Full Text Journal Articles in
Journal BMC Cancer

Advertisement

Find full text journal articles






Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study.

Juan Carlos Núñez-Enríquez, Ana Elena Gil-Hernández, Elva Jiménez-Hernández, Arturo Fajardo-Gutiérrez, Aurora Medina-Sansón, Janet Flores-Lujano, Laura Eugenia Espinoza-Hernández, David Aldebarán Duarte-Rodríguez, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, José Refugio Torres-Nava, Rosa Martha Espinosa-Elizondo, Luz Victoria Flores-Villegas, Laura Elizabeth Merino-Pasaye, María Luisa Pérez-Saldivar, Elisa María Dorantes-Acosta, Beatriz Cortés-Herrera, Karina Anastacia Solis-Labastida, Nora Nancy Núñez-Villegas, Martha Margarita Velázquez-Aviña, Angélica Rangel-López, Ana Itamar González-Ávila, Jessica Denisse Santillán-Juárez, Alejandra Jimena García-Velázquez, Silvia Jiménez-Morales, Vilma Carolina Bekker-Méndez, Haydee Rosas-Vargas, Minerva Mata-Rocha, Omar Alejandro Sepúlveda-Robles, Jorge Alfonso Martín-Trejo, Juan Manuel Mejía-Aranguré,

BACKGROUND:Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood overweight and obesity are reaching epidemic proportions. They have been associated with poor outcomes in children with ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):708]

Cited: 0 times

View full text PDF listing >>



Hyperprogression after immunotherapy in patients with malignant tumors of digestive system.

Zhi Ji, Zhi Peng, Jifang Gong, Xiaotian Zhang, Jian Li, Ming Lu, Zhihao Lu, Lin Shen,

BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of digestive system ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):705]

Cited: 0 times

View full text PDF listing >>



Advertisement

Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness.

Beatrix Bencsikova, Eva Budinska, Iveta Selingerova, Katerina Pilatova, Lenka Fedorova, Kristina Greplova, Rudolf Nenutil, Dalibor Valik, Radka Obermannova, Michael A Sheard, Lenka Zdrazilova-Dubska,

BACKGROUND:In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical outcome. Our primary goal was to investigate whether baseline levels of circulating T cell subsets serve as a potential ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):687]

Cited: 0 times

View full text PDF listing >>



Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.

Timo Gemoll, Elena Miroll, Oliver Klein, Annette Lischka, Murat Eravci, Christoph Thorns, Jens K Habermann,

BACKGROUND:One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de novo identification of tumor sub-populations, imaging mass spectrometry (IMS) provides a powerful technique to elucidate the spatial distribution patterns of peptides ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):710]

Cited: 0 times

View full text PDF listing >>



Afatinib helped overcome subsequent resistance to osimertinib in a patient with NSCLC having leptomeningeal metastasis baring acquired EGFR L718Q mutation: a case report.

Jing Liu, Bo Jin, Hang Su, Xiujuan Qu, Yunpeng Liu,

BACKGROUND:The epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer has been successfully treated with tyrosine kinase inhibitors (TKIs). Acquired resistance becomes a tough issue when patients fail to respond to the third-generation TKI osimertinib. This study aimed to report a case baring acquired EGFR L858R/L718Q mutation in the central ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):702]

Cited: 0 times

View full text PDF listing >>



A clinical model to predict the risk of synchronous bone metastasis in newly diagnosed colorectal cancer: a population-based study.

Xu Guan, Chen-Xi Ma, Ji-Chuan Quan, Shuai Li, Zhi-Xun Zhao, Hai-Peng Chen, Ming Yang, Zheng Liu, Zheng Jiang, Xi-Shan Wang,

BACKGROUND:The early detection of synchronous bone metastasis (BM) in newly diagnosed colorectal cancer (CRC) affects its initial management and prognosis. A clinical model to individually predict the risk of developing BM would be attractive in current clinical practice. METHODS:A total of 55,869 CRC patients were identified from Surveillance, Epidemiology, and ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):704]

Cited: 0 times

View full text PDF listing >>



SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation.

Yuyan Gao, Xianxiu Nan, Xinjue Shi, Xiaoqin Mu, Binbin Liu, Huifen Zhu, Bingqing Yao, Xinyi Liu, Tianyue Yang, Yiting Hu, Shulin Liu,

BACKGROUND:Sterol-regulatory element binding protein 1 (SREBP1), an intracellular cholesterol sensor located in the endoplasmic reticulum, regulates the intracellular cholesterol by the Insig-Srebp-Scap pathway. Over-expression of SREBP1 can cause dyslipidemia. SREBP1 can regulate the metabolic pathway, and then promote the proliferation of tumor cells. However, there is no relevant research of ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):685]

Cited: 0 times

View full text PDF listing >>



Expression patterns of small numbers of transcripts from functionally-related pathways predict survival in multiple cancers.

Jordan Mandel, Huabo Wang, Daniel P Normolle, Wei Chen, Qi Yan, Peter C Lucas, Panayiotis V Benos, Edward V Prochownik,

BACKGROUND:Genetic profiling of cancers for variations in copy number, structure or expression of certain genes has improved diagnosis, risk-stratification and therapeutic decision-making. However the tumor-restricted nature of these changes limits their application to certain cancer types or sub-types. Tests with broader prognostic capabilities are lacking. METHODS:Using RNAseq data from 10,227 ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):686]

Cited: 0 times

View full text PDF listing >>



Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study.

E M Guinan, A E Bennett, S L Doyle, L O'Neill, J Gannon, G Foley, J A Elliott, J O'Sullivan, J V Reynolds, J Hussey,

BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quantified. This study prospectively examines change in physical functioning and ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):682]

Cited: 0 times

View full text PDF listing >>



Evaluating pre- and post-operation plasma miRNAs of papillary thyroid carcinoma (PTC) patients in comparison to benign nodules.

Mahsa Rezaei, Amir Mahdi Khamaneh, Nosratollah Zarghami, Armin Vosoughi, Shahriar Hashemzadeh,

BACKGROUND:Thyroid cancer is the most common endocrinology cancer that its incidence has increased in recent decades. miRNAs are new biomarkers in recent studies in the diagnosis and follow-up of these patients. METHODS:Blood and thyroid tissue samples were obtained from two groups of included patients (PTC and benign nodules), pre- and ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):690]

Cited: 0 times

View full text PDF listing >>



Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.

Mark Laible, Kerstin Hartmann, Claudia Gürtler, Tobias Anzeneder, Ralph Wirtz, Stephan Weber, Thomas Keller, Ugur Sahin, Martin Rees, Annette Ramaswamy,

BACKGROUND:Current evidence suggests that patients with Luminal A early breast cancer can skip chemotherapy or extended endocrine therapy, but immunohistochemistry-based biomarker analysis for St Gallen subtyping may not be reproducible. We asked whether RT-qPCR can be used instead to address this clinical question. METHODS:RNA was extracted from tumor material derived ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):694]

Cited: 0 times

View full text PDF listing >>



Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo.

Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroyuki Tsuchiya,

BACKGROUND:While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle progression and can enhance the cytocidal effects of anti-cancer agents. Citrate has been reported to enhance the cytocidal effect of cisplatin in ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):689]

Cited: 0 times

View full text PDF listing >>



Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.

Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng, Haozhe Piao,

BACKGROUND:Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clinical and preclinical activities against GBM. (Silent mating type information regulation 2 homolog, Sirt1) abbreviated as Sirtuin 1, has been implicated in GBM. ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):706]

Cited: 0 times

View full text PDF listing >>



Lnc-AL445665.1-4 may be involved in the development of multiple uterine leiomyoma through interacting with miR-146b-5p.

E Yang, Luqi Xue, Zhengyu Li, Tao Yi,

BACKGROUND:The clinical behaviors and cytogenetics of solitary uterine leiomyomas (SUL) and multiple uterine leiomyomas (MUL) vary, which greatly affects the choice of treatments for reproductive-aged patients with leiomyomas. Our previous study demonstrated that a series of microRNAs, including miR-146b-5p, are dysregulated and play important roles in the development of SUL ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):709]

Cited: 0 times

View full text PDF listing >>



The burden of leukemia in the Kingdom of Saudi Arabia: 15 years period (1999-2013).

Amen Bawazir, Nouf Al-Zamel, Abeer Amen, Maaged A Akiel, Naif M Alhawiti, Ali Alshehri,

BACKGROUND:Leukemia is a malignant neoplasm that arises from hematopoietic cells. The number of leukemia cases has dramatically increased from 297,000 to 437, 033 cases worldwide. As result, the the Saudi Cancer Registry ramked leukemia as the 5th type of cancer cases among both genders in Saudi Arabia. Data on the ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):703]

Cited: 0 times

View full text PDF listing >>



Combined neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with advanced gastric cancer.

Tetsushi Hirahara, Takaaki Arigami, Shigehiro Yanagita, Daisuke Matsushita, Yasuto Uchikado, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Itaru Omoto, Hiroshi Kurahara, Kosei Maemura, Keishi Okubo, Yoshikazu Uenosono, Sumiya Ishigami, Shoji Natsugoe,

BACKGROUND:The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are representative blood markers of systemic inflammatory responses. However, the clinical significance of the combination of these markers is unclear. This study aimed to investigate the NLR and PLR in patients with advanced gastric cancer treated with chemotherapy and assess the clinical ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):672]

Cited: 0 times

View full text PDF listing >>



Best fitting tumor growth models of the von Bertalanffy-PütterType.

Manfred Kühleitner, Norbert Brunner, Werner-Georg Nowak, Katharina Renner-Martin, Klaus Scheicher,

BACKGROUND:Longitudinal studies of tumor volume have used certain named mathematical growth models. The Bertalanffy-Pütter differential equation unifies them: It uses five parameters, amongst them two exponents related to tumor metabolism and morphology. Each exponent-pair defines a unique three-parameter model of the Bertalanffy-Pütter type, and the above-mentioned named models correspond to ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):683]

Cited: 0 times

View full text PDF listing >>



Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins.

Ying Fang, Ruonan Xu, Bing Zhai, Chunmei Hou, Ning Ma, Liang Wang, Gencheng Han, Zhenyu Jiang, Renxi Wang,

BACKGROUND:Multiple myeloma (MM), characterized by cancerous proliferation of plasmablasts (PB) and plasma cells (PC), remains incurable in many patients. Differentially expressed molecules between MM PCs and healthy PCs have been explored in order to identify novel targets for treating MM. In the present study, we searched for novel MM therapeutic ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):700]

Cited: 0 times

View full text PDF listing >>



Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma.

Liangsong Zhu, Rong Ding, Jianping Zhang, Jin Zhang, Zongming Lin,

BACKGROUND:This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis. METHODS:The data from both of The Cancer Genome Atlas (TCGA) and Gene Expression of Normal and Tumor Tissue (GENT) were analyzed for determining the expression of CDK5 in ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):698]

Cited: 0 times

View full text PDF listing >>



Predictive factors of treatment outcomes after percutaneous ablation of hepatocellular carcinoma in the caudate lobe: a retrospective study.

Baoxian Liu, Jianting Long, Wei Wang, Tongyi Huang, Xiaohua Xie, Shuling Chen, Guangliang Huang, Chunlin Jiang, Jieyi Ye, Haiyi Long, Xiaoyan Xie, Ming Kuang,

BACKGROUND:Hepatocellular carcinomas (HCC) arising in the caudate lobe is rare and the treatment is difficult. The aim of this study is to summarize the experience of ultrasound-guided percutaneous ablation therapy for HCC located in the caudate lobe and to investigate the predictive factors of the treatment outcomes. METHODS:From August 2006 ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):699]

Cited: 0 times

View full text PDF listing >>



Intra-arterial chemotherapy as primary or secondary treatment for infants diagnosed with advanced retinoblastoma before 3 months of age.

Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Jiejun Xia, Jing Zhang, Shuixing Zhang,

BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilateral or bilateral advanced intraocular retinoblastoma (group D and ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):693]

Cited: 0 times

View full text PDF listing >>



Prognostic value of TGF-β in lung cancer: systematic review and meta-analysis.

Jue Li, Cheng Shen, Xin Wang, Yutian Lai, Kun Zhou, Pengfei Li, Lunxu Liu, Guowei Che,

BACKGROUND:Lung cancer is the most important cause of cancer-related deaths worldwide and the overall survival of patients with non-small cell lung cancer has not improved. Transforming growth factor beta or TGF-β is a polypeptide member of the transforming growth factor beta superfamily of cytokines, while far fewer clinical studies addressing ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):691]

Cited: 0 times

View full text PDF listing >>



Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinoma.

Jing Song, Wenqing Wang, Yingyan Wang, Yongxin Qin, Yingzi Wang, Jian Zhou, Xuelian Wang, Yi Zhang, Qi Wang,

BACKGROUND:Re-capture of the differences between tumor and normal tissues observed at the patient level in cell cultures and animal models is critical for applications of these cancer-related differences. The epithelial-mesenchymal transition (EMT) process is essential for tumor migratory and invasive capabilities. Although plenty of EMT markers are revealed, molecular features during ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):680]

Cited: 0 times

View full text PDF listing >>



Outcome of adjuvant radiotherapy after total hysterectomy in patients with uterine leiomyosarcoma or carcinosarcoma: a SEER-based study.

Yuan Li, Haitao Ren, Junmei Wang,

BACKGROUND:The clinical impact of adjuvant radiotherapy on uterine sarcoma is unclear, and may depend on the histological type. Hence, the aim of this study was to evaluate clinical outcomes of adjuvant radiotherapy after total hysterectomy in patients with leiomyosarcoma or carcinosarcoma. METHODS:Data were obtained from the Surveillance, Epidemiology, and End ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):697]

Cited: 0 times

View full text PDF listing >>



Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer.

Weiwei Gong, Yueyang Liu, Christof Seidl, Eleftherios P Diamandis, Marion Kiechle, Enken Drecoll, Matthias Kotzsch, Viktor Magdolen, Julia Dorn,

BACKGROUND:In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern in tumor tissue of patients suffering from high-grade serous ovarian cancer stage FIGO III/IV. Moreover, we have correlated the ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):696]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.0495 s