M Muessig, Jens W Fischer, Brant E Isakson, Sebastian M Haberkorn, Ulrich Flögel, Jürgen Schrader, Christian Jung, Miriam M Cortese-Krott, Gerd Heusch, Malte Kelm,

Anaemia is frequently present in patients with acute myocardial infarction (AMI) and contributes to an adverse prognosis. We hypothesised that, besides reduced oxygen carrying capacity, anaemia is associated with (1) red blood cell (RBC) dysfunction and a reduced circulating nitric oxide (NO) pool, (2) compensatory enhancement of vascular and cardiac ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):43]

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Vascular autophagy in health and disease.

William E Hughes, Andreas M Beyer, David D Gutterman,

Homeostasis is maintained within organisms through the physiological recycling process of autophagy, a catabolic process that is intricately involved in the mobilization of nutrients during starvation, recycling of cellular cargo, as well as initiation of cellular death pathways. Specific to the cardiovascular system, autophagy responds to both chemical (e.g. free ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):41]

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Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities.

Ilona Cuijpers, Steven J Simmonds, Marc van Bilsen, Elżbieta Czarnowska, Arantxa González Miqueo, Stephane Heymans, Annika R Kuhn, Paul Mulder, Anna Ratajska, Elizabeth A V Jones, Ebba Brakenhielm,

Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specific prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fibrosis, inflammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade inflammation have been ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):39]

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Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury.

Junzhuo Wang, Ziwei Chen, Qing Dai, Jinxuan Zhao, Zilun Wei, Jiaxin Hu, Xuan Sun, Jun Xie, Biao Xu,

Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) is identified as an independent risk factor for poor prognosis in patients with acute myocardial infarction (AMI). The inflammatory response induced by ischemia and reperfusion (I/R) injury is considered one of the main mechanisms of MVO. Mesenchymal stem cells (MSCs) are ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):40]

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Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS.

Shanna Hamilton, Radmila Terentyeva, Benjamin Martin, Fruzsina Perger, Jiaoni Li, Andrei Stepanov, Ingrid M Bonilla, Björn C Knollmann, Przemyslaw B Radwański, Sandor Györke, Andriy E Belevych, Dmitry Terentyev,

Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a key role ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):38]

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Longitudinal metabolic profiling of cardiomyocytes derived from human-induced pluripotent stem cells.

Mohamed M Bekhite, Andrés González Delgado, Florian Menz, Tom Kretzschmar, Jasmine M F Wu, Tarek Bekfani, Sandor Nietzsche, Maria Wartenberg, Martin Westermann, Boris Greber, P Christian Schulze,

Human-induced pluripotent stem cells (h-iPSCs) are a unique in vitro model for cardiovascular research. To realize the potential applications of h-iPSCs-derived cardiomyocytes (CMs) for drug testing or regenerative medicine and disease modeling, characterization of the metabolic features is critical. Here, we show the transcriptional profile during stages of cardiomyogenesis of ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):37]

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Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series.

Siddharth Singh, Tarun Chakravarty, Peter Chen, Akbarshakh Akhmerov, Jeremy Falk, Oren Friedman, Tanzira Zaman, Joseph E Ebinger, Mitch Gheorghiu, Linda Marbán, Eduardo Marbán, Raj R Makkar,

There are no definitive therapies for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Therefore, new therapeutic strategies are needed to improve clinical outcomes, particularly in patients with severe disease. This case series explores the safety and effectiveness of intravenous allogeneic cardiosphere-derived cells (CDCs), formulated as CAP-1002, in critically ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):36]

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A future for remote ischaemic conditioning in high-risk patients.

Derek J Hausenloy, Mpiko Ntsekhe, Derek M Yellon,

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):35]

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The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells.

Beatrice Pflüger-Müller, James A Oo, Jan Heering, Timothy Warwick, Ewgenij Proschak, Stefan Günther, Mario Looso, Flávia Rezende, Christian Fork, Gerd Geisslinger, Dominique Thomas, Robert Gurke, Dieter Steinhilber, Marcel Schulz, Matthias S Leisegang, Ralf P Brandes,

Endocannabinoids are important lipid-signaling mediators. Both protective and deleterious effects of endocannabinoids in the cardiovascular system have been reported but the mechanistic basis for these contradicting observations is unclear. We set out to identify anti-inflammatory mechanisms of endocannabinoids in the murine aorta and in human vascular smooth muscle cells (hVSMC). ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):34]

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Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging.

Juan Martínez-Milla, Carlos Galán-Arriola, Manuel Carnero, Javier Cobiella, Daniel Pérez-Camargo, Victor Bautista-Hernández, Montserrat Rigol, Nuria Solanes, Rocío Villena-Gutierrez, Manuel Lobo, Jesús Mateo, Jean Paul Vilchez-Tschischke, Beatriz Salinas, Lorena Cussó, Gonzalo Javier López, Valentín Fuster, Manuel Desco, Javier Sanchez-González, Borja Ibanez,

Nonrevascularizable coronary artery disease is a frequent cause of hibernating myocardium leading to heart failure (HF). Currently, there is a paucity of therapeutic options for patients with this condition. There is a lack of animal models resembling clinical features of hibernating myocardium. Here we present a large animal model of ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):33]

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Matrix metalloproteinase-7 in platelet-activated macrophages accounts for cardiac remodeling in uremic mice.

Yang Yang, Lu Ma, Chao Wang, Minghui Song, Changchun Li, Meihan Chen, Jie Zhou, Changlin Mei,

Heart failure is the leading cause of mortality in patients with end-stage renal disease, and progressive cardiac remodeling is the key pathological basis of heart failure. However, the mechanism by which uremia-induced cardiac remodeling occurs is not well understood. Here, we showed that platelets were significantly activated in 5/6 nephrectomy-operated ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):30]

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Perspective: cardiovascular disease and the Covid-19 pandemic.

Tommaso Gori, Jos Lelieveld, Thomas Münzel,

We summarize the cardiovascular risks associated with Covid-19 pandemic, discussing the risks for both infected and non-infected patients. ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):32]

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CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly.

Yuanbin Li, Pengfei Liang, Bimei Jiang, Yuting Tang, Xuanyou Liu, Meidong Liu, Hui Sun, Cheng Chen, Hong Hao, Zhenguo Liu, Xianzhong Xiao,

Autophagy in cardiomyocyte is involved in myocardial ischemia/reperfusion (M-I/R) injury. Caspase recruitment domain-containing protein 9 (CARD9) plays a critical role in cardiovascular diseases (CVDs) such as hypertension and cardiac fibrosis. However, its role in autophagy following M-I/R injury is yet to be fully elucidated. Here, we found that CARD9 expression ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):29]

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Exercise improves cardiac function and glucose metabolism in mice with experimental myocardial infarction through inhibiting HDAC4 and upregulating GLUT1 expression.

Hao Jiang, Daile Jia, Beijian Zhang, Wenlong Yang, Zhen Dong, Xiaolei Sun, Xiaotong Cui, Leilei Ma, Jian Wu, Kai Hu, Aijun Sun, Junbo Ge,

This study aims to determine the effect of exercise on the cardiac function, metabolic profiles and related molecular mechanisms in mice with ischemic-induced heart failure (HF). HF was induced by myocardial infarction (MI) in C57BL6/N mice. Cardiac function and physical endurance were improved in HF mice after exercise. Micro-PET/CT scanning ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):28]

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Correction to: DNA‑PKcs promotes cardiac ischemia reperfusion injury through mitigating BI‑1‑governed mitochondrial homeostasis.

Hao Zhou, Sam Toan, Pingjun Zhu, Jin Wang, Jun Ren, Yingmei Zhang,

Since the publication of the article, the authors found a small problem with Fig. 7e. Unfortunately, Fig. 7e did not contain the correct images. The correct images are shown below and do not change the conclusions. ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):25]

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Mitochondrial noncoding RNA-regulatory network in cardiovascular disease.

Amela Jusic, Yvan Devaux, ,

Mitochondrial function and integrity are vital for the maintenance of cellular homeostasis, particularly in high-energy demanding cells. Cardiomyocytes have a large number of mitochondria, which provide a continuous and bulk supply of the ATP necessary for cardiac mechanical function. More than 90% of the ATP consumed by the heart is ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):23]

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CRISPLD1: a novel conserved target in the transition to human heart failure.

Sara Khadjeh, Vanessa Hindmarsh, Frederike Weber, Lukas Cyganek, Ramon O Vidal, Setare Torkieh, Katrin Streckfuss-Bömeke, Dawid Lbik, Malte Tiburcy, Belal A Mohamed, Stefan Bonn, Karl Toischer, Gerd Hasenfuss,

Heart failure is a major health problem worldwide with a significant morbidity and mortality rate. Although studied extensively in animal models, data from patients at the compensated disease stage are lacking. We sampled myocardium biopsies from aortic stenosis patients with compensated hypertrophy and moderate heart failure and used transcriptomics to ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(3):27]

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