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Journal BMC Cancer

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Characteristics of 1270 Chinese sibling pairs with cancer.

Ju Liu, Jian Yin, Yiwei Liu, Zhijian Xu, Kai Zhang,

<h4>Background</h4>Previous research found that the cancer history of an individual's sibling may be a better indicator than that of the parents. We aim to provide recommendations for opportunistic screening for individuals whose sibling had been diagnosed with cancer.<h4>Methods</h4>During the physical examination in Cancer Hospital, Chinese Academy of Medical Sciences, 43,300 ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1027]

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Prevalence and associations of axillary web syndrome in Asian women after breast cancer surgery undergoing a community-based cancer rehabilitation program.

Matthew Rong Jie Tay, Chin Jung Wong, Hui Zhen Aw,

<h4>Background</h4>Patients who have breast cancer surgery are at risk of axillary web syndrome (AWS), an under-recognized postsurgical complication which can result in shoulder morbidity and functional impairment. Emerging studies have indicated that AWS may persist beyond the first few months after surgery, although few studies have assessed the prevalence and ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1019]

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A CTLA-4 blocking strategy based on Nanoboby in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects.

Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu, Xiaoling Lu,

<h4>Background</h4>Cytokine-induced killer cells induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, itsefficacy isrestricted by the immunosuppression, which is mediated by the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) pathway. In order to overcome the negative co-stimulation from these T cells,we screened a ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1029]

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A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer.

Miguel Cordova-Delgado, María Loreto Bravo, Elisa Cumsille, Charlotte N Hill, Matías Muñoz-Medel, Mauricio P Pinto, Ignacio N Retamal, María A Lavanderos, Juan Francisco Miquel, Maria Rodriguez-Fernandez, Yuwei Liao, Zhiguang Li, Alejandro H Corvalán, Ricardo Armisén, Marcelo Garrido, Luis A Quiñones, Gareth I Owen,

<h4>Background</h4>Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe fluoropyrimidine toxicity within European populations. However, the frequency of these single nucleotide polymorphisms (SNPs) in the Latin American population is low (< 0.7%). No ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1030]

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Brachytherapy with Iodine-125 seeds for treatment of portal vein-branch tumor thrombus in patients with hepatocellular carcinoma.

Duo Hong, Yi Zhou, Xiaoting Wan, Hongying Su, Haibo Shao,

<h4>Background</h4>There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachytherapy with iodine-125 seeds for the treatment of hepatocellular carcinoma with portal vein-branch tumor thrombus (PVBTT).<h4>Methods</h4>Sixty-nine hepatocellular carcinoma patients with PVBTT were enrolled; 34 ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1020]

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Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.

Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Sachiko Minamiguchi, Takeshi Kawauchi, Masahiro Tanji, Daisuke Kanematsu, Masahiro Nonaka, Yoshiko Okita, Yoshinori Kodama, Masayuki Mano, Takanori Hirose, Yohei Mineharu, Susumu Miyamoto, Yonehiro Kanemura,

<h4>Background</h4>Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS family genes activate MAPK through activation of RAF and PI3K to promote cell proliferation. RAS mutations ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1025]

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eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.

Qi Li, Mulun Xiao, Yibo Shi, Jinhao Hu, Tianxiang Bi, Chaoliang Wang, Liang Yan, Xiaoyan Li,

<h4>Background</h4>Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regulating the immune function of tumor cells. However, the effect mechanism of eIFs in prostate cancer remains to be studied, which is precisely the ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1022]

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Postoperative morbidity and quality of life between totally laparoscopic total gastrectomy and laparoscopy-assisted total gastrectomy: a propensity-score matched analysis.

Shin-Hoo Park, Yun-Suhk Suh, Tae-Han Kim, Yoon-Hee Choi, Jong-Ho Choi, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang,

<h4>Background</h4>This study aimed to evaluate the surgical outcome and quality of life (QoL) of totally laparoscopic total gastrectomy (TLTG) compared with laparoscopy-assisted total gastrectomy (LATG) in patients with clinical stage I gastric cancer.<h4>Methods</h4>From 2012 to 2018, EGC patients who underwent TLTG (n = 223), including the first case with intracorporeal hemi-double stapling, ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1016]

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Correction to: TGFB-induced factor homeobox 1 (TGIF) expression in breast cancer.

Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé, Udo Schumacher, Sibylle Loibl, Volkmar Müller,

BMC Cancer (BMC cancer)
[2021, 21(1):1024]

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Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice.

Chew Leng Lim, Valerie C-L Lin,

<h4>Background</h4>Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly known high-density neutrophils (HDN) based on their separation on density gradient, recent studies have reported the presence of high levels of low-density ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1017]

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Study protocol for OptimalTTF-2: enhancing Tumor Treating Fields with skull remodeling surgery for first recurrence glioblastoma: a phase 2, multi-center, randomized, prospective, interventional trial.

N Mikic, F R Poulsen, K B Kristoffersen, R J Laursen, T L Guldberg, J Skjøth-Rasmussen, E T Wong, S Møller, R H Dahlrot, J C H Sørensen, A R Korshøj,

<h4>Background</h4>OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and best physicians choice medical oncological therapy for first recurrence in glioblastoma patients. OptimalTTF-2 is a phase 2 trial initiated in November 2020. Skull remodeling surgery consists ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1010]

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18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD).

Wolfgang Roll, Philipp Schindler, Max Masthoff, Rebecca Strotmann, Jörn Albring, Christian Reicherts, Matthias Weckesser, Benjamin Noto, Matthias Stelljes, Michael Schäfers, Georg Evers,

<h4>Background</h4>Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestinal GvHD with contrast-enhanced MRI/CT or <sup>18</sup>F-FDG-PET imaging alone. The objective of this retrospective study was to elucidate the diagnostic value of a combined ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1015]

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Analysis of the correlation between high iodized salt intake and the risk of thyroid nodules: a large retrospective study.

Yaohui Wang, Jiangang Wang, Zhihen Chen, Min Ma, Changwei Lin, Qingnan He, Mingzhu Ye,

<h4>Background</h4>Currently, whether daily excess iodized salt intake increases the risk of thyroid nodules and even thyroid cancer remains controversial. Our research group aimed to provide a theoretical basis for the clinical guidance of daily iodized salt intake and the prevention of thyroid nodules through a retrospective analysis of the correlation ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1000]

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Race disparities in mortality by breast cancer from 2000 to 2017 in São Paulo, Brazil: a population-based retrospective study.

Ana Cláudia Marcelino, Bruno Gozzi, Cássio Cardoso-Filho, Helymar Machado, Luiz Carlos Zeferino, Diama Bhadra Vale,

<h4>Background</h4>In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing with other causes of death.<h4>Methods</h4>A population-based retrospective study using mortality rates, age and race as variables. ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):998]

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The role of Magnetic Resonance Images (MRIs) in coping for patients with brain tumours and their parents: a qualitative study.

Natalie Tyldesley-Marshall, Sheila Greenfield, Susan J Neilson, Martin English, Jenny Adamski, Andrew Peet,

<h4>Background</h4>When children and young people (CYP) are diagnosed with a brain tumour, Magnetic Resonance Imaging (MRI) is key to the clinical management of this condition. This can produce hundreds, and often thousands, of Magnetic Resonance Images (MRIs).<h4>Methods</h4>Semi-structured interviews were undertaken with 14 families (15 parents and 8 patients), and analysed ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1013]

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Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma.

Tian Xia, Hui Tian, Kaiwen Zhang, Siyu Zhang, Wenhui Chen, Si Shi, Yiwen You,

<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum drug remains unknown. Endoplasmic reticulum resident protein 44(ERp44), an unfolded protein response (UPR)-induced endoplasmic reticulum(ER) protein, is induced during ER ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1003]

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Comparison of monoclonal antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma: an indirect-comparison Meta-analysis of randomised controlled trials.

Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng, Yuping Gong,

<h4>Background</h4>Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma (MM). The treatment outcomes of comparing different MAbs in combination with the above-mentioned agents remained unclear. We performed the meta-analysis to indirectly ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):994]

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Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma.

Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong, Zhanqin Huang,

<h4>Background</h4>Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, which is associated with the malignant progression of various human cancers. However, the expression and prognostic significance of STX4 in kidney renal clear ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):992]

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Application of CD54 in diagnosing bone marrow involvement by using flow cytometry in patients with diffuse large B-cell lymphoma.

Wei Wang, Yan Li, Xavier Rivera Rivera, Linjun Zhao, Di Mei, Wenqing Hu, Bin Jiang,

<h4>Background</h4>Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this study, we detected the expression CD54 on lymphoma cells in BM specimens from DLBCL patients and clarified ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1011]

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Evaluating the effect of Neoadjuvant chemotherapy for esophageal Cancer using the RECIST system with shorter-axis measurements: a retrospective multicenter study.

Yusuke Taniyama, Kentaro Murakami, Naoya Yoshida, Kozue Takahashi, Hisahiro Matsubara, Hideo Baba, Takashi Kamei,

<h4>Background</h4>Evaluating the effect on primary lesions is important in determining treatment strategies for esophageal cancer. The Response Evaluation Criteria in Solid Tumors system, which employs the longest diameter for measuring tumors, is commonly used for evaluating treatment effects. However, the usefulness of these criteria in assessing primary esophageal tumors remains ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1008]

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Co-expression and prognosis analyses of GLUT1-4 and RB1 in breast cancer.

Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui,

<h4>Background</h4>Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor. It has been reported that glucose transporter 1 (GLUT1) is overexpressed in breast cancer cells; however, its association with the prognosis is mostly unclear. Moreover, retinoblastoma gene 1 (RB1) ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1026]

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Correction to: Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma.

Thomas Powles, Toni K Choueiri, Robert J Motzer, Eric Jonasch, Sumanta Pal, Nizar M Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T Aftab, Bernard Escudier, Daniel J George,

BMC Cancer (BMC cancer)
[2021, 21(1):1023]

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Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans.

Marisa Shiina, Yutaka Hashimoto, Priyanka Kulkarni, Pritha Dasgupta, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Rajvir Dahiya,

<h4>Background</h4>Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critical role in these tumors, leading to tumor progression. In this study, we investigated the role of miR-182 ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1028]

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Weight changes according to treatment in a diverse cohort of breast cancer patients.

Jami Fukui, Kami White, Timothy B Frankland, Caryn Oshiro, Lynne Wilkens,

<h4>Background</h4>Weight changes are common among breast cancer patients. The majority of studies to date have focused on weight gain after a breast cancer diagnosis and its implications on health in survivors. Fewer studies have examined weight loss and its related characteristics. Weight changes have been reported to be influenced by ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1005]

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Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes.

Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley, Christoph Meyer,

<h4>Background</h4>Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is unclear.<h4>Methods</h4>We examined the expression pattern of PRRX1 in nine microarray datasets of human HCC tumour samples (n > 1100) and analyzed its ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1006]

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