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Journal BMC Pharmacol Toxicol

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Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial.

Jean-Pierre Rothen, Jonas Rutishauser, Philipp N Walter, Kurt E Hersberger, Isabelle Arnet,

BACKGROUND:To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration. METHODS:A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 × 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):51]

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Influence of strengthened hemoperfusion combined with continuous venovenous hemofiltration on prognosis of patients with acute paraquat poisoning: SHP + CVVH improve prognosis of acute PQ patients.

An-Bao Chen, Fang Li, E-Mu Di, Xiao Zhang, Qun-Yuan Zhao, Jing Wen,

BACKGROUND:The success rate of rescue is extremely low in acute paraquat poisoning. This study aimed to assess whether strengthened hemoperfusion (SHP) combined with continuous venovenous hemofiltration (CVVH) improves prognosis in patients with acute paraquat poisoning. METHODS:Patients from January 2005 to December 2018 were enrolled retrospectively. All selected patients were administered ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):49]

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Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days.

Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Yoshiko Takai, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura,

BACKGROUND:A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained. Even though the recommended high Cmin of teicoplanin was associated with better clinical outcome, reaching ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):50]

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Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days.

Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Yoshiko Takai, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura,

BackgroundA trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained. Even though the recommended high Cmin of teicoplanin was associated with better clinical outcome, reaching ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21:]

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Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin.

Xuemei Liu, Xiyu Feng, Chao Deng, Lu Liu, Yanping Zeng, Chang-Hua Hu,

BACKGROUND:Prescription of second-generation antipsychotic drugs (SGAs) to childhood/adolescent has exponentially increased in recent years, which was associated with the greater risk of significant weight gain and dyslipidemia. Statin is considered a potential preventive and treatment approach for reducing SGA-induced weight gain and dyslipidemia in schizophrenia patients. However, the effect of ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):48]

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The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study.

Ayala Hirsch, Maor Wanounou, Amichai Perlman, Bruria Hirsh-Raccah, Mordechai Muszkat,

BACKGROUND:In acute intoxication, carbamazepine concentration above 40 mcg/ml is associated with a risk of severe neurological consequences, including depressed consciousness, respiratory depression, cardiac conduction disorders, seizures, and death. Carbamazepine intoxication is often associated with the use of concomitant medications. However, the effect of exposure to other central-nervous-system (CNS) acting medications ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):47]

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Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis.

Sonia Aroui, Hamadi Fetoui, Abderraouf Kenani,

BACKGROUND:Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plant-secondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):46]

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A randomized single-dose, two-period crossover bioequivalence study of two fixed-dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition.

Kit Yee Cheah, Kar Yee Mah, Lai Hui Pang, Shi Min Ng, Jia Woei Wong, Siew Siew Tan, Hong Zhe Tan, Kah Hay Yuen,

BACKGROUND:Paracetamol/Orphenadrine is a fixed dose combination containing 35 mg orphenadrine and 450 mg paracetamol. It has analgesic and muscle relaxant properties and is widely available as generics. This study is conducted to investigate the relative bioavailability and bioequivalence between one fixed dose paracetamol/orphenadrine combination test preparation and one fixed dose paracetamol/orphenadrine combination ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):45]

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The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study.

Boyu Li, Yanjin Hu, Guang Wang, Lihong Liu,

BACKGROUND:Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrated good glycemic efficacy in patients with type 2 diabetes mellitus (T2DM) recent years, whereas studies on GLP-1 RAs' biliary effects were limited. Therefore, we aimed to assess the effect of exenatide on bile acids (BAs) and investigate the role of BAs in the ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):44]

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Effect of aerosolized nicotine on human bronchial epithelial cells is amplified after co-administration with cannabidiol (CBD): a pilot in vitro study.

Noel J Leigh, Maciej L Goniewicz,

BACKGROUND:Population-based studies suggest increasing rates of concurrent use of vaping products that contain either nicotine or cannabinoids. The aim of this pilot study was to test in vitro the acute inhalation toxicity of vaporized flavored and unflavored nicotine solutions co-administered with cannabidiol (CBD). METHODS:Bronchial epithelial cells (H292) were exposed directly ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):42]

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18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice.

Jintao Gao, Junfan Guo, Yuejuan Nong, Wenfei Mo, Huanan Fang, Jing Mi, Qi Qi, Mengjuan Yang,

BACKGROUND:Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the population worldwide. Hyperproliferative keratinocytes were thought to be an amplifier of inflammatory response, thereby sustaining persistence of psoriasis lesions. Agents with the ability to inhibit keratinocyte proliferation or induce apoptosis are potentially useful for psoriasis treatment. 18β-Glycyrrhetinic acid (GA), ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):41]

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Evaluation of disability in patients exposed to fluoroquinolones.

Marsha A Wilcox, Angelina Villasis-Keever, Anthony G Sena, Christopher Knoll, Daniel Fife,

BACKGROUND:Fluoroquinolones are used for conditions including sinusitis, bronchitis, and urinary tract infections. It has been suggested that exposure to fluoroquinolones for these conditions is associated with disability resulting from adverse events in 2 or more organ systems. The objectives were to: describe: 1) fluoroquinolone, azithromycin, and sulfamethoxazole / trimethoprim utilization ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):40]

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Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure.

Christian Siebel, Gudrun Würthwein, Claudia Lanvers-Kaminsky, Nicolas André, Frank Berthold, Ilaria Castelli, Pascal Chastagner, François Doz, Martin English, Gabriele Escherich, Michael C Frühwald, Norbert Graf, Andreas H Groll, Antonio Ruggiero, Georg Hempel, Joachim Boos,

BACKGROUND:Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for infants and younger children is required but is hampered by scarcely ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):37]

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Successful clozapine rechallenge following recurrent clozapine-associated pancreatitis: a case report.

Victoria Rodriguez, Kieran Hanley, Ana Julia Arias, Diego Quattrone, Joseph Kuforiji, Eromona Whiskey, Sukhi S Shergill,

BACKGROUND:Acute pancreatitis is a rare but recognised complication of clozapine leading to termination of treatment. CASE PRESENTATION:We present the case of a 39-year-old man with treatment-resistant schizoaffective disorder and a history of recurrent acute pancreatitis attributed to clozapine. After 15 years of unremitting symptoms with disruptive and aggressive behaviour, he was ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):35]

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Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database.

Aoi Noda, Takamasa Sakai, Taku Obara, Makoto Miyazaki, Masami Tsuchiya, Gen Oyanagi, Yuriko Murai, Nariyasu Mano,

BACKGROUND:There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse Drug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients. METHOD:We aimed to evaluate ADR reports for pediatric patients in the ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):36]

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Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers.

Suprim Tha, Sapana Shakya, Rajani Malla, Pramod Aryal,

BACKGROUND:It is prudent that novel classes of antibiotics be urgently developed to manage the WHO prioritized multi-drug resistant (MDR) pathogens posing an unprecedented medical crisis. Simultaneously, multiple essential proteins have to be targeted to prevent easy resistance development. METHODS:An integration of structure-based virtual screening and ligand-based virtual screening was employed ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):33]

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Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells.

Danning Shi, Piwen Zhao, Lixia Cui, Hongbo Li, Liping Sun, Jianzhao Niu, Meng Chen,

BACKGROUND:Breast cancer is the most frequently diagnosed malignancy among women and the second leading cause of cancer death worldwide. Among which nuclear estrogen receptor (nER) negative breast cancer is always with much poor prognosis. Recently, membrane G protein coupled estrogen receptor (GPER), a newly recognized estrogen receptor has been documented ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):32]

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The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014).

Junhyeong Cho, Jeonggu Na, Eunjin Bae, Tae Won Lee, Ha Nee Jang, Hyun Seop Cho, Se-Ho Chang, Dong Jun Park,

BACKGROUND:Fenoverine is a spasmolytic drug that has been used to treat abdominal pain. Although sporadic case reports or case series of rhabdomyolysis associated with fenoverine have been published, there are no studies evaluating the incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription. METHODS:We retrospectively reviewed the ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):30]

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Dual anti-platelet therapy following percutaneous coronary intervention in a population of patients with thrombocytopenia at baseline: a meta-analysis.

Manyun Long, Ziliang Ye, Jing Zheng, Wuxian Chen, Lang Li,

BACKGROUND:In this meta-analysis, we aimed to systematically compare the post percutaneous coronary interventional (PCI) adverse bleeding events, stent thrombosis, stroke and other cardiovascular outcomes in a population of patients with and without thrombocytopenia at baseline who were followed up on dual antiplatelet therapy (DAPT). METHODS:Relevant English language articles which were ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):31]

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Comparative effect of dipeptidyl-peptidase 4 inhibitors on laboratory parameters in patients with diabetes mellitus.

Yayoi Nishida, Yasuo Takahashi, Kotoe Tezuka, Hayato Akimoto, Tomohiro Nakayama, Satoshi Asai,

BACKGROUND:The purpose of this study was to evaluate and compare the effects on laboratory parameters among monotherapy with five DPP-4 inhibitors in patients with type 2 diabetes mellitus (DM). METHODS:We identified cohorts of new sitagliptin users (n = 879), vildagliptin users (n = 253), teneligliptin users (n = 260), alogliptin users (n = 237), and linagliptin users (n = 180) ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):28]

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In vitro and in vivo effects of flubendiamide and copper on cyto-genotoxicity, oxidative stress and spleen histology of rats and its modulation by resveratrol, catechin, curcumin and α-tocopherol.

Rajesh Mandil, Atul Prakash, Anu Rahal, S P Singh, Deepak Sharma, Rahul Kumar, Satish Kumar Garg,

BACKGROUND:Living organisms are frequently exposed to more than one xenobiotic at a time either by ingestion of contaminated food/fodder or due to house-hold practices, occupational hazards or through environment. These xenobiotics interact individually or in combination with biological systems and act as carcinogen or produce other toxic effects including reproductive ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):29]

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Favorable response to pembrolizumab after durvalumab failure in a stage III sarcomatoid carcinoma of the lung: a case report.

Kazumi Nishino, Kei Kunimasa, Madoka Kimura, Takako Inoue, Motohiro Tamiya, Hanako Kuhara, Toru Kumagai,

Pulmonary sarcomatoid carcinoma is a rare non-small-cell lung cancer (NSCLC) subtype with a poor prognosis. In the phase III PACIFIC study, durvalumab significantly improved progression-free survival and overall survival versus placebo, in patients with stage III NSCLC who do not have disease progression after concurrent chemoradiotherapy. However, treatments for patients ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):26]

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Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices.

Diana Dubrall, Katja S Just, Matthias Schmid, Julia C Stingl, Bernhardt Sachs,

BACKGROUND:Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of spontaneous ADR reports regarding older adults (> 65) in the ADR database of the German Federal Institute for Drugs and Medical Devices (BfArM) and to ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):25]

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The chemotactic properties of various topical brimonidine tartrate ophthalmic preparations.

Ruiz Simonato Alonso, Helena Parente Solari, Eduardo de França Damasceno, Miguel Noel Nascentes Burnier, Marcelo Palis Ventura,

BACKGROUND:The study aimed to evaluate and compare the leukocyte chemotactic activities of various brimonidine tartrate (BT) eye drop formulations. METHODS:A 96-well dot-blot platet using a Boyden-style well was used to study the chemotactic effects of BT ophthalmic preparations. A modification was made to create blind wells where the tested agents ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):24]

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Intravenous calcium Gluconate alleviates Lead-induced abdominal pain, a randomized clinical trial.

Masoud Mayel, Saleh Hamzeh, Salile Shahabi Rabori, Sareh Ghasemirad, Nasim Zamani, Hossein Hassanian-Moghaddam,

BACKGROUND:In 2016, in a lead poisoning outbreak in Iran, physicians reported thousands of opium users who presented to emergency departments (EDs) with intractable severe abdominal pain which did not respond to any narcotic medication. During the same period of time, we investigated the efficacy of intravenous calcium gluconate in alleviating ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):23]

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