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Journal BMC Cancer

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Design and methods of a national, multicenter, randomized and controlled trial to assess the efficacy of a physical activity program to improve health-related quality of life and reduce fatigue in women with metastatic breast cancer: ABLE02 trial.

Lidia Delrieu, Amélie Anota, Olivier Trédan, Damien Freyssenet, Aurélia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Béatrice Fervers, Vincent Pialoux, David Pérol, Olivia Pérol,

BACKGROUND:Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibility of a physical activity program has been demonstrated in this population, ABLE02 aims to assess the efficacy of ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):622]

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The impact on quality of life from informing diagnosis in patients with cancer: a systematic review and meta-analysis.

Miao Wan, Xianggui Luo, Juan Wang, Louis B Mvogo Ndzana, Chen Chang, Zhenfen Li, Jianglin Zhang,

BACKGROUND:The aim of this study was to assess the impact on quality of life from informing patients with cancer of their diagnosis and disease status. METHOD:We searched the follow databases, PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), PsycINFO, WEB OF SCIENCE, Embase, CBM (Chinese Biomedical Literature database), WANFANG database ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):618]

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Impact of the faecal immunochemical test on colorectal cancer survival.

María Angeles Gutierrez-Stampa, Vanessa Aguilar, Cristina Sarasqueta, Joaquín Cubiella, Isabel Portillo, Luis Bujanda,

BACKGROUND:There is already evidence that the faecal immunochemical test (FIT) is a useful tool for the diagnosis of colorectal cancer (CRC) that helps to identify symptomatic patients requiring early colonoscopy. Although the recommendation to use FIT is widely accepted, there are no data concerning whether this strategy improves patient survival.The ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):616]

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High expression of RABL6 promotes cell proliferation and predicts poor prognosis in esophageal squamous cell carcinoma.

Yanfen Feng, Shumei Yan, Yuhua Huang, Qitao Huang, Fang Wang, Yiyan Lei,

BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a common malignant carcinoma of digestive system with high mortality. RAB, member RAS oncogene family like 6 (RABL6), a member of the RAS subfamily, has been reported as an important molecule in several cancers. However, its potential role in ESCC still remains unclear. METHODS:RABL6 ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):602]

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Incidence, prevalence, mortality, and causes of death in Waldenström macroglobulinemia: a nationwide, population-based cohort study.

Seri Jeong, Seom Gim Kong, Da Jung Kim, Sangjin Lee, Ho Sup Lee,

BACKGROUND:The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes of death of patients with WM. METHODS:We used a national population-based database, operated ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):623]

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NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells.

Baili Xia, Lijun Hou, Huan Kang, Wenhui Chang, Yi Liu, Yanli Zhang, Yi Ding,

BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F, ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):626]

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Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms.

Linus D Kloker, Susanne Berchtold, Irina Smirnow, Julia Beil, Andreas Krieg, Bence Sipos, Ulrich M Lauer,

BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic sites. Due to often slow growth ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):628]

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Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization.

Ka-Won Kang, Seung-Jin Lee, Ji Hye Kim, Byung-Hyun Lee, Seok Jin Kim, Yong Park, Byung Soo Kim,

BACKGROUND:We assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclophosphamide with G-CSF or G-CSF alone. METHODS:We compared the clinical features of 173 non-Hodgkin's lymphoma patients who underwent autologous peripheral blood stem cell ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):619]

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Fluctuating expression of miR-584 in primary and high-grade gastric cancer.

Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani, Kamran Ghaedi,

BACKGROUND:Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. miR-584 is a less well-characterized microRNA (miRNA), with apparent activity in human cancers. However, miR-584 expression pattern in gastric cancer development ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):621]

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PODXL might be a new prognostic biomarker in various cancers: a meta-analysis and sequential verification with TCGA datasets.

Siying He, Wenjie Du, Menglan Li, Ming Yan, Fang Zheng,

ABSRACT:BACKGROUND: Several studies have investigated the associations between the podocalyxin-like protein (PODXL) expression quantity or locations and cancers survival, but the results were far from conclusive. Therefore, we proceeded a meta-analysis on PODXL in various human cancers to find its prognostic value and followed confirmation using the TCGA datasets. METHODS:We ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):620]

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Sterile, abscess-like cerebral lesion during trastuzumab therapy after HER2 status switch in a triple negative breast cancer patient: a case report and literature review.

Tamás Mezei, Melinda Hajdu, Gábor Czigléczki, Gábor Lotz, Judit Kocsis, Janina Kulka, Anna Horváth,

BACKGROUND:Breast cancer is a global health problem - it is the most common malignancy among women. Triple negative breast cancers (TNBC) account for 10-20% of female breast cancer. Most TNBC cases confer poor prognosis. Brain metastasis appears in more than 15% in the triple negative breast cancer population, which causes ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):615]

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Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study.

Mengmeng Feng, Mengchao Zhang, Yuanqing Liu, Nan Jiang, Qian Meng, Jia Wang, Ziyun Yao, Wenjuan Gan, Hui Dai,

BACKGROUND:To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC). METHOD:One hundred four participants were enrolled in this retrospective study. Each participant performed preoperative Gd-EOB-DTPA-enhanced MR scanning. Texture features were analyzed by ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):611]

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Analytical evaluation of the clonoSEQ Assay for establishing measurable (minimal) residual disease in acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma.

Travers Ching, Megan E Duncan, Tera Newman-Eerkes, Mollie M E McWhorter, Jeffrey M Tracy, Michelle S Steen, Ryan P Brown, Srivatsa Venkatasubbarao, Nicholas K Akers, Marissa Vignali, Martin E Moorhead, Drew Watson, Ryan O Emerson, Tobias P Mann, B Melina Cimler, Pamela L Swatkowski, Ilan R Kirsch, Charles Sang, Harlan S Robins, Bryan Howie, Anna Sherwood,

BACKGROUND:The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearrangements and IgH-BCL1/2 translocations in malignant B cells. Here, we describe studies to validate the analytical performance of the assay using patient samples and cell lines. ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):612]

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Cardio-toxicity among patients with sarcoma: a cardio-oncology registry.

Sivan Shamai, Zach Rozenbaum, Ofer Merimsky, Matthew Derakhshesh, Yonatan Moshkovits, Joshua Arnold, Yan Topilsky, Yaron Arbel, Michal Laufer-Perl,

BACKGROUND:Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the impact on patients with sarcoma is limited, even though they are exposed to higher ANT doses. The commonly used term for ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):609]

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The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma.

Marcela García, Maria Belen Palma, Jerome Verine, Santiago Miriuka, Ana M Inda, Ana L Errecalde, François Desgrandchamps, Edgardo D Carosella, Diana Tronik-Le Roux,

BACKGROUND:Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as first-line treatment, on the administration of the vascular endothelial growth factor (VEGF) neutralizing antibody termed Bevacizumab. Despite proven benefits, ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):624]

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MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.

Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda, Hiroshi Shiku,

BACKGROUND:Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT antigens, melanoma-associated antigen A4 (MAGE-A4), New York oesophageal squamous cell carcinoma 1 (NY-ESO-1) and sarcoma antigen gene (SAGE). METHODS:MAGE-A4, ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):606]

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Sarcoma epidemiology and cancer-related hospitalisation in Western Australia from 1982 to 2016: a descriptive study using linked administrative data.

Cameron M Wright, Georgia Halkett, Richard Carey Smith, Rachael Moorin,

BACKGROUND:Sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Epidemiological studies on sarcoma from Australia are lacking, as previous studies have focused on a sarcoma type (e.g. soft tissue) or anatomical sites. METHODS:Linked cancer registry, hospital morbidity and death registration data were available for Western Australia (WA) from ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):625]

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Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation.

Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu, Yuan Li, Lixiao Zhen, Qian Zhao, Yuefan Guo, Zhaohui Wang, Evelyne Bischof, Zuoren Yu,

BACKGROUND:Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through interaction with target gene p27. RESULTS:Herein, we determined the ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):627]

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Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference.

Jin Bong Choi, Jun-Pyo Myong, Yunhee Lee, Inah Kim, Jung Ho Kim, Sung-Hoo Hong, U-Syn Ha,

BACKGROUND:We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male population of Korea. METHODS:A total of 1,917,430 men who underwent at least one health examination in 2009 without ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):589]

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Self-identity, lived experiences, and challenges of breast, cervical, and prostate cancer survivorship in Mexico: a qualitative study.

Felicia Marie Knaul, Svetlana V Doubova, María Cecilia Gonzalez Robledo, Alessandra Durstine, Gabriela Sophia Pages, Felicia Casanova, Hector Arreola-Ornelas,

BACKGROUND:Qualitative research on cancer patients' survivor-identity and lived experiences in low- and middle-income countries is scarce. Our study aimed at exploring the concept and experience of survivorship for Mexicans living with breast, cervical, and prostate cancer. METHODS:We conducted a qualitative study in Mexico City, Morelos, Nuevo León, and Puebla. The ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):577]

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Diagnosis of triple negative breast cancer based on radiomics signatures extracted from preoperative contrast-enhanced chest computed tomography.

Qingliang Feng, Qiang Hu, Yan Liu, Tao Yang, Ziyi Yin,

BACKGROUND:To explore the diagnostic value of radiomics features of preoperative computed tomography (CT) for triple negative breast cancer (TNBC) for better treatment of patients with breast cancer. METHODS:A total of 890 patients with breast cancer admitted to our hospital from June 2016 to January 2018 were analyzed. They were diagnosed ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):579]

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Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: a SEER-based study.

Chao-Tao Tang, Ling Zeng, Jing Yang, Chunyan Zeng, Youxiang Chen,

BACKGROUND:Considering that the knowledge of adenocarcinoma in villous adenoma of the colorectum is limited to several case reports, we designed a study to investigate independent prognostic factors and developed nomograms for predicting the survival of patients. METHODS:Univariate and multivariate Cox regression analyses were used to evaluate prognostic factors. A nomogram ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):608]

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Correction to: Comparison of minimally invasive Ivor Lewis esophagectomy and left transthoracic esophagectomy in esophageal squamous cell carcinoma patients: a propensity score-matched analysis.

Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen, Ming Wu,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):593]

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Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.

Jérôme Ruhnau, Jonas Parczyk, Kerstin Danker, Britta Eickholt, Andreas Klein,

BACKGROUND:Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence. To target the driving forces of the tumor microevolution, we focused on synergistic drug combinations of selected compounds. The aim ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):617]

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Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas.

Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka,

BACKGROUND:Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets are needed. Several studies not only reported mutations but also amplifications of the KRAS locus in different cancer entities. More ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):587]

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