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Frequent outpatient attendance among people on the governmental welfare programme in Japan: assessing both patient and supplier characteristics.

Daisuke Nishioka, Junko Saito, Keiko Ueno, Naoki Kondo,

OBJECTIVES:Using linkage data from two municipal public assistance databases and medical assistance claim data, this study aimed to identify characteristics associated with frequent outpatient attendance by people on public assistance, who can access medical care services without copayment in Japan, with simultaneous consideration of supplier factors. DESIGN:We performed a retrospective ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038663]

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Safety of furazolidone-containing regimen in Helicobacter pylori infection: a systematic review and meta-analysis.

Chao-Ran Ji, Jing Liu, Yue-Yue Li, Chuan-Guo Guo, Jun-Yan Qu, Yan Zhang, Xiuli Zuo,

OBJECTIVES:Furazolidone containing regimen is effectivefor Helicobacter pylori (H. pylori) infection, but its safetyremains controversial. To assess the safety of furazolidone containing regimenin H. pylori infection. DESIGN:A systematic review and meta-analysis. DATA SOURCES:PubMed, Embase, Cochrane Library, Web of Science and Scopus databases were systematically searched for eligible randomised controlled trials. ELIGIBILITY ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e037375]

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Efficacy and safety of exogenous surfactant therapy in patients under 12 months of age invasively ventilated for severe bronchiolitis (SURFABRON): protocol for a multicentre, randomised, double-blind, controlled, non-profit trial.

Paolo Biban, Giorgio Conti, Andrea Michele Wolfler, Silvia Carlassara, Eloisa Gitto, Immacolata Rulli, Andrea Moscatelli, Camilla Micalizzi, Fabio Savron, Raffaella Sagredini, Giulia Genoni, Marco Binotti, Fabio Caramelli, Monica Fae, Andrea Pettenazzo, Valentina Stritoni, Luigia D'Amato, Geremia Zito Marinosci, Edoardo Calderini, Stefano Scalia Catenacci, Alberto Berardi, Francesco Torcetta, Ezio Bonanomi, Daniele Bonacina, Giorgio Ivani, Pierantonio Santuz,

INTRODUCTION:Some evidence indicates that exogenous surfactant therapy may be effective in infants with acute viral bronchiolitis, even though more confirmatory data are needed. To date, no large multicentre trials have evaluated the effectiveness and safety of exogenous surfactant in severe cases of bronchiolitis requiring invasive mechanical ventilation (IMV). METHODS AND ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038780]

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Assault-related severe ocular chemical injury at a London ophthalmic referral hospital: a 3-year retrospective observational study.

Jeremy John Hoffman, Edward Joshua Casswell, Alex John Shortt,

OBJECTIVES:To understand the incidence, causes, management and outcomes of intentional (assault) and unintentional severe ocular chemical injuries (SOCI) at an urban tertiary referral centre in the UK. DESIGN:Retrospective observational study. SETTING:A London tertiary referral ophthalmic centre, Moorfields Eye Hospital. PARTICIPANTS:All cases of SOCI presenting between 1 September 2011 and 31 ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038109]

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Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review.

Morris Ogero, Rachel Jelagat Sarguta, Lucas Malla, Jalemba Aluvaala, Ambrose Agweyu, Mike English, Nelson Owuor Onyango, Samuel Akech,

OBJECTIVES:To identify and appraise the methodological rigour of multivariable prognostic models predicting in-hospital paediatric mortality in low-income and middle-income countries (LMICs). DESIGN:Systematic review of peer-reviewed journals. DATA SOURCES:MEDLINE, CINAHL, Google Scholar and Web of Science electronic databases since inception to August 2019. ELIGIBILITY CRITERIA:We included model development studies predicting in-hospital ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e035045]

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Association between neutrophil-to-albumin ratio and mortality in patients with cardiogenic shock: a retrospective cohort study.

Yangpei Peng, Yangjing Xue, Jinsheng Wang, Huaqiang Xiang, Kangting Ji, Jie Wang, Cong Lin,

OBJECTIVES:To investigate the prognostic value of neutrophil-to-albumin ratio (NAR) in critically ill patients with cardiogenic shock (CS). DESIGN:A retrospective cohort study. SETTING:A single centre in Boston, USA. PARTICIPANTS:475 patients with CS were included, among which 272 (57.3%) were men and 328 (69.1%) were white. PRIMARY AND SECONDARY OUTCOME MEASURES:The primary ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039860]

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Impact of expanding smoke-free policies beyond enclosed public places and workplaces on children's tobacco smoke exposure and respiratory health: protocol for a systematic review and meta-analysis.

Márta K Radó, Famke Jm Mölenberg, Aziz Sheikh, Christopher Millett, Wichor M Bramer, Alex Burdorf, Frank J van Lenthe, Jasper V Been,

INTRODUCTION:Tobacco smoke exposure (TSE) has considerable adverse respiratory health impact among children. Smoke-free policies covering enclosed public places are known to reduce child TSE and benefit child health. An increasing number of jurisdictions are now expanding smoke-free policies to also cover outdoor areas and/or (semi)private spaces (indoor and/or outdoor). We ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038234]

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Effectiveness of negative pressure wound therapy in the prevention of surgical wound complications in the cesarean section at-risk population: a parallel group randomised multicentre trial-the CYGNUS protocol.

Kylie Sandy-Hodgetts, Richard Parsons, Richard Norman, Mark W Fear, Fiona M Wood, Scott W White,

INTRODUCTION:Caesarean delivery is steadily becoming one of the more common surgical procedures in Australia with over 100 000 caesarean sections performed each year. Over the last 10 years in Australia, the caesarean section rate has increased from 28% in 2003 to 33% in 2013. On the international stage, the Australian ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e035727]

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Kids' Outcomes And Long-term Abilities (KOALA): protocol for a prospective, longitudinal cohort study of mild traumatic brain injury in children 6 months to 6 years of age.

Miriam H Beauchamp, Fanny Dégeilh, Keith Yeates, Isabelle Gagnon, Ken Tang, Jocelyn Gravel, Antonia Stang, Brett Burstein, Annie Bernier, Catherine Lebel, Ramy El Jalbout, Sonia Lupien, Louis de Beaumont, Roger Zemek, Mathieu Dehaes, Sylvain Deschênes, ,

INTRODUCTION:Mild traumatic brain injury (mTBI) is highly prevalent, especially in children under 6 years. However, little research focuses on the consequences of mTBI early in development. The objective of the Kids' Outcomes And Long-term Abilities (KOALA) study is to document the impact of early mTBI on children's motor, cognitive, social ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e040603]

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Risks of use and non-use of antibiotics in primary care: qualitative study of prescribers' views.

Olga Boiko, Caroline Burgess, Robin Fox, Mark Ashworth, Martin C Gulliford,

PURPOSE:The emergence of antimicrobial resistance has led to increasing efforts to reduce unnecessary use of antibiotics in primary care, but potential hazards from bacterial infection continue to cause concern. This study investigated how primary care prescribers perceive risk and safety concerns associated with reduced antibiotic prescribing. METHODS:Qualitative study using semistructured ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038851]

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First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women.

Charline Bertholdt, Gabriela Hossu, Claire Banasiak, Marine Beaumont, Olivier Morel,

INTRODUCTION:Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to chronic uteroplacental hypoperfusion. Nowadays, there is no screening or diagnostic test for uteroplacental vascularisation deficiency in pregnant women. Since 2004, 3 three-imensional power Doppler (3DPD) angiography has been used for the evaluation of uteroplacental vascularisation and ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e037751]

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The Food provision, cUlture and Environment in secondary schooLs (FUEL) study: protocol of a mixed methods evaluation of national School Food Standards implementation in secondary schools and their impact on pupils' dietary intake and dental health.

Marie Murphy, Miranda Pallan, Emma Lancashire, Rhona Duff, Ashley J Adamson, Suzanne Bartington, Emma Frew, Tania Griffin, Kiya L Hurley, Jayne Parry, Sandra Passmore, Vahid Ravaghi, Alice J Sitch, Suzanne Spence, Maisie K Rowland, Scott Wheeldon, Peymane Adab,

INTRODUCTION:Excess free sugar intake is associated with obesity and poor dental health. Adolescents consume substantially more free sugar than is recommended. National (UK) School Food Standards (SFS) are in place but are not mandatory in all schools, and their impact on the diets of secondary school pupils is unknown. We ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e042931]

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Deaths in people from Black, Asian and minority ethnic communities from both COVID-19 and non-COVID causes in the first weeks of the pandemic in London: a hospital case note review.

Michael Richard Perkin, Sarah Heap, Agatha Crerar-Gilbert, Wendy Albuquerque, Serena Haywood, Zoe Avila, Richard Hartopp, Jonathan Ball, Kate Hutt, Nigel Kennea,

OBJECTIVE:To undertake a case review of deaths in a 6-week period during the COVID-19 pandemic commencing with the first death in the hospital from COVID-19 on 12th of March 2020 and contrast this with the same period in 2019. SETTING:A large London teaching hospital. PARTICIPANTS:Three groups were compared: group 1-COVID-19-associated ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e040638]

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Internet-based patient- primary care physician-cardiologist integrated management model of hypertension in China: study protocol for a multicentre randomised controlled trial.

Runyu Ye, Rufeng Shi, Kai Liu, Xin Zhang, Si Wang, Hang Liao, Xinran Li, Qiling Gou, Xi Rong, Zhipeng Zhang, Changqiang Yang, Xiangyu Yang, Xiaoping Chen,

INTRODUCTION:The control rate of hypertension is low in China, especially in rural, western and minority areas. This is related to poor medical skills among physicians in primary care institutions and low levels of trust among patients. However, primary healthcare institutions are the main battleground for the prevention and treatment of ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039447]

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Platelet transfusion for neonates with thrombocytopaenia: protocol for a systematic review.

Dengjun Liu, Jinlin Wu, Tao Xiong, Yan Yue, Jun Tang,

INTRODUCTION:Thrombocytopaenia is one of the most common haemostatic abnormalities among neonates. It affects approximately one-quarter of neonates admitted into neonatal intensive care units and may lead to a high risk of bleeding and mortality, which are substantial causes for concern by neonatologists. Platelet transfusion (PT) is a specific treatment for ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039132]

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Cohort profile: the mature adults cohort of the Malawi longitudinal study of families and health (MLSFH-MAC).

Iliana V Kohler, Chiwoza Bandawe, Alberto Ciancio, Fabrice Kämpfen, Collin F Payne, James Mwera, James Mkandawire, Hans-Peter Kohler,

PURPOSE:The Mature Adults Cohort of the Malawi Longitudinal Study of Families and Health (MLSFH-MAC) contributes to global ageing studies by providing a rare opportunity to study the processes of individual and population ageing, the public health and social challenges associated with ageing and the coincident shifts in disease burdens, in ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038232]

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Factors associated with non-initiation of mental healthcare after detection of poor mental health at a scheduled health check: a cohort study.

Christine Geyti, Kaj Sparle Christensen, Else-Marie Dalsgaard, Bodil Hammer Bech, Jane Gunn, Helle Terkildsen Maindal, Annelli Sandbaek,

INTRODUCTION:Poor mental health is an important public health concern, but mental health problems are often under-recognised. Providing feedback to general practitioners (GPs) on their patients' mental health status may improve the identification of cases in need of mental healthcare. OBJECTIVES:To investigate the extent of initiation of mental healthcare after identification ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e037731]

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Turnover intention among primary health workers in China: a systematic review and meta-analysis.

Rongxin He, Jinlin Liu, Wei-Hong Zhang, Bin Zhu, Ning Zhang, Ying Mao,

OBJECTIVES:To analyse the prevalence and determinants of turnover intention (TI) among primary health workers (PHWs) in China to provide evidence for improving retention measures. DESIGN:Systemic review and meta-analysis. DATA SOURCES:Four English-language databases (PubMed, EMBASE, Cochrane Library, PsycINFO) and three Chinese databases (CNKI, CSPD, CBM) were searched up to October 2019. ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e037117]

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Prediction of perinatal death using machine learning models: a birth registry-based cohort study in northern Tanzania.

Innocent B Mboya, Michael J Mahande, Mohanad Mohammed, Joseph Obure, Henry G Mwambi,

OBJECTIVE:We aimed to determine the key predictors of perinatal deaths using machine learning models compared with the logistic regression model. DESIGN:A secondary data analysis using the Kilimanjaro Christian Medical Centre (KCMC) Medical Birth Registry cohort from 2000 to 2015. We assessed the discriminative ability of models using the area under ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e040132]

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Benefits finding among Chinese family caregivers of stroke survivors: a qualitative descriptive study.

Yong-Xia Mei, Beilei Lin, Weihong Zhang, Dong-Bin Yang, Shan-Shan Wang, Zhen-Xiang Zhang, Daphne Sze Ki Cheung,

OBJECTIVES:The caregiving experience includes both caregiver burdens and benefits finding. However, the benefits obtained by family caregivers of stroke survivors in Chinese community dwellings are unknown. The objective of this study was to explore the benefits experienced by family caregivers of stroke survivors in Chinese community dwellings. DESIGN:A qualitative descriptive ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038344]

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Group-based intervention to improve developmental status among children age 6-18 months in rural Shanxi province, China: a study protocol for a cluster randomised controlled trial.

Mengxue Xu, Aihua Liu, Chunxia Zhao, Hai Fang, Xiaona Huang, Stephen Berman, Hongyan Guan,

INTRODUCTION:Early childhood development (ECD) is a critical component for building the foundation of future physical and emotional health and subsequent academic success. The quality of the home environment to promote development is an important factor in ECD. Since large rural-urban disparities in the home environment exist in China, there is ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e037156]

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Age-dependent seroprevalence of dengue and chikungunya: inference from a cross-sectional analysis in Esmeraldas Province in coastal Ecuador.

Irina Chis Ster, Alejandro Rodriguez, Natalia Cristina Romero, Andrea Lopez, Martha Chico, Joel Montgomery, Philip Cooper,

OBJECTIVES:There are few population-based estimates for prevalence of past exposure to dengue and chikungunya viruses despite common epidemiological features. Here, we have developed a novel statistical method to study patterns of age-dependent prevalence of immunity in a population following exposures to two viruses which share similar epidemiological features including mode ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e040735]

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Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prostate carcinoma.

Jonas S Heitmann, Juliane S Walz, Martin Pflügler, Joseph Kauer, Richard F Schlenk, Gundram Jung, Helmut R Salih,

INTRODUCTION:Prostate cancer is the second most common cancer in men worldwide. When the disease becomes resistant to androgen-deprivation therapy, treatment options are sparse. To address the high medical need in castration-resistant prostate cancer (CRPC), we generated a novel PSMAxCD3 bispecific antibody termed CC-1. CC-1 binds to prostate-specific membrane antigen that ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039639]

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Impact of incarceration on cardiovascular disease risk factors: a systematic review and meta-regression on weight and BMI change.

Constantin Bondolfi, Patrick Taffe, Aurélie Augsburger, Cécile Jaques, Mary Malebranche, Carole Clair, Patrick Bodenmann,

OBJECTIVE:Cardiovascular disease is an underappreciated issue in prison medicine. Recent studies have revealed a higher prevalence of cardiovascular disease risk factors (CVDRFs) among individuals in prison, but the impact of incarceration on CVDRFs over time is not well understood. This review aimed to assess available literature and quantify the relationship ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039278]

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Treatment success of internet-based vestibular rehabilitation in general practice: development and internal validation of a prediction model.

Vincent A van Vugt, Martijn W Heymans, Johannes C van der Wouden, Henriëtte E van der Horst, Otto R Maarsingh,

OBJECTIVES:To develop and internally validate prediction models to assess treatment success of both stand-alone and blended online vestibular rehabilitation (VR) in patients with chronic vestibular syndrome. DESIGN:Secondary analysis of a randomised controlled trial. SETTING:59 general practices in The Netherlands. PARTICIPANTS:202 adults, aged 50 years and older with a chronic vestibular ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e038649]

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