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Correction: Epley manoeuvre for posterior semicircular canal benign paroxysmal positional vertigo in people with multiple sclerosis: protocol of a randomised controlled trial.

BMJ Open (BMJ open)
[2021, 11(4):1]

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Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19.

Mohammad Bosaeed, Ahmad Alharbi, Mohammad Hussein, Mohammed Abalkhail, Khizra Sultana, Abrar Musattat, Hajar Alqahtani, Majid Alshamrani, Ebrahim Mahmoud, Adel Alothman, Abdulrahman Alsaedy, Omar Aldibasi, Khalid Alhagan, Abdullah Mohammed Asiri, Sameera AlJohani, Majed Al-Jeraisy, Ahmed Alaskar,

<h4>Introduction</h4>A novel coronavirus, designated SARS-CoV-2, caused an international outbreak of a respiratory illness, termed COVID-19 in December 2019. There is a lack of specific therapeutic agents based on evidence for this novel coronavirus infection; however, several medications have been evaluated as a potential therapy. Therapy is required to treat symptomatic ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e047495]

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Determinants of childhood vaccination in Nagaland, India: a cross-sectional study with multilevel modelling.

Young Eun Kim,

<h4>Objectives</h4>Childhood vaccination coverage in Nagaland has lagged almost all states in India for more than two decades. This study aims to find drivers and barriers of childhood vaccination in Nagaland from the perspective of demand, supply and local health governance.<h4>Design</h4>A cross-sectional study was designed using a survey conducted by the ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e045070]

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Use of patient-reported outcome measures (PROMs) in clinical diabetes consultations: the DiaPROM randomised controlled pilot trial.

Ingvild Hernar, Marit Graue, David A Richards, Ragnhild B Strandberg, Roy Miodini Nilsen, Magne Rekdal, Karianne Fjeld Løvaas, Tone V Madsen, Grethe S Tell, Anne Haugstvedt,

<h4>Objective</h4>To pilot test the proposed DiaPROM trial components and address uncertainties associated with conducting a full-scale randomised controlled trial (RCT) to evaluate whether such a trial is feasible.<h4>Design</h4>Two-arm pilot RCT.<h4>Participants</h4>Adults aged ≥18-39 years, with minimum 1 year type 1 diabetes duration, attending outpatient follow-up. Exclusion criteria were pregnancy, severe cognitive, somatic ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e042353]

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How do delirium motor subtypes differ in phenomenology and contributory aetiology? a cross-sectional, multisite study of liaison psychiatry and palliative care patients.

Kevin Glynn, Frank McKenna, Kevin Lally, Muireann O'Donnell, Sandeep Grover, Subho Chakrabarti, Ajit Avasthi, Surendra K Mattoo, Akhilesh Sharma, Abhishek Gosh, Ruchita Shah, David Hickey, James Fitzgerald, Brid Davis, Niamh O'Regan, Dimitrious Adamis, Olugbenja Williams, Fahad Awan, C Dunne, Walter Cullen, Shane McInerney, John McFarland, Faiza Jabbar, Henry O'Connell, Paula T Trzepacz, Maeve Leonard, David Meagher,

<h4>Objectives</h4>To investigate whether delirium motor subtypes differ in terms of phenomenology and contributory aetiology.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>International study incorporating data from Ireland and India across palliative care, old age liaison psychiatry and general adult liaison psychiatry settings.<h4>Participants</h4>1757 patients diagnosed with delirium using criteria from the Diagnostic and Statistical Manual of Mental Disorders, ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e041214]

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Correction: Mindfulness-based programmes to reduce stress and enhance well-being at work: a realist review.

BMJ Open (BMJ open)
[2021, 11(4):1]

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Changes in quality of life (QoL) and other patient-reported outcome measures (PROMs) in living-donor and deceased-donor kidney transplant recipients and those awaiting transplantation in the UK ATTOM programme: a longitudinal cohort questionnaire survey with additional qualitative interviews.

Andrea Gibbons, Janet Bayfield, Marco Cinnirella, Heather Draper, Rachel J Johnson, Gabriel C Oniscu, Rommel Ravanan, Charles Tomson, Paul Roderick, Wendy Metcalfe, John L R Forsythe, Christopher Dudley, Christopher J E Watson, J Andrew Bradley, Clare Bradley,

<h4>Objective</h4>To examine quality of life (QoL) and other patient-reported outcome measures (PROMs) in kidney transplant recipients and those awaiting transplantation.<h4>Design</h4>Longitudinal cohort questionnaire surveys and qualitative semi-structured interviews using thematic analysis with a pragmatic approach.<h4>Setting</h4>Completion of generic and disease-specific PROMs at two time points, and telephone interviews with participants UK-wide.<h4>Participants</h4>101 incident ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e047263]

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Contributions of treatment centre and patient characteristics to patient-reported experience of haemodialysis: a national cross-sectional study.

Janine Hawkins, Nigel Smeeton, Amanda Busby, David Wellsted, Beth Rider, Julia Jones, Retha Steenkamp, Catherine Stannard, Rachel Gair, Sabine N van der Veer, Claire Corps, Ken Farrington,

<h4>Objectives</h4>To examine the relative importance of patient and centre level factors in determining self-reported experience of care in patients with advanced kidney disease treated by maintenance haemodialysis (HD).<h4>Design</h4>Analysis of data from a cross sectional national survey; the UK Renal Registry (UKRR) national Kidney patient-reported experience measure (PREM) survey (2018). Centre-level ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e044984]

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Current smoking status as a predictor of cerebral infarction in men: a retrospective cohort study in South Korea.

Sang Min Lee, Chang-Mo Oh, Min-Ho Kim, Eunhee Ha, Minha Hong, Jae-Hong Ryoo,

<h4>Objectives</h4>We examined the relationship between duration (pack-year) of smoking and the risk of developing cerebral infarction in Korean men.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>National Health Insurance Service-National Sample Cohort in Korea.<h4>Participants</h4>Of 125 743 male participants from the National Health Insurance System undergoing medical health check-up in 2009, 114 377 were included in the final analysis.<h4>Primary ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e042317]

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Risks and benefits of antioxidant dietary supplement use during cancer treatment: protocol for a scoping review.

L Susan Wieland, Ilana Moffet, Sydney Shade, Ashkan Emadi, Cheryl Knott, Emily F Gorman, Christopher D'Adamo,

<h4>Introduction</h4>Antioxidant dietary supplements are used by many patients with cancer to reduce the side effects of chemotherapy and improve prognosis. While some research indicates oral antioxidant supplementation reduces side effects and improves patient survival, other studies suggest the use of antioxidant dietary supplements may interfere with chemotherapy and reduce its ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e047200]

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Feasibility of a ballet-inspired low-impact at-home workout programme for adults with stroke: a mixed-methods exploratory study protocol.

Suzanne Hoi Shan Lo, Janita Pak Chun Chau, Kai Chow Choi, Jonas Yeung, Siu Hung Li, Marika Demers,

<h4>Introduction</h4>Balancing problems are prominent in stroke survivors with unilateral paresis. Recent evidence supports that dance interventions are associated with significant improvements in gait, stability and walking endurance in people with neurological conditions. The aim of this study is to explore the feasibility of a novel ballet-inspired at-home workout programme (Footprints ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e045064]

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Qualitative analysis of stakeholder interviews to identify the barriers and facilitators to the adoption of point-of-care diagnostic tests in the UK.

Jeremy R Huddy, Melody Zhifang Ni, James Barlow, George B Hanna,

<h4>Objectives</h4>This study investigated the barriers and facilitators to the adoption of point-of-care tests (POCTs).<h4>Design</h4>Qualitative study incorporating a constant comparative analysis of stakeholder responses to a series of interviews undertaken to design the Point-of-Care Key Evidence Tool.<h4>Setting</h4>The study was conducted in relation to POCTs used in all aspects of healthcare.<h4>Participants</h4>Forty-three stakeholders ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e042944]

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Impact of cardiac rehabilitation on mortality and morbidity in diabetic versus non-diabetic patients: protocol for a systematic review and meta-analysis.

Emad Hanna Dababneh, Sumanta Saha, Linda Östlundh, Rami H Al-Rifai, Abderrahim Oulhaj,

<h4>Background</h4>Cardiac rehabilitation (CR) decreases the morbidity and mortality risk among patients with cardiac diseases; however, the impact of CR on patients with diabetes remains underexplored. This is a protocol for a systematic review and meta-analysis methodology to explore if the effect of CR on mortality and morbidity is the same ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e047134]

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Association between postsurgical pain and heart rate variability: protocol for a scoping review.

Vincent So, Gregory Klar, Jordan Leitch, Michael McGillion, P J Devereaux, Ramiro Arellano, Joel Parlow, Ian Gilron,

<h4>Introduction</h4>Surgical interventions can elicit neuroendocrine responses and sympathovagal imbalance, ultimately affecting cardiac autonomic function. Cardiac complications account for 30% of postoperative complications and are the leading cause of morbidity and mortality following non-cardiac surgery. One cardiovascular parameter, heart rate variability (HRV), has been found to be predictive of postoperative morbidity ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e044949]

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Symptom burden in multimorbidity: a population-based combined questionnaire and registry study from Denmark.

Tora Grauers Willadsen, Volkert Siersma, Dagny Ros Nicolaisdottir, Dorte Jarbol, Ann Dorrit Guassora, Susanne Reventlow, Rasmus Køster-Rasmussen,

<h4>Objective</h4>Patients with multimorbidity may carry a large symptom burden. Symptoms are often what drive patients to seek healthcare and they also assist doctors with diagnosis. We examined whether symptom burden is additive in people with multimorbidity compared with people with a single morbidity.<h4>Design</h4>This is a longitudinal cohort study drawing on ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e041877]

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Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey.

Sergei Hermelijn, Casper Kersten, Dhanya Mullassery, Nagarajan Muthialu, Nazan Cobanoglu, Silvia Gartner, Pietro Bagolan, Carmen Mesas Burgos, Alberto Sgro, Stijn Heyman, Holger Till, Janne Suominen, Maarten Schurink, Liesbeth Desender, Paul Losty, Kjetil Ertresvag, Harm A W M Tiddens, Rene M H Wijnen, Marco Schnater, , ,

<h4>Introduction</h4>A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing. Either a surgical resection is performed or a wait-and-see policy is employed, depending on the treating physician. Management is largely based on expert opinion and scientific evidence ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e044544]

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Knowledge, attitude and experience of episiotomy practice among obstetricians and midwives: a cross-sectional study from China.

Jingxuan Yang, Hua Bai,

<h4>Objective</h4>Episiotomy is still performed widely by obstetricians and midwives in some Chinese maternity units, but the reasons are unknown. This study aims to determine the knowledge, attitude and experience towards the practice of episiotomy among obstetricians and midwives in China's public hospitals and consider strategies to reduce its practice.<h4>Methods</h4>A cross-sectional ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e043596]

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Practitioners' perceptions of acceptability of a question prompt list about palliative care for advance care planning with people living with dementia and their family caregivers: a mixed-methods evaluation study.

Jenny T van der Steen, Sten Heck, Carla Cm Juffermans, Mirjam Marjolein Garvelink, Wilco P Achterberg, Josephine Clayton, Genevieve Thompson, Raymond Tcm Koopmans, Yvette M van der Linden,

<h4>Objectives</h4>In oncology and palliative care, patient question prompt lists (QPLs) with sample questions for patient and family increased patients' involvement in decision-making and improved outcomes if physicians actively endorsed asking questions. Therefore, we aim to evaluate practitioners' perceptions of acceptability and possible use of a QPL about palliative and end-of-life ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e044591]

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Expert consensus on moving towards a value-based healthcare system in the Netherlands: a Delphi study.

Gijs Steinmann, Diana Delnoij, Hester van de Bovenkamp, Rogier Groote, Kees Ahaus,

<h4>Objectives</h4>While the uptake of value-based health care (VBHC) is remarkable, uncertainty prevails regarding the most important actions and practices in establishing a value-based healthcare system. In this paper, we generate expert consensus on the most important aspects of VBHC.<h4>Design</h4>The Delphi technique was used to reach consensus on the most important ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e043367]

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Minimally invasive versus conventional sternotomy for Mitral valve repair: protocol for a multicentre randomised controlled trial (UK Mini Mitral).

Rebecca H Maier, Adetayo S Kasim, Joseph Zacharias, Luke Vale, Richard Graham, Antony Walker, Grzegorz Laskawski, Ranjit Deshpande, Andrew Goodwin, Simon Kendall, Gavin J Murphy, Vipin Zamvar, Renzo Pessotto, Clinton Lloyd, Malcolm Dalrymple-Hay, Roberto Casula, Hunaid A Vohra, Franco Ciulli, Massimo Caputo, Serban Stoica, Max Baghai, Gunaratnam Niranjan, Prakash P Punjabi, Olaf Wendler, Leanne Marsay, Cristina Fernandez-Garcia, Paul Modi, Bilal H Kirmani, Mark D Pullan, Andrew D Muir, Dimitrios Pousios, Helen C Hancock, Enoch Akowuah,

<h4>Introduction</h4>Numbers of patients undergoing mitral valve repair (MVr) surgery for severe mitral regurgitation have grown and will continue to rise. MVr is routinely performed via median sternotomy; however, there is a move towards less invasive surgical approaches.There is debate within the clinical and National Health Service (NHS) commissioning community about ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e047676]

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Cluster randomised controlled trial of a menu box delivery service for Australian long day care services to improve menu guideline compliance: a study protocol.

Shabnam Kashef, Dorota Zarnowiecki, Victoria Brown, Jennifer C Arguelles, David N Cox, Rebecca K Golley,

<h4>Introduction</h4>Globally, children are not meeting the recommended serves of the five food group foods, particularly vegetables. Childcare is an opportune setting to improve children's diet quality. This study aims to assess the effectiveness of a menu box delivery service tailored to the long day care setting to improve menu compliance ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e045136]

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Peripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol.

Amanda J Ullman, Deanne August, Tricia Kleidon, Rachel Walker, Nicole M Marsh, Andrew Bulmer, Benjamin Pearch, Naomi Runnegar, Jessica A Schults, Joanne Leema, Paul Lee-Archer, Cathy Biles, Katrina Southam, Victoria Gibson, Joshua Byrnes, Robert S Ware, Vineet Chopra, Alan Coulthard, Peter Mollee, Claire M Rickard, Patrick N A Harris,

<h4>Introduction</h4>Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e042475]

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Efficacy of the iDBT-Pain skills training intervention to reduce emotional dysregulation and pain intensity in people with chronic pain: protocol for a single-case experimental design with multiple baselines.

Nell Norman-Nott, Chelsey Wilks, Negin Hesam-Shariati, Jessica Schroeder, Jina Suh, Mary Czerwinski, Sylvia Maria Gustin,

<h4>Introduction</h4>Difficulties in emotional regulation are key to the development and maintenance of chronic pain. Recent evidence shows internet-delivered dialectic behaviour therapy (iDBT) skills training can reduce emotional dysregulation and pain intensity. However, further studies are needed to provide more definitive evidence regarding the efficacy of iDBT skills training in the ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e041745]

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How to manage quarantine-adherence, psychosocial consequences, coping strategies and lifestyle of patients with COVID-19 and their confirmed contacts: study protocol of the CoCo-Fakt surveillance study, Cologne, Germany.

Christine Joisten, Annelene Kossow, Julian Book, Lukas Broichhaus, Monika Daum, Nina Eisenburger, Alisa Fabrice, Sven Feddern, Andreas Gehlhar, Anna Carlotta Graf, Barbara Grüne, Markus Lorbacher, Johannes Nießen, Wanja Noethig, Nikola Schmidt, Marc Tappiser, Gerhard A Wiesmüller,

<h4>Introduction</h4>The current coronavirus (SARS-CoV-2) pandemic has placed unprecedented restrictions on people's lives and routines. To counteract the exponential spread of this virus, a lockdown was implemented in Germany in March 2020. Infected persons and their contacts were also quarantined. Compliance with quarantine measures is essential for containing the spread of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e048001]

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Protocol for a scoping review exploring the use of patient-reported outcomes in adult social care.

Sarah E Hughes, Olalekan Lee Aiyegbusi, Daniel S Lasserson, Philip Collis, Samantha Cruz Rivera, Christel McMullan, Grace M Turner, Jon Glasby, Melanie Calvert,

<h4>Introduction</h4>Patient-reported outcomes (PROs) are measures of a person's own views of their health, functioning and quality of life. They are typically assessed using validated, self-completed questionnaires known as patient-reported outcome measures (PROMs). PROMs are used in healthcare settings to support care planning, clinical decision-making, patient-practitioner communication and quality improvement. PROMs ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e045206]

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