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Journal BMC Pediatr

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Pulmonary hypertension in late-onset Methylmalonic Aciduria and Homocystinemia: a case report.

Ling-Yi Wen, Ying-Kun Guo, Xiao-Qing Shi,

BACKGROUND:Methylmalonic Aciduria and Homocystinemia, cobalamin C (cblC) is an inherited disease of vitamin B12 metabolism with a wide spectrum of clinical manifestations. cblC presenting with pulmonary hypertension (PH) as leading sympotom is rare and easily misdiagnosed because of limited awareness. Timely diagnosis is crucial by the relentless progression without appropriate ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):243]

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Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey.

Melkamu Molla Ferede,

BACKGROUND:Diarrhoea is one of the major contributors to death among under-five children in Ethiopia. Studies conducted in different countries showed that rural children are more severely affected by diarrhoea than urban children. Thus, this study was aimed to identify the socio-demographic, environmental and behavioural associated risk factors of the occurrence ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):239]

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Prevalence and associated factors of acute diarrhea among under-five children in Kamashi district, western Ethiopia: community-based study.

Adugna Fenta, Kassahun Alemu, Dessie Abebaw Angaw,

BACKGROUND:Diarrheal diseases are the second major cause of death among under-five children globally. It kills about 2.5 million people each year, with 60-70% of them being children under 5 years of age. It is also the second leading cause of morbidity in Ethiopia, with Benishangul Gumuz region bearing burden the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):236]

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Microbiological analyses of nasally guided catheters after less invasive surfactant administration - a pilot study.

Christian A Maiwald, Julia Dick, Matthias Marschal, Christian Gille, Axel R Franz, Christian F Poets,

BACKGROUND:Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmonary dysplasia. Surfactant, however, can be inactivated by bacterial infection. Therefore, potential routes of microbe transmission into the airway are of interest. The aim ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):234]

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A concept analysis of children with complex health conditions: implications for research and practice.

Rima Azar, Shelley Doucet, Amanda Rose Horsman, Patricia Charlton, Alison Luke, Daniel A. Nagel, Nicky Hyndman, William J. Montelpare,

BackgroundThis concept analysis aimed to clarify the meaning of “children with complex health conditions” and endorse a definition to inform future research, policy, and practice.MethodsUsing Walker and Avant’s (2011)‘s approach, we refined the search strategy with input from our team, including family representatives.We reviewed the published and grey literature. We ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2020, 20:]

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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Severe acute malnutrition and its associated factors among children under-five years: a facility-based cross-sectional study.

Umesh Ghimire, Binod Kumar Aryal, Ankush Kumar Gupta, Suman Sapkota,

BACKGROUND:Despite consistent efforts to enhance child nutrition, poor nutritional status of children continues to be a major public health problem in Nepal. This study identified the predictors of severe acute malnutrition (SAM) among children aged 6 to 59 months in the two districts of Nepal. METHODS:We used data from a cross-sectional study ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):249]

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Normative values for circulating intestinal fatty acid binding protein and calprotectin across gestational ages.

Darla R Shores, Jennifer Fundora, Mitzi Go, Fauzia Shakeel, Sandra Brooks, Samuel M Alaish, Jun Yang, Chhinder P Sodhi, David J Hackam, Allen Everett,

BACKGROUND:Necrotizing enterocolitis (NEC) is associated with significant morbidity and mortality. Serum biomarkers to aid diagnosis, such as intestinal fatty acid binding protein (IFABP) and calprotectin, are actively being investigated; however, the normative values of these markers among healthy premature and term infants remains unknown. We sought to identify normative values ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):250]

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Risk factors for readmission for phototherapy due to jaundice in healthy newborns: a retrospective, observational study.

Amit Blumovich, Laurence Mangel, Sivan Yochpaz, Dror Mandel, Ronella Marom,

BACKGROUND:The guidelines of the American Academy of Pediatrics (AAP) for monitoring neonatal jaundice recommend universal postnatal screening for hyperbilirubinemia within 48 h from discharge. We observed that neonate with low-risk jaundice were more likely to be readmitted to hospital for phototherapy compared to neonate with high-risk jaundice. The aim of this ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):248]

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Clustering of health-related behaviours and its relationship with individual and contextual factors in Portuguese adolescents: results from a cross-sectional study.

Constança Soares Dos Santos, João Picoito, Isabel Loureiro, Carla Nunes,

BACKGROUND:Health behaviours are shaped early in life and tend to occur in complex specific patterns. We aimed to characterise these patterns among Portuguese adolescents and their association with individual and contextual factors. METHODS:This study was based in the Portuguese 2009/10 survey of Health Behaviour in School-Aged Children Study, comprising 4036 ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):247]

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Anxiety related disorders in adolescents in the United Arab Emirates: a population based cross-sectional study.

Nabeel Al-Yateem, Wegdan Bani Issa, Rachel C Rossiter, Arwa Al-Shujairi, Hadia Radwan, Manal Awad, Randa Fakhry, Ibrahim Mahmoud,

BACKGROUND:Anxiety disorders are common among children and adolescents. However, there is a paucity of up-to-date data on the prevalence and correlates of anxiety-related disorders among children and adolescents in the United Arab Emirates (UAE). METHODS:We conducted a cross sectional study to determine the prevalence of specific anxiety-related disorders (e.g., generalized ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):245]

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CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant.

Stefano Turolo, Alberto Edefonti, Luciana Ghio, Sara Testa, William Morello, Giovanni Montini,

BACKGROUND:We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients. METHODS:Forty-nine patients were genotyped for CYP3A5, ABCB1 and SXR polymorphisms and evaluated with tacrolimus through levels in a retrospective monocenter study. RESULTS:Patients with the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):246]

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Parents' experiences of accessing respite care for children with Autism Spectrum Disorder (ASD) at the acute and primary care interface: a systematic review.

Emma Cooke, Valerie Smith, Maria Brenner,

BACKGROUND:Population prevalence estimates by the World Health Organisation suggest that 1 in 160 children worldwide has an Autism Spectrum Disorder (ASD). Accessing respite care services for children with an ASD can often be a daunting and exhaustive process, with parents sometimes forced to access acute hospital services as an initial ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):244]

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Swedish translation and validation of the Pediatric Insomnia Severity Index.

Charlotte Angelhoff, Peter Johansson, Erland Svensson, Anna Lena Lena Sundell,

BACKGROUND:To increase health and well-being in young children, it is important to acknowledge and promote the child's sleep behaviour. However, there is a lack of brief, validated sleep screening instruments for children. The aims of the study were to (1) present a Swedish translation of the PISI, (2) examine the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):253]

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A concept analysis of children with complex health conditions: implications for research and practice.

Rima Azar, Shelley Doucet, Amanda Rose Horsman, Patricia Charlton, Alison Luke, Daniel A Nagel, Nicky Hyndman, William J Montelpare,

BACKGROUND:This concept analysis aimed to clarify the meaning of "children with complex health conditions" and endorse a definition to inform future research, policy, and practice. METHODS:Using Walker and Avant's (2011)'s approach, we refined the search strategy with input from our team, including family representatives. We reviewed the published and grey ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):251]

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A rare case of pediatric recurrent rhabdomyolysis with compound heterogenous variants in the LPIN1.

Ruochen Che, Chunli Wang, Bixia Zheng, Xuejuan Zhang, Guixia Ding, Fei Zhao, Zhanjun Jia, Aihua Zhang, Songming Huang, Quancheng Feng,

BACKGROUND:Lipin-1, encoded by LPIN1 gene, serves as an enzyme and a transcriptional co-regulator to regulate lipid metabolism and mitochondrial respiratory chain. Autosomal recessive mutations in LPIN1 were recognized as one of the most common causes of pediatric recurrent rhabdomyolysis in western countries. However, to date, there were only a few ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):218]

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A systematic review to assess the effectiveness of technology-based interventions to address obesity in children.

Megan McMullan, Rachel Millar, Jayne V Woodside,

BACKGROUND:Childhood obesity is associated with a multitude of co-morbidities, including hypertension, hyperlipidaemia, cardiovascular disease and type 2 diabetes. Childhood obesity can also affect a young person's social, emotional and mental health if they encounter negative prejudice and social marginalisation. Given the prevalence of overweight and obese children globally, it is ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):242]

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Influence of time under mechanical ventilation on bronchopulmonary dysplasia severity in extremely preterm infants: a pilot study.

Victoria Escobar, Darllyana S Soares, Jane Kreling, Ligia S L Ferrari, Josiane M Felcar, Carlos A M Camillo, Vanessa S Probst,

BACKGROUND:The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time under MV influences the severity of the disease. AIM:To define the duration under MV with greater chance to develop moderate ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):241]

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Right ventricular function among South East Nigeria children with sickle cell anaemia.

Josephat M Chinawa, Bartholomew F Chukwu, Awoere T Chinawa, Edmund N Ossai, Anthony N Ikefuna, Ann E Aronu, Egbuna O Obidike,

BACKGROUND:Sickle cell anaemia (SCA) is characterized by attendant ischemia-reperfusion injury especially to the heart. METHODS:The aim of this work is to compare the right ventricular function of children with SCA in steady state (subjects) with those with haemoglobin AA genotype (controls), using echocardiography. It is a cross-sectional study, which echocardiographic ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):240]

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Derivation and validation of a prognostic score for neonatal mortality in Ethiopia: a case-control study.

Rishi P Mediratta, Ashenafi Tazebew Amare, Rasika Behl, Bradley Efron, Balasubramanian Narasimhan, Alemayehu Teklu, Abdulkadir Shehibo, Mulugeta Ayalew, Saraswati Kache,

BACKGROUND:Early warning scores for neonatal mortality have not been designed for low income countries. We developed and validated a score to predict mortality upon admission to a NICU in Ethiopia. METHODS:We conducted a retrospective case-control study at the University of Gondar Hospital, Gondar, Ethiopia. Neonates hospitalized in the NICU between ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):238]

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Factors affecting tracheostomy in critically ill paediatric patients in Japan: a data-based analysis.

Tadashi Ishihara, Hiroshi Tanaka,

BACKGROUND:There has been an increasing number of children surviving with high medical needs, for whom tracheostomy and/or home ventilation is part of their chronic disease management. The purpose of this study was to describe the indications, epidemiology, frequency, and associated factors for tracheostomy in critically ill paediatric patients using the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):237]

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Determinants of road traffic injuries in Iranian children; results from a National Representative Demographic- Health Survey 2010.

Hesam Ghiasvand, Payam Roshanfekr, Delaram Ali, Hossein Malekafzali Ardakani, Amanda N Stephens, Bahram Armoon,

BACKGROUND:Road Traffic Injuries (RTIs) are a leading cause of disabilities and mortalities in Iran. The occurrence of RTIs among children is increasing. This study aims are to assess RTIs among Iranian children and to determine the main socio-economics determinants. METHODS:The National Institute of Health Research (NIHR) in collaboration with the ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2020, 20(1):231]

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Prognostic nutrition index as a predictor of coronary artery aneurysm in Kawasaki Disease.

I-Hsin Tai, Pei-Lin Wu, Mindy Ming-Huey Guo, Jessica Lee, Chi-Hsiang Chu, Kai-Sheng Hsieh, Ho-Chang Kuo,

BACKGROUND:Kawasaki Disease (KD) is considered a major acquired heart disease in children under the age of 5. Coronary artery aneurysm (CAA) can occur in serious cases despite extreme therapy efforts. Previous studies have reported low serum albumin level was associated with disease outcome, but no further investigation was addressed yet. ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):203]

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Wearable cardioverter-defibrillator as bridging to ICD in pediatric hypertrophic cardiomyopathy with myocardial bridging - a case report.

Stefan Kurath-Koller, Hannes Sallmon, Daniel Scherr, Egbert Bisping, Ante Burmas, Igor Knez, Martin Koestenberger,

BACKGROUND:There is only limited experience with wearable cardioverter-defibrillators (WCD) in pediatric patients. We report on the successful application of a WCD in an adolescent patient with hypertrophic cardiomyopathy and myocardial bridging. CASE PRESENTATION:A 15-year-old girl presented with a history of recurrent syncope, dyspnea, and vertigo with exercise. Diagnostic work-up revealed ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):207]

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Proximal and distal predictors of self-regulatory change in children aged 4 to 7 years.

Kate E Williams, Steven J Howard,

BACKGROUND:Growth in early self-regulation skills has been linked to positive health, wellbeing, and achievement trajectories across the lifespan. While individual studies have documented specific influences on self-regulation competencies in early childhood, few have modelled a comprehensive range of predictors of self-regulation change across health, development, and environment simultaneously. This study ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2020, 20(1):226]

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