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Journal BMJ Open Diabetes Res Care

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Clinical decision support to improve management of diabetes and dysglycemia in the hospital: a path to optimizing practice and outcomes.

Ariana Pichardo-Lowden, Guillermo Umpierrez, Erik B Lehman, Matthew D Bolton, Christopher J DeFlitch, Vernon M Chinchilli, Paul M Haidet,

<h4>Introduction</h4>Innovative approaches are needed to design robust clinical decision support (CDS) to optimize hospital glycemic management. We piloted an electronic medical record (EMR), evidence-based algorithmic CDS tool in an academic center to alert clinicians in real time about gaps in care related to inpatient glucose control and insulin utilization, and ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic.

Merel M Ruissen, Hannah Regeer, Cyril P Landstra, Marielle Schroijen, Ingrid Jazet, Michiel F Nijhoff, Hanno Pijl, Bart E P B Ballieux, Olaf Dekkers, Sasja D Huisman, Eelco J P de Koning,

<h4>Introduction</h4>Lockdown measures have a profound effect on many aspects of daily life relevant for diabetes self-management. We assessed whether lockdown measures, in the context of the COVID-19 pandemic, differentially affect perceived stress, body weight, exercise and related this to glycemic control in people with type 1 and type 2 diabetes.<h4>Research ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Geographical clustering and socioeconomic factors associated with hypoglycemic events requiring emergency assistance in Andalusia (Spain).

Fernando Gomez-Peralta, Cristina Abreu, Manuel Benito, Rafael J Barranco,

<h4>Introduction</h4>The geographical distribution of hypoglycemic events requiring emergency assistance was explored in Andalusia (Spain), and potentially associated societal factors were determined.<h4>Research design and methods</h4>This was a database analysis of hypoglycemia requiring prehospital emergency assistance from the Public Company for Health Emergencies (<i>Empresa Pública de Emergencias Sanitarias</i> (EPES)) in Andalusia during ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Estimating the impact of tax policy interventions on the projected number and prevalence of adults with type 2 diabetes in Germany between 2020 and 2040.

Thaddäus Tönnies, Christin Heidemann, Rebecca Paprott, Esther Seidel-Jacobs, Christa Scheidt-Nave, Ralph Brinks, Annika Hoyer,

<h4>Introduction</h4>As a population-wide intervention, it has been proposed to raise taxes on unhealthy products to prevent diseases such as type 2 diabetes. In this study, we aimed to estimate the effect of tax policy interventions in 2020 on the projected prevalence and number of people with type 2 diabetes in ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study.

Haifa Maalmi, Kristiaan Wouters, Hans H C M Savelberg, Jeroen H P M van der Velde, Jos P H Reulen, Werner Mess, Casper G Schalkwijk, Coen D A Stehouwer, Michael Roden, Dan Ziegler, Christian Herder, Nicolaas C Schaper,

<h4>Introduction</h4>Distal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Vitamin D status and risk of type 2 diabetes in the Norwegian HUNT cohort study: does family history or genetic predisposition modify the association?

Marion Denos, Xiao-Mei Mai, Bjørn Olav Åsvold, Elin Pettersen Sørgjerd, Yue Chen, Yi-Qian Sun,

<h4>Introduction</h4>We sought to investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and the risk of type 2 diabetes mellitus (T2DM) in adults who participated in the Trøndelag Health Study (HUNT), and the possible effect modification by family history and genetic predisposition.<h4>Research design and methods</h4>This prospective study included 3574 diabetes-free ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Variability in preventive care practices among US adults with diabetes mellitus.

Lorena Baccaglini, Adams Kusi Appiah, Mahua Ray, Fang Yu,

<h4>Introduction</h4>Patients with diabetes are advised to follow standard medical care including daily blood glucose and foot checks, eye examinations with pupil dilation, and cholesterol checks to prevent diabetes-related complications. It is unclear how these practices currently vary across different US population subgroups. The objective of this study was to assess ... Read more >>

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[2021, 9(1):]

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Service user and community clinician design of a partially virtual diabetic service improves access to care and education and reduces amputation incidence.

Alastair Watt, Andrea Beacham, Lynne Palmer-Mann, Amy Williams, Jacqueline White, Rebecca Brown, Ellena Williams, Gayle Richards, Lyndon White, Pauline Budge, Katy Darvall, Ed Bond, Richard Paisey,

<h4>Introduction</h4>Design of an integrated diabetes service based on needs of service users (persons living with diabetes) and community clinicians in a semirural low-income health district of the UK.<h4>Research design and methods</h4>One hundred and eighty-five service users engaged through public meetings, questionnaires and focus groups. General practice staff contributed views through ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Prevalence and incidence of microvascular and macrovascular complications over 15 years among patients with incident type 2 diabetes.

Jaejin An, Gregory A Nichols, Lei Qian, Mercedes A Munis, Teresa N Harrison, Zhuoxin Li, Rong Wei, Tracey Weiss, Swapnil Rajpathak, Kristi Reynolds,

<h4>Introduction</h4>Type 2 diabetes (T2D) is a common condition that, if left untreated or poorly managed, can lead to adverse microvascular and macrovascular complications. We estimated the prevalence and incidence of microvascular and macrovascular complications among patients newly diagnosed with T2D within a US integrated healthcare system.<h4>Research design and methods</h4>We conducted ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Risk of morbidity and mortality in patients with type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitor and/or dipeptidyl peptidase-4 inhibitor: a nationwide study.

Gábor Sütő, Gergő A Molnár, Gyorgy Rokszin, Ibolya Fábián, Zoltan Kiss, Zoltán Szekanecz, Gyula Poór, György Jermendy, Peter Kempler, István Wittmann,

<h4>Introduction</h4>Mortality and disability in diabetes mellitus are determined mostly by cardiovascular complications and cancer. The impact of dipeptidyl peptidase-4 inhibitor (DPP-4i) and sodium-glucose cotransporter-2 inhibitor (SGLT2i) monotherapy or combination on long-term complications of type 2 diabetes mellitus was studied.<h4>Research design and methods</h4>Patients with type 2 diabetes treated with DPP-4i or ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Neurovascular coupling alterations in type 2 diabetes: a 5-year longitudinal MRI study.

Yang Zhang, Xiaolu Zhang, Guangyang Ma, Wen Qin, Jiayang Yang, Jiahui Lin, Quan Zhang,

<h4>Introduction</h4>Respective alterations in resting-state brain neural activity and cerebral blood flow (CBF) in type 2 diabetes mellitus (T2DM) have been reported. However, their coupling alteration in T2DM remains largely unknown.<h4>Research design and methods</h4>Twenty-seven patients with T2DM aged 40-67 years and 36 well-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Feasibility study of real-time online text-based CBT to support self-management for people with type 1 diabetes: the Diabetes On-line Therapy (DOT) Study.

Anne M Doherty, Anne Herrmann-Werner, Arann Rowe, Jennie Brown, Scott Weich, Khalida Ismail,

<h4>Introduction</h4>This study examines the feasibility of conducting diabetes-focused cognitive-behavioral therapy (CBT) via a secure online real-time instant messaging system intervention to support self-management and improve glycemic control in people with type 1 diabetes.<h4>Research design and methods</h4>We used a pre-post uncontrolled intervention design over 12 months. We recruited adults with type ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).

Kohjiro Ueki, Yukio Tanizawa, Jiro Nakamura, Yuichiro Yamada, Nobuya Inagaki, Hirotaka Watada, Iichiro Shimomura, Rimei Nishimura, Hideaki Miyoshi, Atsuko Abiko, Hideki Katagiri, Michio Hayashi, Akira Shimada, Keiko Naruse, Shimpei Fujimoto, Masazumi Fujiwara, Kenichi Shikata, Yosuke Okada, Eiichi Araki, Tsutomu Yamazaki, Takashi Kadowaki, ,

<h4>Introduction</h4>Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.<h4>Research design and ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Association of the Diabetes Health Plan with emergency room and inpatient hospital utilization: a Natural Experiment for Translation in Diabetes (NEXT-D) Study.

Tannaz Moin, Neil Steers, Susan L Ettner, Kenrik Duru, Norman Turk, Charles Chan, Abigail M Keckhafer, Robert H Luchs, Sam Ho, Carol M Mangione,

<h4>Introduction</h4>To examine the association of a novel disease-specific health plan, known as the Diabetes Health Plan (DHP), with emergency room (ER) and hospital utilization among patients with diabetes and pre-diabetes.<h4>Research design and methods</h4>Quasi-experimental design, with employer group as the unit of analysis, comparing changes in any ER and inpatient hospital ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels.

Ilze Dirnena-Fusini, Marte Kierulf Åm, Anders Lyngvi Fougner, Sven Magnus Carlsen, Sverre Christian Christiansen,

<h4>Introduction</h4>The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal insulin boluses. There is a lack of studies comparing the insulin appearance in the systemic circulation after intraperitoneal compared with subcutaneous insulin ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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One-year intensive lifestyle intervention and improvements in health-related quality of life and mental health in persons with type 2 diabetes: a secondary analysis of the U-TURN randomized controlled trial.

Christopher Scott MacDonald, Sabrina M Nielsen, Jakob Bjørner, Mette Y Johansen, Robin Christensen, Allan Vaag, Daniel E Lieberman, Bente Klarlund Pedersen, Henning Langberg, Mathias Ried-Larsen, Julie Midtgaard,

<h4>Introduction</h4>The effects of lifestyle interventions in persons with type 2 diabetes (T2D) on health-related quality of life (HRQoL) and subjective well-being are ambiguous, and no studies have explored the effect of exercise interventions that meet or exceed current recommended exercise levels. We investigated whether a 1-year intensive lifestyle intervention is ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus.

Mohammed Alfaifi, Mirza Masroor Ali Beg, Mohammed Yahya Alshahrani, Irfan Ahmad, Ali Gaithan Alkhathami, Prakash C Joshi, Osama M Alshehri, Abdulrahman Manaa Alamri, Amit Kumar Verma,

<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to alterations in gene regulation. Long non-coding RNAs (lncRNAs) have become a major research topic as they are involved in metabolic disorders.<h4>Methods</h4>This study included a total of 400 study subjects; 200 were subjects with T2DM and 200 were healthy ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Association between hemoglobin A1c variability and hypoglycemia-related hospitalizations in veterans with diabetes mellitus.

Molly J Y Zhao, Julia C Prentice, David C Mohr, Paul R Conlin,

<h4>Introduction</h4>To study the impact of hemoglobin A1c (A1c) variability on the risk of hypoglycemia-related hospitalization (HRH) in veterans with diabetes mellitus.<h4>Research design and methods</h4>342 059 veterans with diabetes aged 65 years or older were identified for a retrospective cohort study. All participants had a 3-year baseline period from January 1, 2005 ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Peripheral artery disease, lower limb revascularization, and amputation in diabetes patients with and without coronary artery disease: a cohort study from the Western Denmark Heart Registry.

Kevin Kris Warnakula Olesen, Christine Gyldenkerne, Troels Thim, Reimar Wernich Thomsen, Michael Maeng,

<h4>Introduction</h4>Patients with diabetes have increased risk of lower limb revascularization and amputation due to higher risk of peripheral artery disease (PAD) and peripheral neuropathy. The additive effect of coronary artery disease (CAD) is less clear. We examined the risk of PAD, lower limb revascularization, and amputation in diabetes and non-diabetes ... Read more >>

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[2021, 9(1):]

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Adverse outcomes in COVID-19 and diabetes: a retrospective cohort study from three London teaching hospitals.

Chioma Izzi-Engbeaya, Walter Distaso, Anjali Amin, Wei Yang, Oluwagbemiga Idowu, Julia S Kenkre, Ronak J Shah, Evelina Woin, Christine Shi, Nael Alavi, Hala Bedri, Niamh Brady, Sophie Blackburn, Martina Leczycka, Sanya Patel, Elizaveta Sokol, Edward Toke-Bjolgerud, Ambreen Qayum, Mariana Abdel-Malek, David C D Hope, Nick S Oliver, Vasiliki Bravis, Shivani Misra, Tricia M Tan, Neil E Hill, Victoria Salem,

<h4>Introduction</h4>Patients with diabetes mellitus admitted to hospital with COVID-19 have poorer outcomes. However, the drivers of poorer outcomes are not fully elucidated. We performed detailed characterization of patients with COVID-19 to determine the clinical and biochemical factors that may be drivers of poorer outcomes.<h4>Research design and methods</h4>This is a retrospective ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Corneal confocal microscopy compared with quantitative sensory testing and nerve conduction for diagnosing and stratifying the severity of diabetic peripheral neuropathy.

Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Ioannis N Petropoulos, Anne Worthington, Luca D'Onofrio, Shaishav Dhage, Georgios Ponirakis, Uazman Alam, Andrew Marshall, Catharina G Faber, Giuseppe Lauria, Handrean Soran, Rayaz A Malik,

<h4>Introduction</h4>Diabetic neuropathy can be diagnosed and assessed using a number of techniques including corneal confocal microscopy (CCM).<h4>Research design and methods</h4>We have undertaken quantitative sensory testing, nerve conduction studies and CCM in 143 patients with type 1 and type 2 diabetes without neuropathy (n=51), mild neuropathy (n=47) and moderate to severe ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(2):]

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Glycemic excursion minimization in the management of type 2 diabetes: a novel intervention tested in a randomized clinical trial.

Daniel J Cox, Tom Banton, Matthew Moncrief, Mark Conaway, Anne Diamond, Viola Holmes, Joyce Green Pastors, Anne Wolf, Kun Fang, Anthony McCall,

<h4>Introduction</h4>This study of adults with type 2 diabetes employed a non-inferiority hypothesis to investigate whether an innovative lifestyle focused on minimizing postnutrient blood glucose (BG) excursions (glycemic excursion minimization (GEM)) would be equivalent or superior to conventional weight loss (WL) therapy in regard to reducing HbA1c, and superior to WL ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(2):]

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Associations between physical activity and trimethylamine N-oxide in those at risk of type 2 diabetes.

Stavroula Argyridou, Dennis Bernieh, Joseph Henson, Charlotte L Edwardson, Melanie J Davies, Kamlesh Khunti, Toru Suzuki, Thomas Yates,

<h4>Introduction</h4>Trimethylamine <i>N</i>-oxide (TMAO) has been identified as a novel gut-derived molecule that is associated with the risk of cardiometabolic diseases. However, the relationship between TMAO and physical activity is not well understood. This study prospectively investigates the association between TMAO and objectively assessed physical activity in a population at high ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(2):]

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Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme: an observational study.

Emma Barron, Shivani Misra, Emma English, W Garry John, Michael Sampson, Max O Bachmann, Julian Barth, Nick Oliver, K G M M Alberti, Chirag Bakhai, Simon O'Neill, Bob Young, Nicholas J Wareham, Kamlesh Khunti, Susan Jebb, Jenifer Smith, Jonathan Valabhji,

<h4>Introduction</h4>To report the observations of point-of-care (POC) glycated hemoglobin (HbA1c) testing in people with non-diabetic hyperglycemia (NDH; HbA1c 42-47 mmol/mol (6.0%-6.4%)), applied in community settings, within the English National Health Service Diabetes Prevention Programme (NHS DPP).<h4>Research design and methods</h4>A service evaluation assessing prospectively collected national service-level data from the NHS DPP, ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(2):]

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'Going the distance': an independent cohort study of engagement and dropout among the first 100 000 referrals into a large-scale diabetes prevention program.

Elizabeth Howarth, Peter J Bower, Evangelos Kontopantelis, Claudia Soiland-Reyes, Rachel Meacock, William Whittaker, Sarah Cotterill,

<h4>Introduction</h4>Diabetes prevention programs (DPPs) are effective, in a pre-diabetic population, in reducing weight, lowering glycated hemoglobin and slowing the progression to diabetes. Little is known about the relationship between participation in DPPsand participant characteristics or service delivery. We investigated uptake and retention in England's NHS DPP, reporting on variability among ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(2):]

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