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Journal Asian Pac J Cancer Prev

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Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.

Tialfi Bergamin De Castro, Gabriela Helena Rodrigues-Fleming, Juliana Garcia De Oliveira-Cucolo, Jéssika Nunes Gomes Da Silva, Fabia Pigatti Silva, Luiz Sérgio Raposo, José Victor Maniglia, Erika Cristina Pavarino, Lidia Maria Rebolho Batista Arantes, Ana Lívia Silva Galbiatti-Dias, Eny Maria Goloni Bertollo,

<h4>Background</h4>Folate is essential for DNA synthesis, repair, and methylation. Polymorphisms in genes associated with folate metabolism may alter these processes and, consequently, modulate cancer development.<h4>Aim</h4>We aimed to assess DNMT3B -149C/T (rs2424913), DNMT3B -283T/C (rs6087990), DNMT3B -579G/T (rs2424909), DHFR 19-pb ins/del (rs70991108), SHMT1 1420C/T (rs1979277), and TYMS 28-bp tandem repeat (rs34743033) ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3751-3759]

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Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia.

Entesar M Tebien, Hiba B Khalil, Jeremy Mills, Abozer Y Elderdery,

<h4>Objectives</h4>The N-Acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in xenobiotic metabolism, which contributes to the detoxification of numerous cancer therapy-induced products. However, the NAT2 genotype/phenotype is not fully understood and few studies have reported its relationship with CML. The aim of this study was to determine whether its ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3711-3717]

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The Lived Experiences of Patients with Head and Neck Cancer during Concurrent Chemoradiation Therapy Care Process.

Sirikorn Kongwattanakul, Pranom Othaganont, Wen Chii Tzeng,

<h4>Purpose</h4>An exploration of concurrent chemoradiation therapy care process from the perspective of patients with head and neck cancer can provide an insight to their lived experience and the difficulties they encounter in daily life towards a deeper understanding of this phenomenon to shape nursing service delivery. The aims of this ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3669-3675]

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Effects of Mefenamic Acid in Pain Control during Loop Electrical Excision Procedure:A Prospective Double-Blind Randomized Control Trial.

Poochit Dabpookhiew, Amornrat Temtanakitpaisan, Chumnan Kietpeerakool, Bandit Chumworathayi, Apiwat Aue-Aungkul, Fa-Ngam Chareonpol, Nampet Jampathong,

<h4>Objective</h4>To investigate the effectiveness of pre-procedural oral mefenamic acid compared with placebo in women undergoing Loop Electrosurgical Excision Procedure (LEEP) with intracervical lidocaine injection.<h4>Study designs</h4>A prospective double-blinded randomized control trial. Materials, Setting, Methods: Women undergoing LEEP for any indications were asked to participate in the study. The participants were randomly ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3633-3638]

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Knowledge of Human Papillomavirus (HPV) and Oropharyngeal Cancer and Acceptability of the HPV Vaccine among Dental Students.

Nada J Farsi, Sarah Al Sharif, Marwah Al Qathmi, Mazin Merdad, Hani Marzouki, Leena Merdad,

<h4>Objectives</h4>To assess knowledge about human papillomavirus (HPV), vaccination, and HPV-related oropharyngeal cancer (OPC) and to evaluate HPV vaccine acceptability among a sample of undergraduate dental students.<h4>Methods</h4>All third- and fourth-year dental students enrolled in any of the dental schools in Jeddah, Saudi Arabia, were invited to participate in this cross-sectional study. ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3595-3603]

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The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.

Hala A Karam, Sahar S Bessa, Ehab M M Ali, Thoria Diab, Tarek M Mohamed,

<h4>Background</h4>The relationship of leptin (LEP) and polymorphism of leptin receptor (LEPR) were studied in patients with hepatocellular carcinoma (HCC) and compared with those with liver cirrhosis to find out the extent of the risk of LEPR on patients with HCC.<h4>Methods</h4>Serum LEP level and LEPR Q223R gene polymorphism were determined in ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3557-3565]

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Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia.

Zafar Iqbal, Muhammad Absar, Amer Mahmood, Aamer Aleem, Mudassar Iqbal, Abid Jameel, Tanveer Akhtar, Sajjad Karim, Mahmood Rasool, Zeenat Mirza, Muhammad Khalid, Afia Muhammad Akram, Muhammad Farooq Sabar, Ahmad M Khalid, Khalid Aljarrah, Janhangir Iqbal, Muhammad Khalid, Ijaz H Shah, Nawaf Alanazi,

<h4>Objective</h4>BCR-ABL fusion oncogene is the hallmark of chronic myeloid leukemia (CML), causing genomic instability which leads to accumulation of mutations in BCR-ABL as well as other genes. BCR-ABL mutations are the cause of tyrosine kinase inhibitors (TKIs) resistance in CML. Recently, compound BCR-ABL mutations have been reported to resist all ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3517-3526]

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Gene-Environment Interaction between Arg72Pro SNP and Selected Environmental Exposures among Brazilian Women Diagnosed with Benign Breast Disease.

Rafaela Soares Senra Da Costa, Rosalina Jorge Koifman, Viviane Ferreira Esteves, Marla Presa Raulino Schilling, Sergio Koifman, Ilce Ferreira Da Silva,

<h4>Background</h4>Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There are no studies evaluating these environmental interactions of the aforementioned SNP within BBD.<h4>Aim</h4>To determine the ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3477-3485]

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Inhibitory Effect of Orally Administered 5-Aminolevulinic Acid on Prostate Carcinogenesis in the FVB-Transgenic Adenocarcinoma of a Mouse Prostate (FVB-TRAMP) Model.

Kenta Onishi, Makito Miyake, Yoshihiro Tatsumi, Shunta Hori, Yasushi Nakai, Sayuri Onishi, Yusuke Iemura, Takuya Owari, Yoshitaka Itami, Kota Iida, Satoshi Anai, Nobumichi Tanaka, Keiji Shimada, Kiyohide Fujimoto,

<h4>Background</h4>5-aminolevulinic acid (5-ALA) is a constituent of mitochondrial electron carriers, heme and cytochrome c, which are crucial for aerobic energy metabolism and cell apoptosis. We investigated the chemopreventive efficacy of 5-ALA against prostate cancer using the FVB-transgenic adenocarcinoma of mouse prostate (FVB-TRAMP) model.<h4>Methods</h4>Samples were collected from 24 FVB-TRAMP mice at ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3743-3749]

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Influence of a 5-bp Indel Polymorphism at Promoter of the GAS5 lncRNA and Risk of Breast Cancer.

Rafat Sharifi, S Shirin Shahangian, Zivar Salehi, Farhad Mashayekhi, Soheila Talesh Sasani, Laleh Mirzanezhad,

Long non-coding RNAs (lncRNAs) are RNA molecules (>200 nucleotides in length) with no protein-coding capacity. Recent studies have demonstrated that lncRNAs involve in the regulation of their target genes at transcriptional, post-transcriptional and epigenetic levels. The aim of this case-control study was to explore whether growth arrest-specific 5 (GAS5) lncRNA ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3705-3710]

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Cytotoxic and Apoptotic Effects of Luffa Cylindrica Leaves Extract against Acute Lymphoblastic Leukemic Stem Cells.

Shimaa Yehia, Ibrahim M Abdel-Salam, Basma M Elgamal, Basma El-Agamy, Germine M Hamdy, Hala M Aldouski,

<h4>Background</h4>Acute lymphoblastic leukemia (ALL) is an aggressive malignancy defined by accumulation of lymphoblasts in the bone marrow. Leukemic stem cells (LSCs) are the major cause of the recurrence and metastasis of ALL. This study aimed to develop an effective anti-cancer agent targeting these LSCs. Luffa Cylindrica (L.C.) leaves extract was ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3661-3668]

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APC Promoter Hypermethylation as a Prognostic Marker in Breast Cancer Patients.

Pensri Saelee, Tanett Pongtheerat,

<h4>Background</h4>Adenomatous polyposis coli (APC) promoter hypermethylation implicated in breast cancer development through Wnt signaling pathway, hypermethylation may result in inactivation of APC expression. This study aimed to investigated whether hypermethylation of APC promoter, the aggressive behavior of breast cancer cells, and correlated them with clinicopathological parameters and survival.<h4>Methods</h4>Sixty-one fresh tissues ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3627-3632]

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Different Breast Cancer Subtypes Show Different Metastatic Patterns: A Study from A Large Public Database.

Yi Guo, Cletus A Arciero, Renjian Jiang, Madhusmita Behera, Limin Peng, Xiaoxian Li,

<h4>Background</h4>Receptor status in breast cancer is known to be related to survival. However, the relationship between breast cancer subtype, preferential sites of metastasis, and overall survival is not clear.<h4>Methods</h4>A total of 414,528 patients from the National Cancer Database (2010-2013) were examined. All patients received surgery and systemic treatments. Breast cancer ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3587-3593]

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Determining Skin Cancer Protective Behaviors in the Light of the Protection Motivation Theory among Sailors in Bandar-Bushehr in the South of Iran.

Ahmad Sotoudeh, Seyed Saeed Mazloomy Mahmoodabad, Ali Akbar Vaezi, Mojtaba Fattahi Ardakani, Reza Sadeghi,

<h4>Background</h4>Skin cancer is among the most prevalent cancers in Iran and worldwide. Due to the nature of work, sailors are constantly exposed to the ultraviolet rays of the sun, which in the long run damages their skin and raises the chances of skin cancer. Thus, the present research aimed to ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3551-3556]

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Comparative Study of Smart Scope® Visual Screening Test with Naked Eye Visual Screening and Pap Test.

Veena Rahatgaonkar, Pooja Uchale, Gauri Oka,

<h4>Background</h4>Cervical cancer is a major contributor to mortality and morbidity in women. Naked eye visual screening (NE test) and Pap test are commonly used for cervical cancer screening.  Both tests have inherent limitations like low sensitivity (Pap test) and subjectivity in interpretation, lack of permanent record and overestimation (NE test). ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3509-3515]

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Involvement of EGFR, ERK-1,2 and AKT-1,2 Activity on Human Glioma Cell Growth.

Amir Alahverdi, Ehsan Arefian, Masoud Soleimani, Jafar Ai, Aaliakbar Yousefi-Ahmadipour, Abouzar Babaei, Md Shahidul Islam, Somayeh Ebrahimi-Barough,

GBM (Glioblastoma multiforme) is the  most prevalent and lethal primary brain tumor. Gene therapy is one of the promising approaches and  involves the delivery of genetic therapeutic molecules for specific antitumour response/activity. miRNAs can regulate the cell biology functions including replication, cell growth, and apoptosis by regulating gene expression. In ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3469-3475]

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The Cytotoxic, Apoptotic Induction, and Cell Cycle Arrest Activities of Solanum nigrum L. Ethanolic Extract on MCF-7 Human Breast Cancer Cell.

Churiyah Churiyah, Sri Ningsih, Firdayani Firdayani,

<h4>Objective</h4>The purpose of this research was to evaluate the cytotoxic, cell cycle arrest, and apoptotic induction activities of the fruit of S. nigrum L. ethanolic-70% extract against MCF-7 human breast cancer cell.<h4>Methods</h4>S. nigrum L. ripe fruit was blended and macerated with ethanol 70% and the filtrate was evaporated. The semisolid ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3735-3741]

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Myricetin Apoptotic Effects on T47D Breast Cancer Cells is a P53-Independent Approach.

Mitra Soleimani, Nayereh Sajedi,

<h4>Objective</h4>Using nutraceuticals in cancer therapy is a strategy contributing with other approaches to promote apoptosis in cancer cells. Myricetin is a polyphenol flavonoid that forms main ingredients of various type of foods and beverages. The inducing properties of myricetin in apoptosis is reported by several investigations. The present study aimed ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3697-3704]

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Increasing Engagement for Breast Cancer Screening and Treatment: The "ICANTREAT" Community of Expertise Initiative.

Thejas R Kathrikolly, Suma Nair, Amudha S Poobalan, Ranjitha S Shetty, Sheela Tripathee, Sara J Mac Lennan,

<h4>Background</h4>Incidence of breast cancer and associated mortality are on the rise globally. Breast cancer incidence in India is on the rise and also accounts for a staggering 50% mortality rate among women. Health illiteracy, socio-economic and cultural barriers in addition to lack of an organized nationwide screening and prevention programme ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3655-3659]

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The Role of CYP2D6 Polymorphisms in Determining Response to Tamoxifen in Metastatic Breast Cancer Patients: Review and Egyptian Experience.

Ibrahim Malash, Osman Mansour, Sabry Shaarawy, Mona S Abdellateif, Anan Omar, Rabab Gaafer, Abdel-Rhaman N Zekri, Ola S Ahmed, Abeer Bahnassy,

<h4>Background</h4>Metastatic breast cancer (MBC) represents a major health problem in Egypt and worldwide. Prognostic and predictive factors for patients with MBC are highly required for better management and improved survival. The aim of this study was to assess the prognostic and predictive value(s) of CYP2D6 polymorphisms in Tamoxifen responders and ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3619-3625]

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Activity and Toxicity of Eleutherine palmifolia (L.) Merr. Extract on BALB/c Mice Colitis-Associated Colon Cancer Model.

Roihatul Mutiah, Riza Ambar Sari, Wahyi Yucha Firsyaradha, Anik Listiyana, Yen Yen Ari Indrawijaya, Abdul Wafi, Arief Suryadinata, Retno Susilowati, Ana Rahmawati,

<h4>Objective</h4>Eleutherine palmifolia (L.) Merr. extract (EPE) containing isoliquiritigenin and oxyresveratrol is believed to be an anticancer agent. This study evaluates colon histopathology, TNF-α, TGF-β, and hepatotoxicity on BALB/c mice colitis-associated colon cancer (CAC) model treated with EPE.<h4>Methods</h4>In vivo study was performed on BALB/c mice CAC model induced by 10 mg/kgBW ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3579-3586]

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Omics Integration Analysis Unravel the Landscape of Driving Mechanisms of Colorectal Cancer.

Fatemeh Nikmanesh, Shamim Sarhadi, Mehdi Dadashpour, Yazdan Asghari, Nosratollah Zarghami,

Colorectal cancer (CRC) is one of the most malignant cancers and results in a substantial rate of morbidity and mortality. Diagnosis of this malignancy in early stages increases the chance of effective treatment. High-throughput data analyses reveal omics signatures and also provide the possibility of developing computational models for early ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3539-3549]

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Accuracy of the Triple Test Versus Colposcopy for the Diagnosis of Premalignant and Malignant Cervical Lesions.

Neda Fatahi Meybodi, Mojgan Karimi-Zarchi, Leila Allahqoli, Leila Sekhavat, George Gitas, Azam Rahmani, Arezoo Fallahi, Babak Hassanlouei, Ibrahim Alkatout,

<h4>Background</h4>Despite the World Health Organization (WHO) recommendations concerning the use of alternative tests for the detection of cervical cancer precursor lesions in low-income countries, the accuracy of these tests is a debated issue. In the present study we compare the diagnostic accuracy of the triple test with that of colposcopy ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3501-3507]

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Myricetin Exerts its Apoptotic Effects on MCF-7 Breast Cancer Cells through Evoking the BRCA1-GADD45 Pathway.

Nayereh Sajedi, Mansour Homayoun, Fakhrossadat Mohammadi, Mitra Soleimani,

<h4>Objective</h4>Myricetin is a polyphenol flavonoid with nutraceutical values which is abundantly found as the main ingredient of various foods and beverages. It has been reported that the function of myricetin is to trigger apoptosis in several types of cancers. The present study intended to investigate the apoptotic effects of myricetin ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3461-3468]

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Incremental Value of Post Diuretic 68Ga-PSMA-11 PET-CT in Characterization of Indeterminate lLesions in Prostate Cancer.

Layla Ghadanfer, Sharjeel Usmani, Fahad Marafi, Fareeda Al-Kandari, Rashid Rasheed,

<h4>Objective</h4>The aim of current study is to evaluate the role of diuretic assisted 68Ga-PSMA PET-CT, on image quality and clinical interpretation of indeterminate/equivocal lesions in pre-Lasix imaging of Prostate cancer.<h4>Materials and methods</h4>Forty-five patients underwent baseline 68Ga-PSMA-11 scan 45-60 minutes post tracer injection followed by post Lasix study after ±15 minutes. ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3719-3723]

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