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Journal Asian Pac. J. Cancer Prev.

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Antitumor Effects of Fucoidan Via Apoptotic and Autophagic Induction on HSC-3 Oral Squamous CellCarcinoma.

Pathanin Chantree, Thanakorn Surarak, Kant Sangpairoj, Panuroot Aguilar, Ekarat Hitakomate,

OBJECTIVE:Many studies suggested that fucoidan has anticancer potential. The objective of the present study was to determine the cytotoxic effects and mechanism of cell death induced by fucoidan extracted from Fucus vesiculosus on HSC-3 oral squamous cell carcinoma. METHODS:HSC-3 cells were treated with 0, 100, 200, and 400 μg/mL of ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2469-2477]

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H. pylori Infection and Colorectal Cancers by Anatomical Locations.

Dao Viet Hang, Dinh Thi Minh, Tran Hieu Hoc, Le Hong Phuoc, Tran Que Son, Ngoan Tran Le,

BACKGROUND:H. pylori infection may play a role in the development of colorectal cancers (CRC). We aimed to examine the association between H. pylori infection and the risk of CRC by anatomical locations. METHODS:We conducted a case-control study on 91 incidence cases of CRC and 224 hospital controls. CRC was determined ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2431-2437]

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Effect of Muscle Energy Techniques V/S Active Range of Motion Exercises on Shoulder Function Post Modified Radical Neck Dissection in patients with Head and Neck Cancer - A Randomized Clinical Trial.

Anmol Thomas, Cherishma D'Silva, Leah Mohandas, Sudeep M J Pais, Stephen Rajan Samuel,

PURPOSE:Shoulder and cervical pain, reduced mobility and disability are some of the major complications associated with surgeries of head and neck cancers affecting several domains of quality of life. In the present study we aimed to compare the effectiveness of Muscle Ener-gy Techniques (METS) and Active Range of Motion Exercises ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2389-2393]

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Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements.

Sara Movahed, Abdolreza Norouzy, Ali Ghanbari-Motlagh, Saeid Eslami, Majid Khadem-Rezaiyan, Maryam Emadzadeh, Mohsen Nematy, Majid Ghayour-Mobarhan, Fatemeh Varshoee Tabrizi, Federico Bozzetti, Mehdi Seilanian Toussi,

BACKGROUND:Malnutrition is prevalent in esophageal cancer patients which affects cancer prognosis. The purpose of this study was a comprehensive assessment of nutritional status during Chemoradiation (CRT). METHODS:Newly diagnosed adults with esophageal cancer were recruited for this study. Patient-Generated- Subjective Global Assessment (PG-SGA), anthropometric indices, body composition, dietary intake, laboratory tests, ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2315-2323]

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Identification of Potential Genes for Benign Prostatic Hyperplasia and Prostate Cancer Susceptibility in Four X-chromosome Regions with High Frequency of Microvariant Alleles.

Mohammed H Albujja, Safia A Messaudi, Ramachandran Vasudevan, Saleh Al Ghamdi, Pei Pei Chong, Khairul Asri Ghani, Yazan Ranneh, Mohammed Alaidarous, Patimah Ismail,

BACKGROUND:The X-chromosome has been suggested to play a role in prostate cancer (PrCa) since epidemiological studies have provided evidence for an X-linked mode of inheritance for PrCa based on the higher relative risk among men who report an affected brother(s) as compared to those reporting an affected father. The aim ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2271-2280]

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Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.

Maryam Kohsari, Mohammad Hassan Khadem Ansari, Yousef Rasmi,

OBJECTIVE:The etiology of multiple myeloma (MM) is not known. Enzymes such as xanthine oxidase (XO) and NADPH oxidase 1 (NOX1) as relevant sources of reactive oxygen species (ROS) production may play a crucial role in the incidence and progress of MM. Uric acid generated by XO has a controversial dual ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2237-2242]

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Clinical Significance of Plasma Levels of Gluconeogenic Amino Acids in Esophageal Cancer Patients.

Mahsa Taherizadeh, Masoud Khoshnia, Sedigheh Shams, Zahra Hesari, Hamidreza Joshaghani,

OBJECTIVE:Metabolic processes in the body of people with and without esophageal cancer (EC) are significantly different. Therefore, changes in the metabolism of amino acids in the body of EC patients can lead to metabolic disorders, such as increased gluconeogenesis. The aim of this study was the comparison of the plasma ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2463-2468]

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The Venom of Philippine Tarantula (Theraphosidae) Contains Peptides with Pro-Oxidative and Nitrosative-Dependent Cytotoxic Activities against Breast Cancer Cells (MCF-7) In Vitro.

Simon Miguel M Lopez, Jeremey S Aguilar, Jerene Bashia B Fernandez, Angelic Gayle J Lao, Mitzi Rain R Estrella, Mark Kevin P Devanadera, Anna Beatriz R Mayor, Leonardo A Guevarra, Myla R Santiago-Bautista, Olga M Nuneza, Librado Santiago,

BACKGROUND:Breast cancer is a multifactorial disease that affects women worldwide. Its progression is likely to be executed by oxidative stress wherein elevated levels of reactive oxygen and nitrogen species drive several breast cancer pathologies. Spider venom contains various pharmacological peptides which exhibit selective activity to abnormal expression of ion channels ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2423-2430]

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Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube, and Primary Peritoneal Cancers: A Multi-Institutional Study.

Arb-Aroon Lertkhachonsuk, Prapaporn Suprasert, Tarinee Manchana, Thannaporn Kittisiam, Nuttavut Kantathavorn, Tharintorn Chansoon, Surapan Khunamornpong, Natkrita Pohthipornthawat, Siriwan Tangjitgamol, Taksa Luasiripanthu, Chinachote Teerapakpinyo, Shanop Shuangshot, Nareenart Iemwimangsa, Wasun Chantratita,

BACKGROUND AND OBJECTIVE:Ovarian, fallopian tube, or primary peritoneal cancer patients with BRCA gene mutation have enhanced sensitivity to platinum-based regimens and PARP inhibitors. However, the knowledge regarding BRCA mutation in Thai patients is limited. This study aimed at identifying the prevalence and characteristics of somatic and germline BRCA 1 and ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2381-2388]

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Progression Free Survival and Predictor of Recurrence in DLBCL patients with Negative Interim 18FDG PET/CT Using Standardized Imaging and Reporting Protocols.

Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Sidra Zaman, Rabia Tahseen,

BACKGROUND:To determine progression free survival (PFS) and predictor of recurrence in patients with diffuse large B-cell lymphoma (DLBCL) with negative interim 18FDG PET/CT (iPET) using standardized imaging and reporting protocols. MATERIALS AND METHODS:This prospective study was conducted at PET/CT Section of a JCIA accredited healthcare facility from December 2015 till ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2343-2348]

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Robust Estimation of Breast Cancer Incidence Risk in Presence of Incomplete or Inaccurate Information.

Siva Teja Kakileti, Geetha Manjunath, Andre Dekker, Leonard Wee,

PURPOSE:To evaluate the robustness of multiple machine learning classifiers for breast cancer risk estimation in the presence of incomplete or inaccurate information. DATA AND METHODS:Open data for this study was obtained from the BCSC Data Resource (http://breastscreening.cancer.gov/). We conducted two ablation-type experiments to compare the robustness of different classifiers where ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2307-2313]

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Mutation in Exon2 of BRCA1 Gene in Adult Bengali Bangladeshi Female Patients with Breast Cancer: An Experience from Two Tertiary-Care Hospitals.

Sagana Shahreen Chowdhury, Marjia Khatun, Toufiq Hasan Khan, Anjuman Banu Laila,

BACKGROUND:The occurrence rate of BRCA1 mutations is found to be high in South Asian countries where early onset of breast cancer is common. In Bangladesh, noticeable percentage of patients experience breast cancer in their reproductive ages. The objective of this study was to identify any mutation in exon2 of the ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2265-2270]

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Factors Associated with Participation in Stool Based Colorectal Screening in Brunei Darussalam.

Vui Heng Chong, Lydiana Kadir, Zakaria Kamis, Norhayati Kassim, Muhammad Abdul Mabood Khalil, Jackson Tan, Elvynna Leong, Sok King Ong, Chee Fui Chong,

INTRODUCTION:Colorectal cancers (CRC) continues to increase worldwide and is associated with significant morbidity and mortality. CRC can be prevented through early detection using several modalities. However, like any screening program participation remains suboptimal. This study assessed the factors associated with participation in a stool based CRC screening that was carried ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2231-2236]

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Commentary Regarding the Effect of Long Term Use of Finasteride on Saudi Women.

Wedad Saeed Al-Qahtani, Gadah Albasher, Saad Alkahtani,

In the following commentary, we provided discussions regarding an article bublished by Albasher et al. (2020) concerning the effects of long-term use of finasteride on women. They reported some adverse effects, including abnormal levels in the steroid hormones, irregular menstrual cycles, and heavy menstrual bleeding. Some concerns exist in the ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2197-2198]

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Alangium longiflorum Merr. Leaf Extract Induces Apoptosis in A549 Lung Cancer Cells with Minimal NFκB Transcriptional Activation.

Cielo Mae D Marquez, Jerremiah G Garcia, Jessica G Antonio, Sonia D Jacinto, Michael C Velarde,

The chemotherapy drug doxorubicin (DOX) is effective in treating many types of cancers. However, due to its pro-inflammatory and cardiotoxic side effects, other remedies have also been explored as alternative treatments. The plant Alangium longiflorum was reported to contain cytotoxic activity against cancer cells, but it is unclear whether this ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2453-2461]

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TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values.

Abdulwahab A Abuderman, Ola A Harb, Loay M Gertallah, Nahlah Makki Almansour,

OBJECTIVE:Transcription factor activating protein 2 B (TFAP2 B) is a transcription factor that regulates many steps of embryogenesis, cell growth, apoptosis and recently oncogenesis and cancer progression. AP-1 is a transcription factor that is a downstream molecule of the MAPK signaling pathway. Juxtaposed with zinc finger gene 1 (JAZF1) is ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2415-2421]

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Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma.

Tokuji Ito, Hiroji Shinkawa, Shigekazu Takemura, Shogo Tanaka, Takayoshi Nishioka, Toru Miyazaki, Atsushi Ishihara, Shoji Kubo,

OBJECTIVE:The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS:82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2373-2379]

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Outcome of FOLFOX and Modified DCF Chemotherapy Regimen in Patients with Advanced Gastric Adenocarcinoma.

Mehdi Pourghasemian, Amin Danandeh Mehr, Mohammad Molaei, Afshin Habibzadeh,

OBJECTIVES:Chemotherapy is used as an indispensable therapy for advanced gastric cancer. Different chemotherapy regimens have been used for this purpose. Toxicity due to the Chemotherapy drugs is one limiting factor. In this study we aim to compare the efficacy and toxicity of two regimens FOLFOX (leucoverin, 5-fluorouracil and oxaliplatin) and ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2337-2341]

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Urine Neutrophil Gelatinase-Associated Lipocalin a Possible Diagnostic Marker for Egyptian Hepatocellular Carcinoma Patients.

Eman Abdelsameea, Ali Nada, Nabil Omar, Saleh M Saleh, Mary Naguib, Hosam El-Din M El-Ezawy, Lamiaa Bakry, Maha Elsabaawy,

BACKGROUND:Most effective method for reducing mortality from hepatocellular carcinoma (HCC) is early diagnosis. Despite its lack of adequate sensitivity, ultrasound is considered fundamental for HCC screening. AIM:to evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) as non-invasive marker for HCC diagnosis in Egyptian patients. METHODS:One hundred and twenty patients were divided into ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2259-2264]

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Prognostic Value of CD200 Expression and Soluble CTLA-4 Concentrations in Intermediate and High-Risk Myelodysplastic Syndrome Patients.

Salah Aref, Mohamed El Agdar, Ahmed El Sebaie, Tarek Abouzeid, Mohamed Sabry, Lamiaa Ibrahim,

OBJECTIVE:This study was designed in order to identify the prognostic relevance of CD200 expression and soluble Cytotoxic T-lymphocyte antigen-4 (CTLA-4) levels in myelodysplastic syndrome (MDS) patients. METHODS:The study included 57 MDS (37 intermediate and 20 high risk) patients and 10 controls. For all of included patients; CD200 expression was identified ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2225-2230]

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Predicting Inpatient Length of Stay in Iranian Hospital: Conceptualization and Validation.

Omid Khosravizadeh, Soudabeh Vatankhah, Mina Jahanpour, Negar Yousefzadeh, Saeed Shahsavari, Saeed Yari,

OBJECTIVE:The length of stay is an important indicator of hospital performance and efficiency. Regarding the importance of the length of stay, this study aimed to design a structural model of the inpatients' length of stay in the educational and therapeutic health care facilities of Iran in order to identify the ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2439-2446]

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Promoter Hypermethylation and Expression Changes of BRCA1 Gene in a Cohort of Sporadic Breast Cancer Cases among Pakistani Population.

Taqdees Arif, Natasha Anwar,

OBJECTIVE:The purpose of our study was to determine the frequency of BRCA1 promoter hypermethylation and its association with expression changes of BRCA1 and main morphological features in sporadic breast cancer. METHODS:A retrospective review of cases was performed to select those with specific morphological features suggestive of breast cancer. BRCA1 promoter ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2395-2401]

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Differential Expression of HER2 and SKP2 in Benign and Malignant Colorectal Lesions.

Mona Moussa, Afkar Badawy, Noha Helal, Fatma Hegab, Magdy Youssef, Tarek Aboushousha, Lubna Al Faruok, Dalal Elwy,

BACKGROUND:Colorectal cancer (CRC) is the fourth most common cancer worldwide. Both HER2 and SKP2 have a carcinogenic role in CRC making them attractive targets for tailored treatment. This work aims to correlate HER2 and SKP2 protein expression as well as HER2 gene amplification with clinicopathological parameters aiming at identifying potential ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2357-2366]

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Estimation of Salivary 8-Hydroxydeoxyguanosine (8-OHdG) as a Potential Biomarker in Assessing Progression towards Malignancy: A Case-Control Study.

Arulmozhi Nandakumar, Priyadharsini Nataraj, Amritha James, Rajkumar Krishnan, Mahesh K M,

OBJECTIVE:Squamous Cell Carcinoma is almost always preceded by potentially malignant disorders in the oral cavity before malignant transformation. Characterization of  8-OHdG from the saliva offers a relatively non-invasive, simple and efficient methodology for monitoring oxidative stress in subjects of Premalignant oral disorders (PMOD) and Oral Squamous Cell Carcinoma (OSCC). Hence ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2325-2329]

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Surveillance of Esophageal Cancer in the Republic of Uzbekistan from 2000 to 2018.

Abror Yusupbekov, Mitsuro Kanda, Bekhzod Usmanov, Otabek Tuychiev, Sayfiddin Baymakov, Junichi Sakamoto, Akhrorbek Yusupbekov,

BACKGROUND:Differences in the geographical distributions of esophageal cancer (EC) are associated with environmental influences and genetic risk factors. The inhabitants of the Republic of Uzbekistan are at high-risk for EC; however, detailed epidemiological data regarding the dynamics of EC are not available. METHODS:To address this gap in our knowledge, here ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(8):2281-2285]

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