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Journal BJU Int

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Dynamic biomarker and imaging changes from a phase II study of pre- and post-surgical sunitinib.

Sarah J Welsh, Nicola Thompson, Anne Warren, Andrew N Priest, Tristan Barrett, Stephan Ursprung, Ferdia A Gallagher, Fulvio Zaccagna, Grant D Stewart, Kate M Fife, Athena Matakidou, Andrea J Machin, Wendi Qian, Victoria Ingleson, Jean Mullin, Antony Cp Riddick, James N Armitage, Stephen Connolly, Timothy Gq Eisen,

<h4>Objective</h4>To explore translational biological and imaging biomarkers for Sunitinib treatment prior to and after debulking nephrectomy.<h4>Methods</h4>Treatment-naïve patients with metastatic renal cell carcinoma (mRCC) received 50mg OD Sunitinib for 12 days pre-surgically, then post-surgery on 4 week-on, 2 week-off, repeating 6 week cycles until disease progression in a single arm phase ... Read more >>

BJU Int (BJU international)
[2021, :]

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Validation and Public Health Modelling of Risk Prediction Models for Kidney Cancer using UK Biobank.

Hannah Harrison, Lisa Pennells, Angela Wood, Sabrina H Rossi, Grant D Stewart, Simon J Griffin, Juliet A Usher-Smith,

<h4>Objectives</h4>Early detection of kidney cancer improves survival; however, low prevalence means that population-wide screening based on age alone is inefficient. Stratifying the population, using risk models, could enable an individually tailored screening program. Risk models exist but very few have been externally validated.<h4>Methods</h4>We validated the performance of 30 existing phenotypic ... Read more >>

BJU Int (BJU international)
[2021, :]

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Novel syphon ureteral access sheath has potential to improve renal pressures and irrigant flow.

John Lazarus, Lisa Kaestner,

<h4>Objective</h4>This paper describes a novel syphoning ureteral access sheath (UAS) intended for use during flexible uretero-renoscopy (URS). We aimed to assess if in vitro it could reduce intrarenal pressure (IRP) and increase irrigation flow compared to traditional UAS.<h4>Methods</h4>A validated phantom kidney with fiber optic pressure sensing capabilities was used to ... Read more >>

BJU Int (BJU international)
[2021, :]

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Adjuvant therapy in patients with sarcomatoid renal cell carcinoma: post hoc analysis from Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) E2805.

Jose A Karam, Maneka Puligandla, Keith T Flaherty, Robert G Uzzo, Surena F Matin, Michael R Pins, Christopher G Wood, Christopher Kane, Michael A S Jewett, Se Eun Kim, Janice P Dutcher, Robert S DiPaola, Naomi B Haas,

<h4>Objectives</h4>To study the effects of adjuvant therapy in patients with sarcomatoid renal cell carcinoma (sRCC) enrolled in the randomised phase III clinical trial E2805.<h4>Patients and methods</h4>The original trial (E2805) was a randomised, double-blinded phase III clinical trial comparing outcomes in 1943 patients with RCC accrued between 2006 and 2010 and ... Read more >>

BJU Int (BJU international)
[2021, :]

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Urine DNA for monitoring chemoradiotherapy response in muscle-invasive bladder cancer: a pilot study.

Naheema S Gordon, Laura A Baxter, Anshita Goel, Roland Arnold, Baljit Kaur, Wenyu Liu, Sarah J Pirrie, Syed Hussain, Richard Viney, Daniel Ford, Anjali Zarkar, Mary A Wood, Timur Mitin, Reid F Thompson, Nicholas D James, Douglas G Ward, Richard T Bryan,

BJU Int (BJU international)
[2021, :]

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Outcomes of Freehand Transperineal Prostate Biopsy with Omission of Antibiotic Prophylaxis.

Shaan Setia, John Smith, Demetri Cendo, Michael Gorin, Matthew Allaway, Srinivas Vourganti,

<h4>Objective</h4>To assess the utility of antimicrobial prophylaxis when performing freehand systematic transperineal biopsy.<h4>Patients and methods</h4>From 1/2012 to 2/2020, freehand transperineal prostate biopsy via angiocatheters or the PrecisionPoint Transperineal Access System was performed on consecutive men with clinical suspicion of prostate cancer or confirmed prostate cancer. Biopsies were performed by a ... Read more >>

BJU Int (BJU international)
[2021, :]

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Learning curve analysis of single-port robot-assisted extraperitoneal prostatectomy using the cumulative sum (CUSUM) method.

Louis Lenfant, Dillon Corrigan, Alp Tuna Beksac, Zeyad Schwen, Jihad Kaouk,

BJU Int (BJU international)
[2021, :]

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A sevenfold increase in NHS urological litigation in 20 years? Are we practising in a litigation culture?

John Reynard,

BJU Int (BJU international)
[2021, 128(3):265-266]

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Case of the month from San Raffaele Hospital, Milan, Italy: Pushing the limits of simultaneous bilateral endoscopic surgery for renal stones.

Silvia Proietti, Mario Basulto-Martínez, Giuseppe Saitta, Yuyi Yeow, Franco Gaboardi, Guido Giusti,

BJU Int (BJU international)
[2021, 128(3):294-297]

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World News.

BJU Int (BJU international)
[2021, 128(3):269-270]

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Update from the Canadian Urological Association.

Heather Morris,

BJU Int (BJU international)
[2021, 128(3):395]

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Adjusting penis length and the potential impact on female sexual satisfaction.

Kevan R Wylie,

BJU Int (BJU international)
[2021, 128(3):267-268]

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Robot-assisted salvage seminal vesicle excision for isolated recurrence after low-dose-rate prostate brachytherapy.

Stephen Langley, Christopher Eden, Matthew Perry, Krishna Patil, Dimitrios Moschonas, Donna Higgins, Claire Deering, Robert Laing, Carla Perna, Sara Khaksar, Santiago Uribe-Lewis, Jennifer Uribe,

<h4>Objectives</h4>To report clinical and functional outcomes for patients who have undergone salvage robot-assisted seminal vesicle excision (RA-SVE) for the focal treatment of isolated seminal vesical (SV) recurrence after treatment for prostate cancer by low-dose-rate brachytherapy.<h4>Patients and methods</h4>Patients with rising prostate-specific antigen (PSA) after low-dose-rate prostate brachytherapy (LDR-PB) underwent multi-parametric magnetic ... Read more >>

BJU Int (BJU international)
[2021, :]

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Outcomes in robotic-assisted partial nephrectomy for imperative versus elective indications.

J Tan, N Sathianathen, M Cumberbatch, P Dasgupta, A Mottrie, R Abaza, K H Rha, T B Yuvaraja, D J Parekh, U Capitanio, R Ahlawat, S Rawal, N M Buffi, A Sivaraman, K K Maes, G Gautham, F Porpiglia, L Turkeri, M Bhandari, B Challacombe, J Porter, C Rogers, D Moon,

<h4>Objectives</h4>To assess and compare perioperative outcomes of patients undergoing robotic-assisted partial nephrectomy (RAPN) for imperative versus elective indications.<h4>Patient and methods</h4>We retrospectively reviewed a multinational database of 3,802 adult patients who underwent RAPN for elective and imperative indications. Laparoscopic or open PN were excluded. Baseline data for age, gender, BMI, ASA ... Read more >>

BJU Int (BJU international)
[2021, :]

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Predictive value of immunological markers after bacille Calmette-Guérin induction in bladder cancer.

Amr A Elsawy, Hassan Abol-Enein, Mahmoud Laymon, Asmaa E Ahmed, Ahmed Essam, Eman T Hamam, Abdel-Aziz A Zidan, Mohamed H Zahran, Ahmed A Shokeir, Amira Awadalla,

<h4>Objectives</h4>To investigate the predictive value of different immunological markers on treatment outcomes after bacille Calmette-Guérin (BCG) induction in high-risk non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>Patients who underwent transurethral resection of bladder tumour for NMIBC were assessed for study eligibility. Urine and blood samples were taken from patients at baseline (immediately ... Read more >>

BJU Int (BJU international)
[2021, :]

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Long-term survival after low-dose-rate brachytherapy for prostate cancer: the Royal Surrey experience.

Santiago Uribe-Lewis, Jennifer Uribe, Vincent Bourke, Claire Deering, Donna Higgins, Sheel Mehta, Christos Mikropoulos, Sophie Otter, Carla Perna, Sara Khaksar, Robert Laing, Stephen Langley,

<h4>Objectives</h4>To assess the long-term treatment efficacy of low-dose-rate (LDR) brachytherapy for the treatment of localized prostate cancer.<h4>Patients and methods</h4>Cause-of-death annotation in our prospective database was supplemented with death certificate information obtained via an internal audit of patients treated from 1999 to 2017 with LDR prostate brachytherapy as monotherapy or as ... Read more >>

BJU Int (BJU international)
[2021, :]

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A longitudinal study evaluating interim assessment of neoadjuvant chemotherapy for bladder cancer.

Marc A Furrer, Nathan Papa, Sandro Luetolf, Beat Roth, Marcus Cumberbatch, Mihai Dorin Vartolomei, Benjamin C Thomas, Harriet C Thoeny, Roland Seiler, George N Thalmann, Bernhard Kiss,

<h4>Objectives</h4>To evaluate the usefulness of radiological re-staging after two and four cycles of neoadjuvant chemotherapy (NAC), the impact of re-staging on further patient management, and the correlation between clinical and final pathological tumour stage at radical cystectomy (RC).<h4>Patients and methods</h4>We conducted a longitudinal, single-centre, cohort study of prospectively collected consecutive ... Read more >>

BJU Int (BJU international)
[2021, :]

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Influence of hydrogel spacer placement with prostate brachytherapy on rectal and urinary toxicity.

Achiraya Teyateeti, Craig Grossman, Marisa A Kollmeier, Megan Fiasconaro, Margaret Hopkins, Sean McBride, Daniel Gorovets, Daniel Shasha, Gilad Cohen, Zhigang Zhang, David J Lesser, Antonio Damato, Michael J Zelefsky,

<h4>Objective</h4>To determine the influence of rectal hydrogel spacer placement (HSP) on late rectal toxicity outcomes in prostate cancer patients treated with low-dose-rate (LDR) brachytherapy, with or without supplemental external beam radiotherapy (EBRT).<h4>Patients and methods</h4>A total of 224 patients underwent LDR brachytherapy with HSP, as monotherapy or combined with EBRT, between ... Read more >>

BJU Int (BJU international)
[2021, :]

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Intravesical mitomycin C (MMC) and MMC + cytosine arabinoside for non-muscle-invasive bladder cancer: a randomised clinical trial.

Yasuyoshi Miyata, Toshifumi Tsurusaki, Yasushi Hayashida, Yushi Imasato, Kosuke Takehara, Daiyu Aoki, Masaharu Nishikido, Junichi Watanabe, Kensuke Mitsunari, Tomohiro Matsuo, Kojiro Ohba, Keisuke Taniguchi, Hideki Sakai, ,

<h4>Objectives</h4>To compare the urinary pH, recurrence-free survival (RFS), and safety of adjuvant intravesical therapy in patients with non-muscle-invasive bladder cancer (NMIBC) receiving mitomycin C (MMC) therapy and MMC + cytosine arabinoside (Ara-C) therapy.<h4>Patients and methods</h4>A total of 165 patients with NMIBC from six hospitals were randomly allocated to two groups: weekly instillation ... Read more >>

BJU Int (BJU international)
[2021, :]

Cited: 1 time

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Incidence of testicular cancer in trans women using gender-affirming hormonal treatment: a nationwide cohort study.

Iris de Nie, Chantal M Wiepjes, Christel J M de Blok, R Jeroen A van Moorselaar, Garry L S Pigot, Tim M van der Sluis, Ellis Barbé, Patrick van der Voorn, Norah M van Mello, Judith Huirne, Martin den Heijer,

<h4>Objective</h4>To assess the incidence of testicular cancer in trans women (male sex assigned at birth, female gender identity) using gender-affirming hormonal treatment.<h4>Patients and methods</h4>Data of trans women starting hormonal treatment at our gender identity clinic between 1972 and 2017 were linked to the national pathology database to obtain testicular cancer ... Read more >>

BJU Int (BJU international)
[2021, :]

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Lower urinary tract electrical sensory assessment: A systematic review and meta-analysis.

Stéphanie van der Lely, Melanie R Schmidhalter, Stephanie C Knüpfer, Andrea M Sartori, Marc P Schneider, Stephanie A Stalder, Thomas M Kessler, Martina D Liechti, Ulrich Mehnert,

<h4>Objective</h4>To summarize the current literature on lower urinary tract electrical sensory assessment (LUTESA), with regard to current perception thresholds (CPTs) and sensory evoked potentials (SEPs). The applied methods will be discussed in terms of technical aspects, confounding factors, and potential for lower urinary tract (LUT) diagnostics.<h4>Methods</h4>The review was performed according ... Read more >>

BJU Int (BJU international)
[2021, :]

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Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette-Guérin immunotherapy.

José Daniel Subiela, Óscar Rodríguez Faba, Júlia Aumatell, Julio Calderón, Asier Mercadé, Josep Balañà, Cristina Esquinas, Ferran Algaba, Alberto Breda, Joan Palou,

<h4>Objective</h4>To assess whether bacillus Calmette-Guérin (BCG) responsiveness after initiation of an adequate BCG treatment (at least five of six instillations of induction and at least two of three instillations of maintenance) impacts oncological outcomes in patients with carcinoma in situ (CIS) of the bladder treated with BCG immunotherapy.<h4>Patients and methods</h4>Data were ... Read more >>

BJU Int (BJU international)
[2021, :]

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Genomic profile - a possible diagnostic and prognostic marker in upper tract urothelial carcinoma.

Alexandra Grahn, Jesper Eisfeldt, Camilla Malm, Hassan Foroughi Asl, Georg Jaremko, Emma Tham, Marianne Brehmer,

<h4>Objectives</h4>To investigate gene alterations as diagnostic and prognostic markers in upper tract urothelial carcinoma (UTUC).<h4>Patients and methods</h4>Patients with UTUC who underwent nephroureterectomy between 2005 and 2012 were followed until November 2020. DNA was extracted from paraffin-embedded tumour tissue. Next-generation sequencing using a 388-gene panel was performed. First a blinded analysis ... Read more >>

BJU Int (BJU international)
[2021, :]

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A comparison of prostate cancer prediction models in men undergoing both magnetic resonance imaging and transperineal biopsy: Are the models still relevant?

Paul Doan, Petra Graham, John Lahoud, Sebastiaan Remmers, Monique J Roobol, Lawrence Kim, Manish I Patel,

<h4>Objective</h4>To externally validate and compare the performance of the European Randomized Study of Screening for Prostate Cancer risk calculator 3/4 (ERSPC-RC3/4), the Prostate Biopsy Collaborative Group risk calculator (PBCG-RC) and the van Leeuwen model to determine which prediction model would perform the best in a contemporary Australian cohort undergoing transperineal ... Read more >>

BJU Int (BJU international)
[2021, :]

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The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia.

Juan Morote, Iván Schwartzmann, Anna Celma, Sarai Roche, Inés M de Torres, Richard Mast, Maria E Semidey, Lucas Regis, Anna Santamaria, Jacques Planas, Enrique Trilla,

<h4>Objective</h4>To analyse the current predictive value of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) for clinically significant prostate cancer (csPCa) detection in repeat biopsies.<h4>Patients and methods</h4>A cohort of 293 men with isolated HGPIN detected in previous biopsies performed without multiparametric magnetic resonance imaging (mpMRI), and who underwent repeat biopsy within 1 ... Read more >>

BJU Int (BJU international)
[2021, :]

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