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Journal Asian Pac J Cancer Prev

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Investigation the Cytotoxicity of 5-AZA on Acute Lymphoblastic Leukemia Cell Line In Vitro and Characterization the Underlying Molecular Mechanisms of Cell Death and Motility.

Maryam Mogadasi, Ali Mohammadi, Behnam Emamgolizadeh, Mohammad Reza Alivand, Dara Rahmanpour, Saeed Solali,

DNA methylation is a reversible biochemical process determinant of gene expression that is frequently observed in acute lymphoblastic leukemia (ALL). This is believed to arise from aberrant DNA methyltransferase activity establishing abnormal levels of DNA methylation in tumor cells. DNA methyltransferase inhibitor, 5-azacytidine (5-AZA), is a clinically used epigenetic drug ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3723-3734]

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ABO Blood Group Differentials on Survival in Hepatocellular Carcinoma Patients Treated with Chemoembolization.

Kittipitch Bannangkoon, Keerati Hongsakul, Pimsiri Sripongpun, Apichat Kaewdech, Naichaya Chamroonkul, Teeravut Tubtawee, Teerha Piratvisuth,

<h4>Background</h4>The association between ABO blood group and the prognosis of hepatocellular carcinoma (HCC) remains unclear. We investigated the impact of ABO blood groups as a prognostic factor in HCC patients treated with transarterial chemoembolization (TACE).<h4>Materials and methods</h4>We revisited records of all HCC patients who underwent TACE between January 2007 and ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3685-3692]

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Evaluation the Presence of SERPINA5 (Exon 3) and FTO rs9939609 Polymorphisms in Papillary Thyroid Cancer Patients.

Seyed Mohammad Moshtaghioun, Nasim Fazel-Yazdi, Mohammad Mandegari, Ahmad Shirinzadeh-Dastgiri, Mohammad Vakili, Habib Fazel-Yazdi,

<h4>Background</h4>A few researches evaluated the association of polymorphisms at SERPINA5 and fat mass and obesity-associated protein (FTO) genes with papillary thyroid cancer (PTC) globally. Here, we examined the presence of genetic variations within coding exon 3 of SERPINA5 gene and FTO rs9939609 polymorphism in Iranian PTC patients.<h4>Methods</h4>A total of 122 ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3641-3646]

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Efficacy of Rivaroxaban Use in Solid Tumour Malignancy: Experience from a Tertiary Care Cancer Centre.

Azmi Nor Mohd Farez Ahmat, Sharifa Ezat Wan Puteh, Suhana Yusak,

<h4>Objective</h4>Cancer-associated venous thromboembolism (CAT) is a common disease or complication which is associated with reduced survival and incurring a substantial health-care cost. Low molecular weight heparin (LMWH) remained the gold standard treatment option available. Direct oral anticoagulants (DOACs) have recently become more popular in the guidelines, they are still few ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3601-3606]

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The Effects of Phyllanthus niruri Linn on Infiltrating Dendritic Cell and Ratio of Neutrophile/Lymphocytes in Chemotherapy of Sprague-Dawley Rats with Colorectal Cancer.

Michael Tendean, Ignatius Riwanto,

<h4>Background</h4>Chemotherapy as part of colorectal cancer management can cause death to immunologically active tumor cell, but also it has immune suppressive effect. Phyllanthus niruri Linn is known to has immunomodulatory effect. This study was intended to prove P. niruri Linn effect on infiltrating dendritic cells and Neutrophil/lymphocyte ratios (NLRs) in ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3561-3568]

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Serum Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Patients with Hepatocellular Carcinoma.

Ekawee Sripariwuth, Setthachai Piwchan, Sutatip Pongcharoen,

<h4>Objective</h4>To evaluate the clinical value of carcinoembryonic-antigen-related cell-adhesion molecule 1 (CEACAM1) in predicting the severity of hepatocellular carcinoma(HCC).<h4>Methods</h4>We evaluated 40 healthy subjects and 40 HCC patients by collecting venous blood for the comparison. Serum CEACAM1 was detected using the Human CEACAM1 ELISA Kit. Other laboratory chemistries were analyzed by standard ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3521-3524]

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Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India.

Gopal Puri, Kush Raj Lohani, Sarada Khadka, Kamal Kataria, Piyush Ranjan, Smriti Hari, Sandeep Mathur, Anita Dhar, Anurag Srivastava,

<h4>Objective</h4>Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive carcinomas with squamous and/or mesenchymal differentiation. Because of their rare occurrence, the information regarding the clinical behaviour of metaplastic carcinomas is limited. The purpose of our study was to delineate the clinicopathological and radiological features, treatment outcomes, prognostic factors, and ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3483-3492]

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The Distribution of M2 Macrophage and Treg in Nasopharyngeal Carcinoma Tumor Tissue and the Correlation with TNM Status and Clinical Stage.

Siti Hamidatul Aliyah, Yustina Nuke Ardiyan, Iffah Mardhiyah, Camelia Herdini, Ery Kus Dwianingsih, Sumartiningsih Aning, Niken Satuti Nur Handayani, Widya Asmara, Jajah Fachiroh, Dewi Kartikawati Paramita,

<h4>Objective</h4>This study aimed to identify the distribution of M2 macrophage and Treg in Nasopharyngeal Carcinoma (NPC) tumor tissue samples. The presence of these two groups of cells was further correlated to clinical stage, tumor size, the lymphatic node involvement, and metastasis.<h4>Methods</h4>The total of 50 formalin-fixed paraffin-embedded (FFPE) NPC tissue samples ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3447-3453]

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Health Warning Label Compliance for Smokeless Tobacco Products and Bidis in Five Indian States.

Sejal Saraf, Kevin Welding, Michael Iacobelli, Joanna E Cohen, Prakash C Gupta, Katherine C Smith,

<h4>Background</h4>The burden of tobacco use In India is very high. To inform users of harm, India has a strong health warning label law that applies to all tobacco products. This study examines the extent of compliance of health warning labels on smokeless tobacco (SLT) and bidi products with the Indian ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(S2):59-64]

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Compliance to Online Retail of Electronic Nicotine Delivery Systems (ENDS) in India before and after the 2018 Ban Order of the Government of India.

Pranay Lal, Ragini Kapoor, Rana Jugdeep Singh,

Since their launch globally in 2012, electronic nicotine delivery systems (ENDS) were positioned as a harm reduction strategy and cessation device but it is yet to be proven to have clinical safety or public health benefits. Instead, recent reports suggest that the tobacco industry targeted youth and sponsored research whose ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(S2):13-17]

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MiR-98-5p/IGF2 Axis Influence Herceptin Sensitivity through IGF1R/HER2 Heterodimer Formation and AKT/mTOR Signal Pathway in HER2 Positive Breast Cancer.

Mingliang Zhang, Zhixiang Li, Xianfu Liu,

<h4>Background and aim</h4>IGF1R and HER2 are both members of the growth factor receptor family which is known to play a different role in breast cancer. However, correlation between IGF1R and HER2 has created a controversial situation that need to be fully delineated in development of Herceptin resistance. The aim of ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3693-3703]

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Chemopreventive Role of Black Tea Extract in Swiss Albino Mice Exposed to Inorganic Arsenic.

Archismaan Ghosh, Sutapa Mukherjee, Madhumita Roy,

<h4>Objective</h4>Chronic exposure to inorganic arsenic (iAs) may cause a number of health problems including skin cancer. Present study is aimed to look into the potential of black tea extract (BTE) to prevent the development of skin carcinoma in Swiss albino mice.<h4>Methods</h4>The study was done on Swiss albino mice, chronically exposed ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3647-3661]

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Opuntiol Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Upregulating Active Caspase 3 Expression.

Ambreen Ashfaque, Farina Hanif, Shabana Usman Simjee, Muhammad Furqan Bari, Shaheen Faizi, Sumbul Zehra, Talat Mirza, Sumreen Begum, Lubna Khan,

<h4>Background</h4>Glioblastoma Multiforme (GBM) is a deadly tumor with poor prognosis. Resistance to apoptosis considered as an important factor in treatment failure. Therefore, identification of new compounds that facilitates apoptosis is crucial. Natural Anti-inflammatory compounds have emerged as potential anti-cancer agents and should be explored for their apoptotic activity against GBM. ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3607-3613]

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Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam.

Duong Dinh Le, Thang Van Vo, Pongdech Sarakarn,

<h4>Background</h4>This study investigated the overall survival (OS) at 1-year, 3-years, and 5-years after colorectal cancer (CRC) diagnosis and examined the prognostic factors of mortality among patients with CRC in Vietnam's central region.<h4>Methods</h4>This ambidirectional cohort study included patients newly diagnosed with CRC at a tertiary hospital in Vietnam's central region between ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3569-3575]

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CD133 Act as an Essential Marker in Ovarian Carcinogenesis.

Dzul Ikram, Rina Masadah, Berti J Nelwan, Andi Alfian Zainuddin, Mahmud Ghaznawie, Syarifuddin Wahid,

<h4>Objective</h4>To analyze the role of cancer stem cells (CSC) in ovarian carcinogenesis through the identification of CD133 expression in the normal ovary (NO), serous cystadenoma (SC), borderline serous tumour (BST), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC).<h4>Materials and methods</h4>A total of 48 tissue samples contain 5 NO, 10 ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3525-3531]

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Determination of β-catenin Expression in Breast Cancer and Its Relationship with Clinicopathologic Parameters.

Salma Sefidbakht, Hanieh Saeedipour, Hiva Saffar, Elham Mirzaian,

<h4>Background</h4>Abnormal activation of the β-catenin signaling pathway is involved in various malignancies, including breast carcinoma.Aberrant expression of β-catenin has been associated with more aggressive behaviors of breast cancer in some previous studies. . In the present study, we intend to evaluate the β-catenin expression in breast cancer specimens and study ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3493-3498]

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Effect of Cognitive Behavioral Therapy on Improving Anxiety, Depression, and Quality of Life in Pre-Diagnosed Lung Cancer Patients.

Yusup Subagio Sutanto, Dede Ibrahim, Debree Septiawan, Aris Sudiyanto, Hendra Kurniawan,

<h4>Objective</h4>To evaluate the effectiveness of cognitive behavior therapy on anxiety, depression, and quality of life of pre-diagnosed lung cancer patients.<h4>Methods</h4>A total of 32 pre-diagnosed subjects were divided into 16 Cognitive behaviour theraphy (CBT)-intervention patients and 16 control subjects. The study subjects were pre-diagnosed lung cancer patients hospitalized at Regional Public ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3455-3460]

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COVID-19 Vaccination and Cancer: Correspondence.

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit,

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3417]

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Raising the Age of Purchase and Use of Tobacco Product in Bangladesh: Benefits and Challenges in Protecting Youth from the Tobacco Epidemic.

Pranay Lal, Arpita Mitra, Amit Yadav, Raju Sarkar, Sven Gudmund Hinderaker, Nirmalya Mukherjee,

<h4>Background</h4>Tobacco use among young and adolescents is the biggest threat to public health globally. In Bangladesh, every one in 14 youth (13-15 years) uses tobacco in some form. While this problem is growing in the country, we estimate the underage initiation of tobacco use and present evidence that policy measures ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(S2):65-70]

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The Implementation Activist: How One Determined Person with a Camera Has Achieved Enforcement of Smoke-Free Laws throughout Thailand.

Naowarut Charoenca, Nipapun Kungskulniti, Vasin Pipattanachat, Siriwan Pitayarangsarit, Stephen Hamann, Jeremiah Mock,

<h4>Background</h4>Smoking and exposure to secondhand smoke are leading causes of disease and premature death in low- and middle-income countries (LMICs), where over 80% of smokers live. Over 152 LMICs, including Thailand, have passed laws designating that indoor and outdoor public spaces should be smoke-free. Throughout LMICs, implementation of laws has ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(S2):19-34]

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Effect of Ionizing Radiation on the Transcript Variants Expression of p21 Gene.

Amir Danyaei, Ali Teimoori, Hashem Khanbabaei, Halime Mansoury Asl,

<h4>Purpose</h4>CDK1A is one of the most important genes that have different key roles in cell lines. This gene has several transcript variants. Investigating of expression of each one actually can be so important because any one of them may have a separate unknown role in cancer cells so can be ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3717-3722]

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Knowledge and Practices of Female Nurses at Primary Health Care Clinics in Gaza Strip-Palestine Regarding Early Detection of Breast Cancer.

Husam H Mansour, Fatma A Shallouf, Ahmed A Najim, Yasser S Alajerami, Khaled M Abushab,

<h4>Background</h4>Breast cancer (BC) is the leading cause of cancer deaths among females in Palestine. Female nurses play a vital role in increasing women's awareness of BC early detection.<h4>Objective</h4>This study aimed to assess the knowledge and practices of female nurses at Primary Health Care Clinics (PHCCs) in the Gaza Strip regarding ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3679-3684]

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Suppression of Cholangiocarcinoma Cell Growth and Proliferation by Atractylodes lancea (Thunb) DC. through ERK-Signaling Cascade.

Pongsakorn Martviset, Luxsana Panrit, Pathanin Chantree, Phunuch Muhamad, Kesara Na-Bangchang,

<h4>Objective</h4>The study aimed to investigate the inhibitory effects of AL on the ERK signaling molecules (ERK, p-ERK, cyclin D, and eIF4B) and the growth and proliferation of CCA cells.<h4>Materials and methods</h4>The viability of the three CCA cell lines CL-6, HuCCT1, and HuH28 was determined using MTT assay. The effect of ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3633-3640]

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Cytogenetic Consequences of Food Industry Workers Occupationally Exposed to Cooking Oil Fumes (COFs).

Manikantan Pappuswamy, Arun Meyyazhagan, Balamuralikrishnan Balasubramanian, Haripriya Kuchi Bhotla, Karthika Pushparaj, Murugesh Eswaran, Vijaya Anand Arumugam, Thirunavukkarasu Periyaswamy, Aditi Chaudhary, Nanditha Rajesh, Rajkumar Sundaram, Karthick Dhandapani,

<h4>Background</h4>Cooking oil fumes (COFs) with smoking habits is a substantial risk that aggravates genetic modifications. The current study was to estimate the biological markers of genetic toxicity counting Micronucleus changes (MN), Chromosome Aberrations (CA) and DNA modifications among COFs exposures and control subjects inherent from South India.<h4>Materials and methods</h4>Present analysis ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3591-3599]

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Prognostic Significance of p27 and Survivin in H. pylori Gastritis and Gastric Cancer.

Noha Said Helal, Zeinab Omran, Tarek Aboushousha, Magdy Youssef, Afkar Badawy, Mohammed A Aboul-Ezz, Mona Moussa,

<h4>Objective</h4>to assess expression of p27 and survivin in chronic gastritis with/without H. pylori ± intestinal metaplasia (IM) and in intestinal-type gastric cancer (IGC).<h4>Materials and methods</h4>Immunohistochemical staining for p27 and survivin on paraffin-embedded sections of 20 chronic gastritis, 20 H. pylori gastritis, 15 H. pylori gastritis with IM, 50 IGC, and ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2021, 22(11):3553-3559]

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