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Journal BMC Cancer

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Effects of reduced platelet count on the prognosis for patients with non-small cell lung cancer treated with EGFR-TKI: a retrospective study.

Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye, Yanbei Zhang,

BACKGROUND:Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the predictive and prognostic effects of platelet count on non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1152]

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Short-term mortality risks among patients with non-metastatic bladder cancer.

Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen, Xiao Guo,

BACKGROUND:Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and quantify cause of death after bladder cancer diagnosis. METHODS:The custom Surveillance, Epidemiology, and End Results (SEER) dataset for standardized mortality ratios (SMRs) ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1148]

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Benefit of dosimetry distribution for patients with multiple brain metastases from non-small cell lung cancer by a Cyberknife stereotactic radiosurgery (SRS) system.

Xuyao Yu, Yuwen Wang, Zhiyong Yuan, Hui Yu, Yongchun Song, Lujun Zhao, Ping Wang,

BACKGROUND:In order to obtain a high dose conformal index of tumor and steep dose fall-off in healthy tissues for brain metastasis stereotactic radiosurgery (SRS), the aim of this study was to investigate SRS planning optimization by comparing one multiple-lesions plan (MLP) with multiple single-lesion plans (SLPs) for patients with multiple ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1144]

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Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods.

Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin, Jian Zhang,

BACKGROUND:Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined. METHODS:We obtained IL1RN expression data from The Cancer Genome Atlas (TCGA) database. Enrichment analysis of coexpressed genes and IL1RN methylation analysis were performed via ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1143]

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Expression and prognostic analyses of the insulin-like growth factor 2 mRNA binding protein family in human pancreatic cancer.

Xiao-Han Cui, Shu-Yi Hu, Chun-Fu Zhu, Xi-Hu Qin,

BACKGROUND:Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1160]

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Risk factors and socio-economic burden in pancreatic ductal adenocarcinoma operation: a machine learning based analysis.

Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan, Tao Chen,

BACKGROUND:Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the intensive care unit (ICU). Therefore, establishing a risk model that predicts admission to ICU is meaningful in preventing ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1161]

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Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer.

Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah, Kartiki V Desai,

BACKGROUND:Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional pathways that are activated by higher amounts of JMJD6. METHODS:We used Gene Set Enrichment Analysis (GSEA) data to identify factors that ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1159]

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Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous.

Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor, Hendrik Bläker,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1151]

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Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

Citrawati Dyah Kencono Wungu, Fis Citra Ariyanto, Gwenny Ichsan Prabowo, Soetjipto, Retno Handajani,

BACKGROUND:Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, - 863 C/A, - 857 C/T, - 308 G/A, and - 238 G/A with HCC risk. METHODS:We interrogated articles ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1134]

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Interferon-lambda (IFNL) germline variations and their significance for HCC and PDAC progression: an analysis of The Cancer Genome Atlas (TCGA) data.

Henriette Huschka, Sabine Mihm,

BACKGROUND:Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study investigated the relationship between germline genetic variations in type III IFN genes and cancer disease progression from The Cancer Genome Atlas (TCGA) data. The ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1131]

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High cumulative doxorubicin dose for advanced soft tissue sarcoma.

Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao, Xin Wang,

BACKGROUND:The recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective studies of breast cancer patients. However, the treatment and prognosis of STS and breast cancer are quite different, and reference to breast cancer data alone may not reflect the efficacy of doxorubicin ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1139]

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Correction to: Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines.

Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer, Birgit Luber,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1127]

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Phase II randomized trial of capecitabine with bevacizumab and external beam radiation therapy as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: long term results.

Ramón Salazar, Jaume Capdevila, Jose Luis Manzano, Carles Pericay, Mercedes Martínez-Villacampa, Carlos López, Ferrán Losa, María José Safont, Auxiliadora Gómez-España, Vicente Alonso-Orduña, Pilar Escudero, Javier Gallego, Beatriz García-Paredes, Amalia Palacios, Sebastiano Biondo, Cristina Grávalos, Enrique Aranda, ,

BACKGROUND:Preoperative chemoradiotherapy with capecitabine is considered as a standard of care for locally advanced rectal cancer. The "Tratamiento de Tumores Digestivos" group (TTD) previously reported in a randomized Ph II study that the addition of Bevacizumab to capecitabine-RT conferred no differences in the pre-defined efficacy endpoint (pathological complete response). We ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1164]

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A novel TGF-β receptor II mutation (I227T/N236D) promotes aggressive phenotype of oral squamous cell carcinoma via enhanced EGFR signaling.

Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim, Iha Park,

BACKGROUND:Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but promotes tumor progression in later stages. We have previously identified various mutations of TGF-β receptor II (TβRII) in human oral squamous ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1163]

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An aggressive systemic mastocytosis preceded by ovarian dysgerminoma.

Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa, Hiroki Kurahashi,

BACKGROUND:Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe a female ASM patient with a previous history of ovarian dysgerminoma. METHODS:Molecular cytogenomic analyses were performed to elucidate an etiological link between the ASM and dysgerminoma of the patient. ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1162]

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Radiotherapy plays an important role in improving the survival outcome in patients with T1-2N1M0 breast cancer - a joint analysis of 4262 real world cases from two institutions.

Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang, Shu-Nan Qi, Ning Li, Bo Chen, Ning-Ning Lu, Shu-Lian Wang, Ye-Xiong Li,

BACKGROUND:To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1-2N1M0 breast cancer. METHODS:A total of 4262 women with T1-2N1M0 breast cancer treated at two institutions were retrospectively reviewed. A total of 3858 patients underwent ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1155]

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Linguistic validation of the simplified Chinese version of the US National Cancer Institute's patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE™).

Cheng Kkf, S A Mitchell, N Chan, E Ang, W Tam, R Kanesvaran,

BACKGROUND:The aim of this study was to translate and linguistically validate the U.S. National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) into Simplified Chinese for use in Singapore. METHODS:All 124 items of the English source PRO-CTCAE item library were translated into Simplified Chinese ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1153]

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Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial.

Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho, Hye-Young Kang,

BACKGROUND:Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemotherapy (CC, 15.4 vs. 4.07 months). We conducted an economic evaluation of pralatrexate from a societal perspective in Korea based on data from the PROPEL ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1157]

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Impact of superselective intra-arterial and systemic chemoradiotherapy for gingival carcinoma; analysis of treatment outcomes and prognostic factors.

Yuki Mukai, Yuichiro Hayashi, Izumi Koike, Toshiyuki Koizumi, Madoka Sugiura, Senri Oguri, Shoko Takano, Mitomu Kioi, Mizuki Sato, Kenji Mitsudo, Masaharu Hata,

BACKGROUND:We compared outcomes and toxicities between concurrent retrograde super-selective intra-arterial chemoradiotherapy (IACRT) and concurrent systemic chemoradiotherapy (SCRT) for gingival carcinoma (GC). METHODS:We included 84 consecutive patients who were treated for non-metastatic GC ≥ stage III, from 2006 to 2018, in this retrospective analysis (IACRT group: n = 66; SCRT group: n = 18). RESULTS:The median follow-up ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1154]

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Toluidine blue versus frozen section for assessment of mucosal tumor margins in oral squamous cell carcinoma.

Hana'a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali, Louloua Mohamed Fathy,

BACKGROUND:When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sampling error. This study evaluated the effectiveness of using toluidine blue (TB) as an intraoperative triage screening tool to detect ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1147]

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The effect of postmastectomy radiotherapy in node-positive triple-negative breast cancer.

Lei Zhang, Ru Tang, Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, San-Gang Wu, Zhen-Yu He,

BACKGROUND:The value of postmastectomy radiotherapy (PMRT) for pathological node-positive triple-negative breast cancers (TNBC) remains debatable. The aim of this population-based retrospective study was to evaluate the effect of PMRT on survival outcomes in this population. METHODS:Patients diagnosed with stage T1-4N1-N3M0 TNBC between 2010 and 2014 were identified from the Surveillance, ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1146]

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Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis.

Caizhi Chen, Yeqian Feng, Jingjing Wang, Ye Liang, Wen Zou,

BACKGROUND:The snoRNA host gene SNHG15 produces a long non-coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1156]

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Human CD133-positive hematopoietic progenitor cells enhance the malignancy of breast cancer cells.

Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu, Xinhan Zhao,

BACKGROUND:Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer has not been reported. METHODS:CD133+ HPCs were isolated and purified from human umbilical cord blood (UCB). We used in ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1158]

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Risk factors, prognostic factors, and nomograms for bone metastasis in patients with newly diagnosed infiltrating duct carcinoma of the breast: a population-based study.

Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao, Chanchan Hu,

BACKGROUND:Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients; the most common pathological type of BC is infiltrating duct carcinoma (IDC). Some nomograms have been developed to predict bone metastasis (BM) in patients with breast cancer. However, there ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1145]

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Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis.

Zhao-Hua Gao, Cun-Xin Li, Ming Liu, Jia-Yuan Jiang,

BACKGROUND:Whether tumour-infiltrating lymphocytes (TILs) play different roles in different molecular subtypes of breast cancer remains unknown. Additionally, their prognostic and predictive value in different molecular subtypes of breast cancer is still controversial. The aim of our meta-analysis was to assess the prognostic and predictive value of TILs in different molecular ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1150]

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