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Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996-2016.

Bendix Carstensen, Pernille Falberg Rønn, Marit Eika Jørgensen,

INTRODUCTION:The objective of this study was to give an overview of prevalence, incidence and mortality of type 1 (T1D) and type 2 diabetes (T2D) in Denmark, and their temporal trends. RESEARCH DESIGN AND METHODS:We constructed a diabetes register from existing population-based healthcare registers, including a classification of patients as T1D ... Read more >>

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Role of fructosamine-3-kinase in protecting against the onset of microvascular and macrovascular complications in patients with T2DM.

Giovanni Sartore, Eugenio Ragazzi, Silvia Burlina, Renata Paleari, Nino Cristiano Chilelli, Andrea Mosca, Francesca Avemaria, Annunziata Lapolla,

INTRODUCTION:Microangiopathic and macroangiopathic complications are the main cause of morbidity and mortality in the diabetic population. Numerous publications have highlighted the role of glycation in the onset of complications of diabetes. In this context, the detection of fructosamine-3-kinase (FN3K)-an enzyme capable of counteracting the effect of hyperglycemia by intervening in ... Read more >>

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Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport.

Ele Ferrannini, Ricardo Pereira-Moreira, Marta Seghieri, Eleni Rebelos, Aglécio L Souza, Valeria B Chueire, Caterina Arvia, Elza Muscelli,

INTRODUCTION:Insulin regulates renal glucose production and utilization; both these fluxes are increased in type 2 diabetes (T2D). Whether insulin also controls urinary glucose excretion is not known. METHODS:We applied the pancreatic clamp technique in 12 healthy subjects and 13 T2D subjects. Each participant received a somatostatin infusion and a variable ... Read more >>

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Association of glucose variability at the last day of hospitalization with 30-day readmission in adults with diabetes.

Elias K Spanakis, Lakshmi G Singh, Tariq Siddiqui, John D Sorkin, George Notas, Michelle F Magee, Jeffrey C Fink, Min Zhan, Guillermo E Umpierrez,

OBJECTIVE:To evaluate whether increased glucose variability (GV) during the last day of inpatient stay is associated with increased risk of 30-day readmission in patients with diabetes. RESEARCH DESIGN AND METHODS:A comprehensive list of clinical, pharmacy and utilization files were obtained from the Veterans Affairs (VA) Central Data Warehouse to create ... Read more >>

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Decreased arterial distensibility and postmeal hyperinsulinemia in young Japanese women with family history of diabetes.

Mika Takeuchi, Bin Wu, Mari Honda, Ayaka Tsuboi, Kaori Kitaoka, Satomi Minato, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo,

INTRODUCTION:To assess vascular function and characterize insulin secretion using a physiological approach in Japanese women with family history of type 2 diabetes (FHD). RESEARCH DESIGN AND METHODS:Standardized mixed-meal tests were performed with multiple postprandial glucose, insulin and free fatty acids (FFA) measurements over a 30-120 min period in 31 Japanese women ... Read more >>

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Long-term changes in carbohydrate tolerance, insulin secretion and action in African-American patients with obesity and history of hyperglycemic crises.

Priyathama Vellanki, Darko Stefanovski, Isabel I Anzola, Dawn D Smiley, Limin Peng, Guillermo E Umpierrez,

INTRODUCTION:Many African-Americans (AA) with obesity with newly diagnosed diabetes presenting with diabetic ketoacidosis (DKA) or severe hyperglycemia (SH) discontinue insulin therapy and achieve near-normoglycemia remission (hemoglobin A1c (HbA1c) <7%, fasting blood glucose (FBG) <130 mg/dL) and able to be managed on oral antidiabetic agents (OAD) during follow-up. Using combined data from ... Read more >>

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Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation.

Andrew P McGovern, Michael Hogg, Beverley M Shields, Naveed A Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Angus G Jones, John M Dennis, ,

INTRODUCTION:To identify risk factors, absolute risk, and impact on treatment discontinuation of genital infections with sodium-glucose co-transporter-2 inhibitors (SGLT2i). RESEARCH DESIGN AND METHODS:We assessed the relationship between baseline characteristics and genital infection in 21 004 people with type 2 diabetes initiating SGLT2i and 55 471 controls initiating dipeptidyl peptidase-4 inhibitors (DPP4i) in ... Read more >>

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Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis.

Peng Qu, Yachun Wang, Lei Liu, Mengmeng Qi, Yimeng Sun, Siyang Zheng, Zichen Xu, Changhong Liu, Xiaoyan Bai, Qinggao Zhang, Limin Yang,

INTRODUCTION:The habenular nucleus (Hb), a famous relay station in the midbrain, is vital for controlling many physiological functions of vertebrates. The role of Hb in the pathogenesis of depression has been thoroughly studied, but whether it functions in the pathogenesis of diabetes remains unknown. In this study, we found that ... Read more >>

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Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes.

Akiko Itoga, Xinmin Zha, Keiko Nagase, Yoshitaka Aoki, Hideaki Ito, Osamu Yokoyama,

INTRODUCTION:Sexual dysfunction is a common complication in men with type 2 diabetes and is often refractory to treatment. This study investigated the long-term influence of the phosphodiesterase 5 inhibitor (PDE5I) tadalafil on the level of sex hormones and sexual function in male Otsuka Long-Evans Tokushima Fatty (OLETF) rats as an ... Read more >>

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'Turning the tide' on hyperglycemia in pregnancy: insights from multiscale dynamic simulation modeling.

Louise Freebairn, Jo-An Atkinson, Yang Qin, Christopher J Nolan, Alison L Kent, Paul M Kelly, Luke Penza, Ante Prodan, Anahita Safarishahrbijari, Weicheng Qian, Louise Maple-Brown, Roland Dyck, Allen McLean, Geoff McDonnell, Nathaniel D Osgood, ,

INTRODUCTION:Hyperglycemia in pregnancy (HIP, including gestational diabetes and pre-existing type 1 and type 2 diabetes) is increasing, with associated risks to the health of women and their babies. Strategies to manage and prevent this condition are contested. Dynamic simulation models (DSM) can test policy and program scenarios before implementation in ... Read more >>

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Systematic review and meta-analysis of mouse models of diabetes-associated ulcers.

Pacific Huynh, James Phie, Smriti Murali Krishna, Jonathan Golledge,

Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed to determine whether wound healing is impaired in mouse models of diabetes and assess the quality of the past research. A systematic literature ... Read more >>

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Effects of a multifactorial ecosustainable isocaloric diet on liver fat in patients with type 2 diabetes: randomized clinical trial.

Giuseppe Della Pepa, Claudia Vetrani, Valentina Brancato, Marilena Vitale, Serena Monti, Giovanni Annuzzi, Gianluca Lombardi, Anna Izzo, Marianna Tommasone, Paola Cipriano, Gennaro Clemente, Peppino Mirabelli, Marcello Mancini, Marco Salvatore, Gabriele Riccardi, Angela Albarosa Rivellese, Lutgarda Bozzetto,

INTRODUCTION:Treatment options for non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D) are still a matter of debate. We compared the effects of a diet including different components versus a proven beneficial diet rich in monounsaturated fatty acids (MUFAs) on liver fat in T2D. RESEARCH DESIGN AND ... Read more >>

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Glycated hemoglobin (HbA1c) as diagnostic criteria for diabetes: the optimal cut-off points values for the Pakistani population; a study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017.

Abdul Basit, Asher Fawwad, Khalid Abdul Basit, Nazish Waris, Bilal Tahir, Iftikhar Ahmed Siddiqui, ,

AIM:Glycated hemoglobin (HbA1c) cut-off values as diagnostic tool in diabetes and prediabetes with its concordance to oral glucose tolerance test (OGTT) in Pakistani population. METHODOLOGY:Data for this substudy was obtained from second National Diabetes Survey of Pakistan (NDSP) 2016-2017. With this survey, 10 834 individuals were recruited and after excluding known ... Read more >>

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Preventing diabetes after pregnancy with gestational diabetes in a Cree community: an inductive thematic analysis.

Romina Pace, Orenda Loon, Deborah Chan, Helene Porada, Catherine Godin, Jonathan Linton, Paul Linton, Jill Torrie, Kaberi Dasgupta,

INTRODUCTION:Historical and political factors underpin the disproportional burden of type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) in women, a harbinger of future T2DM, in Indigenous populations. There is a need for T2DM prevention strategies driven by the voices of Indigenous women. In this study, we aimed to ... Read more >>

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Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study.

Salwa S Zghebi, Mamas A Mamas, Darren M Ashcroft, Chris Salisbury, Christian D Mallen, Carolyn A Chew-Graham, David Reeves, Harm Van Marwijk, Nadeem Qureshi, Stephen Weng, Tim Holt, Iain Buchan, Niels Peek, Sally Giles, Martin K Rutter, Evangelos Kontopantelis,

OBJECTIVE:Clinically applicable diabetes severity measures are lacking, with no previous studies comparing their predictive value with glycated hemoglobin (HbA1c). We developed and validated a type 2 diabetes severity score (the DIabetes Severity SCOre, DISSCO) and evaluated its association with risks of hospitalization and mortality, assessing its additional risk information to ... Read more >>

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Predicting the risk of future diabetic foot ulcer occurrence: a prospective cohort study of patients with diabetes in Tanzania.

Roozbeh Naemi, Nachiappan Chockalingam, Janet K Lutale, Zulfiqarali G Abbas,

OBJECTIVES:The aim of this study was to identify the parameters that predict the risk of future foot ulcer occurrence in patients with diabetes. RESEARCH DESIGN AND METHODS:1810 (male (M)/female (F): 1012/798) patients, with no foot ulcer at baseline, participated in this study. Data from a set of 28 parameters were ... Read more >>

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Improved diabetes control among low-income Mexican Americans through community-clinical interventions: results of an RCT.

Belinda M Reininger, MinJae Lee, Manouchehr Hessabi, Lisa A Mitchell-Bennett, Maribel R Sifuentes, Jose A Guerra, Ciara D Ayala, Tianlin Xu, Valerie Polletta, Amy Flynn, Mohammad H Rahbar,

INTRODUCTION:This randomized controlled trial investigated community-clinical intervention strategies for a Mexican American population who had not demonstrated control of their diabetes. We tested a control program (Salud y Vida 1.0) supporting diabetes management versus an enhanced version (Salud y Vida 2.0) for reductions in HbA1c at 12 months. RESEARCH DESIGN ... Read more >>

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Impaired fasting glucose and development of chronic kidney disease in non-diabetic population: a Mendelian randomization study.

Hyoungnae Kim, Suyeon Park, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh,

INTRODUCTION:Diabetes mellitus is a risk factor of chronic kidney disease (CKD); however, the relationship between fasting glucose and CKD remains controversial in non-diabetic population. This study aimed to assess causal relationship between genetically predicted fasting glucose and incident CKD. RESEARCH DESIGN AND METHODS:This study included 5909 participants without diabetes and ... Read more >>

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Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan.

Zahid Miyan, Nazish Waris, ,

OBJECTIVE:To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin. METHODOLOGY:Between May 2018 and January 2019, this prospective multicenter observational study recruited participants from seven centers in four provinces of Pakistan (Sindh, Punjab, Baluchistan and Khyber Pakhtunkhwa). Participants with ... Read more >>

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KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats.

Xuanxin Yang, Rongshuai Yang, Min Chen, Qingde Zhou, Yingying Zheng, Chao Lu, Jianing Bi, Wenzhe Sun, Tongzhou Huang, Lijia Li, Jianxiang Gong, Xiaokun Li, Qi Hui, Xiaojie Wang,

OBJECTIVE:The present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats. RESEARCH DESIGN AND METHODS:In this study, a poloxamer 407 thermosensitive hydrogel ... Read more >>

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Effect of high-salt diet on blood pressure and body fluid composition in patients with type 1 diabetes: randomized controlled intervention trial.

Eliane F E Wenstedt, Nienke M G Rorije, Rik H G Olde Engberink, Kim M van der Molen, Youssef Chahid, A H Jan Danser, Bert-Jan H van den Born, Liffert Vogt,

INTRODUCTION:Patients with type 1 diabetes are susceptible to hypertension, possibly resulting from increased salt sensitivity and accompanied changes in body fluid composition. We examined the effect of a high-salt diet (HSD) in type 1 diabetes on hemodynamics, including blood pressure (BP) and body fluid composition. RESEARCH DESIGN AND METHODS:We studied ... Read more >>

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Comparison of a new versus standard removable offloading device in patients with neuropathic diabetic foot ulcers: a French national, multicentre, open-label randomized, controlled trial.

Louis Potier, Maud François, Dured Dardari, Marilyne Feron, Narimene Belhatem, Estelle Nobecourt-Dupuy, Manuel Dolz, Lyse Bordier, Roxane Ducloux, Abdelkader Chibani, Dominique-François Eveno, Teresa Crea Avila, Ariane Sultan, Laurence Baillet-Blanco, Vincent Rigalleau, Elise Gand, Pierre-Jean Saulnier, Gilberto Velho, Ronan Roussel, Quentin Pellenc, Jean-Claude Dupré, Dominique Malgrange, Michel Marre, Kamel Mohammedi, ,

INTRODUCTION:The offloading is crucial to heal neuropathic diabetic foot ulcer (DFU). Removable offloading are the most used devices. Orthèse diabète is a new customized removable knee-high offloading device immobilizing foot and ankle joints, with some specific and innovative features that may improve offloading. We aimed to evaluate the efficiency of ... Read more >>

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Correlation between markers of renal function and sight-threatening diabetic retinopathy in type 2 diabetes: a longitudinal study in an Indian clinic population.

Ramachandran Rajalakshmi, Coimbatore Subramanian Shanthi Rani, Ulagamathesan Venkatesan, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ganesan UmaSankari, Sobha Sivaprasad, Rajiv Raman, Viswanathan Mohan,

INTRODUCTION:Previous epidemiological studies have reported on the prevalence of diabetic kidney disease (DKD) and diabetic retinopathy (DR) from India. The aim of this study is to evaluate the effect of DKD on the development of new-onset DR and sight-threatening diabetic retinopathy (STDR) in Asian Indians with type 2 diabetes (T2D). ... Read more >>

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Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a prospective cross-sectional study.

Nikolai Carl Hodel, Ali Hamad, Klaus Reither, Grace Mwangoka, Irene Kasella, Claudia Praehauser, Salim Abdulla, Christoph F R Hatz, Michael Mayr,

INTRODUCTION:Epidemiological data about diabetes mellitus (DM) for sub-Saharan Africa (SSA) are scarce and the utility of glycated hemoglobin (HbA1c) to diagnose DM is uncertain in African populations with a high proportion of anemia. RESEARCH DESIGN AND METHODS:In a cross-sectional study, age-adjusted prevalence rates and predictors for DM and pre-DM were ... Read more >>

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Proinsulin to insulin ratio is associated with incident type 2 diabetes but not with vascular complications in the KORA F4/FF4 study.

Cornelia Then, Christina Gar, Barbara Thorand, Cornelia Huth, Holger Then, Christa Meisinger, Margit Heier, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Andreas Lechner, Jochen Seissler,

INTRODUCTION:We investigated the association of the proinsulin to insulin ratio (PIR) with prevalent and incident type 2 diabetes (T2D), components of the metabolic syndrome, and renal and cardiovascular outcomes in the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study (2006-2008)/FF4 study (2013-2014). RESEARCH DESIGN AND METHODS:The ... Read more >>

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